{"id":10660,"date":"2020-09-08T18:01:47","date_gmt":"2020-09-08T09:01:47","guid":{"rendered":"https:\/\/ebn2.arkray.co.jp\/english\/?page_id=10660"},"modified":"2020-11-25T09:30:31","modified_gmt":"2020-11-25T00:30:31","slug":"glycation-stress_02","status":"publish","type":"page","link":"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_02\/","title":{"rendered":"\u7cd6\u5316\u5e94\u6fc0\u6807\u5fd7\u7269\u7684\u68c0\u6d4b\u65b9\u6cd5(1)\u3000\u8840\u7cd6\u3001\u7cd6\u5316\u86cb\u767d\u3001\u7cd6\u5316\u53cd\u5e94\u4e2d\u95f4\u4f53\u7684\u68c0\u6d4b\u3000"},"content":{"rendered":"\n<h2>\u7cd6\u5316\u5e94\u6fc0\u6807\u5fd7\u7269\u7684\u68c0\u6d4b\u65b9\u6cd5(1)\u3000\u8840\u7cd6\u3001\u7cd6\u5316\u86cb\u767d\u3001\u7cd6\u5316\u53cd\u5e94\u4e2d\u95f4\u4f53\u7684\u68c0\u6d4b<\/h2>\n\n\n<p class=\"author\">\u540c\u5fd7\u793e\u5927\u5b66\u5927\u5b66\u9662 \u751f\u547d\u533b\u79d1\u5b66\u7814\u7a76\u79d1 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\u4e3b\u7f16<\/p>\n\n\n<p>\u9ad8\u8840\u7cd6\u3001\u7fb0\u57fa\u5316\u5408\u7269\u7684\u4ea7\u751f\u548c\u84c4\u79ef\uff0c\u5bfc\u81f4\u7cd6\u5316\u5e94\u6fc0\u4ea2\u8fdb\u3002\u7d2b\u5916\u7ebf\u548c\u6c27\u5316\u4f1a\u52a0\u901f\u8fd9\u4e00\u7cfb\u5217\u53cd\u5e94\u3002\u6297\u7cd6\u5316\u4e0d\u5e94\u4ec5\u5e94\u5bf9\u72ed\u4e49\u7684\u7cd6\u5316\u53cd\u5e94\uff0c\u8fd8\u9700\u8981\u5e94\u5bf9\u5e7f\u4e49\u6982\u5ff5\u7684\u6297\u7cd6\u5316\u5e94\u6fc0\u3002\u4f53\u5185\u7684\u8461\u8404\u7cd6\u548c\u86cb\u767d\u8d28\u7684\u975e\u9176\u53cd\u5e94\u8fc7\u7a0b\u4e2d\u4ea7\u751f\u7684\u5404\u79cd\u7269\u8d28\u4e3a\u8bc4\u4ef7\u7cd6\u5316\u5e94\u6fc0\u7684\u6807\u5fd7\u7269\u3002<\/p>\n\n\n\n<p>\u672c\u6587\u5c06\u4ecb\u7ecd\u5173\u4e8e\u8840\u7cd6\u3001HbA1c\u3001\u7cd6\u5316\u767d\u86cb\u767d\u3001\u7cd6\u5316\u53cd\u5e94\u4e2d\u95f4\u4f53\u7684\u68c0\u6d4b\u65b9\u6cd5\u3002<\/p>\n\n\n\n<h3>\u8840\u7cd6\u7684\u68c0\u6d4b<\/h3>\n\n\n<p>\u4ece\u8bc4\u4ef7\u9910\u540e\u9ad8\u8840\u7cd6\u72b6\u6001\u7684\u89c2\u70b9\u6765\u770b\uff0c\u8840\u7cd6\uff08\u8461\u8404\u7cd6\uff09\u662f\u7cd6\u5316\u5e94\u6fc0\u7684\u6807\u5fd7\u7269\u3002\u68c0\u6d4b\u8840\u7cd6\u503c\u6700\u7b80\u5355\u7684\u65b9\u6cd5\u662f\u8840\u7cd6\u81ea\u6211\u68c0\u6d4b\uff08self-monitoring of blood glucose\uff1bSMBG\uff09\u3002\u8840\u7cd6\u7684\u68c0\u6d4b\u539f\u7406\u5305\u62ec\u9176\u7535\u6781\u6cd5\u548c\u9176\u6bd4\u8272\uff08\u6bd4\u8272\u5b9a\u91cf\uff09\u6cd5<sup>(1<\/sup><sup>\uff09<\/sup>\u3002<\/p>\n<p>\u6839\u636e\u6240\u7528\u8461\u8404\u7cd6\u5206\u89e3\u9176\u7684\u4e0d\u540c\uff0c\u9176\u7535\u6781\u6cd5\u53ef\u5206\u4e3a\u8461\u8404\u7cd6\u6c27\u5316\u9176\uff08glucose