{"id":10775,"date":"2020-09-24T12:45:56","date_gmt":"2020-09-24T03:45:56","guid":{"rendered":"https:\/\/ebn2.arkray.co.jp\/english\/?page_id=10775"},"modified":"2020-11-24T12:55:26","modified_gmt":"2020-11-24T03:55:26","slug":"glycation-stress_07","status":"publish","type":"page","link":"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_07\/","title":{"rendered":"\u7cd6\u5316\u5e94\u6fc0\u548c\u76ae\u80a4\u8001\u5316"},"content":{"rendered":"\n<h2>\u7cd6\u5316\u5e94\u6fc0\u548c\u76ae\u80a4\u8001\u5316<\/h2>\n\n\n<p class=\"author\">\u540c\u5fd7\u793e\u5927\u5b66\u5927\u5b66\u9662 \u751f\u547d\u533b\u79d1\u5b66\u7814\u7a76\u79d1 \u7cd6\u5316\u5e94\u6fc0\u7814\u7a76\u4e2d\u5fc3<br>\u516b\u6728\u96c5\u4e4b \u6559\u6388 \u4e3b\u7f16<\/p>\n\n\n<h3>\u76ae\u80a4\u7684\u7ed3\u6784\u548c\u529f\u80fd<\/h3>\n\n\n<p>\u76ae\u80a4\u662f\u4f4d\u4e8e\u751f\u7269\u4f53\u6700\u5916\u5c42\u7684\u7ec4\u7ec7\uff0c\u8d77\u4fdd\u62a4\u751f\u7269\u4f53\u5185\u90e8\u4e0d\u53d7\u51b2\u51fb\u3001\u6e29\u5ea6\u3001\u7d2b\u5916\u7ebf\u3001\u5316\u5b66\u7269\u8d28\u7b49\u5916\u90e8\u73af\u5883\u5f71\u54cd\u7684\u4f5c\u7528\u3002\u4ece\u5916\u4fa7\u770b\uff0c\u76ae\u80a4\u7531\u8868\u76ae(epidermis)\u3001\u771f\u76ae(dermis)\u548c\u76ae\u4e0b\u8102\u80aa\u7ec4\u7ec7(subcutaneous fat tissue)3\u5c42\u6784\u6210<sup>(1)<\/sup>\u3002<\/p>\n<p>\u8868\u76ae\u662f\u6700\u5916\u5c42\u7684\u76ae\u80a4\u7ec4\u7ec7\uff0c\u5e73\u5747\u539a\u5ea6\u4e3a0.2mm\u3002\u6b64\u5916\uff0c\u8868\u76ae\u75314\u5c42\u6784\u6210\uff0c\u7531\u5916\u5411\u5185\u4f9d\u6b21\u4e3a\u89d2\u8d28\u5c42(stratum corneum)\u3001\u9897\u7c92\u5c42(granular cell layer)\u3001\u68d8\u5c42(prickle cell layer)\u548c\u57fa\u5e95\u5c42(basal cell layer)(\u56fe1)\u3002\u4f4d\u4e8e\u6700\u5916\u5c42\u7684\u89d2\u8d28\u5c42\u9632\u6c34\uff0c\u5728\u9632\u6b62\u7ec6\u83cc\u548c\u75c5\u6bd2\u7b49\u4fb5\u5165\u4f53\u5185\u7684\u540c\u65f6\uff0c\u5177\u6709\u4fdd\u62a4\u808c\u8089\u3001\u795e\u7ecf\u548c\u8840\u7ba1\u7b49\u8eab\u4f53\u5185\u90e8\u5668\u5b98\u514d\u53d7\u5916\u4f24\u7684\u4f5c\u7528\u3002\u56e0\u6b64\uff0c\u89d2\u8d28\u5c42\u5bf9\u7ef4\u6301\u751f\u7269\u4f53\u800c\u8a00\u53d1\u6325\u4e86\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u3002\u6b64\u5916\uff0c\u6784\u6210\u8868\u76ae\u7684\u7ec6\u80de\u4e2d\u670995\uff05\u662f\u89d2\u8d28\u5f62\u6210\u7ec6\u80de\uff0c\u5728\u8868\u76ae\u5c42\u7684\u6700\u5e95\u5c42\u5206\u88c2\uff0c\u5e76\u968f\u7740\u6210\u719f\u8fc1\u79fb\u5230\u8868\u5c42\u3002\u4ece\u57fa\u5e95\u7ec6\u80de\u5206\u88c2\u3001\u751f\u6210\u5b50\u7ec6\u80de\u3001\u76f4\u5230\u81f3\u8868\u76ae\u8868\u9762\u8131\u843d\uff0c\u901a\u5e38\u4e3a40\uff5e56\u5929\uff0c\u8fd9\u6bb5\u65f6\u95f4\u79f0\u4e3a\u8868\u76ae\u66f4\u65b0\u65f6\u95f4(turnover