{"id":10693,"date":"2020-09-09T15:24:19","date_gmt":"2020-09-09T06:24:19","guid":{"rendered":"https:\/\/ebn2.arkray.co.jp\/english\/?page_id=10693"},"modified":"2020-11-24T12:45:58","modified_gmt":"2020-11-24T03:45:58","slug":"glycation-stress_04","status":"publish","type":"page","link":"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_04\/","title":{"rendered":"\u7cd6\u5316\u5e94\u6fc0\u6807\u5fd7\u7269\u7684\u68c0\u6d4b\u65b9\u6cd5(3)\u3000\u6297\u7cd6\u5316\u4f5c\u7528\u8bc4\u4ef7"},"content":{"rendered":"\n<h2>\u7cd6\u5316\u5e94\u6fc0\u6807\u5fd7\u7269\u7684\u68c0\u6d4b\u65b9\u6cd5(3)\u3000\u6297\u7cd6\u5316\u4f5c\u7528\u8bc4\u4ef7<\/h2>\n\n\n\n<p class=\"author\">\u540c\u5fd7\u793e\u5927\u5b66\u5927\u5b66\u9662 \u751f\u547d\u533b\u79d1\u5b66\u7814\u7a76\u79d1 \u7cd6\u5316\u5e94\u6fc0\u7814\u7a76\u4e2d\u5fc3<br>\u516b\u6728\u96c5\u4e4b \u6559\u6388 \u4e3b\u7f16<\/p>\n\n\n\n<p>\u81ea2009\u5e74\u79cb\u5b63\u4ee5\u6765\uff0c\u5728\u5316\u5986\u54c1\/\u7f8e\u5bb9\/\u4fdd\u5065\u98df\u54c1\/\u6297\u8870\u8001\u9886\u57df\uff0c\u4ee5\u201c\u6297\u7cd6\u5316(anti-glycation\uff09\u201d\u4e3a\u5173\u952e\u8bcd\u7684\u539f\u6599\u3001\u4ea7\u54c1\u3001\u751f\u6d3b\u65b9\u5f0f\u7b49\u5f00\u59cb\u53d7\u5230\u4eba\u4eec\u7684\u5173\u6ce8\u3002\u5728\u672c\u6587\u4e2d\uff0c\u6211\u4eec\u5c06\u4ece\u6297\u8870\u8001\u533b\u5b66\u7684\u89d2\u5ea6\uff0c\u7ed3\u5408\u5177\u4f53\u4e8b\u4f8b\u4ecb\u7ecd\u6297\u7cd6\u5316\u4f5c\u7528\u7684\u8bc4\u4ef7\u65b9\u6cd5\u3002<\/p>\n\n\n\n<h3>\u5929\u7136\u4ea7\u7269\u7684<em><em>in vitro<\/em><\/em>\u6297\u7cd6\u5316\u4f5c\u7528\u8bc4\u4ef7<\/h3>\n\n\n<p>\u8bc4\u4ef7\u5929\u7136\u4ea7\u7269\u7684\u6297\u7cd6\u5316\u4f5c\u7528\u65f6\uff0c\u5c06\u4eba\u8840\u6e05\u767d\u86cb\u767d(human serum albumin : HSA)\u7b49\u7684\u6a21\u578b\u86cb\u767d\uff0c\u4e0e\u8461\u8404\u7cd6\u3001\u679c\u7cd6\u7b49\u7684\u8fd8\u539f\u7cd6\u53ca\u8bc4\u4ef7\u539f\u6599(\u53d7\u8bd5\u7269)\u6295\u5165\u78f7\u9178\u7f13\u51b2\u6db2(pH 7.4)\u4e2d\uff0c\u572860\u2103\u4e0b\u53cd\u5e9440\u5c0f\u65f6\u3002\u7136\u540e\uff0c\u5728\u6709\u65e0\u53d7\u8bd5\u7269\u7684\u6761\u4ef6\u4e0b\u6bd4\u8f83\u53cd\u5e94\u6db2\u4e2d\u7684AGEs\u91cf\uff0c\u5e76\u8ba1\u7b97\u51faAGEs\u751f\u6210\u6291\u5236\u7387(\uff05)\u3002\u572860\u2103\u4e0b\u57f9\u517bHSA\u548c\u8461\u8404\u7cd640\u5c0f\u65f6\uff0c\u8fd9\u65f6AGEs \u7684\u751f\u6210\u6c34\u5e73\u76f8\u5f53\u4e8e\u572837\u2103\u4e0b\u57f9\u517b\u7ea660\u5929(\u56fe\uff11)<sup>(1)<\/sup>\u3002<\/p>\n<p><img loading=\"lazy\" class=\"aligncenter wp-image-12692 size-full\" src=\"http:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/stressmarker3-figure01_zh.png\" alt=\"\" width=\"344\" height=\"204\" srcset=\"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/stressmarker3-figure01_zh.png 344w, https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/stressmarker3-figure01_zh-300x178.png 300w\" sizes=\"(max-width: 344px) 100vw, 344px\" \/><\/p>\n<h6 style=\"text-align: center;\"><strong>\u56fe<\/strong><strong>1<\/strong><strong>\u3000\u4eba\u8840\u6e05\u767d\u86cb\u767d<\/strong><strong>\/<\/strong><strong>\u8461\u8404\u7cd6\u53cd\u5e94\u4e2d\u7684<\/strong><strong> AGEs<\/strong><strong>\u751f\u6210\u91cf<br><\/strong>\u4eba\u8840\u6e05\u767d\u86cb\u767d(8mg\/mL)+ 0.05mol\/L\u78f7\u9178\u76d0\u7f13\u51b2\u6db2(pH 7.4)+ \u8461\u8404\u7cd6(0.2mol\/L)\uff0c<br>\u572860\u2103(\u5b9e\u7ebf)\u300137\u2103(\u865a\u7ebf)\u3001\u6fc0\u53d1\u6ce2\u957f370nm\u3001\u53d1\u751f\u6ce2\u957f440nm\u4e0b\u8fdb\u884c\u68c0\u6d4b\uff0cn=3<\/h6>\n<p>\u8bc4\u4ef7\u6297\u7cd6\u5316\u4f5c\u7528\u65f6\uff0c\u68c0\u6d4b\u6765\u81eaAGEs\u7684\u8367\u5149(\u6fc0\u53d1\u6ce2\u957f370 nm\u3001\u53d1\u5c04\u6ce2\u957f 440 nm)\u662f\u6700\u7b80\u5355\u7684\u3002\u8367\u5149\u6027AGEs\u5305\u62ec\u620a\u7cd6\u7d20(pentosidine : \u6fc0\u53d1\u6ce2\u957f(ex) 335 nm \/ \u53d1\u5c04\u6ce2\u957f(em) 385 nm)<sup>(2)<\/sup>\u3001\u4ea4\u8054\u7d20(crossline : ex 379 nm \/ em 463 nm)<sup>(3)<\/sup>\u3001\u5421\u54af\u5421\u5576(pyrropyridine : ex 370 nm \/ em 455 nm)<sup>(4)<\/sup>\u7b49\u3002\u53cd\u5e94\u6eb6\u6db2\u4e2d\u8fd8\u6709CML\u3001\u620a\u7cd6\u7d20\u30013DG\u3001GO\u548cMGO\u751f\u6210\uff0c\u56e0\u6b64\u8fd8\u53ef\u4ee5\u901a\u8fc7\u5404\u79cd\u65b9\u6cd5\u68c0\u6d4b\u8fd9\u4e9b\u4ea7\u7269\u7684\u751f\u6210\u91cf\u3002\u5173\u4e8e\u6297\u7cd6\u5316\u4f5c\u7528\uff0c\u5c06\u6240\u6dfb\u52a0\u53d7\u8bd5\u7269\u7684\u6d53\u5ea6\u8bbe\u5b9a\u4e3a3\u4e2a\u6d53\u5ea6\u53ca\u4ee5\u4e0a\uff0c\u4f7f\u4e4b\u53cd\u5e94\u540e\uff0c\u6839\u636e\u5404\u53cd\u5e94\u6db2\u4e2d\u7684AGEs\u548c\u7cd6\u5316\u53cd\u5e94\u4e2d\u95f4\u4f53\u7684\u68c0\u6d4b\u503c\uff0c\u8ba1\u7b97\u51fa\u53d7\u8bd5\u7269\u768450\uff05\u6291\u5236\u6d53\u5ea6(50\uff05 inhibitory concentration : IC<sub>50<\/sub>)\u3002<\/p>\n<p>\u901a\u5e38\u4f7f\u7528\u7cd6\u5316\u53cd\u5e94\u6291\u5236\u5242\u7684\u6c28\u57fa\u80cd(aminoguanidine)\u4f5c\u4e3aAGEs\u751f\u6210\u6291\u5236\u4f5c\u7528\u7684\u9633\u6027\u5bf9\u7167\u3002\u6c28\u57fa\u80cd\u662f\u4e00\u79cd\u4ee5\u6cbb\u7597\u7cd6\u5c3f\u75c5\u5e76\u53d1\u75c7\u4e3a\u76ee\u7684\u5f00\u53d1\u7684\u836f\u7269\uff0c\u662f\u963b\u65ad\u7cd6\u5316\u53cd\u5e94\u4e2d\u95f4\u4f53\u5206\u5b50\u4e2d\u7684\u7fb0\u57fa\u7684 AGEs\u751f\u6210\u6291\u5236\u5242<sup>(5)<\/sup>\u3002\u4f46\u5728\u65e5\u672c\u56fd\u5185\uff0c\u56e0\u526f\u4f5c\u7528\u7b49\u7684\u5f71\u54cd\u672a\u53d6\u5f97\u836f\u54c1\u8bb8\u53ef\u3002<\/p>\n<p>\u5728<em>in vitro<\/em>\u6297\u7cd6\u5316\u4f5c\u7528\u8bc4\u4ef7\u4f53\u7cfb\u4e2d\uff0c\u901a\u8fc7\u68c0\u6d4b\u5404\u79cdAGEs\u7269\u8d28\uff0c\u53ef\u63a8\u6d4b\u539f\u6599\u5bf9\u590d\u6742\u591a\u8def\u5f84\u7cd6\u5316\u53cd\u5e94\u7684\u4f5c\u7528\u70b9<sup>(6)<\/sup>\u3002\u4e0a\u8ff0\u8bc4\u4ef7\u4f53\u7cfb\u7528\u4e8e\u6df7\u5408\u8349\u836f<sup>(7)<\/sup>\u3001\u7d2b\u83ca\u82b1<sup>(8)<\/sup>\u3001\u7ef4\u6c0f\u718a\u7af9<sup>(9)<\/sup>\u3001\u4fdd\u5065\u8336<sup>(10)<\/sup>\u3001\u6c34\u679c<sup>(11)<\/sup>\u7b49\u591a\u79cd\u539f\u6599\u63d0\u53d6\u7269\u7684\u6297\u7cd6\u5316\u4f5c\u7528\u7b5b\u9009\u3002\u636e\u62a5\u544a\uff0c\u867d\u7136\u8bc4\u4ef7\u65b9\u6cd5\u7565\u6709\u4e0d\u540c\uff0c\u4f46\u8336\u53f6<sup>(12)<\/sup>\u3001\u8349\u836f<sup>(13)<\/sup>\u548c\u9999\u6599<sup>(14)<\/sup>\u3001\u751f\u836f<sup>(15)<\/sup>\u7b49\u5404\u79cd\u690d\u7269\u539f\u6599\u4e5f\u6709\u6297\u7cd6\u5316\u4f5c\u7528\u3002\u63a8\u6d4b\u6297\u7cd6\u5316\u4f5c\u7528\u4e3b\u8981\u662f\u56e0\u4e3a\u690d\u7269\u6240\u542b\u7684\u591a\u915a\u7c7b\u6210\u5206\u3002<\/p>\n<p>\u53e6\u4e00\u65b9\u9762\uff0c\u8fd8\u6709\u62a5\u544a\u6307\u51fa\uff0c\u8336\u6811(<em>Camellia sinensis<\/em>)\u4e2d\u6240\u542b\u513f\u8336\u7d20(catechin)\u3001\u8868\u513f\u8336\u7d20(epicatechin)\u7b49\u7684\u9ec4\u916e\u7c7b(flavonoids)\uff0c\u4ee5\u53ca\u76d0\u80a4\u6728(<em>Rhus javanica<\/em>)\u7684\u766d(\u4e94\u500d\u5b50)\u4e2d\u5bcc\u542b\u7684\u6ca1\u98df\u5b50\u9178(gallic acid)\u7b49\u5177\u6709\u513f\u8336\u915a(catechol)\u9aa8\u67b6\u7684\u5316\u5408\u7269\uff0c\u572810\u03bcmol\/L\u53ca\u4ee5\u4e0b\u7684\u4f4e\u6d53\u5ea6\u65f6\u4f1a\u6291\u5236 CML \u751f\u6210\uff0c\u4f46\u57281 mmol\/L\u53ca\u4ee5\u4e0a\u7684\u9ad8\u6d53\u5ea6\u65f6\u4f1a\u4fc3\u8fdb CML \u751f\u6210(\u56fe\uff12)<sup>(16-17)<\/sup>\u3002\u5929\u7136\u4ea7\u7269\u6240\u542b\u6297\u7cd6\u6210\u5206\u7684\u4f5c\u7528\u673a\u5236\u5c1a\u672a\u5145\u5206\u9610\u660e\uff0c\u56e0\u6b64\u5728\u4f7f\u7528\u65f6\u9700\u8981\u6ce8\u610f\u3002<\/p>\n<p><img loading=\"lazy\" class=\"aligncenter wp-image-12693 size-full\" src=\"http:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/stressmarker3-figure02.jpg\" alt=\"\" width=\"446\" height=\"250\" srcset=\"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/stressmarker3-figure02.jpg 