oxidase\uff1bGOD\uff09\u6cd5\u548c\u8461\u8404\u7cd6\u8131\u6c22\u9176\uff08glucose dehydrogenase\uff1bGDH\uff09\u6cd5<sup>(2<\/sup><sup>\uff09<\/sup>\u3002\u8fd9\u4e24\u79cd\u65b9\u6cd5\u5747\u662f\u5c06\u9176\u5206\u89e3\u8840\u4e2d\u8461\u8404\u7cd6\u65f6\u4ea7\u751f\u7684\u7535\u5b50\u4f20\u9012\u7ed9\u7535\u5b50\u8f7d\u4f53\uff08\u4ecb\u4f53\uff09\u516d\u6c30\u5408\u94c1\u7edc\u5408\u79bb\u5b50\uff08ferricyanide ion\uff09\uff0c\u8f6c\u6362\u4e3a\u516d\u6c30\u5408\u4e9a\u94c1\u7edc\u5408\u79bb\u5b50\uff08ferrocyanide ion\uff09\uff08\u56fe1\uff09\u3002\u4e4b\u540e\uff0c\u7531\u4e8e\u5411\u7535\u6781\u65bd\u52a0\u6052\u5b9a\u7535\u538b\u65f6\u4ea7\u751f\u7684\u7535\u6d41\u4e0e\u8840\u7cd6\u6d53\u5ea6\u5bf9\u5e94\uff0c\u56e0\u6b64\u68c0\u6d4b\u51fa\u7684\u7535\u6d41\u91cf\u5373\u4e3a\u8461\u8404\u7cd6\u6d53\u5ea6\u3002<\/p>\n<p><img loading=\"lazy\" class=\"size-full wp-image-12668 aligncenter\" src=\"http:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/stressmarker-figure01_zh.png\" alt=\"\" width=\"508\" height=\"326\" srcset=\"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/stressmarker-figure01_zh.png 508w, https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/stressmarker-figure01_zh-300x193.png 300w\" sizes=\"(max-width: 508px) 100vw, 508px\" \/><\/p>\n<h6 style=\"text-align: center;\"><strong>\u56fe\uff11\u3000\u9176\u7535\u6781\u6cd5\u7684\u8461\u8404\u7cd6\u4f20\u611f\u5668\u53cd\u5e94\u6d41\u7a0b\u56fe<\/strong><strong>2<br><\/strong>GOD\uff1aglucose oxidase\uff0cGDH\uff1aglucose dehydrogenase<\/h6>\n<p>\u9176\u6bd4\u8272\uff08\u6bd4\u8272\u5b9a\u91cf\uff09\u6cd5\u5305\u542b\u5df1\u7cd6\u6fc0\u9176\uff08hexokinase\uff1bHX\uff09\u6cd5\u548c\u8461\u8404\u7cd6\u6c27\u5316\u9176\/\u8fc7\u6c27\u5316\u7269\u9176\uff08GOD \/ POD\uff09\u6cd5\u3002HX\u6cd5\u662f\u5c06\u8840\u7cd6\u8f6c\u53d8\u4e3a\u8461\u8404\u7cd6-6-\u78f7\u9178\uff08glucose-6-phosphate\uff1bG6P\uff09\u540e\uff0c\u5728\u8461\u8404\u7cd6-6-\u78f7\u9178\u8131\u6c22\u9176\uff08glucose-6-phosphate dehydrogenase\uff1bG6PDH\uff09\u4f5c\u7528\u4e0b\u751f\u6210NADH\u548c\u56db\u5511\uff0c\u4f7f\u9ec4\u9012\u9176\u4f5c\u7528\u4e8e\u8fd9\u4e9b\u7269\u8d28\uff0c\u5bf9\u663e\u84dd\u8272~\u7ea2\u8272\u7b49\u7684\u7532\u74d2\uff08formazan\uff09\u8fdb\u884c\u6bd4\u8272\u5b9a\u91cf\u3002GOD \/ POD\u6cd5\uff0c\u662f\u6307\u5728 GOD \u4f5c\u7528\u4e0b\u7531\u8840\u7cd6\u91cf\u751f\u6210\u8fc7\u6c27\u5316\u6c22\uff0c\u5176\u5728 