{"id":10747,"date":"2020-09-10T15:52:22","date_gmt":"2020-09-10T06:52:22","guid":{"rendered":"https:\/\/ebn2.arkray.co.jp\/english\/?page_id=10747"},"modified":"2020-11-19T10:35:11","modified_gmt":"2020-11-19T01:35:11","slug":"glycation-stress_06","status":"publish","type":"page","link":"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_06\/","title":{"rendered":"\u7cd6\u5316\u5e94\u6fc0\u4e0e\u80be\u75be\u75c5"},"content":{"rendered":"\n

\u7cd6\u5316\u5e94\u6fc0\u4e0e\u80be\u75be\u75c5<\/strong><\/strong><\/strong><\/h2>\n\n\n

\u540c\u5fd7\u793e\u5927\u5b66\u5927\u5b66\u9662 \u751f\u547d\u533b\u79d1\u5b66\u7814\u7a76\u79d1 \u7cd6\u5316\u5e94\u6fc0\u7814\u7a76\u4e2d\u5fc3
\u516b\u6728\u96c5\u4e4b \u6559\u6388 \u4e3b\u7f16<\/p>\n\n\n

\u4f55\u8c13\u80be\u75be\u75c5<\/strong><\/strong><\/h3>\n\n\n

\u80be\u810f\u662f\u8c46\u5f62\u5668\u5b98\uff0c\u5728\u8179\u90e8\u80cc\u9762\u7684\u5de6\u53f3\u4fa7\u5404\u67091\u4e2a\u3002\u80be\u810f\u4e3b\u8981\u6709\u4ee5\u4e0b5\u4e2a\u529f\u80fd(\u56fe1)(1-2)<\/sup>\u3002<\/p>\n

    \n
  1. \u4ee5\u5c3f\u6db2\u5f62\u5f0f\u5c06\u4f53\u5185\u5e9f\u7269\u6392\u51fa\u4f53\u5916<\/li>\n
  2. \u91cd\u5438\u6536\u4eba\u4f53\u6240\u9700\u7684\u7535\u89e3\u8d28\uff0c\u4f7f\u4eba\u4f53\u7535\u89e3\u8d28\u6d53\u5ea6\u4fdd\u6301\u6052\u5b9a<\/li>\n
  3. \u4ea7\u751f\u4e00\u79cd\u79f0\u4e3a\u80be\u7d20\u7684\u9176\uff0c\u63a7\u5236\u8840\u4e2d\u7684\u8840\u7ba1\u6536\u7f29\u4f5c\u7528\u7269\u8d28(\u8840\u7ba1\u7d27\u5f20\u7d20\u2161)\uff0c\u5e76\u8c03\u8282\u8840\u538b<\/li>\n
  4. \u5206\u6ccc\u4fc3\u7ea2\u7ec6\u80de\u751f\u6210\u7d20\uff0c\u4fc3\u4f7f\u9aa8\u9ad3\u4ea7\u751f\u7ea2\u7ec6\u80de<\/li>\n
  5. \u5c06\u7ef4\u751f\u7d20D\u8f6c\u5316\u4e3a\u6d3b\u6027\u7ef4\u751f\u7d20D3\uff0c\u4f7f\u9499\u6c89\u79ef\u4e8e\u9aa8\u9abc\u4e2d<\/li>\n<\/ol>\n

    \"\"<\/p>\n

    \u56fe<\/strong>1 <\/strong>\u80be\u810f\u7ed3\u6784
    <\/strong>\u4fee\u6539\u81ea\u8d35\u5802\u660e\u4e16(2014)(1)<\/sup>\u548c\u5742\u4e95\u5efa\u96c4(2011)(2)<\/sup><\/h6>\n

