{"id":10729,"date":"2020-09-10T13:33:12","date_gmt":"2020-09-10T04:33:12","guid":{"rendered":"https:\/\/ebn2.arkray.co.jp\/english\/?page_id=10729"},"modified":"2020-11-24T12:53:33","modified_gmt":"2020-11-24T03:53:33","slug":"glycation-stress_05","status":"publish","type":"page","link":"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_05\/","title":{"rendered":"\u7cd6\u5316\u5e94\u6fc0\u548cAGEs\u53d7\u4f53"},"content":{"rendered":"\n

\u7cd6\u5316\u5e94\u6fc0\u548cAGEs\u53d7\u4f53<\/h2>\n\n\n\n

\u540c\u5fd7\u793e\u5927\u5b66\u5927\u5b66\u9662 \u751f\u547d\u533b\u79d1\u5b66\u7814\u7a76\u79d1 \u7cd6\u5316\u5e94\u6fc0\u7814\u7a76\u4e2d\u5fc3
\u516b\u6728\u96c5\u4e4b \u6559\u6388 \u4e3b\u7f16<\/p>\n\n\n\n

\u968f\u7740\u7cd6\u5316\u5e94\u6fc0\u7684\u589e\u5f3a,\u5f53AGEs\u5728\u8840\u4e2d\u548c\u7ec4\u7ec7\u4e2d\u5f62\u6210\u5e76\u84c4\u79ef\uff0c\u751f\u7406\u529f\u80fd\u7684\u4e0b\u964d\u548c\u969c\u788d\u4f1a\u8fdb\u5c55\u3002\u8fd1\u5e74\u6765\uff0c\u4e86\u89e3\u4e86AGEs\u901a\u8fc7\u53d7\u4f53\u5728\u7ec6\u80de\u5185\u4f20\u9012\u4fe1\u53f7\u7684\u9014\u5f84\uff0c\u5e76\u660e\u786e\u4e86\u6355\u83b7\u548c\u6e05\u9664AGEs\u7684\u53d7\u4f53\u662f\u5b58\u5728\u7684(\u56fe1)(1)<\/sup>\u3002<\/p>\n\n\n\n

\"\" \u56fe1\u3000AGEs\u53d7\u4f53
<\/strong>\u6df1\u6c34\u572d\u7b49(2013)(1)<\/sup><\/h6>\n\n\n\n

AGEs\u7684\u53d7\u4f53\u53ef\u5927\u81f4\u5206\u4e3a(1)\u4e0e\u708e\u75c7\u6709\u5173\u7684\u53d7\u4f53\uff0c(2)\u4e0eAGEs\u7684\u5206\u89e3\u548c\u6e05\u9664\u6709\u5173\u7684\u53d7\u4f53\u3002 (1)\u4e2d\u5305\u62ecreceptor for AGEs(RAGE)\u3001AGE-R2\u3002 (2)\u4e2d\u5305\u62ecAGE-R1\u3001AGE-R3\u3001CD36\u3001SR-A\u3001SR-BI\u3001FEEL-1,2\u3001ERM\u548c\u5de8\u86cb\u767d\u3002\u8fd9\u4e9b\u53d7\u4f53\u5728\u8840\u7ba1\u3001\u80be\u810f\u3001\u795e\u7ecf\u3001\u5de8\u566c\u7ec6\u80de\u3001\u9020\u8840\u5e72\u7ec6\u80de\u4e2d\u8868\u8fbe(\u88681)(1)<\/sup>\u3002\u672c\u6587\u603b\u7ed3\u4e86\u5178\u578b\u7684AGEs\u53d7\u4f53\u53ca\u5176\u529f\u80fd\u3002<\/p>\n\n\n