POD\uff08peroxidase\uff09\u7684\u4f5c\u7528\u4e0b\u4e0e\u53d1\u8272\u56e2\u8fdb\u884c\u53cd\u5e94\uff0c\u751f\u6210\u918c\u7c7b\u8272\u7d20\uff0c\u5bf9\u918c\u7c7b\u8272\u7d20\u8fdb\u884c\u6bd4\u8272\u5b9a\u91cf\u3002<\/p>\n<p>SMBG \u65f6\uff0c\u5982\u679c\u8840\u7ec6\u80de\u6bd4\u5bb9\u503c\u63a5\u8fd1\u53c2\u8003\u8303\u56f4\uff0820\uff5e60\uff05\uff09\uff0c\u5219\u53ef\u4ee5\u51c6\u786e\u68c0\u6d4b\u8840\u7cd6\u3002\u4f46\u662f\uff0c\u8bf8\u5982\u8d2b\u8840\u60a3\u8005\u548c\u900f\u6790\u60a3\u8005\u5728\u8840\u6db2\u6c34\u5e73\u4f4e\u4e8e 20% \u65f6\u5448\u9ad8\u503c\uff0c\u65b0\u751f\u513f\u548c\u6708\u7ecf\u524d\u5973\u6027\u7b49\u56e0\u8d85\u8fc7 55% \u7684\u591a\u8840\u75c7\u8840\u65f6\u5448\u4f4e\u503c\u3002\u6b64\u5916\uff0c\u5bf9\u4e8e GOD \u6cd5\uff0c\u8840\u6db2\u4e2d\u7684\u6eb6\u89e3\u6c27\u5206\u538b\u8d8a\u5927\uff0c\u68c0\u6d4b\u7684\u8840\u7cd6\u6c34\u5e73\u8d8a\u4f4e<sup>(3<\/sup><sup>\uff09<\/sup>\u3002<\/p>\n<p>\u65e5\u672c\u5df2\u6709\u591a\u5bb6\u751f\u4ea7\u5546\u51fa\u552e\u5177\u6709\u591a\u79cd\u7279\u5f81\u7684 SMBG \u4eea\uff0c\u53ef\u4ee5\u6839\u636e\u7528\u9014\u8fdb\u884c\u9009\u62e9<sup>(4<\/sup><sup>\uff09<\/sup>\u3002\u68c0\u6d4b\u65f6\u95f4\u56e0\u4eea\u5668\u800c\u5f02\uff0c\u901a\u5e38\u7ea6\u4e3a 5\uff5e30 \u79d2\u3002\u9700\u8bf4\u660e\u7684\u662f\uff0c\u5728\u65e5\u672c\uff0c\u6839\u636e\u836f\u54c1\u6ce8\u518c\u6cd5\uff0cSMBG \u88ab\u5f52\u7c7b\u4e3a\u9ad8\u5ea6\u53d7\u63a7\u533b\u7597\u5668\u68b0\uff08\u2162\u7c7b\uff09\uff0c\u56e0\u6b64\u5e7f\u544a\u5ba3\u4f20\u53d7\u9650\u3002<\/p>\n\n\n<h3>HbA1c\u3001\u7cd6\u5316\u767d\u86cb\u767d\u7684\u68c0\u6d4b<\/h3>\n\n\n<p>\u7cd6\u5316\u53cd\u5e94\u5206\u4e3a\u524d\u671f\u53cd\u5e94\u3001\u4e2d\u95f4\u4f53\u751f\u6210\u548c\u540e\u671f\u53cd\u5e94\u3002\u524d\u671f\u53cd\u5e94\u4e2d\u751f\u6210\u7684 Amadori \u5316\u5408\u7269\u5305\u62ec HbA1c \u548c\u7cd6\u5316\u767d\u86cb\u767d\uff08glycoalbumin\uff1bGA\uff09\u7b49\u7cd6\u5316\u86cb\u767d\u3002\u8fd9\u4e9b\u5316\u5408\u7269\u4f5c\u4e3a\u53cd\u6620\u8fc7\u53bb\u8840\u7cd6\u72b6\u6001\u7684\u6307\u6807\u7528\u4e8e\u7cd6\u5c3f\u75c5\u7684\u8bc4\u4f30\uff0c\u4e0e\u8840\u7cd6\u503c\u4e00\u6837\uff0c\u662f\u4e00\u79cd\u6709\u6548\u7684\u7cd6\u5316\u5e94\u6fc0\u6807\u5fd7\u7269<sup>(5<\/sup><sup>\uff09<\/sup>\u3002<\/p>\n<p>HbA1c \u662f\u4e00\u79cd\u901a\u8fc7\u7f2c\u6c28\u9178\uff08\u8840\u7ea2\u86cb\u767d A \u7684\u03b2\u94feN\u672b\u7aef\u7684\u6c28\u57fa\u9178\uff09\u4e0e\u8461\u8404\u7cd6\u7684\u7cd6\u5316\u53cd\u5e94\uff0c\u7ecf\u5e2d\u592b\u78b1\u5f62\u6210\u7684\u916e\u80fa\u5316\u5408\u7269\uff08\u7cd6\u5316\u86cb\u767d\uff09\u3002\u7531\u4e8e\u7cd6\u5316\u53cd\u5e94\u53d6\u51b3\u4e8e\u8840\u7cd6\u6d53\u5ea6\uff0c\u56e0\u6b64\u4ea7\u7269 