    \u80be\u529f\u80fd\u4e0b\u964d\u65f6\u4f1a\u51fa\u73b0\u5404\u79cd\u75c7\u72b6\uff0c\u5982\u56e0\u4f53\u5185\u79ef\u805a\u5e9f\u7269\u548c\u8fc7\u591a\u6c34\u5206\u800c\u51fa\u73b0\u6c34\u80bf\u3001\u7535\u89e3\u8d28\u5931\u8861\u3001\u8840\u538b\u5347\u9ad8\u3001\u8d2b\u8840\u3001\u9aa8\u9abc\u53d8\u8106\u7b49\u3002\u80be\u75be\u75c5\u6709\u6162\u6027\u80be\u708e(\u6162\u6027\u80be\u5c0f\u7403\u80be\u708e)\u3001\u7cd6\u5c3f\u75c5\u80be\u75c5\u3001\u80be\u786c\u5316\u3001\u591a\u56ca\u80be\u3001\u80be\u75c5\u7efc\u5408\u5f81\u7b49\u591a\u79cd\u7c7b\u578b\u3002\u53e6\u4e00\u65b9\u9762\uff0c2002\u5e74\u7f8e\u56fd\u80be\u810f\u75c5\u57fa\u91d1\u4f1a(national kidney foundation)\u63d0\u51fa\u4e86\u6162\u6027\u80be\u810f\u75c5(chronic kidney disease\uff1bCKD)\u7684\u6982\u5ff5\uff0c\u662f\u6db5\u76d6\u80be\u810f\u6162\u6027\u8870\u7aed\u75c7\u72b6\u7684\u672a\u75c5\u72b6\u6001\u5230\u665a\u671f\u7684\u4e00\u79cd\u75be\u75c5\uff0c\u5df2\u88ab\u8ba4\u4e3a\u662f\u8868\u660e\u80be\u529f\u80fd\u4e0b\u964d\u72b6\u6001\u7684\u8bca\u65ad\u6307\u6807(3)<\/sup>\u3002<\/p>\n

    \u622a\u81f32012\u5e74\u5e95\uff0c\u65e5\u672c\u7684\u80be\u900f\u6790\u60a3\u8005\u6570\u5df2\u8d85\u8fc730\u4e07\u4eba\uff0c\u5e76\u4ee5\u6bcf\u5e745,000\uff5e6,000\u4eba\u7684\u6570\u91cf\u6301\u7eed\u589e\u957f(4)<\/sup>\u3002\u56e0\u6b64\uff0c\u6beb\u4e0d\u5938\u5f20\u5730\u8bf4\uff0c\u80be\u75be\u75c5\u662f\u4e00\u79cd\u56fd\u6c11\u75be\u75c5\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u5173\u4e8e\u5bfc\u5165\u80be\u900f\u6790\u7684\u539f\u53d1\u75be\u75c5\uff0c\u6392\u5728\u7b2c\u4e00\u4f4d\u7684\u662f\u7cd6\u5c3f\u75c5\u80be\u75c5(44.1\uff05)\uff0c\u7b2c\u4e8c\u4f4d\u662f\u6162\u6027\u80be\u5c0f\u7403\u80be\u708e(19.4\uff05)\uff0c\u7b2c\u4e09\u4f4d\u662f\u80be\u786c\u5316(12.3\uff05)\u3002\u7cd6\u5c3f\u75c5\u80be\u75c5\u57281998\u5e74\u4e0e\u73b0\u4eca\u7b2c\u4e8c\u4f4d\u7684\u6162\u6027\u80be\u5c0f\u7403\u80be\u708e\u4e92\u6362\u4f4d\u6b21\u540e\u4ecd\u5728\u6301\u7eed\u589e\u52a0\uff0c\u56e0\u6b64\u7cd6\u5316\u5e94\u6fc0\u4f5c\u4e3a\u80be\u75be\u75c5\u7684\u8fdb\u5c55\u8981\u7d20\u800c\u53d7\u5230\u5173\u6ce8\u3002<\/p>\n

    \u7cd6\u5c3f\u75c5\u80be\u75c5\u7684\u53d1\u4f5c\u59cb\u4e8e\u6301\u7eed\u7684\u5fae\u91cf\u767d\u86cb\u767d\u5c3f(20\uff5e200 \u03bcg\/min)\u3002\u5982\u5ffd\u89c6\u5fae\u91cf\u767d\u86cb\u767d\u5c3f\u72b6\u6001\uff0c\u5219\u5728\u4e4b\u540e15\u5e74\u5185\uff0c80\uff05\u76841\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u4f1a\u53d1\u5c55\u4e3a\u663e\u6027\u767d\u86cb\u767d\u5c3f(\uff1e200 \u03bcg\/min)\uff0c\u4e14\u5176\u4e2d\u768450\uff05\u4f1a\u572810\u5e74\u5185\u8f6c\u53d8\u4e3a\u7ec8\u672b\u671f\u80be\u75c5(end-stage kidney disease\uff1bESKD)\u3002 20\uff5e40\uff05\u76842\u578b\u7cd6\u5c3f\u75c5\u4f1a\u53d1\u5c55\u4e3a\u663e\u6027\u767d\u86cb\u767d\u5c3f\uff0c\u5176\u4e2d\u768420\uff05\u4f1a\u572820\u5e74\u5185\u8f6c\u53d8\u4e3aESKD(5)<\/sup>\u3002<\/p>\n\n\n