\n\n\n\n\n\n\n\n\n\n\n\n\n\n
AGEs\u53d7\u4f53<\/th>\n\u5927\u5c0f<\/th>\n\u914d\u4f53<\/th>\n\u4e3b\u8981\u529f\u80fd<\/th>\n\u8868\u8fbe\u90e8\u4f4d<\/th>\n<\/tr>\n
RAGE<\/td>\n45<\/td>\nAGEs, HMGB1, \u03b2-amyloid, S100\/calgranulins<\/td>\n\u52a8\u8109\u786c\u5316\u3001\u7cd6\u5c3f\u75c5\u5e76\u53d1\u75c7\u3001\u4fc3\u8fdb\u708e\u75c7<\/td>\n\u5355\u6838\u7ec6\u80de\u3001\u5de8\u566c\u7ec6\u80de\u3000\u795e\u7ecf\u548c\u80be\u810f\u3001\u8840\u7ba1\u5e73\u6ed1\u808c\u7ec6\u80de\u3001\u5185\u76ae\u7ec6\u80de<\/td>\n<\/tr>\n
AGE-R1
(OST-48)<\/td>\n		48<\/td>\nAGEs<\/td>\n\u6e05\u9664AGEs\u3001\u964d\u4f4e\u6c27\u5316\u5e94\u6fc0<\/td>\n\u5185\u76ae\u7ec6\u80de\u3001\u7cfb\u819c\u7ec6\u80de\u3001\u5de8\u566c\u7ec6\u80de\u3001\u5355\u4e2a\u6838\u7ec6\u80de<\/td>\n<\/tr>\n
AGE-R2
(80K-H)<\/td>\n		80<\/td>\nNone<\/td>\n\u6fc0\u6d3b\u7ec6\u80de\u5185\u4fe1\u53f7<\/td>\n\u5355\u4e2a\u6838\u7ec6\u80de\u3001\u80be\u810f\u3001\u5185\u76ae\u3001\u8111\u3001\u795e\u7ecf<\/td>\n<\/tr>\n
AGE-R3
(galectlin3)<\/td>\n		32<\/td>\nAGEs<\/td>\n\u6e05\u9664AGEs\u3001\u6291\u5236\u7ec6\u80de\u589e\u6b96\u548c\u51cb\u4ea1<\/td>\n\u5de8\u566c\u7ec6\u80de\u3001\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u3001\u80a5\u5927\u7ec6\u80de\u3001\u6d88\u5316\u5668\u5b98\u548c\u547c\u5438\u5668\u5b98\u7684\u9ecf\u819c\u3001\u795e\u7ecf\u3001\u80be\u810f<\/td>\n<\/tr>\n
SR-A<\/td>\n220~250<\/td>\nAGEs\u3001Ac-LDL
Ox-LDL<\/td>\n		\u4fc3\u8fdb\u52a8\u8109\u786c\u5316\u3001\u80be\u75c5\u3001\u6ce1\u6cab\u7ec6\u80de\u5316<\/td>\n\u5355\u4e2a\u6838\u7ec6\u80de\u3001\u5de8\u566c\u7ec6\u80de<\/td>\n<\/tr>\n
CD36<\/td>\n88<\/td>\nAGEs, Ox-LDL<\/td>\n\u6e05\u9664AGEs<\/td>\n\u5de8\u566c\u7ec6\u80de\u3001\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u3001\u8102\u80aa\u7ec6\u80de<\/td>\n<\/tr>\n
SR-BI<\/td>\n57<\/td>\nAGEs, HDL,
Ac-LDL, Ox-LDL<\/td>\n		\u5206\u89e3AGEs\u3001\u62bd\u53d6HDL\u7684CE<\/td>\n\u5de8\u566c\u7ec6\u80de\u3001\u809d\u810f\u3001\u80be\u4e0a\u817a\u3001\u5375\u5de2\u3001\u777e\u4e38\u3001\u80ce\u76d8<\/td>\n<\/tr>\n
FEEL1,2<\/td>\n\u00a0<\/td>\nAGEs\u3001\u7ec6\u83cc\u3001LDL<\/td>\n\u7ec6\u80de\u3001\u4fee\u9970LDL\u3001AGEs\u7684\u7ec6\u80de\u5185\u63ba\u5165\u3001\u5206\u89e3<\/td>\n\u813e\u810f\u3001\u6dcb\u5df4\u7ed3\u3001\u5355\u4e2a\u6838\u7ec6\u80de\u3001\u5185\u76ae\u7ec6\u80de<\/td>\n<\/tr>\n
ezrin, radixin, moesin (ERM)<\/td>\n\u00a0<\/td>\nAGEs,
\u5404\u79cd\u4f4e\u5206\u5b50\u91cf\u86cb\u767d<\/td>\n		\u7ec6\u80de\u7684\u7ed3\u6784\u53d8\u5316\u3001\u7ec6\u80de\u7684\u8fd0\u52a8\u3001\u7c98\u9644<\/td>\n\u8fd1\u7aef\u5c0f\u7ba1\u7ec6\u80de<\/td>\n<\/tr>\n
megalin<\/td>\n600<\/td>\nAGEs,
\u5404\u79cd\u4f4e\u5206\u5b50\u91cf\u86cb\u767d<\/td>\n		\u6e05\u9664AGEs<\/td>\n\u8fd1\u7aef\u5c0f\u7ba1\u7ec6\u80de<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n\n\n
\u8868<\/strong>1<\/strong>\u3000AGEs\u53d7\u4f53\u548c\u529f\u80fd
<\/strong>\u6df1\u6c34\u572d\u7b49(2013)(1)<\/sup><\/h6>\n\n\n\n

