{"id":10789,"date":"2020-09-24T13:22:27","date_gmt":"2020-09-24T04:22:27","guid":{"rendered":"https:\/\/ebn2.arkray.co.jp\/english\/?page_id=10789"},"modified":"2020-11-19T11:22:09","modified_gmt":"2020-11-19T02:22:09","slug":"glycation-stress_08","status":"publish","type":"page","link":"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_08\/","title":{"rendered":"\u7cd6\u5316\u5e94\u6fc0\u4e0e\u52a8\u8109\u786c\u5316"},"content":{"rendered":"\n<h2>\u7cd6\u5316\u5e94\u6fc0\u4e0e\u52a8\u8109\u786c\u5316<\/h2>\n\n\n<p class=\"author\">\u540c\u5fd7\u793e\u5927\u5b66\u5927\u5b66\u9662 \u751f\u547d\u533b\u79d1\u5b66\u7814\u7a76\u79d1 \u7cd6\u5316\u5e94\u6fc0\u7814\u7a76\u4e2d\u5fc3<br>\u516b\u6728\u96c5\u4e4b \u6559\u6388 \u4e3b\u7f16<\/p>\n\n\n<h3>\u52a8\u8109\u786c\u5316\u7684\u5206\u7c7b\u548c\u5b9a\u4e49<\/h3>\n\n\n<p>\u52a8\u8109\u786c\u5316\u6027\u75be\u75c5(arteriosclerotic disease)\u4e3b\u8981\u6307\u5fc3\u8840\u7ba1\u75be\u75c5\u548c\u8111\u8840\u7ba1\u75be\u75c5\uff0c\u4f46\u8fd1\u5e74\u6765\u5df2\u88ab\u8ba4\u4e3a\u662f\u5305\u62ec\u5468\u56f4\u52a8\u8109\u786c\u5316\u6027\u75be\u75c5\u5728\u5185\u7684multiple vessel disease(\u591a\u652f\u8840\u7ba1\u75c5\u53d8)<sup>(1)<\/sup>\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u52a8\u8109\u786c\u5316\u662f\u8868\u793a\u52a8\u8109\u58c1\u589e\u539a\u3001\u786c\u5316\u3001\u91cd\u5efa\u7684\u52a8\u8109\u75c5\u53d8\u7684\u603b\u79f0\uff0c\u53ef\u5206\u4e3a\u52a8\u8109\u7ca5\u6837\u786c\u5316(atherosclerosis)\u3001\u7ec6\u5c0f\u52a8\u8109\u786c\u5316(arteriolosclerosis)\u3001Monckeberg\u6c0f\u52a8\u8109\u4e2d\u5c42\u9499\u5316(Monckeberg\u2019s medial calcific sclerosis)\u3002\u5176\u4e2d\uff0c\u52a8\u8109\u7ca5\u6837\u786c\u5316\u662f\u4e0e\u751f\u6d3b\u65b9\u5f0f\u75c5\u53d1\u75c5\u6700\u5bc6\u5207\u76f8\u5173\u7684\u4e00\u79cd\u52a8\u8109\u786c\u5316\u75c5\u53d8\uff0c\u53d1\u751f\u5728\u76f8\u5bf9\u8f83\u5927\u7684\u5f39\u6027\u52a8\u8109\u4e2d\u3002\u4ece\u7ec4\u7ec7\u5b66\u4e0a\u8bb2\uff0c\u52a8\u8109\u7ca5\u6837\u786c\u5316\u662f\u6307\uff0c\u88ab\u79f0\u4e3a\u7ca5\u7624(atheroma)\u7684\u8102\u8d28\u4e2d\u5bcc\u542b\u7684\u574f\u6b7b\u5206\u89e3\u4ea7\u7269\u84c4\u79ef\u5728\u8840\u7ba1\u5185\u819c\uff0c\u7ec6\u80de\u7ea4\u7ef4\u56ca\u8986\u76d6\u5176\u8868\u5c42\u7684\u4e00\u79cd\u75c5\u53d8<sup>(2)<\/sup>\u3002\u6b64\u5916\uff0c\u4e16\u754c\u536b\u751f\u7ec4\u7ec7(World Health