time)<sup>(2-3)<\/sup>\u3002<\/p>\n<p><img loading=\"lazy\" class=\"aligncenter wp-image-12728 size-full\" src=\"http:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/slide0013_image001_zh.png\" alt=\"\" width=\"445\" height=\"371\" srcset=\"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/slide0013_image001_zh.png 445w, https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/slide0013_image001_zh-300x250.png 300w\" sizes=\"(max-width: 445px) 100vw, 445px\" \/><\/p>\n<h6 style=\"text-align: center;\"><strong>\u56fe<\/strong><strong>1<\/strong><strong>\u3000\u6784\u6210\u8868\u76ae\u7684<\/strong><strong>4<\/strong><strong>\u5c42\u7ed3\u6784<br \/><\/strong>\u4fee\u6539\u81ea\u6e05\u6c34\u5b8f(2011)<sup>(1)<\/sup><\/h6>\n<p>\u89d2\u8d28\u5c42\u662f\u7531\u7ea610\u5c42\u7ec6\u80de\u6838\u5df2\u6d88\u5931\u7684\u7ec6\u80de\u91cd\u53e0\u800c\u6210\u7684\u819c\u72b6\u7ec4\u7ec7\uff0c\u7531\u8868\u81f3\u91cc\u4f9d\u6b21\u5448\u201c\u57a2\u201d\u8131\u843d\u3002\u89d2\u8d28\u5c42\u7531\u89d2\u8d28\u5f62\u6210\u7ec6\u80de\u4ea7\u751f\u7684\u89d2\u86cb\u767d\u548c\u8102\u8d28\u7b49\u5404\u79cd\u7269\u8d28\u6784\u6210\u3002\u89d2\u8d28\u5f62\u6210\u7ec6\u80de\u5728\u57fa\u5e95\u5c42\u5206\u88c2\u4ea7\u751f\u89d2\u86cb\u767d\uff0c\u540c\u65f6\u9010\u6e10\u5206\u5316\u3001\u6210\u719f\uff0c\u5e76\u5411\u4e0a\u5c42\u8fc1\u79fb\u3002\u5728\u57fa\u5e95\u7ec6\u80de\u5c42\u5f62\u6210\u89d2\u86cb\u767d5\u548c\u89d2\u86cb\u767d14\uff0c\u5728\u68d8\u5c42\u548c\u9897\u7c92\u5c42\u5f62\u6210\u89d2\u86cb\u767d1\u548c\u89d2\u86cb\u767d10\u3002<\/p>\n<p>\u8868\u76ae\u5c42\u5185\u4fa7\u6709\u4ea7\u751f\u8272\u7d20\u4f7f\u76ae\u80a4\u6697\u6de1\u7684\u8272\u7d20\u7ec6\u80de(melanocytes)\u548c\u4e0e\u76ae\u80a4\u514d\u75ab\u529f\u80fd\u6709\u5173\u7684\u6717\u683c\u6c49\u65af\u7ec6\u80de(langerhans cell)\u3001\u4ee5\u53ca\u4f5c\u4e3a\u89e6\u89c9\u611f\u53d7\u7ec6\u80de\u7684\u6885\u514b\u5c14\u7ec6\u80de(merkel cell)\u3002<\/p>\n<p>\u771f\u76ae\u662f\u4f4d\u4e8e\u8868\u76ae\u4e0b\u65b9\u7ea62.0\uff5e3.0mm\u539a\u7684\u5c42\u72b6\u7ec4\u7ec7\uff0c\u4e0e\u8868\u76ae\u4e4b\u95f4\u6709\u57fa\u5e95\u819c\u963b\u9694\u3002\u5728\u89e3\u5256\u5b66\u4e0a\uff0c\u771f\u76ae\u5177\u6709\u4e73\u5934\u5c42(papillary layer)\u3001\u4e73\u5934\u4e0b\u5c42(subpapillary layer)\u548c\u7f51\u72b6\u5c42(reticular