RAGE<\/h3>\n\n\n

RAGE\u4ece\u5c5e\u4e8e\u5206\u5b50\u91cf\u4e3a45kDa\u7684\u514d\u75ab\u7403\u86cb\u767d\u8d85\u5bb6\u65cf\uff0c\u662f\u4e00\u79cd\u5355\u8de8\u819c\u578b\u7684\u819c\u86cb\u767d\uff0c\u5728\u5355\u6838\u7ec6\u80de\u3001\u5de8\u566c\u7ec6\u80de\u3001\u795e\u7ecf\u3001\u80be\u5c0f\u7ba1\u7ec6\u80de\u3001\u7cfb\u819c\u7ec6\u80de\u7b49\u4e2d\u8868\u8fbe\u3002 \u9664AGEs\u5916\uff0cRAGE\u8fd8\u53ef\u4e0e\u03b2-\u6dc0\u7c89\u6837\u86cb\u767d\u3001S100\/calgranulins\u548chigh mobility group box 1(HMGB-1)\u7ed3\u5408\uff0c\u5e76\u53c2\u4e0e\u708e\u75c7\u548c\u6c27\u5316\u5e94\u6fc0\u7684\u589e\u5f3a\u3002<\/p>\n

RAGE\u7531\u5b58\u5728\u4e8e\u7ec6\u80de\u5916\u7684V\u7ed3\u6784\u57df\u548c\u4e24\u4e2aC\u7ed3\u6784\u57df\u3001\u8de8\u819c\u7ed3\u6784\u57df\u3001\u80de\u5185\u7ed3\u6784\u57df\u8fd95\u4e2a\u7ed3\u6784\u57df\u7ec4\u6210(\u56fe2)\u3002<\/p>\n

\"\"<\/p>\n

\u56fe<\/strong>2<\/strong> RAGE<\/strong>\u53ca\u5176\u53d8\u5f02\u4f53
<\/strong>RAGE = receptor for advanced glycation end-products;
sRAGE = soluble form of RAGE;
esRAGE = endogenous secretory RAGE;
C = immunoglobulin-like constant domains;
V = immunoglobulin-like variable domains
Katakami N, et al.<\/em> (2007)(12)<\/sup><\/h6>\n