Organization\uff1bWHO)\u5c06\u52a8\u8109\u7ca5\u6837\u786c\u5316\u5b9a\u4e49\u4e3a\u201c\u4e3b\u8981\u53d1\u751f\u5728\u5185\u819c\u4e0a\u7684\u53d8\u5316\uff0c\u662f\u7531\u8102\u8d28\u3001\u9178\u6027\u7c98\u591a\u7cd6\u7c7b\u3001\u8840\u6e90\u6027\u7684\u7269\u8d28\u3001\u7ea4\u7ef4\u548c\u9499\u5316\u7269\u7b49\u7684\u79ef\u805a\u800c\u5f15\u53d1\u7684\u75c5\u53d8\u201d\u3002<\/p>\n\n\n<h3>\u52a8\u8109\u7ca5\u6837\u786c\u5316\u548cAGEs<\/h3>\n\n\n<p>\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u5f62\u6210\u6d89\u53ca\u591a\u79cd\u673a\u5236\u3002\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u65e9\u671f\u75c5\u53d8\u79f0\u4e3a\u8102\u7eb9(fatty streak)\u3002\u5728\u8102\u7eb9\u4e2d\uff0c\u8840\u6db2\u4e2d\u7684\u8102\u8d28\u6c89\u79ef\u5728\u7ec6\u80de\u7ea4\u7ef4\u6027\u589e\u539a\u7684\u8840\u7ba1\u5185\u819c\uff0c\u5e76\u5728\u6b64\u5f15\u53d1\u5de8\u566c\u7ec6\u80de\u6e90\u6027\u7684\u6ce1\u6cab\u7ec6\u80de\u79ef\u805a\u548cT\u6dcb\u5df4\u7ec6\u80de\u6d78\u6da6\u3002\u8be5\u75c5\u53d8\u662f\u7531\u4ece\u8840\u6db2\u7a7f\u8fc7\u5185\u76ae\u7ec6\u80de\u7684\u8102\u86cb\u767d\uff0c\u5c24\u5176\u662fLDL(low-density lipoprotein)\u4e0e\u86cb\u767d\u805a\u7cd6(proteoglycan)\u7ed3\u5408\uff0c\u5e76\u84c4\u79ef\u5728\u5185\u819c\u6240\u5f15\u8d77\u7684<sup>(2)<\/sup>\u3002<\/p>\n<p>\u7cd6\u5316LDL\u4e0d\u80fd\u88abLDL\u53d7\u4f53\u8bc6\u522b\uff0c\u5e76\u84c4\u79ef\u5728\u5185\u76ae\u7ec6\u80de\u4e2d\u3002\u5728\u7cd6\u5316LDL\u53d8\u6210AGE\u540e\uff0c\u4f1a\u4e0e\u5728\u5185\u76ae\u7ec6\u80de\u3001\u5e73\u6ed1\u808c\u7ec6\u80de\u7b49\u8840\u7ba1\u7ec6\u80de\u8868\u8fbe\u7684AGEs\u53d7\u4f53(RAGE)\u7ed3\u5408\uff0c\u901a\u8fc7\u4ea7\u751f\u6d3b\u6027\u6c27\u3001\u6fc0\u6d3bPKC(protein kinase C)\u3001\u6fc0\u6d3bMAP\u6fc0\u9176(mitogen-activated protein kinase)\u6765\u589e\u5f3a\u708e\u6027\u7ec6\u80de\u56e0\u5b50\u548c\u7c98\u9644\u56e0\u5b50\u7684\u8868\u8fbe\u3002\u6700\u7ec8\u5f15\u8d77\u5e73\u6ed1\u808c\u7ec6\u80de\u8fc1\u79fb\/\u589e\u6b96\u3001\u5185\u76ae\u7ec6\u80de\u5f02\u5e38\u548c\u6c27\u5316\u5e94\u6fc0\u589e\u5f3a\u3002\u6c27\u5316\u5e94\u6fc0\u4ea7\u751f\u7684\u6d3b\u6027\u6c27\u4e0d\u4ec5\u4f1a\u6c27\u5316\u8840\u7ba1\u58c1\u7ec6\u80de\uff0c\u8fd8\u4f1a\u6c27\u5316\u7cd6\u5316LDL\u3002\u5f53\u7cd6\u5316LDL\u8fdb\u884c\u6c27\u5316\u65f6\uff0c\u4f5c\u4e3a\u8fc7\u6c27\u5316\u8102\u8d28\u7684\u8102\u8d28\u6c22\u8fc7\u6c27\u5316\u7269(lipid hydroperoxide)\u84c4\u79ef\uff0c\u5e76\u8fdb\u4e00\u6b65\u751f\u6210\u4e8c\u6b21\u4ea7\u7269\u7684\u4e19\u4e8c\u919b(malondialdehyde\uff1bMDA)\u3002 