446w, https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/stressmarker3-figure02-300x168.jpg 300w\" sizes=\"(max-width: 446px) 100vw, 446px\" \/><\/p>\n<h6 style=\"text-align: center;\"><strong>\u56fe\uff12\u3000\u5929\u7136\u4ea7\u7269\u7684<\/strong><strong> CML<\/strong><strong>\u751f\u6210\u4f5c\u7528<br><\/strong>HSA 2 mg\/mL + \u6838\u7cd6 5 mg\/mL + \u53d7\u8bd5\u7269 1 mmol\/L\uff0c37\u2103\u4e0b\u57f9\u517b10\u5929<br>CML \uff1a \u5229\u7528ELISA\u6cd5\u68c0\u6d4b\uff0c*P &lt; 0.01 vs control<br>Fujiwara Y, et al (2011)<sup>(7)<\/sup><\/h6>\n\n\n<h3>\u6297\u7cd6\u5316\u539f\u6599\u7684\u4e34\u5e8a\u8bc4\u4ef7<\/h3>\n\n\n<p><em>in vitro<\/em>\u83b7\u5f97\u6297\u7cd6\u5316\u4f5c\u7528\u7684\u8bc4\u4ef7\u65f6\uff0c\u5c06\u901a\u8fc7\u4eba\u4f53\u4e34\u5e8a\u8bd5\u9a8c\u9a8c\u8bc1\u6548\u679c\u3002\u5b9e\u65bd\u4e34\u5e8a\u8bd5\u9a8c\u65f6\u5fc5\u987b\u786e\u4fdd\u5b89\u5168\u6027\u3002\u56e0\u6b64\uff0c\u4f5c\u4e3a\u53d7\u8bd5\u98df\u54c1\u7684\u539f\u6599\u6216\u7269\u8d28\uff0c\u9700\u8981\u901a\u8fc7\u836f\u98df\u5206\u7c7b\u3001\u4eba\u7c7b\u98df\u7528\u7ecf\u9a8c\u8c03\u67e5\u3001\u6025\u6027\u6bd2\u6027\u8bd5\u9a8c(\u5355\u6b21\u7ed9\u836f\u6bd2\u6027\u8bd5\u9a8c)\u3001\u4e9a\u6025\u6027\u6bd2\u6027\u8bd5\u9a8c(\u91cd\u590d\u7ed9\u836f\u6bd2\u6027\u8bd5\u9a8c)\u3001\u56de\u590d\u7a81\u53d8\u8bd5\u9a8c(Ames\u8bd5\u9a8c)\u3001DNA\u4fee\u590d\u8bd5\u9a8c(Rec-assay)\u548c\u519c\u836f\u6b8b\u7559\u8bd5\u9a8c\u7b49\u786e\u8ba4\u5176\u4f5c\u4e3a\u98df\u54c1\u7684\u5b89\u5168\u6027\u3002\u53e6\u5916\uff0c\u5e0c\u671b\u5c3d\u91cf\u67e5\u660e\u4e0e\u4e0b\u5217\u5185\u5bb9\u7684\u76f8\u5173\u6027\uff1a\u6240\u542b\u6210\u5206\u7684\u65e0\u660e\u663e\u635f\u5bb3\u4f5c\u7528\u6c34\u5e73(no observed adverse effect level : NOAEL)\u3001\u672a\u89c2\u5bdf\u5230\u4f5c\u7528\u6c34\u5e73(no observed effect level : NOEL)\u3001\u6bcf\u65e5\u5141\u8bb8\u6444\u5165\u91cf(acceptable daily intake : ADI)\u3001\u6bcf\u65e5\u8010\u53d7\u6444\u5165\u91cf(tolerable daily intake : TDI)\u3002\u8bc4\u4ef7\u8fd9\u4e9b\u7ed3\u679c\u65f6\uff0c\u53c2\u8003\u300a\u4fdd\u5065\u98df\u54c1\u5b89\u5168\u6027\u8bc4\u4ef7\u6307\u5357\u300b<sup>(18)<\/sup>\u300a\u7247\u5242\u3001\u80f6\u56ca\u5242\u7b49\u98df\u54c1\u539f\u6750\u6599\u7684\u5b89\u5168\u6027\u81ea\u67e5\u6307\u5357\u300b<sup>(19)<\/sup>\u300a\u836f\u7269\u5f00\u53d1\u4e2d\u4eba\u4f53\u9996\u6b21\u7ed9\u836f\u8bd5\u9a8c\u7684\u5b89\u5168\u6027\u4fdd\u8bc1\u6307\u5357\u300b<sup>(20)<\/sup>\u300a\u836f\u54c1\u5f00\u53d1\u4e0e\u63d0\u4f9b\u6b63\u786e\u4fe1\u606f\u7684\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u6307\u5357(\u8349\u6848)\u300b<sup>(21)<\/sup>\u7b49\u3002<\/p>\n<p>\u5173\u4e8e\u4eba\u4f53\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5728\u660e\u786e\u4e86\u53d7\u8bd5\u98df\u54c1\u5b89\u5168\u6027\u7684\u57fa\u7840\u4e0a\uff0c\u5236\u5b9a\u4eba\u4f53\u4e34\u5e8a\u8bd5\u9a8c\u534f\u8bae\uff0c\u5e76\u5728\u83b7\u5f97\u4eba\u4f53\u8bd5\u9a8c\u4f26\u7406\u59d4\u5458\u4f1a\u7684\u6279\u51c6\u540e\uff0c\u62db\u52df\u53d7\u8bd5\u8005\uff0c\u53d6\u5f97\u53d7\u8bd5\u8005\u7684\u77e5\u60c5\u540c\u610f\u4e66\uff0c\u7136\u540e\u8fdb\u884c\u8bd5\u9a8c\u3002\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6210\u8d25\u4e0d\u4ec5\u53d6\u51b3\u4e8e\u53d7\u8bd5\u98df\u54c1\u6297\u7cd6\u5316\u4f5c\u7528\u7684\u5f3a\u5f31\uff0c\u8fd8\u53d7\u5230\u53d7\u8bd5\u8005\u5065\u5eb7\u72b6\u51b5\u7684\u5f71\u54cd\u3002\u8bd5\u9a8c\u524d\uff0cAGEs \u84c4\u79ef\u91cf\u5c11\u4e14\u7cd6\u5316\u5e94\u6fc0\u4f4e\u7684\u53d7\u8bd5\u8005\uff0c\u56e0\u6444\u5165\u6297\u7cd6\u5316\u4f5c\u7528\u539f\u6599\u6216\u7269\u8d28\u800c\u4ea7\u751f\u7684\u53d8\u5316\u8f83\u5c11\u3002\u4ee5\u5065\u5eb7\u4eba\u4e3a\u5bf9\u8c61\u8fdb\u884c\u8bd5\u9a8c\u65f6\uff0c\u53d7\u8bd5\u8005\u5e94\u9009\u62e9\u65e0\u7cd6\u4ee3\u8c22\u5f02\u5e38\u7b49\u75be\u75c5\u3001\u9910\u540e\u8840\u7cd6\u503c\u9ad8\u3001\u76ae\u80a4\u4e2dAGEs\u84c4\u79ef\u91cf\u591a\u7684\u4eba\uff0c\u6362\u8a00\u4e4b\uff0c\u4ee5\u7cd6\u5316\u5e94\u6fc0\u6c34\u5e73\u9ad8\u7684\u4eba\u4e3a\u5bf9\u8c61\u65f6\uff0c\u5bb9\u6613\u51fa\u73b0\u6297\u7cd6\u5316\u4f5c\u7528\u7684\u5f71\u54cd\u3002<\/p>\n<h3><strong>\u6297\u7cd6\u5316\u539f\u6599\u201cAG Herb MIX<sup>TM<\/sup>\u201d\u7684\u7814\u53d1\u4e8b\u4f8b<\/strong><\/h3>\n\n\n<p>\u6211\u4eec\u5728\u6709\u4e30\u5bcc\u98df\u7528\u7ecf\u9a8c\u7684\u8349\u836f\uff0c\u4e14\u5728\u690d\u7269\u5206\u7c7b\u5b66\u4e0a\u5c5e\u4e0d\u540c\u7ec4\u7684\u9c7c\u8165\u8349(<em>Houttuynia cordata<\/em>)\u3001\u897f\u6d0b\u5c71\u6942(<em>Crataegus laevigata<\/em>)\u3001\u7f57\u9a6c\u6d0b\u7518\u83ca(<em>Chamaemelum nobile<\/em>)\u3001\u8461\u8404(<em>Vitis vinifera<\/em>)\u63d0\u53d6\u7269\u4e2d\u53d1\u73b0\u4e86\u5bf9HSA\u7684<em>in vitro<\/em>\u6297\u7cd6\u5316\u4f5c\u7528(\u8367\u5149\u6027AGEs\u751f\u6210\u6291\u5236\u4f5c\u7528)\uff0c\u5e76\u4f5c\u4e3a\u6297\u7cd6\u5316\u98df\u54c1\u539f\u6599\u201cAG Herb MIX\u201d\u5236\u6210\u4ea7\u54c1<sup>(22)<\/sup>\u3002\u4e0b\u6587\u5c06\u4ee5\u8be5\u539f\u6599\u5f00\u53d1\u4e3a\u4f8b\uff0c\u4ecb\u7ecd\u6297\u7cd6\u5316\u539f\u6599\u7684\u5b89\u5168\u6027\/\u529f\u80fd\u6027\u8bc4\u4ef7\u6848\u4f8b\u3002<\/p>\n\n\n\n<p>\u9996\u5148\uff0c\u53d1\u73b0\u901a\u8fc7<em>in vitro<\/em>\u6297\u7cd6\u5316\u4f5c\u7528\u7b5b\u9009\u83b7\u5f97\u7684\u4e0a\u8ff04\u79cd\u690d\u7269\u63d0\u53d6\u7269\u5bf93DG\u3001\u620a\u7cd6\u7d20\u3001 CML \u7684\u751f\u6210\u6291\u5236\u4f5c\u7528\u4e0d\u540c\u3002\u4f46\u901a\u8fc7\u6df7\u5408\u63d0\u53d6\u8fd9\u4e9b\u6210\u5206\uff0c\u53ef\u5236\u6210\u6291\u5236\u5404\u79cdAGEs\u751f\u6210\u7684\u6df7\u5408\u8349\u836f\u63d0\u53d6\u7269\u3002\u53e6\u5916\uff0c\u8fd8\u4e86\u89e3\u5230\u6df7\u5408\u8349\u836f\u63d0\u53d6\u7269\u5bf9\u725b\u76ae\u6e90\u2160\u578b\u80f6\u539f\u4e5f\u5177\u6709\u6297\u7cd6\u5316\u4f5c\u7528\uff0c\u5e76\u80fd\u540c\u65f6\u6291\u5236 CMA \u7684\u751f\u6210\uff0cCMA \u662f\u4e00\u79cd\u80f6\u539f\u7279\u5f02\u6027\u751f\u6210\u7684AGEs\u3002\u968f\u540e\uff0c\u5bf9\u94fe\u8132\u4f50\u83cc\u7d20\u8bf1\u5bfc\u7cd6\u5c3f\u75c5\u5927\u9f20\u8fdb\u884c\u6df7\u5408\u8349\u836f\u63d0\u53d6\u7269\u7ed9\u836f\u8bd5\u9a8c\uff0c\u786e\u8ba4\u5176\u4e0e\u6c28\u57fa\u80cd\u5177\u6709\u540c\u7b49\u7684\u6297\u7cd6\u5316\u4f5c\u7528<sup>(23)<\/sup>\u3002<\/p>\n\n\n\n<p>\u7136\u540e\uff0c\u5c06\u6df7\u5408\u8349\u836f\u63d0\u53d6\u7269\u4f5c\u4e3aAG Herb MIX\u5236\u6210\u4ea7\u54c1\uff0c\u901a\u8fc7\u98df\u7528\u7ecf\u9a8c\u8c03\u67e5\u3001\u6025\u6027\u6bd2\u6027\u8bd5\u9a8c\u3001DNA\u4fee\u590d\u8bd5\u9a8c\u3001\u519c\u836f\u6b8b\u7559\u8bd5\u9a8c\u7b49\u786e\u8ba4\u5176\u98df\u54c1\u5b89\u5168\u6027\uff0c\u540c\u65f6\u53d6\u5f97\u4eba\u4f53\u8bd5\u9a8c\u4f26\u7406\u59d4\u5458\u4f1a\u7684\u6279\u51c6\u4ee5\u53ca\u53d7\u8bd5\u8005\u7684\u77e5\u60c5\u540c\u610f\uff0c\u4ee5\u5065\u5eb7\u4eba\u4e3a\u5bf9\u8c61\u8fdb\u884c\u8fde\u7eed2\u5468\u6444\u5165AG Herb MIX 3,000 mg\/\u65e5(\u6444\u5165\u63a8\u8350\u91cf\u76845\u500d)\u7684\u8bd5\u9a8c\u3002\u5176\u7ed3\u679c\u786e\u8ba4\u4e86\uff0c\u6444\u5165AG Herb MIX\u7ed9\u809d\u529f\u80fd\u3001\u80be\u529f\u80fd\u3001\u7cd6\u53ca\u8102\u8d28\u4ee3\u8c22\u529f\u80fd\u3001\u4eba\u4f53\u836f\u7269\u4ee3\u8c22\u529f\u80fd\u7b49\u5e26\u6765\u4e0d\u826f\u5f71\u54cd\u7684\u53ef\u80fd\u6027\u8f83\u4f4e\u3002<\/p>\n\n\n\n<p>\u518d\u91c7\u7528\u76f8\u540c\u5b9e\u65bd\u6b65\u9aa4\uff0c\u4ee5\u7cd6\u5c3f\u75c5\u9ad8\u5371\u4eba\u7fa4(\u968f\u6d4b\u8840\u7cd6\u503c\u4e3a 110\uff5e199 mg\/dL \u4e14 HbA1c(JDS\u503c)\u4e3a 5.5\uff5e6.5\uff05)\u4e3a\u5bf9\u8c61\uff0c\u4f7f\u4e4b\u6444\u5165 AG Herb MIX 3,000 