layer)3\u5c42\u7ed3\u6784\u3002\u771f\u76ae\u8d4b\u4e88\u4e86\u76ae\u80a4\u5f39\u6027\u548c\u97e7\u6027\u3002<\/p>\n<p>\u6784\u6210\u771f\u76ae\u7684\u6210\u5206\u5305\u62ec\u6784\u6210\u7ea4\u7ef4\u7ec4\u7ec7\u7684\u57fa\u8d28\u6210\u5206(\u7ec6\u80de\u5916\u57fa\u8d28)\u53ca\u5176\u751f\u4ea7\u7ec6\u80de\u7b49\u3002\u57fa\u8d28\u6210\u5206\u7684\u4e3b\u8981\u6210\u5206\u4e3a\u80f6\u539f\u7ea4\u7ef4(\u4e3b\u8981\u4e3a\u2160\u548c\u2162\u578b\u80f6\u539f)\uff0c\u9664\u6b64\u4ee5\u5916\u8fd8\u6709\u5f39\u6027\u7ea4\u7ef4(\u5f39\u6027\u86cb\u767d\u7ea4\u7ef4)\u3001\u86cb\u767d\u805a\u7cd6(\u900f\u660e\u8d28\u9178\u3001\u786b\u9178\u8f6f\u9aa8\u7d20\u7b49)\u7b49\u3002<\/p>\n<p>\u771f\u76ae\u5e72\u91cd\u768470\uff05\u662f\u80f6\u539f\u86cb\u767d\uff0c\u8d4b\u4e88\u76ae\u80a4\u201c\u7d27\u81f4\u201d\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u5360\u6bd41\uff5e2\uff05\u7684\u5f39\u6027\u86cb\u767d\u5177\u6709\u4ea4\u8054\u7ed3\u6784\uff0c\u8d4b\u4e88\u76ae\u80a4\u201c\u5f39\u6027\u201d\u3002\u86cb\u767d\u805a\u7cd6\u5f62\u6210\u542b\u6d78\u5927\u91cf\u6c34\u5206\u7684\u51dd\u80f6\uff0c\u8d4b\u4e88\u76ae\u80a4\u201c\u6e7f\u6da6\u201d\u3002\u9664\u6b64\u4ee5\u5916\uff0c\u771f\u76ae\u5185\u8fd8\u6709\u611f\u53d7\u89e6\u89c9\u3001\u8212\u9002\u6027\u3001\u6e29\u5ea6\u7684\u795e\u7ecf\u672b\u68a2\uff0c\u8c03\u8282\u4f53\u6e29\u3001\u6da6\u6cfd\u76ae\u80a4\u5e76\u4f7f\u76ae\u80a4\u4fdd\u6301\u67d4\u8f6f\u72b6\u6001\u7684\u5206\u6ccc\u817a(\u6c57\u817a\u3001\u76ae\u8102\u817a)\u3001\u6bdb\u56ca\u3001\u8840\u7ba1\u7b49\u3002<\/p>\n<p>\u76ae\u4e0b\u7ec4\u7ec7\u662f\u4f4d\u4e8e\u771f\u76ae\u4e0b\u65b9\u7684\u51e0\u6beb\u7c73\u7684\u8102\u80aa\u5c42\uff0c\u5176\u539a\u5ea6\u56e0\u8eab\u4f53\u90e8\u4f4d\u4e0d\u540c\u800c\u6709\u6240\u5dee\u5f02\u3002\u4fdd\u62a4\u673a\u4f53\u514d\u53d7\u5916\u754c\u7a7a\u6c14\u51b7\u70ed\u4fb5\u88ad\uff0c\u540c\u65f6\u5177\u6709\u7f13\u51b2\u4f5c\u7528\u3002\u53e6\u5916\uff0c\u76ae\u4e0b\u7ec4\u7ec7\u4e2d\u7684\u8102\u80aa\u7ec6\u80de\u80fd\u84c4\u79ef\u8102\u80aa\uff0c\u4f5c\u4e3a\u80fd\u91cf\u8d2e\u5b58\u90e8\u4f4d\u53d1\u6325\u4f5c\u7528\u3002<\/p>\n\n\n<h3>\u76ae\u80a4\u8001\u5316<\/h3>\n\n\n<ol>\n<li><strong>\u201c\u8868\u89c2\u5e74\u9f84\u201d\u964d\u4f4e<\/strong><br>\u4ece\u4eba\u7684\u5916\u8c8c\u4f30\u7b97\u5e74\u9f84\u65f6\uff0c\u76ae\u80a4\u7684\u76b1\u7eb9\u3001\u5f39\u6027\u3001\u677e\u5f1b\u5ea6\u3001\u8272\u8c03\u3001\u5149\u6cfd\u3001\u7eb9\u7406(\u808c\u7406)\u7b49\u5747\u53ef\u4f5c\u4e3a\u6709\u529b\u7684\u4fe1\u606f\u6e90<sup>(4)<\/sup><span style=\"font-size: inherit;\">\u3002\u8868\u89c2\u5e74\u9f84\u672a\u5fc5\u4e0e\u5b9e\u9645\u5e74\u9f84\u4e00\u81f4\uff0c\u5373\u4fbf\u662f\u5b9e\u9645\u5e74\u9f84\u76f8\u540c\u7684\u4eba\uff0c\u5176\u8868\u89c2\u5e74\u9f84\u4e5f\u4f1a\u56e0\u751f\u6d3b\u73af\u5883\u3001\u751f\u6d3b\u4e60\u60ef\u3001\u996e\u98df\u4e60\u60ef\u7b49\u5b58\u5728\u8f83\u5927\u5dee\u5f02\u3002\u9762\u90e8\u7b49\u66b4\u9732\u8f83\u591a\u7684\u90e8\u4f4d\u66f4\u5bb9\u6613\u51fa\u73b0\u53d8\u5316(\u8001\u5316)\u3002\u53e6\u5916\uff0c\u76f8\u8f83\u4e8e\u5b9e\u9645\u5e74\u9f84\uff0c\u8868\u89c2\u5e74\u9f84\u8d8a\u9ad8\uff0c\u52a8\u8109\u786c\u5316\u7684\u98ce\u9669\u8d8a\u9ad8<\/span><sup>(5)<\/sup><span