LDL\u88ab\u7cd6\u5316\u540e\uff0c\u751f\u6210\u5df1\u7cd6\u8d56\u6c28\u9178(hexitollysine\uff1bHL)\u3002\u540c\u65f6\uff0c\u5728\u6d3b\u6027\u6c27\u7684\u5b58\u5728\u4e0b\u7531LDL\u751f\u6210CML\u3002\u6b64\u5916\uff0c\u7ecf\u6c27\u5316\u3001\u7cd6\u5316\u3001\u7cd6\u6c27\u5316\u4fee\u9970\u7684LDL\u5728\u5185\u819c\u4e2d\u84c4\u79ef(\u56fe1)<sup>(4)<\/sup>\u3002\u4e0e\u80f6\u539f\u86cb\u767d\u7684\u7ed3\u5408\u589e\u5f3a\u5f71\u54cd\u6c27\u5316LDL\u7684\u84c4\u79ef<sup>(5)<\/sup>\u3002<br><img loading=\"lazy\" class=\"size-full wp-image-12737 aligncenter\" src=\"http:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/figure02.jpg\" alt=\"\" width=\"500\" height=\"337\" srcset=\"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/figure02.jpg 500w, https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/figure02-300x202.jpg 300w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><\/p>\n<h6 class=\"has-text-align-center\"><strong>\u56fe1\u3000\u7ec6\u80de\u7ea4\u7ef4\u6027\u5185\u819c\u589e\u539a\u90e8\u4f4d\u4e2d\u7684AGEs<\/strong><br>A\uff1a CML\u6297\u4f53\u67d3\u8272,<br>B\uff1a \u6297AGEs(non-CML)\u6297\u4f53\u67d3\u8272,<br>C\uff1a \u6297ApoB\u6297\u4f53\u67d3\u8272, D\uff1a \u6297\u5de8\u566c\u7ec6\u80de(HAM56)\u6297\u4f53\u67d3\u8272<br>\u7bad\u5934\u6240\u6307\u67d3\u6210\u6df1\u8272\u7684\u533a\u57df\u8868\u793a\u84c4\u79ef\u3002<br>\u4fee\u6539\u81ea\u5742\u7530\u5247\u884c(2012)<sup>(4)<\/sup><\/h6>\n<p>\u84c4\u79ef\u5728\u5185\u819c\u7684\u4fee\u9970LDL\u4e0e\u751f\u6210\u7684CML\u548c\u4f5c\u4e3a\u8102\u8d28\u8fc7\u6c27\u5316\u7269\u7684\u6c27\u5316\u78f7\u8102\u9170\u80c6\u78b1(oxidized phosphatidylcholine\uff1bOxPC)\u4e00\u8d77\u63ba\u5165\u6d78\u6da6\u5185\u819c\u7684\u5de8\u566c\u7ec6\u80de\uff0c\u5e76\u6ce1\u6cab\u7ec6\u80de\u5316<sup>(6)<\/sup>\u3002\u53e6\u4e00\u65b9\u9762\uff0cApoB\u662f\u4f5c\u4e3a\u52a8\u8109\u786c\u5316\u6027\u75be\u75c5\u6307\u6807\u7684\u4e00\u79cd\u8f7d\u8102\u86cb\u767d\uff0c\u5421\u54af\u7d20(pyrraline)\u662f\u4e00\u79cdAGEs\uff0cApoB\u548c\u5421\u54af\u7d20\u56e0\u4e0d\u63ba\u5165\u5de8\u566c\u7ec6\u80de\u800c\u5206\u5e03\u5728\u5185\u819c\u7684\u80de\u5916\u57fa\u8d28\u4e2d(\u56fe2)<sup>(6)<\/sup>\u3002<\/p>\n<p><img loading=\"lazy\" class=\"size-full wp-image-12738 aligncenter\" src=\"http:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/figure03.jpg\" alt=\"\" width=\"500\" height=\"251\" srcset=\"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/figure03.jpg 500w, https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/figure03-300x151.jpg 