    \u80be\u810f\u4e2d\u7684AGEs\u6392\u6cc4<\/strong><\/h3>\n\n\n

    \u80be\u810f\u5728AGEs\u7684\u6392\u6cc4\u548c\u6291\u5236\u84c4\u79ef\u4e2d\u8d77\u91cd\u8981\u4f5c\u7528\u3002\u80be\u810f\u7684\u8fd1\u7aef\u5c0f\u7ba1\u4e2d\u5b58\u5728\u4e00\u79cd\u79f0\u4e3a\u5de8\u86cb\u767d\u7684\u819c\u53d7\u4f53\uff0c\u53ef\u4ee5\u91cd\u5438\u6536\u4ece\u5c3f\u4e2d\u6ee4\u8fc7\u7684\u4f4e\u5206\u5b50\u91cf\u86cb\u767d\u3002\u5728\u4f53\u5185\u5f62\u6210\u5e76\u5728\u8840\u6db2\u4e2d\u5faa\u73af\u7684\u4f4e\u5206\u5b50\u91cfAGEs\uff0c\u5728\u80be\u810f\u4e2d\u4e0e\u5de8\u86cb\u767d\u7ed3\u5408\u540e\uff0c\u901a\u8fc7\u5185\u541e\u4f5c\u7528\u5438\u6536\u5230\u80be\u5c0f\u7ba1\u7ec6\u80de\u4e2d\u3002\u4f46\u662f\uff0c\u5927\u91cfAGEs\u5438\u6536\u5230\u5de8\u86cb\u767d\u4e2d\u65f6\uff0c\u4f1a\u4f7f\u6eb6\u83cc\u9176\u4e2d\u7684AGEs\u5206\u89e3\u9971\u548c\u3002\u6700\u7ec8\uff0c\u80be\u5c0f\u7ba1\u7ec6\u80de\u4e2dAGEs\u84c4\u79ef(6-7)<\/sup>\u3002<\/p>\n

    \u53e6\u5916\uff0c\u80be\u810f\u8fd8\u53c2\u4e0e\u901a\u8fc7\u996e\u98df\u5438\u6536\u7684AGEs\u7684\u4ee3\u8c22\u6392\u6cc4\u3002\u8fd8\u6709\u62a5\u544a\u663e\u793a\uff0c\u5411\u5927\u9f20\u9759\u8109\u6ce8\u5c04\u620a\u7cd6\u7d20\u540e\uff0c35\uff05\u84c4\u79ef\u5230\u80be\u810f\u4e2d(6)<\/sup>\uff0c\u6444\u5165\u4f4eAGEs\u996e\u98df\u7684\u5065\u5eb7\u4eba\u7684\u5c3f\u4e2dAGEs\u6d53\u5ea6\u964d\u4f4e(7-8)<\/sup>\u3002<\/p>\n\n\n

    AGEs\u548c\u7cd6\u5c3f\u75c5\u80be\u75c5<\/strong><\/h3>\n\n\n\n

    \u7cd6\u5c3f\u75c5\u80be\u75c5\u7684\u7ec4\u7ec7\u5b66\u7279\u5f81\u5305\u62ec\u80be\u5c0f\u7403\u57fa\u5e95\u819c\u589e\u539a\u548c\u7cfb\u819c\u57fa\u8d28\u589e\u591a\u3002\u6b64\u5916\uff0c\u5728\u80be\u5c0f\u7403\u57fa\u5e95\u819c\u3001\u7cfb\u819c\u3001\u8db3\u7ec6\u80de\u3001\u80be\u5c0f\u7ba1\u7ec6\u80de\u3001\u5185\u76ae\u7ec6\u80de\u7b49\u5404\u79cd\u7ec6\u80de\u548c\u90e8\u4f4d\u5747\u53ef\u89c2\u5bdf\u5230AGEs\u7684\u84c4\u79ef(\u56fe2)(9-10)<\/sup>\u3002\u5e76\u6700\u7ec8\u5bfc\u81f4\u4f34\u80be\u5c0f\u7403\u786c\u5316\u7684\u80be\u8870\u7aed\u3002<\/p>\n\n\n

