{"id":10795,"date":"2020-09-24T15:35:11","date_gmt":"2020-09-24T06:35:11","guid":{"rendered":"https:\/\/ebn2.arkray.co.jp\/english\/?page_id=10795"},"modified":"2020-11-24T16:28:08","modified_gmt":"2020-11-24T07:28:08","slug":"glycation-stress_09","status":"publish","type":"page","link":"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_09\/","title":{"rendered":"\u7cd6\u5316\u5e94\u6fc0\u548c\u7cbe\u795e\u5206\u88c2\u75c7"},"content":{"rendered":"\n<h2>\u7cd6\u5316\u5e94\u6fc0\u548c\u7cbe\u795e\u5206\u88c2\u75c7 <\/h2>\n\n\n\n<p class=\"author\">\u540c\u5fd7\u793e\u5927\u5b66\u5927\u5b66\u9662 \u751f\u547d\u533b\u79d1\u5b66\u7814\u7a76\u79d1 \u7cd6\u5316\u5e94\u6fc0\u7814\u7a76\u4e2d\u5fc3<br>\u516b\u6728\u96c5\u4e4b \u6559\u6388 \u4e3b\u7f16<\/p>\n\n\n\n<h3>\u4ec0\u4e48\u662f\u7cbe\u795e\u5206\u88c2\u75c7 <\/h3>\n\n\n<p>\u7cbe\u795e\u5206\u88c2\u75c7(schizophrenia)\u7ea6100\u4eba\u4e2d\u5c31\u67091\u4eba\u60a3\u75c5\u7684\u75be\u75c5\u4e4b\u4e00\uff0c\u4e0e\u91cd\u5ea6\u6291\u90c1\u75c7(major depression)\u3001\u53cc\u76f8\u969c\u788d(bipolar disorder)\u7b49\u5fc3\u5883\u969c\u788d(mood disorder)\u540c\u5c5e\u4e8e\u7cbe\u795e\u6027\u75be\u75c5\u3002\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u5178\u578b\u75c7\u72b6\u5305\u62ec\u5e7b\u89c9\u548c\u5984\u60f3\u3002\u60a3\u8005\u5728\u5bb6\u5ead\u548c\u793e\u4f1a\u4e2d\u4e0e\u4ed6\u4eba\u4ea4\u6d41\u7684\u751f\u6d3b\u80fd\u529b\u53d7\u963b\uff0c\u56e0\u6b64\uff0c\u5176\u5f88\u96be\u81ea\u5df1\u56de\u60f3\u201c\u56e0\u75c5\u60c5\u800c\u5bfc\u81f4\u7684\u611f\u89c9\u3001\u601d\u8003\u548c\u884c\u52a8\u7684\u4e0d\u534f\u8c03\u201d\u3002\u8be5\u75be\u75c5\u7684\u8fdb\u5c55\u5f88\u53ef\u80fd\u662f\u6162\u6027\u7684\uff0c\u5e76\u5728\u6b64\u8fc7\u7a0b\u4e2d\u51fa\u73b0\u5e7b\u89c9\u548c\u5984\u60f3\u589e\u5f3a\u7684\u6025\u6027\u671f\u3002\u6839\u636e2014\u5e74\u7684\u60a3\u8005\u8c03\u67e5(\u539a\u751f\u52b3\u52a8\u7701)\uff0c\u524d\u5f80\u533b\u7597\u673a\u5173\u5c31\u8bca\u7684\u7cbe\u795e\u6027\u75be\u75c5\u7684\u4f4f\u9662\u60a3\u8005\u6570\u4e3a26.6\u4e07\u4eba\uff0c\u5176\u4e2d\uff0c\u7cbe\u795e\u5206\u88c2\u75c7\u3001\u7cbe\u795e\u5206\u88c2\u75c7\u578b\u969c\u788d\u548c\u5984\u60f3\u6027\u969c\u788d\u670916.6\u4e07\u4eba\uff0c\u56e0\u6b64\uff0c\u8fd9\u51b3\u4e0d\u662f\u7f55\u89c1\u7684\u75be\u75c5<sup>(1)<\/sup>\u3002\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u666e\u904d\u8ba4\u77e5\u5ea6\u8f83\u4f4e\u7684\u539f\u56e0\u6709\uff1a\u4e0d\u6613\u4e86\u89e3\u75c7\u72b6\u3001\u53d7\u5230\u793e\u4f1a\u504f\u89c1\u3001\u6cbb\u7597\u65b9\u6cd5\u4ec5\u6709\u836f\u7269\u5bf9\u75c7\u6cbb\u7597\u7b49\u3002<\/p>\n\n\n<h3>\u7cbe\u795e\u5206\u88c2\u75c7\u548cAGEs<\/h3>\n\n\n\n<p>\u5173\u4e8e\u7cbe\u795e\u5206\u88c2\u75c7\uff0c\u6709\u5f88\u591a\u4e0e6\u53f7\u67d3\u8272\u4f53\u76f8\u5173\u6027\u7684\u62a5\u544a<sup>(2)<\/sup>\u3002\u8be5\u67d3\u8272\u4f53\u4e2d\u5b58\u5728\u4e00\u79cd\u88ab\u79f0\u4e3a\u4e59\u4e8c\u919b\u91761(glyoxalase 