mg\/\u65e5\u6216\u7b49\u91cf\u5b89\u6170\u5242\u98df\u54c1\uff0c\u8fdb\u884c\u4e86\u53cc\u76f2\u5e73\u884c\u7ec4\u95f4\u5bf9\u7167\u8bd5\u9a8c<sup>(24)<\/sup>\u3002\u5176\u7ed3\u679c\u8bc1\u5b9e\u4e86\uff0c\u5728\u6444\u5165\u5f00\u59cb 8 \u5468\u540e\u8840\u7cd6\u503c\u4e3a 110 mg\/dL\u53ca\u4ee5\u4e0a\u7684\u4e9a\u7ec4\u5206\u6790\u4e2d\uff0c\u4e0e\u5b89\u6170\u5242\u98df\u54c1\u6444\u5165\u7ec4\u76f8\u6bd4\uff0c\u53d7\u8bd5\u98df\u54c1\u6444\u5165\u7ec4\u7684\u8840\u4e2d 3DG \u589e\u52a0\u6709\u88ab\u6291\u5236\u503e\u5411(p = 0.094)\uff0c\u5728 HbA1c 5.9\uff05\u53ca\u4ee5\u4e0a\u7684\u4e9a\u7ec4\u5206\u6790\u4e2d\uff0c\u8be5\u7ec4\u7684CML \u663e\u8457\u6027\u964d\u4f4e(p = 0.048)(\u56fe3)\u3002<\/p>\n\n\n<p><img loading=\"lazy\" class=\"size-full wp-image-12694 aligncenter\" src=\"http:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/stressmarker3-figure03.jpg\" alt=\"\" width=\"481\" height=\"230\" srcset=\"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/stressmarker3-figure03.jpg 481w, https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/stressmarker3-figure03-300x143.jpg 300w\" sizes=\"(max-width: 481px) 100vw, 481px\" \/><\/p>\n<h6 style=\"text-align: center;\"><strong>\u56fe<\/strong><strong>3 <\/strong><strong>\u6444\u5165\u6df7\u5408\u8349\u836f\u63d0\u53d6\u7269\u524d\u540e\u7684\u8840\u4e2d\u7cd6\u5316\u53cd\u5e94\u4ea7\u7269\u542b\u91cf\u53d8\u5316<br><\/strong>\u7cd6\u5c3f\u75c5\u9ad8\u5371\u4eba\u7fa4(\u968f\u6d4b\u8840\u7cd6\u503c\u4e3a110\uff5e199 mg\/dL \u4e14 HbA1c(JDS\u503c)<br>\u4e3a 5.5\uff5e6.5\uff05\u8005\uff09\u4e2d\u8840\u7cd6\u503c\u4e3a 110 mg\/dL\u53ca\u4ee5\u4e0a\u7684\u4e9a\u7ec4\u5206\u6790\u7ed3\u679c<br>Control : \u5b89\u6170\u5242\u98df\u54c1\u6444\u5165\u7ec4(N=8)\uff0cTest : \u53d7\u8bd5\u98df\u54c1\u6444\u5165\u7ec4(N=11)\uff0c\u914d\u5bf9t\u68c0\u9a8c<\/h6>\n\n\n<p>\u53e6\u5916\uff0c\u5728\u91c7\u7528\u540c\u6837\u7684\u5b9e\u65bd\u6b65\u9aa4\uff0c\u4ee52\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005(HbA1c(JDS\u503c): 5.7\uff5e9.2\uff05)\u4e3a\u5bf9\u8c61\u8fdb\u884c\u7684\u8fde\u7eed12\u5468\u6444\u5165 AG Herb MIX 600 mg\/\u65e5\u7684\u8bd5\u9a8c<sup>(25)<\/sup>\u4e2d\uff0c\u8840\u4e2d 3DG \u5728\u5f00\u59cb\u6444\u51658\u300112\u5468\u540e\u663e\u8457\u6027\u964d\u4f4e(p &lt; 0.001)\u3002\u53e6\u5916\uff0c\u8840\u4e2dCML \u572812\u5468\u540e\u4e5f\u663e\u8457\u6027\u964d\u4f4e(p &lt; 0.001)\u3002\u5173\u4e8e\u76ae\u80a4\u5f39\u6027\uff0c\u6444\u5165\u5f00\u59cb8\u5468\u540e(p = 0.001)\u300112\u5468\u540e(p &lt; 0.001)\uff0c\u76ae\u80a4\u5f39\u6027\u6307\u6570(R2 : Ua\/Uf)\u663e\u8457\u6027\u6539\u5584(\u56fe\uff14)\u3002<\/p>\n\n\n<h6 style=\"text-align: center;\"><img loading=\"lazy\" class=\"wp-image-12695 size-full aligncenter\" src=\"http:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/stressmarker3-figure04_zh.png\" alt=\"\" width=\"311\" height=\"220\" srcset=\"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/stressmarker3-figure04_zh.png 311w, https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/stressmarker3-figure04_zh-300x212.png 300w\" sizes=\"(max-width: 311px) 100vw, 311px\" \/><\/h6>\n<h6 style=\"text-align: center;\"><strong>\u56fe<\/strong><strong>4 <\/strong><strong>\u5f00\u59cb\u6444\u5165\u6df7\u5408\u8349\u836f\u63d0\u53d6\u7269\u540e\u7684\u76ae\u80a4\u5f39\u6027\u53d8\u5316<br><\/strong>2\u578b\u7cd6\u5c3f\u75c5\u60a3\u80057\u540d(HbA1c(JDS\u503c): 5.7\uff5e9.2\uff05)<br>R2:\u4f7f\u7528\u7cbe\u5bc6\u4eea\u5668\u7684\u68c0\u6d4b\u503c\u5206\u6790\u53c2\u6570\uff0cDunnett\u591a\u91cd\u6bd4\u8f83\u68c0\u9a8c<\/h6>\n\n\n<p>\u7136\u540e\uff0c\u6309\u7167\u76f8\u540c\u7684\u5b9e\u65bd\u6b65\u9aa4\uff0c\u4ee5\u7edd\u7ecf\u540e\u7cd6\u5316\u5e94\u6fc0\u5f3a\u7684\u5973\u6027(\u6444\u5165\u7c73\u996d60\u5206\u949f\u540e\u7684\u8840\u7cd6\u503c\u548c\u76ae\u80a4AGEs\u84c4\u79ef\u91cf\u9ad8)\u4e3a\u5bf9\u8c61\uff0c\u8fdb\u884c\u4e86\u8fde\u7eed\u6444\u51658\u5468\u542b\u96be\u6d88\u5316\u6027\u7cca\u7cbe 