HbA1c \u968f\u9ad8\u8840\u7cd6\u7a0b\u5ea6\uff08\u6d53\u5ea6\u3001\u65f6\u95f4\u7b49\uff09\u7684\u589e\u9ad8\u800c\u589e\u52a0\u3002\u7531\u4e8e\u751f\u6210\u7684 HbA1c \u6301\u7eed\u5b58\u5728 120 \u5929\uff08\u5373\u7ea2\u7ec6\u80de\u7684\u5bff\u547d\uff09\uff0c\u56e0\u6b64\u8840\u4e2d\u603b\u8840\u7ea2\u86cb\u767d\uff08\u8840\u7ea2\u86cb\u767dA\uff09\u6240\u542b HbA1c \u7684\u6bd4\u4f8b\uff08\uff05\uff09\u80fd\u53cd\u6620\u8fc7\u53bb 1\uff5e2 \u4e2a\u6708\u5185\u7684\u8840\u7cd6\u72b6\u6001\u3002<\/p>\n<p>HbA1c \u7684\u68c0\u6d4b\u65b9\u6cd5\u5305\u542b HPLC \u6cd5\u3001\u514d\u75ab\u6cd5\u548c\u9176\u6cd5<sup>(6<\/sup><sup>\uff09<\/sup>\u3002 HPLC \u6cd5\u91c7\u7528\u79bb\u5b50\u4ea4\u6362\u8272\u8c31\u6cd5\u5206\u79bb\u548c\u5206\u6790\u8840\u7ea2\u86cb\u767d\uff0c\u5e76\u6839\u636e HbA1c \u548c\u603b\u8840\u7ea2\u86cb\u767d\u7684\u5cf0\u9762\u79ef\u8ba1\u7b97 HbA1c \u503c\u3002 HPLC \u6cd5\u7684\u4f18\u70b9\u5728\u4e8e\u9664 HbA1c \u5916\uff0c\u8fd8\u53ef\u4ee5\u68c0\u6d4b HbF\uff08\u80ce\u513f\u8840\u7ea2\u86cb\u767d\uff09\u548c\u5f02\u5e38\u8840\u7ea2\u86cb\u767d\u7b49\u3002\u514d\u75ab\u6cd5\u662f\u4f7f\u7528\u4ee5 HbA1c \u4e3a\u6297\u539f\u5236\u5907\u7684\u6297\u4f53\u8fdb\u884c\u68c0\u6d4b\u7684\u4e00\u79cd\u65b9\u6cd5\uff0c\u53ef\u4ee5\u9009\u62e9\u6027\u5730\u4ec5\u68c0\u6d4b HbA1c\u3002\u7531\u4e8e\u4f7f\u7528\u7684\u662f\u9ad8\u5ea6\u7279\u5f02\u6027\u6297\u4f53\uff0c\u56e0\u6b64\u9664 HbA1c \u5916\uff0c\u4e0d\u6613\u53d7\u5176\u4ed6\u8840\u7ea2\u86cb\u767d\u7684\u5f71\u54cd\u3002\u9176\u6cd5\u662f\u901a\u8fc7\u86cb\u767d\u6c34\u89e3\u9176\u91ca\u653e\u8840\u7ea2\u86cb\u767d\u03b2\u94feN\u672b\u7aef\u7684\u7cd6\u5316\u4e8c\u80bd\uff0c\u7136\u540e\u5229\u7528\u5177\u6709\u679c\u7cd6\u57fa\u80bd\u6c27\u5316\u9176\u7684\u6bd4\u8272\u7cfb\u7edf\u8fdb\u884c\u68c0\u6d4b\u3002\u9176\u6cd5\u9002\u5408\u4f7f\u7528\u81ea\u52a8\u5206\u6790\u4eea\u8fdb\u884c\u5927\u91cf\u6837\u672c\u5904\u7406\u3002\u4f46\u662f\uff0c\u514d\u75ab\u6cd5\u548c\u9176\u6cd5\u9700\u8981\u53e6\u884c\u68c0\u6d4b\u603b\u8840\u7ea2\u86cb\u767d\u91cf\uff0c\u4ee5\u8ba1\u7b97 HbA1c \u503c\u3002\u6b64\u5916\uff0cHbA1c \u68c0\u6d4b\u503c\u5df2\u8fdb\u884c\u56fd\u9645\u6807\u51c6\u5316\uff0c\u5e76\u5df2\u5f15\u5165 NGSP\uff08National Glycohemoglobin Standardization Program\uff1b\u56fd\u9645\u6807\u51c6\uff09\u503c<sup>(7<\/sup><sup>\uff09<\/sup>\u3002\u56e0\u6b64\uff0c\u4e0e NGSP \u503c\u76f8\u6bd4\uff0c\u65e5\u672c\u56fd\u5185\u65e5\u5e38\u533b\u7597\u4e00\u76f4\u4ee5\u6765\u4f7f\u7528\u7684 JDS\uff08Japan Diabetes