300w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><\/p>\n<h6 style=\"text-align: center;\"><strong>\u56fe<\/strong><strong>2 <\/strong><strong>\u8102\u7eb9\u4e2d<\/strong><strong>AGEs<\/strong><strong>\u7684\u84c4\u79ef<br><\/strong>\u56e0\u6076\u6027\u6dcb\u5df4\u7624(malignant lymphoma)\u6b7b\u4ea1\u768470\u5c81\u5973\u6027<br>A\uff1a \u6297\u4e19\u4e8c\u919b(MDA)\u6297\u4f53\u67d3\u8272,<br>B\uff1a \u6297CML\u6297\u4f53\u67d3\u8272<br>C\uff1a \u6297\u5421\u54af\u7d20\u6297\u4f53\u67d3\u8272,<br>\u2605\uff1a \u7ca5\u7624\u90e8\u4f4d, \u203b\uff1a \u5421\u54af\u7d20\u84c4\u79ef\u90e8\u4f4d<br>\u4fee\u6539\u81eaSakata N, et al(2001)<sup>(6)<\/sup><\/h6>\n<p>\u6b64\u5916\uff0c\u5de8\u566c\u7ec6\u80de\u4f1a\u91ca\u653eTNF-\u03b1\u3001TNF-\u03b2\u3001IL\u7b49\u708e\u6027\u7ec6\u80de\u56e0\u5b50\u548c\u751f\u957f\u56e0\u5b50\u3002\u56e0\u6b64\uff0c\u5e73\u6ed1\u808c\u7ec6\u80de\u8f6c\u5316\uff0c\u4fc3\u8fdb\u8fc1\u79fb\/\u589e\u6b96\u548c\u80f6\u539f\u86cb\u767d\u7684\u4ea7\u751f\u3002\u5e76\u4e14\uff0c\u7531\u4e8e\u5176\u8fd8\u4f1a\u5206\u6ccc\u57fa\u8d28\u91d1\u5c5e\u86cb\u767d\u9176(atrix metalloproteinase)\u7b49\u86cb\u767d\u6c34\u89e3\u9176\uff0c\u5c06\u91cd\u590d\u7834\u574f\u548c\u4fee\u590d\u5185\u819c\u7ec4\u7ec7\u7684\u8fc7\u7a0b\u3002\u6700\u7ec8\u5728\u5185\u819c\u5f62\u6210\u52a8\u8109\u7ca5\u6837\u786c\u5316\u3002<br>\u5f53\u8986\u76d6\u7ca5\u7624\u7684\u7ea4\u7ef4\u56ca\u53d1\u751f\u7834\u88c2\u3001\u81f4\u7624\u548c\u51fa\u8840\u7b49\u65f6\uff0c\u4f1a\u5f62\u6210\u8840\u6813\uff0c\u4ece\u800c\u5f15\u8d77\u6025\u6027\u51a0\u72b6\u52a8\u8109\u7efc\u5408\u5f81\u548c\u8111\u6897\u6b7b\u3002<\/p>\n\n\n<h3><strong><strong>\u52a8\u8109\u9499\u5316\u548cAGEs<\/strong><\/strong><\/h3>\n\n\n<p>\u5728\u8fdb\u884c\u6027\u7684\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u7ca5\u7624\u4e2d\u53ef\u89c1\u9499\u6c89\u79ef\uff0c\u8fd9\u88ab\u8ba4\u4e3a\u662f\u52a8\u8109\u58c1\u53d8\u6027\u3001\u574f\u6b7b\u8fc7\u7a0b\u7684\u672b\u671f\u5f62\u6001\u3002\u5f53\u52a8\u8109\u7ca5\u6837\u786c\u5316\u90e8\u4f4d\u5468\u56f4\u7684\u5e73\u6ed1\u808c\u7ec6\u80de\u548c\u6ce1\u6cab\u7ec6\u80de\u53d1\u751f\u51cb\u4ea1\u65f6\uff0c\u968f\u540e\u7ec6\u80de\u89e3\u4f53\u4ea7\u751f\u7684\u819c\u6ce1(membranous