\u6b64\u5916\uff0cRAGE\u4e2d\u9664\u5b58\u5728\u4e8e\u7ec6\u80de\u8868\u9762\u7684\u5168\u957f\u578b(full length RAGE\uff1aF-RAGE)\u5916\uff0c\u8fd8\u5b58\u5728\u4f5c\u4e3a\u526a\u63a5\u53d8\u5f02\u4f53(splicing variant)\u7684\u80de\u5185\u7ed3\u6784\u57df\u7f3a\u5931\u578b(C-terminally truncated RAGE\uff1aC-RAGE)\u548c\u80de\u5916V\u7ed3\u6784\u57df\u7f3a\u5931\u578b(N-terminally truncated RAGE\uff1aN-RAGE)(3)<\/sup>\u3002<\/p>\n

\u5176\u4e2d\uff0c\u80de\u5185\u7ed3\u6784\u57df\u7f3a\u5931\u578bRAGE\u88ab\u79f0\u4e3a\u53ef\u6eb6\u6027RAGE(soluble RAGE\uff1asRAGE)\u3002\u800csRAGE\u5b58\u5728\u5728\u80de\u5185\u4ea7\u751f\u5e76\u5206\u6ccc\u5230\u80de\u5916\u7684endgenous secretory RAGE(esRAGE)\uff0c\u4ee5\u53caF-RAGE\u88ab\u86cb\u767d\u6c34\u89e3\u9176\u548cmatrix metalloproteinases(MMP)\u7684a disintegrin and metalloproteinase 10(ADAM 10)\u5207\u65ad\u5e76\u91ca\u653e\u5230\u8840\u6db2\u4e2d\u7684cleaved-type soluble RAGE(CL-RAGE)(4)<\/sup>\u3002<\/p>\n

\u5f53F-RAGE\u5728\u7ec6\u80de\u819c\u4e0a\u4e0eAGEs\u7ed3\u5408\u65f6\uff0cNADPH\u6c27\u5316\u9176\u88ab\u6fc0\u6d3b\uff0c\u7ec6\u80de\u5185\u6c27\u5316\u5e94\u6fc0\u589e\u5f3a\uff0c\u5e76\u901a\u8fc7\u6fc0\u6d3bNF-kB\uff0c\u8bf1\u5bfc\u5404\u79cd\u7ec6\u80de\u56e0\u5b50\u3001\u751f\u957f\u56e0\u5b50\u7684\u5206\u6ccc\u548c\u7c98\u9644\u5206\u5b50\u7684\u8868\u8fbe\u4e0a\u8c03(5)<\/sup>\u3002\u6b64\u5916\uff0c\u53ef\u8ba4\u4e3a\u6c27\u5316\u5e94\u6fc0\u589e\u5f3a\u4f7f\u4e00\u6c27\u5316\u6c2e(NO)\u5931\u6d3b\uff0c\u8fdb\u4e00\u6b65\u52a0\u5267\u708e\u75c7\u53cd\u5e94\u548c\u8840\u6813\u7684\u5f62\u6210\u8d8b\u52bf\uff0c\u5e76\u53c2\u4e0e\u52a8\u8109\u786c\u5316\u7684\u8fdb\u5c55\u3002<\/p>\n

\u800c\u4e14\uff0cAGEs\u4fc3\u8fdb\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u4e2d\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50(VEGF)\u7684\u81ea\u5206\u6ccc\u4ea7\u751f\uff0c\u8bf1\u5bfc\u8840\u7ba1\u751f\u6210(6)<\/sup>\u3002<\/p>\n

\u53e6\u5916\uff0cF-RAGE\u4e0eAGEs\u7684\u7ed3\u5408\u4f1a\u6291\u5236\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u4e2d\u524d\u5217\u73af\u7d20(PGI2)\u7684\u4ea7\u751f\uff0c\u540c\u65f6\u4fc3\u8fdb\u7ea4\u6eb6\u9176\u539f\u6fc0\u6d3b\u7269\u6291\u5236\u7269-1(PAI-1)\u7684\u5408\u6210\uff0c\u5e76\u6291\u5236\u7ea4\u6eb6\u6d3b\u6027\uff0c\u5f71\u54cd\u8840\u6813\u7684\u7a33\u5b9a(7)<\/sup>\u3002 \u5df2\u77e5AGEs\u4f1a\u5728\u589e\u5f3a\u8840\u5c0f\u677f\u805a\u96c6\u7684\u540c\u65f6\uff0c\u4fc3\u8fdb\u51dd\u8840\u7ea7\u8054\u3002<\/p>\n