Society\uff1a\u65e5\u672c\u7cd6\u5c3f\u75c5\u5b66\u4f1a\uff09\u503c\u9700\u8981\u5411\u4e0a\u6821\u6b63\u7ea60.4\uff05\u3002<\/p>\n<p>GA \u662f\u8840\u6e05\u767d\u86cb\u767d\u7684\u7cd6\u5316\u86cb\u767d\u3002\u767d\u86cb\u767d\u7684\u534a\u8870\u671f\u7ea6\u4e3a 20 \u5929\uff0c\u56e0\u6b64\u80fd\u53cd\u6620\u8fc7\u53bb 2 \u5468\uff5e1 \u4e2a\u6708\u5185\u7684\u5e73\u5747\u8840\u7cd6\u6c34\u5e73\u3002\u56e0\u6b64\uff0cGA \u8fd8\u53ef\u4ee5\u9002\u7528\u4e8e\u8840\u7cd6\u503c\u6ce2\u52a8\u8f83\u5927\u7684\u7cd6\u5c3f\u75c5\u60a3\u8005\u548c\u6b63\u5728\u63a5\u53d7\u836f\u7269\u6cbb\u7597\uff08\u80f0\u5c9b\u7d20\u7ed9\u836f\u7b49\uff09\u7684\u60a3\u8005\u3002\u6b64\u5916\uff0c\u5728\u767d\u86cb\u767d\u5206\u5b50\u5185\u53d1\u73b0\u4e86 4 \u4e2a\u7cd6\u57fa\u5316\u4f4d\u70b9\uff08Lys-199\u3001281\u3001439\u3001525)<sup> (8<\/sup><sup>\uff09<\/sup>\uff0c\u4e0e HbA1c \u76f8\u6bd4\uff0c\u5176\u7279\u70b9\u662f\u5bf9\u8840\u7cd6\u6c34\u5e73\u7684\u6ce2\u52a8\u4f5c\u51fa\u76f8\u5bf9\u8f83\u5feb\u8f83\u5927\u7684\u54cd\u5e94\u548c\u8f6c\u53d8\u3002<\/p>\n<p>GA \u7684\u68c0\u6d4b\u65b9\u6cd5\u6709 HPLC \u6cd5\u548c\u9176\u6cd5\u3002\u4f46\u662f\uff0c\u76ee\u524d\u5728\u4e34\u5e8a\u68c0\u67e5\u4e2d\u4f7f\u7528\u7684\u68c0\u6d4b\u65b9\u6cd5\u4e3b\u8981\u662f\u9176\u6cd5\u3002\u9176\u6cd5\u662f\u901a\u8fc7\u86cb\u767d\u6c34\u89e3\u9176\u5206\u89e3\u8840\u4e2d\u7684\u767d\u86cb\u767d\u91ca\u653e\u7cd6\u5316\u8d56\u6c28\u9178\uff0c\u7136\u540e\u5229\u7528\u5177\u6709\u916e\u80fa\u6c27\u5316\u9176\u7684\u6bd4\u8272\u7cfb\u7edf\u8fdb\u884c\u68c0\u6d4b\u3002\u6b64\u5916\uff0c\u53e6\u884c\u91c7\u7528\u6eb4\u7532\u915a\u7d2b\uff08bromocresol purple\uff1bBCP\uff09\u6cd5\u7279\u5f02\u6027\u5730\u68c0\u6d4b\u8840\u767d\u86cb\u767d\uff0c\u8ba1\u7b97\u8840\u767d\u86cb\u767d\u6240\u542bGA\u7684\u6bd4\u4f8b\uff08\uff05\uff09\u3002<\/p>\n<p>HbA1c \u548c\u7cd6\u5316\u767d\u86cb\u767d\u540c\u65f6\u4e5f\u662f\u751f\u6d3b\u4e60\u60ef\u75c5\u7b5b\u67e5\u548c\u732e\u8840\u7b49\u65f6\u8840\u6db2\u68c0\u67e5\u7684\u68c0\u6d4b\u9879\u76ee\u4e4b\u4e00\uff0c\u53ef\u4ee5\u5728\u4e34\u5e8a\u68c0\u67e5\u5408\u540c\u673a\u6784\u7b49\u8fdb\u884c\u68c0\u6d4b\u3002<\/p>\n<h3>\u7cd6\u5316\u53cd\u5e94\u4e2d\u95f4\u4f53<\/h3>\n<p>\u8840\u4e2d\u7684\u7cd6\u5316\u53cd\u5e94\u4e2d\u95f4\u4f53\u5305\u62ec 3DG\uff083-deoxyglucosone\uff09\u3001\u4e59\u4e8c\u919b\uff08glyoxal\uff1bGO\uff09\u3001\u7532\u57fa\u4e59\u4e8c\u919b\uff08methylglyoxal\uff1bMG\uff09\u3001\u7518\u6cb9\u919b\uff08glyceraldehyde\uff09\u548c\u4e59\u9187\u919b\uff08glycolaldehyde\uff09\u7b49\uff08\u56fe2\uff09<sup>(9<\/sup><sup>\uff09<\/sup>\u3002<\/p>\n<h6 style=\"text-align: center;\"><span