style=\"font-size: inherit;\">\u3002<\/span><\/li>\n<li><strong>\u808c\u80a4\u201c\u7eb9\u7406\u201d\u51cf\u5c11<\/strong><br>\u5728\u76ae\u80a4\u8868\u9762\u6709\u4ee5\u6bdb\u5b54(\u7ec6\u5b54)\u4e3a\u4e2d\u5fc3\u5f62\u6210\u7eb5\u6a2a\u4ea4\u9519\u3001\u5448\u653e\u5c04\u72b6\u8d70\u5411\u7684\u76ae\u6c9f\uff0c\u4ee5\u53ca\u7531\u88ab\u76ae\u6c9f\u56f4\u6210\u7684\u76ae\u4e18\u800c\u4ea7\u751f\u7684\u76ae\u7eb9\u3002\u5e74\u8f7b\u4eba\u7684\u76ae\u7eb9\u7ec6\u817b\u3001\u51f9\u51f8\u6e05\u6670\u4e14\u5f62\u72b6\u89c4\u5219\uff0c\u4f7f\u76ae\u80a4\u5177\u6709\u7ec6\u5bc6\u7684\u8d28\u611f\u3001\u5373\u201c\u7eb9\u7406\u201d\u3002\u4f46\u662f\uff0c\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\uff0c\u76ae\u80a4\u7684\u76ae\u6c9f\u53d8\u6d45\u4e14\u53d8\u5f97\u4e0d\u6e05\u6670\uff0c\u540c\u65f6\u6bdb\u5b54\u7684\u5927\u5c0f\u589e\u5927\uff0c\u76ae\u7eb9\u6539\u53d8\uff0c\u7eb9\u7406\u51cf\u5c11\u3002\u8fd9\u79cd\u72b6\u6001\u7684\u76ae\u80a4\u7684\u8d28\u611f\u53d8\u5f97\u7c97\u7cd9\u4e0d\u5e73\uff0c\u800c\u4e14\u770b\u8d77\u6765\u4f1a\u6bd4\u5b9e\u9645\u5e74\u9f84\u66f4\u8001\u3002<\/li>\n<li><strong>\u76b1\u7eb9\u589e\u591a<\/strong><br>\u4e0d\u540c\u4e8e\u201c\u7eb9\u7406\u201d\uff0c\u201c\u76b1\u7eb9\u201d\u662f\u5728\u5b8f\u89c2\u5c42\u9762\u4e0a\u53d1\u751f\u7684\u76ae\u80a4\u5f62\u6001\u53d8\u5316\uff0c\u4e8e30\u5c81\u4ee5\u540e\u51fa\u73b0\u5728\u773c\u775b\u548c\u5634\u5df4\u5468\u56f4\u3001\u989d\u5934\u3001\u9888\u90e8\u7b49<sup>(6)<\/sup><span style=\"font-size: inherit;\">\u3002\u5e76\u4e14\uff0c\u76b1\u7eb9\u7684\u6570\u91cf\u548c\u6df1\u5ea6\u968f\u5e74\u9f84\u7684\u589e\u957f\u800c\u589e\u52a0\u3002\u9762\u90e8\u548c\u9888\u90e8\u7b49\u90e8\u4f4d\u51fa\u73b0\u7684\u76b1\u7eb9\u4e0e\u808c\u8089\u6d3b\u52a8\u548c\u65e5\u6652\u6709\u5173\u3002\u7d2b\u5916\u7ebf\u4f1a\u5bfc\u81f4\u76ae\u80a4\u7ec4\u7ec7\u7ea4\u7ef4\u65ad\u88c2\u3001\u5931\u53bb\u67d4\u97e7\u6027\u3001\u5bf9\u53d8\u5f62\u7684\u6062\u590d\u529b\u4e0b\u964d\u3002<\/span><\/li>\n<li><strong>\u8272\u8c03\u53d8\u5316\uff0c\u201c\u6697\u6c89\u201d\u589e\u52a0<\/strong><br>\u76ae\u80a4\u7684\u8272\u8c03\u4e3b\u8981\u53d6\u51b3\u4e8e\u9ed1\u8272\u7d20(\u68d5\u8272)\u3001\u80e1\u841d\u535c\u7d20(\u9ec4\u8272)\u548c\u8840\u7ea2\u86cb\u767d(\u7ea2\u8272~\u84dd\u8c03\u7ea2\u8272)\u3002\u6b64\u5916\uff0c\u4e5f\u4f1a\u53d7\u89d2\u8d28\u5c42\u539a\u5ea6\u548c\u8868\u9762\u72b6\u6001(\u7eb9\u7406\u3001\u76b1\u7eb9)\u7b49\u4ea7\u751f\u7684\u5149\u7684\u53cd\u5c04\u548c\u5438\u6536\u7684\u5f71\u54cd\u3002\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\uff0c\u5728\u8272\u8c03\u53d8\u5316\u65b9\u9762\uff0c\u53ef\u89c2\u5bdf\u5230\u7ea2\u8272\u51cf\u5c11\u3001\u9ec4\u8272\u589e\u52a0\u3001\u4eae\u5ea6\u964d\u4f4e\uff0c\u6700\u7ec8\u5bfc\u81f4\u80a4\u8272\u6697\u6de1<sup>(7)<\/sup><span