\u53e6\u4e00\u65b9\u9762\uff0c\u7531\u4e8esRAGE\u5177\u6709\u4e0eAGEs\u7ed3\u5408\u7684\u4f4d\u70b9\uff0c\u56e0\u6b64\u53ef\u8ba4\u4e3a\u5176\u4f1a\u8bf1\u6355\u5b58\u5728\u4e8e\u7ec6\u80de\u5916\u7684AGEs\uff0c\u4f5c\u4e3a\u6291\u5236\u4e0e\u5b58\u5728\u4e8e\u7ec6\u80de\u8868\u9762\u7684RAGE\u7ed3\u5408\u7684\u8bf1\u9a97\u53d7\u4f53\u53d1\u6325\u4f5c\u7528(8)<\/sup>\u3002 2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u8840esRAGE\u663e\u8457\u6027\u4f4e\u4e8e\u975e\u7cd6\u5c3f\u75c5\u60a3\u8005\uff0c\u8868\u660e\u5176\u53ef\u80fd\u4e0e2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u53d1\u75c5\u6709\u5173(9-10)<\/sup>\u3002\u53e6\u6709\u62a5\u544a\u663e\u793a\uff0c\u57281\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u8840esRAGE\u6c34\u5e73\u8f83\u4f4e\u7684\u75c5\u4f8b\u4e2d\uff0c\u89c6\u7f51\u819c\u75c5\u53d8\u7684\u53d1\u75c5\u98ce\u9669\u8f83\u9ad8(\u56fe3)(11)<\/sup>\u3002\u800c\u4e14\uff0c\u8fd8\u663e\u793a\u4e862\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u8840esRAGE\u6c34\u5e73\uff0c\u4e0e\u9888\u52a8\u8109\u786c\u5316\u3001\u51a0\u72b6\u52a8\u8109\u75be\u75c5\u7684\u4e25\u91cd\u7a0b\u5ea6\u5448\u8d1f\u76f8\u5173(12-13)<\/sup>\u3002<\/p>\n

\"\"<\/h6>\n
\u56fe<\/strong>3<\/strong>\u3000<\/strong> 1<\/strong>\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u8840\u6e05<\/strong>esRAGE
<\/strong>\u4e0e\u89c6\u7f51\u819c\u75c5\u53d8\u7684\u5173\u7cfb
<\/strong>\u6c34\u5e73\u7ebf\u8868\u793a\u5404\u7ec4\u7684\u5e73\u5747\u503c;Scheffe\u00b4s F-test.
Sakurai S, et al.<\/em> (2006)(11)<\/sup><\/h6>\n\n\n

AGE-R1\u3001-R2\u3001-R3\u590d\u5408\u7269<\/h3>\n\n\n

AGE-R1\u4e5f\u88ab\u79f0\u4e3aOST-48(oligosaccharyltransferase-48)\uff0c\u4ece\u5c5e\u4e8e\u5206\u5b50\u91cf\u4e3a48kDa\u7684\u51dd\u96c6\u7d20\u5bb6\u65cf\uff0c\u662f\u4e00\u79cd\u5355\u8de8\u819c\u578b\u86cb\u767d\u3002 AGE-R1\u5728\u5185\u76ae\u7ec6\u80de\u3001\u7cfb\u819c\u7ec6\u80de\u3001\u5de8\u566c\u7ec6\u80de\u7b49\u4e2d\u8868\u8fbe\uff0c\u901a\u8fc7\u5185\u541e\u4f5c\u7528(endocytosis)\u6e05\u9664AGEs\u3002\u6b64\u5916\uff0cAGE-R1\u53ef\u80fd\u4e0e\u5bff\u547d\u5ef6\u957f\u6709\u5173(14)<\/sup>\u3002<\/p>\n