1 : GLO1)\u7684\u9176\u57fa\u56e0\u3002\u4e59\u4e8c\u919b\u9176\u5206\u89e3\u7fb0\u57fa\u5316\u5408\u7269\uff0c\u7fb0\u57fa\u5316\u5408\u7269\u662f\u4e00\u79cd\u7531\u6c27\u5316\u5e94\u6fc0\u548c\u7cd6\u5316\u5e94\u6fc0\u751f\u6210\u7684\u7cd6\u5316\u53cd\u5e94\u4e2d\u95f4\u4f53\u3002\u901a\u8fc7\u5bf9\u7cbe\u795e\u5206\u88c2\u75c7\u9ad8\u53d1\u5bb6\u7cfb\u7684\u5148\u8bc1\u8005\u7684DNA\u5206\u6790\u5df2\u77e5\uff0c\u5728\u7fb0\u57fa\u5e94\u6fc0\u6027\u7684\u7cbe\u795e\u5206\u88c2\u75c7\u60a3\u8005\u4e2d\uff0cGLO1\u57fa\u56e0\u53d1\u751f\u79fb\u7801\u7a81\u53d8\uff0cGLO1\u7684\u8868\u8fbe\u4e0b\u964d\u81f3\u5065\u5eb7\u4eba\u768450\uff05<sup>(2)<\/sup>\u3002\u5728\u8be5\u75c5\u75c7\u7684\u60a3\u8005\u4e2d\uff0c\u8fd8\u786e\u8ba4\u4e86\u620a\u7cd6\u7d20(\u4e00\u79cd\u8840\u6db2\u4e2d\u7684AGEs)\u7684\u6c34\u5e73\u589e\u52a0\u81f3\u5065\u5eb7\u4eba\u76843.7\u500d\uff0c\u5e76\u4e14\u4f53\u5185\u5177\u6709\u4e0e\u4e59\u4e8c\u919b\u9176\u76f8\u540c\u7fb0\u57fa\u6e05\u9664\u6d3b\u6027\u7684\u7ef4\u751f\u7d20B<sub>6<\/sub>\u964d\u4f4e\u81f320\uff05\u3002\u6b64\u5916\uff0c\u5728\u5bf9\u6ca1\u6709\u7cd6\u5c3f\u75c5\u3001\u80be\u529f\u80fd\u969c\u788d\u6216\u708e\u75c7\u6027\u75be\u75c5\u7684\u7cbe\u795e\u5206\u88c2\u75c7\u60a3\u8005\u8fdb\u884c\u7684\u8c03\u67e5\u4e2d\u8bc1\u5b9e\uff0c\u8840\u620a\u7cd6\u7d20\u6c34\u5e73\u663e\u8457\u6027\u5347\u9ad8\uff0c\u7ef4\u751f\u7d20B<sub>6<\/sub>\u6c34\u5e73\u663e\u8457\u6027\u964d\u4f4e(\u56fe1)<sup>(3)<\/sup>\u3002<\/p>\n\n\n<p><img loading=\"lazy\" class=\"size-full wp-image-12753 aligncenter\" src=\"http:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_09_01.jpg\" alt=\"\" width=\"550\" height=\"367\" srcset=\"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_09_01.jpg 550w, https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_09_01-300x200.jpg 300w\" sizes=\"(max-width: 550px) 100vw, 550px\" \/><\/p>\n\n\n<h6 class=\"has-text-align-center\"><strong>\u56fe1 \u8840\u6d46\u4e2d\u620a\u7cd6\u7d20\u548c\u8840\u6e05\u4e2d\u5421\u54c6\u919b(\u7ef4\u751f\u7d20B<sub>6<\/sub>)\u7684\u542b\u91cf<\/strong><br>A :\u620a\u7cd6\u7d20\u3001B\uff1a\u5421\u54c6\u919b(\u7ef4\u751f\u7d20B<sub>6<\/sub>)<br>Arai M, et al (2010)<sup>(3)<\/sup><\/h6>\n\n\n\n<h3>\u901a\u8fc7\u6291\u5236\u7cd6\u5316\u5e94\u6fc0\u6765\u6cbb\u7597\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u53ef\u80fd\u6027<\/h3>\n\n\n<p>\u5728\u60a3\u6709\u7fb0\u57fa\u5e94\u6fc0\u6027\u7684\u7cbe\u795e\u5206\u88c2\u75c7\u60a3\u8005\u4e2d\uff0c\u56e0\u89c2\u5bdf\u5230\u8840\u4e2d\u7ef4\u751f\u7d20B<sub>6<\/sub>\u7684\u964d\u4f4e\uff0c\u6240\u4ee5\u7ef4\u751f\u7d20B<sub>6<\/sub>\u8865\u5145\u7597\u6cd5\u6709\u671b\u5177\u5907\u6709\u6548\u6027\u3002\u7ef4\u751f\u7d20B<sub>6<\/sub>\u4e2d\u6709\u5421\u54c6\u9187(pyridoxine)\u3001\u5421\u54c6\u919b(pyridoxal)\u3001\u5421\u591a\u80fa(pyridoxamine)\u8fd9\u4e09\u79cd\u7269\u8d28\uff0c\u5728\u6eb6\u6db2\u4e2d\u5177\u6709\u76f8\u4e92\u5e73\u8861\u7684\u5173\u7cfb(\u56fe2)\u3002<\/p>\n<p><img