5 g\/\u65e5 \u548c AG Herb MIX 100 mg\/\u65e5\u7684\u918b\u996e\u6599(\u53d7\u8bd5\u98df\u54c1)\u7684\u53cc\u76f2\u5e73\u884c\u5bf9\u7167\u8bd5\u9a8c<sup>(26)<\/sup>\u3002\u7ed3\u679c\u663e\u793a\uff0c\u5728\u6444\u5165200g\u7c73\u996d60\u5206\u949f\u540e\u8840\u7cd6\u503c\u4e3a150 mg\/dL\u53ca\u4ee5\u4e0a\u7684\u4e9a\u7ec4\u5206\u6790\u4e2d\uff0c\u53d7\u8bd5\u98df\u54c1\u6444\u5165\u7ec4\u91c7\u7528\u80f6\u5e26\u7c98\u8d34\u6cd5\u68c0\u6d4b\u7684\u76ae\u80a4\u89d2\u8d28\u5c42CML\u91cf(\u53d8\u5316\u6bd4)\u5728\u6444\u5165\u5f00\u59cb8\u5468\u540e\u663e\u8457\u6027\u964d\u4f4e(p=0.025)(\u56fe\uff15)\u3002<\/p>\n\n\n<p><img loading=\"lazy\" class=\"aligncenter wp-image-12948 size-full\" src=\"http:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/stressmarker3-figure05_zh.png\" alt=\"\" width=\"349\" height=\"250\" srcset=\"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/stressmarker3-figure05_zh.png 349w, https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/stressmarker3-figure05_zh-300x215.png 300w\" sizes=\"(max-width: 349px) 100vw, 349px\" \/><\/p>\n<h6 style=\"text-align: center;\"><strong>\u56fe<\/strong><strong>5 <\/strong><strong>\u6444\u5165\u542b\u6709\u6df7\u5408\u8349\u836f\u63d0\u53d6\u7269\u7684\u918b\u996e\u6599\u540e\uff0c\u89d2\u8d28\u5c42<\/strong><strong>CML<\/strong><strong>\u91cf\u7684\u53d8\u5316<br \/><\/strong>\u6444\u5165200g\u7c73\u996d60\u5206\u949f\u540e\u8840\u7cd6\u503c\u4e3a150mg\/dL\u53ca\u4ee5\u4e0a\u7684\u4e9a\u7ec4\u5206\u6790\u7ed3\u679c\u914d\u5bf9t\u68c0\u9a8c<\/h6>\n<p>\u5982\u4e0a\u6240\u8ff0\uff0c\u4e34\u5e8a\u8bc4\u4ef7\u5fc5\u987b\u5728\u5145\u5206\u786e\u8ba4\u6297\u7cd6\u5316\u4f5c\u7528\u7684\u539f\u6599\u7684\u5b89\u5168\u6027\u540e\uff0c\u6839\u636e<em>in vitro<\/em>\u8bd5\u9a8c\u7ed3\u679c\u548c\u9884\u671f\u4f5c\u7528\uff0c\u8bbe\u5b9a\u5f85\u68c0\u6d4b\u8bc4\u4ef7\u7684\u7cd6\u5316\u5e94\u6fc0\u6807\u5fd7\u7269\uff0c\u62df\u5b9a\u8bd5\u9a8c\u65b9\u6848\uff0c\u5e76\u5728\u83b7\u5f97\u4eba\u4f53\u8bd5\u9a8c\u4f26\u7406\u59d4\u5458\u4f1a\u7684\u6279\u51c6\u540e\u6267\u884c\u3002<\/p>\n\n\n<h3>\u6297\u7cd6\u5316\u4f5c\u7528\u6570\u636e\u7684\u8868\u793a\u65b9\u6cd5<\/h3>\n\n\n\n<p><em>in vitro<\/em>\u6297\u7cd6\u5316\u4f5c\u7528\u901a\u5e38\u4ee5\u53d7\u8bd5\u7269\u7684IC<sub>50<\/sub>\u8868\u793a\uff0c\u5e76\u901a\u8fc7\u4e0e\u4f5c\u4e3a\u9633\u6027\u5bf9\u8c61\u7684\u6c28\u57fa\u80cd\u4f5c\u7528\u6bd4\u8f83\u6765\u8fdb\u884c\u8bc4\u4ef7\u3002\u4f46\u662f\uff0cIC<sub>50<\/sub>\u4e5f\u4f1a\u56e0<em>in vitro<\/em>\u6297\u7cd6\u5316\u4f5c\u7528\u8bc4\u4ef7\u4f53\u7cfb\u4e2d\u4f7f\u7528\u7684\u86cb\u767d\u548c\u7cd6\u7684\u79cd\u7c7b\u53ca\u6d53\u5ea6\u3001\u53cd\u5e94\u6e29\u5ea6\u548c\u65f6\u95f4\u3001\u5f85\u6d4bAGEs\u7684\u79cd\u7c7b\u4e0d\u540c\u800c\u6539\u53d8\u3002\u56e0\u6b64\uff0c\u4e3a\u4e0e\u5176\u4ed6\u6587\u732e\u6570\u636e\u8fdb\u884c\u6bd4\u8f83\uff0c\u9700\u8981\u4f7f\u68c0\u6d4b\u6761\u4ef6\u4e00\u81f4\u3002\u5e76\u4e14\uff0c\u591a\u6570\u60c5\u51b5\u4e0b\u5929\u7136\u4ea7\u7269\u4e2d\u7684\u6d3b\u6027\u6210\u5206\u65e0\u6cd5\u8fdb\u884c\u7269\u8d28\u9274\u5b9a\uff0c\u56e0\u6b64\u53ef\u57fa\u4e8e\u63d0\u53d6\u6db2\u7684\u56fa\u4f53\u542b\u91cf(\u84b8\u53d1\u6b8b\u6e23)\u548c\u603b\u591a\u915a\u91cf\u7b49\uff0c\u8ba1\u7b97\u51faIC<sub>50<\/sub>\u3002\u6b64\u5916\uff0c\u7cd6\u5316\u53cd\u5e94\u8def\u5f84\u6709\u591a\u79cd\uff0c\u751f\u6210\u7684 AGEs \u4e5f\u6709\u5f88\u591a\u79cd<sup>(6)<\/sup>\u3002\u56e0\u6b64\uff0c\u6297\u7cd6\u5316\u4f5c\u7528\u7684\u8bc4\u4ef7\u6570\u636e\u8fd8\u9700\u8981\u53e6\u884c\u9a8c\u8bc1\u539f\u6599\u548c\u7269\u8d28\u53ef\u80fd\u4f5c\u7528\u4e8e\u54ea\u4e2a AGEs\u751f\u6210\u9014\u5f84\u3002<\/p>\n\n\n\n<p>\u6700\u7ec8\uff0c\u6297\u7cd6\u5316\u4f5c\u7528\u7684\u6709\u7528\u6027\u5728\u4eba\u4f53\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5f97\u4ee5\u786e\u8ba4\u3002\u6b64\u65f6\uff0c\u53ef\u57fa\u4e8e\u5728\u6444\u5165\u539f\u6599\u548c\u7269\u8d28\u7684<em>in