AGE-R2\u4e5f\u88ab\u79f0\u4e3a80K-H(80kDa protein kinase C substrate)\uff0c\u662f\u4e00\u79cd\u5206\u5b50\u91cf\u4e3a80kDa\u7684\u916a\u6c28\u9178\u78f7\u9178\u5316\u86cb\u767d\u8d28\uff0c\u5b58\u5728\u4e8e\u7ec6\u80de\u8d28\u4e2d\u3002 AGE-R2\u5728\u5355\u4e2a\u6838\u7ec6\u80de\u3001\u80be\u810f\u3001\u8840\u7ba1\u5185\u76ae\u3001\u8111\u3001\u795e\u7ecf\u7b49\u4e2d\u8868\u8fbe\uff0c\u53c2\u4e0e\u7ec6\u80de\u5185\u4fe1\u53f7\u7684\u6fc0\u6d3b\u3002<\/p>\n

AGE-R3\u4e5f\u88ab\u79f0\u4e3agalectin-3\uff0c\u662f\u4e00\u79cd\u5c5e\u4e8e\u5206\u5b50\u91cf\u4e3a32kDa\u7684\u51dd\u96c6\u7d20\u5bb6\u65cf\u7684\u53d7\u4f53\u3002 AGE-R3\u901a\u8fc7\u7ec6\u80de\u4e0a\u7684\u78b3\u6c34\u5316\u5408\u7269\u8bc6\u522b\u7ed3\u6784\u57df\uff0c\u5e76\u4e0eAGEs\u76f4\u63a5\u7ed3\u5408\uff0c\u5728\u5de8\u566c\u7ec6\u80de\u3001\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u3001\u80a5\u5927\u7ec6\u80de\u3001\u795e\u7ecf\u3001\u80be\u810f\u7b49\u4e2d\u8868\u8fbe\u3002 AGE-R3\u7684\u4f5c\u7528\u5305\u62ec\uff1a\u7ec6\u80de\u4e0e\u4f5c\u4e3a\u57fa\u8d28\u7684\u5c42\u7c98\u8fde\u86cb\u767d(laminin)\u7684\u7c98\u9644\u6291\u5236\u3001\u80a5\u5927\u7ec6\u80de\u7684\u6fc0\u6d3b\u3001\u7ec6\u80de\u751f\u957f\u548c\u51cb\u4ea1\u7684\u8c03\u63a7\u3001\u4ee5\u53ca\u901a\u8fc7\u5185\u541e\u4f5c\u7528\u5206\u89e3AGEs\u7b49\u3002\u6b64\u5916\uff0cAGE-R3\u7684\u8868\u8fbe\u5728\u5e74\u9f84\u589e\u957f\u548c\u7cd6\u5c3f\u75c5\u65f6\u4e0a\u8c03\uff0c\u56e0\u6b64\u5bf9\u8870\u8001\u53ef\u80fd\u5177\u6709\u4fdd\u62a4\u4f5c\u7528(15)<\/sup>\u3002<\/p>\n\n\n

SR-A, CD36, SR-BI, FEEL-1, FEEL-2<\/h3>\n\n\n\n

SR-A\u3001CD36\u3001SR-BI\u3001FEEL-1\u3001FEEL-2\u4e5f\u88ab\u79f0\u4e3a\u6e05\u9053\u592b\u53d7\u4f53\uff0c\u5bf9AGEs\u7684\u5206\u89e3\u6392\u6cc4\u8d77\u4f5c\u7528\u3002<\/p>\n\n\n\n