vesicle)\u4f1a\u88ab\u91ca\u653e\u5230\u80de\u5916\u57fa\u8d28\u4e2d\uff0c\u5e76\u751f\u6210\u7f9f\u57fa\u78f7\u7070\u77f3(hydoroxyapatite)\u3002\u6b64\u65f6\u5982\u5f15\u8d77\u77ff\u5316(mineralization)\uff0c\u5c06\u6c89\u79ef\u65e0\u5b9a\u5f62\u7684\u9499\u3002<\/p>\n<p>\u7cd6\u5c3f\u75c5\u5c06\u4fc3\u8fdb\u8840\u7ba1\u9499\u5316\u3002\u7cd6\u5c3f\u75c5\u4f1a\u589e\u5f3a\u7cd6\u5316\uff0c\u5728\u52a8\u8109\u58c1\u80f6\u539f\u86cb\u767d\u4e0a\u5f62\u6210AGEs\uff0c\u6539\u53d8AGEs\u5316\u540e\u7684\u80f6\u539f\u86cb\u767d\u7684\u5206\u5b50\u7ed3\u6784\uff0c\u6613\u53d1\u751f\u9499\u6c89\u79ef<sup>(2)<\/sup>\u3002\u56e0\u6b64\uff0c\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u52a8\u8109\u4e2d\u819c\u53ef\u89c1\u9897\u7c92\u72b6\u9499\u5316\uff0c\u8fd9\u88ab\u89c6\u4e3aMonckeberg\u6c0f\u52a8\u8109\u4e2d\u5c42\u9499\u5316\u7684\u65e9\u671f\u75c5\u53d8\u3002CML\u5c40\u90e8\u5b58\u5728\u4e8e\u9499\u5316\u7684\u4e2d\u819c\u4e2d\u3002 \u8868\u660eCML\u4e5f\u53ef\u5728\u52a8\u8109\u80f6\u539f\u86cb\u767d\u4e2d\u5f62\u6210<sup>(7)<\/sup>\u3002<\/p>\n<p>\u5728\u80be\u8870\u7aed\u60a3\u8005\u4e2d\uff0c\u5728\u6cbf\u4e3b\u52a8\u8109\u7b49\u5f39\u6027\u52a8\u8109\u7684\u5f39\u6027\u7ea4\u7ef4\u4e0a\u53ef\u89c1\u9499\u6c89\u79ef\u3002\u80be\u8870\u7aed\u60a3\u8005\u7684\u8840\u7ba1\u9499\u5316\uff0c\u4e0e\u9499\u548c\u78f7\u7684\u4ee3\u8c22\u5f02\u5e38\uff0c\u4ee5\u53ca\u8840\u6e05\u4e2dAGEs\u5316\u80bd\u3001\u620a\u7cd6\u7d20\u3001CML\u7b49AGEs\u548c\u7cd6\u5316\u53cd\u5e94\u4e2d\u95f4\u4ea7\u7269\u4e8c\u7fb0\u57fa\u5316\u5408\u7269\u7684\u5347\u9ad8\u6709\u5173<sup>(8-9)<\/sup>\u3002\u80be\u8870\u7aed\u65f6AGEs\u548c\u7cd6\u5316\u53cd\u5e94\u4e2d\u95f4\u4ea7\u7269\u4f1a\u5728\u4f53\u5185\u84c4\u79ef\uff0c\u5e76\u5f62\u6210\u8fdb\u4e00\u6b65\u4fc3\u8fdbAGEs\u5316\u7684\u6076\u6027\u5faa\u73af\uff0c\u81f4\u4f7f\u5305\u62ec\u52a8\u8109\u7ca5\u6837\u786c\u5316\u5728\u5185\u7684\u8840\u7ba1\u786c\u5316\u8fdb\u5c55\uff0c\u4fc3\u8fdb\u9499\u5316\u3002<\/p>\n<p>\u8840\u7ba1\u9499\u5316\u4f1a\u5f15\u8d77\u52a8\u8109\u529f\u80fd\u4e0b\u964d\uff0c\u5bfc\u81f4\u8109\u538b\u5347\u9ad8\u3001\u5fc3\u810f\u8d1f\u8377\u589e\u52a0\u3001\u5916\u5468\u5faa\u73af\u8870\u7aed\uff0c\u540c\u65f6\u8fd8\u4e0e\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u4e0d\u7a33\u5b9a\u6027\u6709\u5173\u3002\u56e0\u6b64\uff0c\u6291\u5236\u7531AGEs\u5f15\u8d77\u7684\u52a8\u8109\u9499\u5316\uff0c\u5bf9\u9884\u9632\u548c\u6539\u5584\u7cd6\u5c3f\u75c5\u548c\u80be\u8870\u7aed\u60a3\u8005\u7684\u5fc3\u8840\u7ba1\u5e76\u53d1\u75c7\u800c\u8a00\u5341\u5206\u91cd\u8981\u3002<\/p>\n<div class=\"ref_css\">\n<h5><span lang=\"en\">References<\/span><\/h5>\n<ol class=\"ref_css\">\n<li style=\"list-style-type: none;\">\n<ol>\n<li>\u5bfa\u672c\u6c11\u751f\uff1a\u6804\u990a\u5b66\u96d1\u8a8c. 2013 ; 71 : 3-13.