    \"\"<\/p>\n\n\n

    \u56fe2\u3000\u80be\u5c0f\u7403\u4e2d\u7684CML\u3001\u620a\u7cd6\u7d20\u84c4\u79ef\u548cRAGE\u8868\u8fbe<\/strong>
    (A)\uff5e(C);\u5065\u5eb7\u4eba\u7684\u80be\u5c0f\u7403,
    (D)\uff5e(F);\u4e2d\u5ea6\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u80be\u5c0f\u7403
    (A)(D);CML\u6297\u4f53\u67d3\u8272,
    (B)(E);\u620a\u7cd6\u7d20\u6297\u4f53\u67d3\u8272,
    (C)(F);RAGE\u6297\u4f53\u67d3\u8272
    \u4fee\u6539\u81eaTanji N. , et al.<\/em> (2000)(9)<\/sup><\/h6>\n\n\n\n

    \u7cd6\u5c3f\u75c5\u80be\u75c5\u7684\u75c5\u56e0\u662f\u6301\u7eed\u9ad8\u8840\u7cd6\uff0c\u4ece\u53d1\u75c5\u5230\u80be\u8870\u7aed\u7684\u8fdb\u5c55\u8fc7\u7a0b\u4e2d\u6d89\u53ca\u590d\u6742\u7684\u56e0\u7d20\u3002\u7cd6\u5c3f\u75c5\u53d1\u75c5\u540e\uff0c\u65e9\u671f\u53d1\u751f\u5728\u80be\u5c0f\u7403\u4e2d\u7684\u6700\u663e\u8457\u53d8\u5316\u662f\u80be\u5c0f\u7403\u8fc7\u5ea6\u6ee4\u8fc7\u548c\u80be\u5c0f\u7403\u9ad8\u8840\u538b\u3002\u80be\u5c0f\u7403\u8fc7\u5ea6\u6ee4\u8fc7\u548c\u80be\u5c0f\u7403\u5185\u538b\u5347\u9ad8\u4f1a\u635f\u4f24\u5185\u76ae\u7ec6\u80de\uff0c\u5f15\u53d1\u5de8\u566c\u7ec6\u80de\u6d78\u6da6\u548c\u8840\u5c0f\u677f\u805a\u96c6\u3002\u4ece\u8fd9\u4e9b\u7ec6\u80de\u4e2d\u91ca\u653e\u7684\u7ec6\u80de\u56e0\u5b50\u7b49\u4f1a\u4fc3\u8fdb\u7cfb\u819c\u7ec6\u80de\u4e2d\u7684\u7ec6\u80de\u5916\u57fa\u8d28\u4ea7\u751f\uff0c\u4fc3\u4f7f\u80be\u5c0f\u7403\u786c\u5316\u8fdb\u5c55\u3002\u6b64\u5916\uff0c\u7cfb\u819c\u7ec6\u80de\u7684\u4f38\u5c55\u523a\u6fc0\u4e5f\u4f1a\u4fc3\u8fdb\u7ec6\u80de\u5916\u57fa\u8d28\u7684\u751f\u6210\u3002\u5e76\u4e14\uff0c\u56e0\u9ad8\u8840\u7cd6\u5f15\u8d77\u7684\u7ec6\u80de\u5185\u4e8c\u9170\u57fa\u7518\u6cb9\u589e\u591a\u6240\u5bfc\u81f4\u7684\u86cb\u767d\u6fc0\u9176C(protein kinase C\uff1bPKC)\u6d3b\u6027\u589e\u5f3a\uff0c\u4ee5\u53ca\u7cd6\u5316\u5e94\u6fc0\u548c\u6c27\u5316\u5e94\u6fc0\u5bfc\u81f4\u7684AGEs\u84c4\u79ef\u662f\u80be\u75c5\u7684\u5173\u952e\u8fdb\u5c55\u56e0\u7d20(11)<\/sup>\u3002<\/p>\n\n\n\n