class=\"Apple-converted-space\"> <img loading=\"lazy\" class=\"size-full wp-image-12669 aligncenter\" src=\"http:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/stressmarker-figure02_zh.png\" alt=\"\" width=\"556\" height=\"399\" srcset=\"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/stressmarker-figure02_zh.png 556w, https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/stressmarker-figure02_zh-300x215.png 300w\" sizes=\"(max-width: 556px) 100vw, 556px\" \/><\/span><strong><br \/>\u56fe<\/strong><strong>2<\/strong><strong>\u3000\u7cd6\u5316\u53cd\u5e94\u8def\u7ebf\u56fe<br \/><\/strong>\u6539\u81eaTakeuchi M, <em>et al.<\/em><sup>(8)<\/sup><\/h6>\n<p>3DG\u662f\u7531Amadori\u5316\u5408\u7269\u751f\u6210\u7684\u03b1-\u4e8c\u7fb0\u57fa\u5316\u5408\u7269\uff0c\u5176\u53cd\u5e94\u6d3b\u6027\u6bd4\u8461\u8404\u7cd6\u9ad8 10,000 \u500d\uff0c\u5e76\u53c2\u4e0e AGEs \u7684\u5f62\u6210\u3002\u8840\u6d46\u4e2d 3DG \u6d53\u5ea6\u6bcf\u5347\u9ad8 100 nmol\/L\uff0c\u7cd6\u5c3f\u75c5\u6027\u89c6\u7f51\u819c\u75c5\u53d8\u3001\u80be\u75c5\u7684\u98ce\u9669\u589e\u52a0\u7ea6 2 \u500d\uff08\u56fe3\uff09<sup>(10\uff09<\/sup><\/p>\n<p><img loading=\"lazy\" class=\"aligncenter size-full wp-image-12848\" src=\"http:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/ages-figure03-1.jpg\" alt=\"\" width=\"370\" height=\"377\" srcset=\"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/ages-figure03-1.jpg 370w, https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/ages-figure03-1-294x300.jpg 294w\" sizes=\"(max-width: 370px) 100vw, 370px\" \/><\/p>\n<h6 style=\"text-align: center;\"><strong>\u56fe\uff13\u3000\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u8840<\/strong><strong>3DG<\/strong><strong>\u6d53\u5ea6\u548c\u80be\u75c5\u3001\u89c6\u7f51\u819c\u75c5\u53d8\u7684\u8fdb\u5c55\u7a0b\u5ea6<sup>(10)<\/sup><\/strong><strong><sup><br \/><\/sup><\/strong>Benferroni \/ Dunn \u591a\u91cd\u6bd4\u8f83\u68c0\u9a8c<\/h6>\n<p>GO \u5728\u8461\u8404\u7cd6\u7684\u81ea\u6c27\u5316\u548c\u8102\u8d28\u8fc7\u6c27\u5316\u8fc7\u7a0b\u4e2d\u4ea7\u751f\u3002 MG \u4e5f\u53ef\u5728\u7ec6\u80de\u5185\u7ecf\u7cd6\u9175\u89e3\u7cfb\u7edf\u548c\u591a\u5143\u9187\u9014\u5f84\u4ea7\u751f\u3002\u7cd6\u5316\u53cd\u5e94\u4e2d\u95f4\u4f53\u56e0\u5404\u5316\u5408\u7269\u7684\u7cd6\u5316\u53cd\u5e94\u9014\u5f84\u4e0d\u540c\uff0c\u5176\u6700\u7ec8\u751f\u6210\u7684 AGEs \u7684\u7c7b\u578b\u4e5f\u4e0d\u540c\u3002\u7279\u522b\u662f\u4ee5\u7518\u6cb9\u919b\u4e3a\u4e2d\u95f4\u4f53\u7684 AGEs \u88ab\u79f0\u4e3a