style=\"font-size: inherit;\">\u3002\u6697\u6c89\u7684\u56e0\u7d20\u6d89\u53ca\u8272\u7d20\u6c89\u7740\u3001\u8840\u6d41\u51cf\u5c11\u3001\u89d2\u8d28\u5c42\u589e\u539a\u3001\u76ae\u80a4\u86cb\u767d\u7684\u7cd6\u5316\u548c\u6c27\u5316\u3002<\/span><\/li>\n<li><strong>\u76ae\u80a4\u529f\u80fd\u4e0b\u964d<\/strong><br>\u8868\u76ae\u4e2d\u57fa\u5e95\u7ec6\u80de\u7684\u589e\u6b96\u4f1a\u968f\u7740\u5e74\u9f84\u589e\u957f\u800c\u964d\u4f4e\u53d8\u8584\uff0c\u5e76\u4e14\u8868\u76ae\u66f4\u65b0\u65f6\u95f4\u4e5f\u4f1a\u5ef6\u957f<sup>(8)<\/sup><span style=\"font-size: inherit;\">\u3002\u5728\u771f\u76ae\u7684\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e2d\uff0c\u589e\u6b96\u529f\u80fd\u548c\u57fa\u8d28\u6210\u5206\u7684\u5408\u6210\u80fd\u529b\u4e0b\u964d\u3002\u5176\u7ed3\u679c\u5c06\u662f\uff0c\u771f\u76ae\u840e\u7f29\uff0c\u53d8\u6210\u6ca1\u6709\u5f39\u6027\u7684\u76ae\u80a4\u3002\u7ec6\u80de\u529f\u80fd\u4e0b\u964d\u7684\u4e3b\u8981\u539f\u56e0\u662f\u6fc0\u7d20\u548c\u751f\u957f\u56e0\u5b50\u7b49\u65e0\u6cd5\u4e0e\u76ae\u80a4\u7ec6\u80de\u5145\u5206\u53cd\u5e94\u3002\u76ae\u80a4\u529f\u80fd\u53d8\u5316\u7684\u4e3b\u8981\u56e0\u7d20\u5305\u62ec\u89d2\u8d28\u5c42\u5c4f\u969c\u529f\u80fd\u6062\u590d\u5ef6\u8fdf\u3001\u4fdd\u6e7f\u529f\u80fd\u4e0b\u964d(\u5e72\u71e5)\u3001\u6027\u6fc0\u7d20\u5206\u6ccc\u53d8\u5316\u5e26\u6765\u7684\u76ae\u8102\u5206\u6ccc\u91cf\u53d8\u5316\uff0c\u76ae\u80a4\u8840\u6d41\u91cf\u51cf\u5c11\u3001\u8102\u8d28\u548c\u7cd6\u7c7b\u7684\u4ee3\u8c22\u53d8\u5316\u7b49\u3002<\/span><\/li>\n<\/ol>\n\n\n<h3>\u76ae\u80a4\u7684\u7cd6\u5316\u4e0e\u8001\u5316<\/h3>\n\n\n\n<p>\u771f\u76ae\u4e2d\u7684\u4e3b\u8981\u6210\u5206\u80f6\u539f\u86cb\u767d\u548c\u5f39\u6027\u86cb\u767d\u7b49\uff0c\u56e0\u534a\u8870\u671f\u957f\u800c\u5bb9\u6613\u88ab\u7cd6\u57fa\u5316<sup>(9-10)<\/sup>\u3002\u901a\u5e38\uff0c\u80f6\u539f\u86cb\u767d\u548c\u5f39\u6027\u86cb\u767d\u4f1a\u5728\u7ec4\u7ec7\u4e2d\u7684\u7ea4\u7ef4\u5f62\u6210\u8fc7\u7a0b\u4e2d\uff0c\u901a\u8fc7\u8d56\u6c28\u9178\u548c\u7f9f\u8d56\u6c28\u9178\u6b8b\u57fa\u5f62\u6210\u7ea4\u7ef4\u5316\u4ea4\u8054\u3002\u4f46\u662f\uff0c\u5f53\u5728\u76ae\u80a4\u7ec4\u7ec7\u4e2d\u8fdb\u884c\u7cd6\u5316\uff0c\u4e14\u5728\u86cb\u767d\u8d28\u7684\u8d56\u6c28\u9178\u6b8b\u57fa\u4e2d\u751f\u6210CML\u65f6\uff0c\u86cb\u767d\u8d28\u8d56\u6c28\u9178\u6b8b\u57fa\u7684\u4ea4\u8054\u5f62\u6210\u5c06\u88ab\u6291\u5236\u3002\u56e0\u6b64\uff0c\u7cd6\u5316\u5bf9\u76ae\u80a4\u7ea4\u7ef4\u7ec4\u7ec7\u7684\u7a33\u5b9a\u6027\u6709\u5de8\u5927\u5f71\u54cd\u3002<\/p>\n\n\n\n<p>\u5149\u7ebf\u6027\u5f39\u529b\u7ea4\u7ef4\u75c5(solar