vitro<\/em>\u6297\u7cd6\u5316\u4f5c\u7528\u8bc4\u4ef7\u4e2d\u5f97\u5230\u7684\u4f5c\u7528\u70b9\uff0c\u9009\u62e9\u8981\u8bc4\u4ef7\u7684\u7cd6\u5316\u5e94\u6fc0\u6807\u5fd7\u7269\u3002\u6839\u636e\u5728\u7f8e\u56fd\u5b9e\u65bd\u7684\u6c28\u57fa\u80cd\u7684\u5927\u89c4\u6a21\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\uff0c\u4ee5\u53ca\u5df2\u5236\u6210\u4ea7\u54c1\u7684\u6297\u7cd6\u5316\u539f\u6599\u7684\u4e34\u5e8a\u8bc4\u4ef7\u6570\u636e\u7b49\uff0c\u6765\u8bbe\u5b9a\u6444\u5165\u91cf\u3002\u7ed3\u679c\u8868\u660e\uff0c\u5f53\u8fde\u7eed\u6444\u51656\uff5e36\u4e2a\u6708\u6c28\u57fa\u80cd\uff0c\u6bcf\u65e5150mg\u6216 300 mg\u65f6\uff0c\u53ef\u6539\u5584\u7cd6\u5c3f\u75c5\u6027\u80be\u75c5<sup>(5)<\/sup>\u3002\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u4e0d\u4ec5\u663e\u793a\u51fa\u8840\u4e2d\u548c\u76ae\u80a4\u4e2dAGEs \u7684\u751f\u6210\u548c\u84c4\u79ef\u6291\u5236\u4f5c\u7528\uff0c\u800c\u4e14\u5728\u76d1\u6d4b\u76ae\u80a4\u7684\u5f20\u529b\u548c\u5f39\u6027\u3001\u6697\u6c89\u3001\u808c\u7406\u7b49\u76ae\u80a4\u6307\u6807\u7684\u53d8\u5316\u540e\uff0c\u4e5f\u663e\u793a\u51fa\u4e86\u5bf9\u4e8e\u6297\u7cd6\u5316\u4f5c\u7528\u7684\u9884\u9632\u8870\u8001\u7684\u6709\u7528\u6027\u3002<\/p>\n\n\n<div class=\"ref_css\">\n<h5><span lang=\"en\">References<\/span><\/h5>\n<ol class=\"ref_css\">\n<li style=\"list-style-type: none\">\n<ol>\n<li>Hori M, <i>et al.<\/i> : Anti-Aging Medicine. 2012; 9, 125-134.<\/li>\n<li>Sell DR, <i>et al.<\/i> : J Biol Chem. 1989; 264, 21597?21602.<\/li>\n<li>Obayashi H, <i>et al.<\/i> : Biochem Biophys Res Commun. 1996; 226, 37-41.<\/li>\n<li>Hayase F : Food Science and Technology Research. 2000; 6, 79-86.<\/li>\n<li>Bolton WK, <i>et al.<\/i> : Am J Nephrol. 2004; 24, 32-40.<\/li>\n<li>Takeuchi M, <i>et al.<\/i> : Journal of Alzheimer\u2019s Disease. 2009; 16, 845?858.<\/li>\n<li>Yonei Y, <i>et al.<\/i>: Anti-Aging Medicine. 2008; 5, 93-98.<\/li>\n<li>Yagi M, <i>et al.<\/i>: Anti-Aging Medicine. 2012; 9, 61-74.<\/li>\n<li>\u5800\u672a\u592e\u3089\uff1a\u540c\u5fd7\u793e\u5927\u5b66\u7406\u5de5\u5b66\u7814\u7a76. 2011; 52, 61-67.<\/li>\n<li>Hori M, <i>et al.<\/i> : Anti-Aging Medicine. 2012; 9, 135-148.<\/li>\n<li>Lanny P, <i>et al.<\/i> : Anti-Aging Medicine.2013; 10, 70-76.<\/li>\n<li>Kinae N, <i>et al.<\/i>: The maillard reaction in the food processing human nutrition and physiology. 1990; 221-226.<\/li>\n<li>Matsuura N, <i>et al.<\/i> : J Health Sci. 2002; 48, 520-526.<\/li>\n<li>Dearlove RP, <i>et al.<\/i> : J Med Food. 2008; 11, 275-281.<\/li>\n<li>Yokozawa T, <i>et al.<\/i> : J Trad Med. 2001; 18, 107-112.<\/li>\n<li>Fjiwara Y, <i>et al.<\/i> : Ann NY Acad Sci. 2008; 1126, 152?154.<\/li>\n<li>Fujiwara Y, <i>et al.<\/i> : Free Radical Biology &amp; Medicine. 2011; 50, 883?891.<\/li>\n<li>(\u8ca1) \u65e5\u672c\u5065\u5eb7\uff65\u6804\u990a\u98df\u54c1\u5354\u4f1a. 2008.<\/li>\n<li>\u539a\u751f\u52b4\u50cd\u7701 : \u98df\u5b89\u767a\u7b2c0201003\u53f7. 2010.<\/li>\n<li>\u539a\u751f\u52b4\u50cd\u7701 : \u85ac\u98df\u5be9\u67fb\u767a0402\u7b2c1\u53f7. 2012.<\/li>\n<li>\u539a\u751f\u52b4\u50cd\u7701 : \u610f\u898b\u52df\u96c6, \u6848\u4ef6\u756a\u53f7495130206\u53f7. 2013.<\/li>\n<li>\u516b\u6728\u96c5\u4e4b\u3089 : COSMETIC STAGE. 2011; 15, 23-32.<\/li>\n<li>Yonei Y, <i>et al.<\/i> : Anti-Aging_Medicine. 2008; 5, 93-98.<\/li>\n<li>Yonei Y, <i>et al.<\/i> : Anti_Aging_Medicine. 2010; 7, 26-35.<\/li>\n<li>Kubo M, <i>et al.<\/i> : J Clin Biochem Nutr. 2008; 43(suppl 1), 66-69.<\/li>\n<li>Yagi M, <i>et al.<\/i> : Glycative Stress Research. 2014; 1, 14-24.