toxic-AGEs\uff08TAGE\uff09\uff0c\u4e0e\u7cd6\u5c3f\u75c5\u5e76\u53d1\u75c7\u7684\u53d1\u75c5\u8fdb\u5c55\u5bc6\u5207\u76f8\u5173<sup>(11<\/sup><sup>\uff09<\/sup>\u3002<\/p>\n<p>\u53ef\u4ee5\u91c7\u7528\u9884\u6807\u8bb0 HPLC \u6cd5\u7814\u7a76\u6027\u5730\u68c0\u6d4b 3DG\u3001GO\u3001MG <sup>(12<\/sup><sup>\uff09<\/sup>\u3002\u5728\u5bf9\u8840\u6db2\u6837\u672c\u9664\u86cb\u767d\u540e\uff0c\u6dfb\u52a0 2,3-diaminonaphthalene\uff08DAN\uff09\uff0c\u5c06\u7cd6\u5316\u53cd\u5e94\u4e2d\u95f4\u4f53\u8fdb\u884c\u6c28\u57fa\u8418\u884d\u751f\u5316\u5e76\u7eaf\u5316\uff0c\u7136\u540e\u91c7\u7528\u53cd\u76f8 HPLC \u68c0\u6d4b\u4ee5\u4e0a\u7269\u8d28\u3002\u7d2b\u5916\u5149\uff08\u6ce2\u957f 268 nm\uff09\u6216\u8367\u5149\uff08\u6fc0\u53d1\u6ce2\u957f 271 nm\u3001\u53d1\u5c04\u6ce2\u957f 503 nm\uff09\u53ef\u7528\u4e8e\u68c0\u6d4b\u6c28\u57fa\u8418\u5316\u7684\u7cd6\u5316\u53cd\u5e94\u4e2d\u95f4\u4f53\u3002<\/p>\n<div class=\"ref_css\">\n<h5>References<\/h5>\n<ol class=\"ref_css\">\n<li style=\"list-style-type: none;\">\n<ol>\n<li>Benjamin EM, <i>et al.<\/i> : Clinical Diabetes. 2002; 20; 45-47.<\/li>\n<li>\u7530\u53e3\u5c0a\u4e4b\u3089\uff1a\u5316\u5b66\u3068\u751f\u7269. 2008; 44: 192-197.<\/li>\n<li>\u5185\u6f5f\u5b89\u5b50\uff1aCDEJ News Letter. 2007;15: 7.<\/li>\n<li>\u5c0f\u6797\u54f2\u90ce\uff1a\u7cd6\u5c3f\u75c5\u306e\u6700\u65b0\u6cbb\u7642. 2011; 2: 122-127.<\/li>\n<li>Tahara Y, <i>et al.<\/i> : Diabetes Care. 1995; 18: 440-447.<\/li>\n<li>Weykamp C, <i>et al.<\/i> : J Diabetes Sci Technol 2009; 3: 439-445.<\/li>\n<li>Goodall I. : Clin Biochem Rev. 2005; 26: 5-19.<\/li>\n<li>Ibreg N, <i>et al.<\/i> : J Biol Chem. 1986; 261: 13542-13545.<\/li>\n<li>Takeuchi M, <i>et al.<\/i> : Journal of Alzheimer\u2019s Disease. 2009; 16: 845?858.<\/li>\n<li>Kusunoki H, <i>et al.<\/i> : Diabetes Care. 2003; 26: 1889-1894.<\/li>\n<li>\u7af9\u5185\u6b63\u7fa9\uff1a\u5317\u9678\u5927\u5b66\u7d00\u8981. 2004; 28: 33-48.<\/li>\n<li>Yamada H, <i>et al.<\/i> : J Biol Chem. 1994; 269: 20275-20280.<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/div>\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<h5>\u7cd6\u5316\u5e94\u6fc0\u548c\u6297\u8870\u8001<\/h5>\n\n\n\n<ul><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_01\/\">\u4ec0\u4e48\u662f\u7cd6\u5316\u5e94\u6fc0\uff1f<\/a><\/li><li>\u7cd6\u5316\u5e94\u6fc0\u6807\u5fd7\u7269\u7684\u68c0\u6d4b\u65b9\u6cd5(1)\u3000\u8840\u7cd6\u3001\u7cd6\u5316\u86cb\u767d\u3001\u7cd6\u5316\u53cd\u5e94\u4e2d\u95f4\u4f53\u7684\u68c0\u6d4b<\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_03\">\u7cd6\u5316\u5e94\u6fc0\u6807\u5fd7\u7269\u7684\u68c0\u6d4b\u65b9\u6cd5(2)\u3000AGEs\u7684\u68c0\u6d4b<