elastosis)\u662f\u6307\u5728\u65e5\u5149\u7167\u5c04\u90e8\u4f4d\u7684\u771f\u76ae\u4e2d\uff0c\u5f02\u5e38\u5f39\u6027\u86cb\u767d\u7ea4\u7ef4\u84c4\u79ef\u7684\u72b6\u6001\u3002\u6211\u4eec\u8ba4\u4e3a\u8fd9\u662f\u56e0\u957f\u671f\u66b4\u9732\u4e8e\u7d2b\u5916\u7ebf\u800c\u5bfc\u81f4\u7684\u9762\u90e8\u5f39\u6027\u86cb\u767d\u7cd6\u57fa\u5316\u3002\u572830\uff5e40\u5c81\u7684\u6b63\u5e38\u4eba\u4e2d\uff0c\u5747\u4f1a\u5728\u4e0d\u540c\u7a0b\u5ea6\u4e0a\u5448\u73b0\u5149\u7ebf\u6027\u5f39\u529b\u7ea4\u7ef4\u75c5\u72b6\u6001\uff0c\u4e14\u4e0e\u9762\u90e8\u7684\u76b1\u7eb9\u548c\u677e\u5f1b\u5ea6\u5f62\u6210\u6709\u5173\u3002\u5728\u4f7f\u7528\u6297CML\u6297\u4f53\u5bf9\u6b63\u5e38\u4eba\u7684\u9762\u90e8\u76ae\u80a4\u8fdb\u884c\u67d3\u8272\u540e\uff0c\u4ece30\uff5e40\u5c81\u5f00\u59cb\u53ef\u89c1CML\u5728\u5f39\u6027\u7ea4\u7ef4\u4e2d\u7684\u84c4\u79ef\uff0c\u8001\u5e74\u4eba\u4e2d\u5219\u53d8\u4e3a\u5728\u6574\u4e2a\u5f39\u6027\u86cb\u767d\u7ea4\u7ef4\u4e2d\u53ef\u89c1\u84c4\u79ef(\u56fe2)<sup>(11)<\/sup>\u3002 CML\u5316\u540e\u7684\u5f39\u6027\u86cb\u767d\u4e0d\u6613\u88ab\u55dc\u4e2d\u6027\u7c92\u7ec6\u80de\u5f39\u6027\u86cb\u767d\u9176\u5206\u89e3\uff0c\u4ece\u800c\u5bfc\u81f4\u805a\u96c6\u80fd\u529b\u589e\u5f3a\u3001\u7ea4\u7ef4\u76f4\u5f84\u589e\u52a0\u3001\u5f39\u6027\u7387\u548c\u4f38\u957f\u7387\u964d\u4f4e\u3002\u56e0\u6b64\uff0c\u5f39\u6027\u86cb\u767d\u7684\u7cd6\u57fa\u5316\u4f1a\u5bfc\u81f4\u76ae\u80a4\u8001\u5316\u3002<\/p>\n\n\n<p><img loading=\"lazy\" class=\"aligncenter size-full wp-image-12858\" src=\"http:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/figure02_zh-1.png\" alt=\"\" width=\"539\" height=\"467\" srcset=\"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/figure02_zh-1.png 539w, https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/figure02_zh-1-300x260.png 300w\" sizes=\"(max-width: 539px) 100vw, 539px\" \/><\/p>\n\n\n<h6 class=\"has-text-align-center\"><strong>\u56fe2\u3000\u5e74\u9f84\u589e\u957f\u548c\u65e5\u6652\u5e26\u6765\u7684\u76ae\u80a4\u4e2dCML\u7684\u84c4\u79ef<\/strong><br>A\uff1aElastica van Gieson(EVG)\u67d3\u8272\uff0c<br>B\uff1a\u6297CML\u67d3\u8272<br>\u7167\u7247A\u4e2d\u67d3\u6210\u9ed1\u7d2b\u8272\u7684\u533a\u57df<br>\u8868\u793a\u5f39\u6027\u86cb\u767d(\u5f39\u6027\u7ea4\u7ef4)\u3002<br>\u7167\u7247B\u4e2d\u67d3\u6210\u6df1\u8272\u7684\u533a\u57df<br>\u8868\u793aCML\u7684\u84c4\u79ef\u3002<br>\u4fee\u6539\u81ea\u591a\u5c9b\u65b0\u543e(2013)<sup>(11)<\/sup><\/h6>\n\n\n\n<p>\u53e6\u4e00\u65b9\u9762\uff0c\u5728\u76ae\u80a4\u66f4\u65b0\u65f6\u95f4\u8f83\u77ed\u7684\u8868\u76ae\u4e2d\u4e5f\u53ef\u89c2\u5bdf\u5230AGEs\u7684\u84c4\u79ef\u3002CML\u5728\u8868\u76ae\u6240\u542b\u7684\u89d2\u86cb\u767d10\u4e2d\u84c4\u79ef(\u56fe3)<sup>(12)<\/sup>\u3002<\/p>\n\n\n<p><img