<\/li>\n<li>\u5742\u7530\u5247\u884c\u3089\uff1a\u52d5\u8108\u786c\u5316\u3068\u7cd6\u5316, \u7cd6\u5316\u306b\u3088\u308b\u75be\u60a3\u3068\u6297\u7cd6\u5316\u98df\u54c1\uff65\u7d20\u6750. 2011 : 66-76, \u30b7\u30fc\u30a8\u30e0\u30b7\u30fc\u51fa\u7248.<\/li>\n<li>Nakashima Y,&nbsp;<i>et al.<\/i>&nbsp;: Arterioscler Thromb Vasc Biol. 2007 ; 27 : 1159-1165.<\/li>\n<li>\u5742\u7530\u5247\u884c\uff1a\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u533b\u5b66. 2012 ; 8 : 42-48<\/li>\n<li>Jimi S,&nbsp;<i>et al.<\/i>&nbsp;: Atherosclerosis. 1994 ; 107 : 109-116.<\/li>\n<li>Sakata N,&nbsp;<i>et al.<\/i>&nbsp;: Cardiovasc Res. 2001 ; 49 : 466-475.<\/li>\n<li>Sakata N,&nbsp;<i>et al.<\/i>&nbsp;: J Vasc Res. 2003 ; 40 : 567-574.<\/li>\n<li>Sakata N,&nbsp;<i>et al.<\/i>&nbsp;: Nephrol Dial Transplant. 2003 ; 18 : 1601-1609.<\/li>\n<li>Miyata T,&nbsp;<i>et al.<\/i>&nbsp;: J Am Soc Nephrol. 1998 ; 9 : 2349-2356.<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/div>\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<h5><strong>\u7cd6\u5316\u5e94\u6fc0\u548c\u6297\u8870\u8001<\/strong><\/h5>\n\n\n\n<ul><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_01\/\">\u4ec0\u4e48\u662f\u7cd6\u5316\u5e94\u6fc0\uff1f<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_02\">\u7cd6\u5316\u5e94\u6fc0\u6807\u5fd7\u7269\u7684\u68c0\u6d4b\u65b9\u6cd5(1)\u3000\u8840\u7cd6\u3001\u7cd6\u5316\u86cb\u767d\u3001\u7cd6\u5316\u53cd\u5e94\u4e2d\u95f4\u4f53\u7684\u68c0\u6d4b<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_03\">\u7cd6\u5316\u5e94\u6fc0\u6807\u5fd7\u7269\u7684\u68c0\u6d4b\u65b9\u6cd5(2)\u3000AGEs\u7684\u68c0\u6d4b<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_04\">\u7cd6\u5316\u5e94\u6fc0\u6807\u5fd7\u7269\u7684\u68c0\u6d4b\u65b9\u6cd5(3)\u3000\u6297\u7cd6\u5316\u4f5c\u7528\u8bc4\u4ef7<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_05\">\u7cd6\u5316\u5e94\u6fc0\u548cAGEs\u53d7\u4f53<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_06\">\u7cd6\u5316\u5e94\u6fc0\u4e0e\u80be\u75be\u75c5<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_07\/\">\u7cd6\u5316\u5e94\u6fc0\u548c\u76ae\u80a4\u8001\u5316<\/a><\/li><li>\u7cd6\u5316\u5e94\u6fc0\u4e0e\u52a8\u8109\u786c\u5316<\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_09\">\u7cd6\u5316\u5e94\u6fc0\u548c\u7cbe\u795e\u5206\u88c2\u75c7<\/a><\/li><li><a 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