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_04\">\u7cd6\u5316\u5e94\u6fc0\u6807\u5fd7\u7269\u7684\u68c0\u6d4b\u65b9\u6cd5(3)\u3000\u6297\u7cd6\u5316\u4f5c\u7528\u8bc4\u4ef7<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_05\">\u7cd6\u5316\u5e94\u6fc0\u548cAGEs\u53d7\u4f53<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_06\">\u7cd6\u5316\u5e94\u6fc0\u4e0e\u80be\u75be\u75c5<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_07\/\">\u7cd6\u5316\u5e94\u6fc0\u548c\u76ae\u80a4\u8001\u5316<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_08\">\u7cd6\u5316\u5e94\u6fc0\u4e0e\u52a8\u8109\u786c\u5316<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_09\">\u7cd6\u5316\u5e94\u6fc0\u548c\u7cbe\u795e\u5206\u88c2\u75c7<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_10\">\u7cd6\u5316\u5e94\u6fc0\u4e0e\u809d\u75c5<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_11\">\u7cd6\u5316\u5e94\u6fc0\u4e0e\u4e0d\u5b55\u75c7<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_12\">\u7cd6\u5316\u5e94\u6fc0\u4e0e\u963f\u5c14\u5179\u6d77\u9ed8\u75c7<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_13\/\">\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56(1)\u3000\u8840\u7cd6\u63a7\u5236<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_14\/\">\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56(2)\u3000\u7cd6\u5316\u53cd\u5e94\u7684\u6291\u5236<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_15\/\">\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56(3)\u3000AGEs\u7684\u964d\u89e3\u548c\u6392\u6cc4<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_16\/\">\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56(4)\u3000\u81b3\u98df\u6765\u6e90\u7684AGEs<\/a><\/li>\n<li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_17\/\">\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56\u7684\u8bfe\u9898\u548c\u5c55\u671b<\/a><\/li><\/ul>\n\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<p><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/\">-\u5b66\u672f\u4fe1\u606f top<\/a><br><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/\">-Top<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"\u7cd6\u5316\u5e94\u6fc0\u6807\u5fd7\u7269\u7684\u68c0\u6d4b\u65b9\u6cd5(1)\u3000\u8840\u7cd6\u3001\u7cd6\u5316\u86cb\u767d\u3001\u7cd6\u5316\u53cd\u5e94\u4e2d\u95f4\u4f53\u7684\u68c0\u6d4b \u540c\u5fd7\u793e\u5927\u5b66\u5927\u5b66\u9662 \u751f\u547d\u533b\u79d1\u5b66\u7814\u7a76\u79d1 \u7cd6\u5316\u5e94\u6fc0\u7814\u7a76\u4e2d\u5fc3\u516b\u6728\u96c5\u4e4b \u6559\u6388 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