loading=\"lazy\" class=\"aligncenter wp-image-12731 size-full\" src=\"http:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/slide0012_image005.png\" alt=\"\" width=\"363\" height=\"270\" srcset=\"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/slide0012_image005.png 363w, https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/slide0012_image005-300x223.png 300w\" sizes=\"(max-width: 363px) 100vw, 363px\" \/><\/p>\n<h6 style=\"text-align: center;\"><strong>\u56fe<\/strong><strong>3<\/strong><strong>\u3000\u8868\u76ae\u4e2d\u7684<\/strong><strong>CML<\/strong><strong>\u84c4\u79ef<br><\/strong>\u76ae\u80a4\u7ec4\u7ec7\u67d3\u8272\u56fe\u50cf(71\u5c81\u5973\u6027\u3001\u8179\u90e8)<br>K10: cytokeratin 10<br>CML(\u7ea2\uff1a\u6297CML\u6297\u4f53\u67d3\u8272)<br>+ K10(\u7eff\uff1a\u6297K10\u6297\u4f53\u67d3\u8272)<br>\u2192\u5408\u6210\u56fe\u50cf(\u9ec4)<br>\u4fee\u6539\u81eaKawabata K, et al (2011)<sup>(12)<\/sup><\/h6>\n\n\n<p>\u6b64\u5916\uff0c\u5728\u4f4d\u4e8e\u76ae\u80a4\u6700\u5916\u5c42\u7684\u89d2\u8d28\u5c42\u4e2d\u4e5f\u53ef\u89c2\u5bdf\u5230CML\u7684\u84c4\u79ef\u3002 CML\u84c4\u79ef\u91cf\u591a\u7684\u89d2\u8d28\u5c42\u7684\u808c\u80a4\u7eb9\u7406\u51cf\u5c11(\u56fe4)<sup>(13)<\/sup>\u3002\u53e6\u5916\uff0c\u7531\u4e8e\u89d2\u8d28\u5c42CML\u7684\u84c4\u79ef\u4e0e\u76ae\u80a4\u8868\u9762\u51f9\u9677\u7684\u5404\u5411\u540c\u6027\u4e0b\u964d\u3001\u76ae\u80a4\u8868\u9762\u7684\u7b97\u672f\u7c97\u7cd9\u5ea6\u6307\u6570\u4e0b\u964d\u6709\u5173\uff0c\u56e0\u6b64\u89d2\u8d28\u5c42\u4e2dCML\u7684\u84c4\u79ef\u4e0e\u9762\u90e8\u53d8\u5f97\u8870\u8001\u6709\u5173\u3002\u800c\u4e14\uff0c\u89d2\u8d28\u5c42\u4e2dCML\u84c4\u79ef\u91cf\u7684\u589e\u52a0\u4e0e\u76ae\u80a4\u5f39\u6027\u4e0b\u964d\u6709\u5173\uff0c\u540c\u65f6\u8fd8\u663e\u793a\u4e0e\u76ae\u80a4\u4e2d\u8367\u5149\u6027AGEs\u7684\u84c4\u79ef\u91cf\u4e5f\u6709\u76f8\u5173\u6027<sup>(14)<\/sup>\u3002<\/p>\n\n\n<h6 style=\"text-align: center;\"><strong><img loading=\"lazy\" class=\"size-full wp-image-12730 aligncenter\" src=\"http:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/figure04.png\" alt=\"\" width=\"427\" height=\"359\" srcset=\"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/figure04.png 427w, https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/figure04-300x252.png 300w\" sizes=\"(max-width: 427px) 100vw, 