SR-A(scavenger receptor class A)\u5c06\u4e59\u9170\u5316LDL(low density lipoprotein)\u548c\u6c27\u5316LDL\u8bc6\u522b\u4e3a\u914d\u4f53\uff0c\u5728\u5de8\u566c\u7ec6\u80de\u7684\u7ec6\u80de\u8868\u9762\u5c06AGEs\u63ba\u5165\u5230\u7ec6\u80de\u5185\u5f62\u6210\u6ce1\u6cab\uff0c\u7531\u6b64\u8868\u660e\u5176\u4e0e\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6709\u5173(16)<\/sup>\u3002<\/p>\n\n\n\n

CD36(cluster of differentiation 36)\u5728\u5de8\u566c\u7ec6\u80de\u3001\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u548c\u8102\u80aa\u7ec6\u80de\u8868\u9762\u8868\u8fbe\u3002 CD36\u4e0e\u8102\u80aa\u9178\u3001\u80f6\u539f\u86cb\u767d\u3001\u6c27\u5316LDL\u7ed3\u5408\uff0c\u53d1\u6325\u5c06\u6c27\u5316LDL\u63ba\u5165\u5de8\u566c\u7ec6\u80de\u5185\u548c\u5c06\u8102\u80aa\u9178\u8fd0\u8f93\u5230\u8102\u80aa\u7ec6\u80de\u4e2d\u7684\u4f5c\u7528\u3002 \u7531\u4e8eCD36\u53ef\u5c06AGEs\u63ba\u5165\u8102\u80aa\u7ec6\u80de\u5185\u5206\u89e3\u6e05\u9664AGEs\uff0c\u56e0\u6b64\u63a8\u6d4b\u5176\u5bf9\u52a8\u8109\u786c\u5316\u5177\u6709\u4fdd\u62a4\u4f5c\u7528(17)<\/sup>\u3002<\/p>\n\n\n\n

SR-BI(scavenger receptor-BI)\u5728\u5de8\u566c\u7ec6\u80de\u3001\u809d\u810f\u3001\u80be\u4e0a\u817a\u548c\u5375\u5de2\u7b49\u4e2d\u8868\u8fbe\uff0c\u5177\u6709\u4fc3\u8fdbHDL(high density lipoprotein)\u80c6\u56fa\u9187\u916f\u5411\u809d\u810f\u63ba\u5165\u7684\u4f5c\u7528(18)<\/sup>\u3002<\/p>\n\n\n\n

FEEL-1(fasciclin EFG-like laminin-type EGF-like and link domain-containing scavenger receptor-1)\u3001FEEL-2\u5728\u813e\u810f\u3001\u6dcb\u5df4\u7ed3\u4e2d\u8868\u8fbe\uff0c\u53c2\u4e0eAGEs\u7684\u7ec6\u80de\u5185\u63ba\u5165\u548c\u5206\u89e3(19)<\/sup>\u3002<\/p>\n\n\n\n

\u5de8\u86cb\u767d<\/h3>\n\n\n\n

\u5de8\u86cb\u767d(megalin)\u662f\u5206\u5b50\u91cf\u7ea6\u4e3a600kDa\u7684\u7cd6\u86cb\u767d\uff0c\u5c5e\u4e8eLDL\u53d7\u4f53\u57fa\u56e0\u5bb6\u65cf\uff0c\u5b58\u5728\u4e8e\u8fd1\u7aef\u5c0f\u7ba1\u7ec6\u80de\u4e2d(20)<\/sup>\u3002\u5de8\u86cb\u767d\u4e3b\u8981\u53c2\u4e0e\u4f4e\u5206\u5b50\u91cf\u86cb\u767d\uff0c\u5982\u7ef4\u751f\u7d20D\u7ed3\u5408\u86cb\u767d\u3001\u89c6\u9ec4\u9187\u7ed3\u5408\u86cb\u767d\u3001\u7532\u72b6\u817a\u6fc0\u7d20\u3001\u80f0\u5c9b\u7d20\u7b49\u7684\u91cd\u5438\u6536\u548c\u4ee3\u8c22\u3002\u8fd1\u5e74\u7684\u62a5\u544a\u663e\u793a\uff0cin vitro<\/em>\u5b9e\u9a8c\u4e2d\u8bc1\u5b9e\u4e86\u5de8\u86cb\u767d\u4f1a\u4e0eAGE\u7ed3\u5408\uff0c\u901a\u8fc7\u80be\u5c0f\u7403\u7684AGEs\u88ab\u5de8\u86cb\u767d\u6355\u83b7\uff0c\u5e76\u88ab\u6eb6\u9176\u4f53\u5438\u6536\u5206\u89e3(21)<\/sup>\u3002<\/p>\n\n\n\n