<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/div>\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<h5><strong>Glycative stress and Anti-aging<\/strong><\/h5>\n\n\n\n<ul><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_01\/\">\u4ec0\u4e48\u662f\u7cd6\u5316\u5e94\u6fc0\uff1f<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_02\">\u7cd6\u5316\u5e94\u6fc0\u6807\u5fd7\u7269\u7684\u68c0\u6d4b\u65b9\u6cd5(1)\u3000\u8840\u7cd6\u3001\u7cd6\u5316\u86cb\u767d\u3001\u7cd6\u5316\u53cd\u5e94\u4e2d\u95f4\u4f53\u7684\u68c0\u6d4b<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_03\">\u7cd6\u5316\u5e94\u6fc0\u6807\u5fd7\u7269\u7684\u68c0\u6d4b\u65b9\u6cd5(2)\u3000AGEs\u7684\u68c0\u6d4b<\/a><\/li><li>\u7cd6\u5316\u5e94\u6fc0\u6807\u5fd7\u7269\u7684\u68c0\u6d4b\u65b9\u6cd5(3)\u3000\u6297\u7cd6\u5316\u4f5c\u7528\u8bc4\u4ef7<\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_05\">\u7cd6\u5316\u5e94\u6fc0\u548cAGEs\u53d7\u4f53<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_06\">\u7cd6\u5316\u5e94\u6fc0\u4e0e\u80be\u75be\u75c5<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_07\/\">\u7cd6\u5316\u5e94\u6fc0\u548c\u76ae\u80a4\u8001\u5316<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_08\">\u7cd6\u5316\u5e94\u6fc0\u4e0e\u52a8\u8109\u786c\u5316<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_09\">\u7cd6\u5316\u5e94\u6fc0\u548c\u7cbe\u795e\u5206\u88c2\u75c7<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_10\">\u7cd6\u5316\u5e94\u6fc0\u4e0e\u809d\u75c5<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_11\">\u7cd6\u5316\u5e94\u6fc0\u4e0e\u4e0d\u5b55\u75c7<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_12\">\u7cd6\u5316\u5e94\u6fc0\u4e0e\u963f\u5c14\u5179\u6d77\u9ed8\u75c7<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_13\/\">\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56(1)\u3000\u8840\u7cd6\u63a7\u5236<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_14\/\">\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56(2)\u3000\u7cd6\u5316\u53cd\u5e94\u7684\u6291\u5236<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_15\/\">\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56(3)\u3000AGEs\u7684\u964d\u89e3\u548c\u6392\u6cc4<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_16\/\">\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56(4)\u3000\u81b3\u98df\u6765\u6e90\u7684AGEs<\/a><\/li>\n<li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_17\/\">\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56\u7684\u8bfe\u9898\u548c\u5c55\u671b<\/a><\/li><\/ul>\n\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<p><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/\">-\u5b66\u672f\u4fe1\u606f top<\/a><br><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/\">-Top<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"\u7cd6\u5316\u5e94\u6fc0\u6807\u5fd7\u7269\u7684\u68c0\u6d4b\u65b9\u6cd5(3)\u3000\u6297\u7cd6\u5316\u4f5c\u7528\u8bc4\u4ef7 \u540c\u5fd7\u793e\u5927\u5b66\u5927\u5b66\u9662 \u751f\u547d\u533b\u79d1\u5b66\u7814\u7a76\u79d1 \u7cd6\u5316\u5e94\u6fc0\u7814\u7a76\u4e2d\u5fc3\u516b\u6728\u96c5\u4e4b \u6559\u6388 \u4e3b\u7f16 \u81ea2009\u5e74\u79cb\u5b63\u4ee5\u6765\uff0c\u5728\u5316\u5986&#8230;","protected":false},"author":3,"featured_media":0,"parent":9191,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-json\/wp\/v2\/pages\/10693"}],"collection":[{"href":"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-json\/wp\/v2\/comments?post=10693"}],"version-history":[{"count":7,"href":"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-json\/wp\/v2\/pages\/10693\/revisions"}],"predecessor-version":[{"id":12949,"href":"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-json\/wp\/v2\/pages\/10693\/revisions\/12949"}],"up":[{"embeddable":true,"href":"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-json\/wp\/v2\/pages\/9191"}],"wp:attachment":[{"href":"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-json\/wp\/v2\/media?parent=10693"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}