427px\" \/><\/strong><strong>\u56fe<\/strong><strong>4<\/strong><strong>\u3000\u89d2\u8d28\u5c42\u4e2d\u7684<\/strong><strong>AGEs<\/strong><strong>\u84c4\u79ef<br><\/strong>A\u3001B\uff1a\u6297AGEs\u6297\u4f53\u67d3\u8272<br>C\u3001D\uff1a\u76ae\u80a4\u8868\u9762\u590d\u5236\u56fe\u50cf<br>A\u3001C\uff1a\u89d2\u8d28\u5c42AGEs\u5c11\u7684\u540c\u4e00\u53d7\u8bd5\u8005<br>B\u3001D\uff1a\u89d2\u8d28\u5c42AGEs\u591a\u7684\u540c\u4e00\u53d7\u8bd5\u8005<br>\u4fee\u6539\u81ea\u4e94\u5473\u8d35\u4f18(2011)<sup>(13)<\/sup><\/h6>\n<div class=\"ref_css\">\n<h5><span lang=\"en\">References<\/span><\/h5>\n<ol class=\"ref_css\">\n<li style=\"list-style-type: none;\">\n<ol>\n<li>\u6e05\u6c34\u5b8f\uff1a\u65b0\u3057\u3044\u76ae\u819a\u79d1\u5b66\u3000\u7b2c\uff12\u7248, 2011, \u4e2d\u5c71\u66f8\u5e97.<\/li>\n<li>Halprin KM,&nbsp;<i>et al.<\/i>&nbsp;: Br J Dermatol 1972 ; 86 : 14-19.<\/li>\n<li>Iizuka H,&nbsp;<i>et al.<\/i>&nbsp;: J Dermatol Sci. 1994 ; 8 : 215-217.<\/li>\n<li>\u5c71\u7530\u79c0\u548c\uff1a\u898b\u305f\u76ee\u306e\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0, 2011, \u6587\u5149\u5802.<\/li>\n<li>Kido M,&nbsp;<i>et al.<\/i>&nbsp;: Geriatr Gerontol In 2012 : 12 : 733\u2013740.<\/li>\n<li>Ichihasi M,&nbsp;<i>et al.<\/i>&nbsp;: Anti-Aging Medicine. 2011 ; 8 : 23-29.<\/li>\n<li>\u5c0f\u6fa4\u9054\u4e5f\uff1a\u30a8\u30a4\u30b8\u30f3\u30b0\u306e\u5316\u7ca7\u5b66. 1998, \u65e9\u7a32\u7530\u5927\u5b66\u51fa\u7248\u90e8.<\/li>\n<li>Baumann L : J Pathol. 2007 ; 211 : 241-251.<\/li>\n<li>Dyer DG,&nbsp;<i>et al.<\/i>&nbsp;: J Clin Invest. 1993 ; 91 : 2463\u20132469.<\/li>\n<li>Mizutani K,&nbsp;<i>et al.<\/i>&nbsp;: J Clin Invest. 1997 ; 108 : 797\u2013802.<\/li>\n<li>\u591a\u5cf6\u65b0\u543e\uff1a\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u533b\u5b66. 2013 ; 8 : 35-41.<\/li>\n<li>Kawabata K,&nbsp;<i>et al.<\/i>&nbsp;: Biochimica et Biophysica Acta. 2011 ; 1814 : 1246\u20131252.<\/li>\n<li>\u4e94\u5473\u8cb4\u512a\uff1aBIO INDUSTRY. 2011; 28 : 20-26.<\/li>\n<li>\u516b\u6728\u96c5\u4e4b\u3089\uff1a\u7b2c14\u56de\u65e5\u672c\u6297\u52a0\u9f62\u533b\u5b66\u4f1a\u7dcf\u4f1a\u8981\u65e8. 2014.<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/div>\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<h5><strong>\u7cd6\u5316\u5e94\u6fc0\u548c\u6297\u8870\u8001<\/strong><\/h5>\n\n\n\n<ul><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_01\/\">\u4ec0\u4e48\u662f\u7cd6\u5316\u5e94\u6fc0\uff1f<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_02\">\u7cd6\u5316\u5e94\u6fc0\u6807\u5fd7\u7269\u7684\u68c0\u6d4b\u65b9\u6cd5(1)\u3000\u8840\u7cd6\u3001\u7cd6\u5316\u86cb\u767d\u3001\u7cd6\u5316\u53cd\u5e94\u4e2d\u95f4\u4f53\u7684\u68c0\u6d4b<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_03\">\u7cd6\u5316\u5e94\u6fc0\u6807\u5fd7\u7269\u7684\u68c0\u6d4b\u65b9\u6cd5(2)\u3000AGEs\u7684\u68c0\u6d4b<\/a><\/li><li><a 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