    \u5e76\u4e14\uff0c\u8fd1\u7aef\u5c0f\u7ba1\u7ec6\u80de\u7684\u840e\u7f29\u548c\u80be\u5c0f\u7ba1\u95f4\u8d28\u7684\u7ea4\u7ef4\u5316\u4e5f\u4f1a\u8fdb\u5c55\u3002\u8fd9\u4e9b\u7ec4\u7ec7\u5b66\u53d8\u5316\u7684\u56e0\u7d20\u8fd8\u6d89\u53ca\u4ee3\u8c22\u7d0a\u4e71\u3001\u8840\u6d41\u53d8\u5316\u3001\u7ec6\u80de\u56e0\u5b50\u548c\u751f\u957f\u56e0\u5b50TGF-\u03b2(transforming growth factor-\u03b2)\u7684\u8868\u8fbe\u3002<\/p>\n\n\n

    \n
    References<\/span><\/h5>\n
      \n
    1. \n
        \n
      1. \u8cb4\u5802\u660e\u4e16 : \u56f3\u89e3\u3067\u308f\u304b\u308b\u7cd6\u5c3f\u75c5. \u7247\u5c71\u9686\u53f8\uff08\u7de8\uff09. 2014; 48-49.<\/li>\n
      2. \u5742\u4e95\u5efa\u96c4 : \u65e5\u814e\u4f1a\u8a8c. 2001; 43: 572-579.<\/li>\n
      3. \u69c7\u91ce\u535a\u53f2\u3089 : CKD\u6cbb\u7642\u30ac\u30a4\u30c92012. \u65e5\u672c\u900f\u6790\u533b\u5b66\u4f1a\uff08\u7de8\uff09. \u65e5\u814e\u4f1a\u8a8c. 2012; 54: 1031-1189.<\/li>\n
      4. \u65e5\u672c\u900f\u6790\u533b\u5b66\u4f1a : \u56f3\u8aac \u308f\u304c\u56fd\u306e\u6162\u6027\u900f\u6790\u7642\u6cd5\u306e\u73fe\u6cc1. 2012\u5e7412\u670831\u65e5\u73fe\u5728. 2013;<\/li>\n
      5. \u57ce\u611b\u7406\u3089 : AGEs\u3068\u7cd6\u5c3f\u75c5\u6027\u814e\u75c7. AGEs\u3068\u8001\u5316. \u592a\u7530\u535a\u660e\uff08\u76e3\uff09, \u30e1\u30c7\u30a3\u30ab\u30eb\u30ec\u30d3\u30e5\u30fc\u793e. 2013: 125-133.<\/li>\n
      6. Miyata T, et al.<\/i> : Kidny Int. 1998; 53: 416-422.<\/li>\n
      7. Gugliucci A, et al.<\/i> : Diabetologia. 1996; 39: 149-160.<\/li>\n
      8. Foesrter A, et al.<\/i> : Biochem Soc Trans. 2003; 31: 1383-1385.<\/li>\n
      9. Tanji N, et al.<\/i> : J Am Soc Nephrol. 2000; 11: 1656-1666.<\/li>\n
      10. Biohlender JM, et al.<\/i> : Am J Physiol Renal Physiol. 2005; 289: F645-F659.<\/li>\n
      11. \u56db\u65b9\u8ce2\u4e00\u3089 : \u7cd6\u5c3f\u75c5\u6027\u814e\u75c7, \u30d7\u30ed\u30b9\u30bf\u30b5\u30a4\u30af\u30ea\u30f3\u306e\u591a\u69d8\u6027\u3068\u4eca\u5f8c\u306e\u5c55\u671b, \u30e1\u30c7\u30a3\u30ab\u30eb\u30ec\u30d3\u30e5\u30fc\u793e. 2002; 165-171.<\/li>\n
      12. Soulis-Liparota T, et al.<\/i> : Diabetes. 1991; 40: 1328-1334.<\/li>\n
      13. Tsuchida K, et al.<\/i> : Diabetologia. 1999; 4: 579-588.<\/li>\n
      14. Bolton WK, et al.<\/i> : Am J Nephrol. 2004; 24: 32-40.<\/li>\n
      15. Rabbani N, et al.<\/i> : Diabetologia. 2009; 52: 208-212.<\/li>\n
      16. Lewis EJ, et al.<\/i> : J Am Soc Nephrol, 2012; 23: 131-136.<\/li>\n
      17. Reiniger N, et al.<\/i> : Diabetes. 2010; 59: 2043-254.<\/li>\n
      18. Rabbini N, et al.<\/i> : Semin Cell Dev Biol. 2011; 309-317.<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/div>\n\n\n
        \n\n\n\n
        \u7cd6\u5316\u5e94\u6fc0\u548c\u6297\u8870\u8001<\/strong><\/h5>\n\n\n\n