\u5176\u4ed6AGEs\u53d7\u4f53<\/h3>\n\n\n\n

ERM\u86cb\u767d(ezrin\u3001radixin\u3001moesin)\u662f\u4e00\u79cd\u8054\u7ed3\u7ec6\u80de\u819c\u548c\u7ec6\u80de\u5185\u808c\u52a8\u86cb\u767d\u4e1d\u7684\u86cb\u767d\uff0c\u5728\u7ec6\u80de\u7684\u8fd0\u52a8\u3001\u7c98\u9644\u548c\u7ed3\u6784\u53d8\u5316\u7b49\u4e2d\u8d77\u4f5c\u7528\u3002\u8fd1\u5e74\u6709\u62a5\u544a\u6307\u51fa\uff0cERM\u5bb6\u65cf\u86cb\u767d\u7684N\u672b\u7aef\u4f1a\u4e0eAGEs\u7ed3\u5408(22)<\/sup>\u3002<\/p>\n\n\n\n

\u7cd6\u5316\u5e94\u6fc0\u6291\u5236\u548cAGEs\u53d7\u4f53<\/h3>\n\n\n\n

 AGEs\u4e0eRAGE\u7684\u7ed3\u5408\u4f1a\u589e\u5f3a\u7ec6\u80de\u5185\u7684\u6c27\u5316\u5e94\u6fc0\uff0c\u4fc3\u4f7f\u7ec6\u80de\u56e0\u5b50\u8868\u8fbe\uff0c\u5728\u7ec6\u80de\u5185\u8bf1\u53d1\u708e\u75c7\uff0c\u5e76\u5f15\u8d77\u5668\u5b98\u548c\u7ec4\u7ec7\u635f\u4f24\u3002\u56e0\u6b64\uff0c\u6291\u5236RAGE\u7684\u8868\u8fbe\u662f\u6291\u5236\u7cd6\u5316\u5e94\u6fc0\u7684\u4e00\u4e2a\u9776\u6807\u3002\u53e6\u4e00\u65b9\u9762\uff0cAGE-R1\u548cAGE-R3\u8d77\u4fdd\u62a4\u5668\u5b98\u548c\u7ec4\u7ec7\u7684\u4f5c\u7528\u3002\u6b64\u5916\uff0csRAGE\u8bf1\u9a97\u6027\u5730\u4f5c\u7528\u4e8eAGEs\uff0c\u6291\u5236\u7531RAGE\u8868\u8fbe\u5f15\u8d77\u7684\u708e\u75c7\uff0c\u963b\u6b62\u5404\u79cd\u75be\u75c5\u7684\u8fdb\u5c55\u3002\u56e0\u6b64\u8ba4\u4e3a\uff0c\u6e05\u9664AGEs\u7684\u53d7\u4f53\u548c\u6291\u5236sRAGE\u7684\u8868\u8fbe\uff0c\u53ef\u80fd\u5728\u4eca\u540e\u6210\u4e3a\u6291\u5236\u7cd6\u5316\u5e94\u6fc0\u7684\u65b0\u624b\u6bb5\u3002<\/p>\n\n\n\n

\n\n\n\n

\u7cd6\u5316\u5e94\u6fc0\u548c\u6297\u8870\u8001<\/strong><\/h5>\n\n\n\n