loading=\"lazy\" class=\"size-full wp-image-12754 aligncenter\" src=\"http:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_09_02_zh.png\" alt=\"\" width=\"550\" height=\"166\" srcset=\"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_09_02_zh.png 550w, https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_09_02_zh-300x91.png 300w\" sizes=\"(max-width: 550px) 100vw, 550px\" \/><\/p>\n<h6 style=\"text-align: center;\"><strong>\u56fe2 \u7ef4\u751f\u7d20B<sub>6<\/sub>\u7684\u7ed3\u6784\u5f0f<\/strong><\/h6>\n<p>\u5176\u4e2d\u5421\u591a\u80fa\u5177\u6709\u6d88\u9664\u7fb0\u57fa\u7684\u4f5c\u7528<sup>(4)<\/sup>\u3002\u56e0\u6b64\uff0c\u5421\u591a\u80fa\u6709\u671b\u901a\u8fc7\u6291\u5236\u7531\u751f\u7269\u4f53\u7684\u7cd6\u5316\u3001\u6c27\u5316\u5f15\u8d77\u7684\u7fb0\u57fa\u5e94\u6fc0\u6765\u6539\u5584\u7cbe\u795e\u5206\u88c2\u75c7(\u56fe3)<sup>(5)<\/sup>\u3002\u76ee\u524d\uff0c\u6b63\u5728\u8fdb\u884c\u5411\u7cbe\u795e\u5206\u88c2\u75c7\u60a3\u8005\u5b9e\u65bd\u5421\u591a\u80fa\u7ed9\u836f\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5e76\u5bf9\u6570\u636e\u8fdb\u884c\u5206\u6790<sup>(6)<\/sup>\u3002<\/p>\n<p><img loading=\"lazy\" class=\"size-full wp-image-12752 aligncenter\" src=\"http:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_09_03_zh.png\" alt=\"\" width=\"550\" height=\"296\" srcset=\"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_09_03_zh.png 550w, https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_09_03_zh-300x161.png 300w\" sizes=\"(max-width: 550px) 100vw, 550px\" \/><\/p>\n<h6 style=\"text-align: center;\"><strong>\u56fe<\/strong><strong>3 <\/strong><strong>\u8840\u6d46\u4e2d\u620a\u7cd6\u7d20\u548c\u8840\u6e05\u4e2d\u5421\u54c6\u919b<\/strong><strong>(<\/strong><strong>\u7ef4\u751f\u7d20<\/strong><strong>B<sub>6<\/sub>)<\/strong><strong>\u7684\u542b\u91cf<br><\/strong>A\uff1a\u620a\u7cd6\u7d20\u3001B\uff1a\u5421\u54c6\u919b(\u7ef4\u751f\u7d20B<sub>6<\/sub>)<\/h6>\n<div class=\"ref_css\">\n<h5><span lang=\"en\">References<\/span><\/h5>\n<ol class=\"ref_css\">\n<li style=\"list-style-type: none;\">\n<ol>\n<li>\u539a\u751f\u52b4\u50cd\u7701, \u5e73\u621026\u5e74\u60a3\u8005\u8abf\u67fb<\/li>\n<li>Turecki G,&nbsp;<i>et al.<\/i>&nbsp;: Am J Med Genet. 1997 ; 74 :195\u2013198.<\/li>\n<li>Arai M,&nbsp;<i>et al.<\/i>&nbsp;: Arch Gen Psychiatry. 2010 ; 67 : 589-597.<\/li>\n<li>Voziyan PA,&nbsp;<i>et al.<\/i>&nbsp;: J Biol Chem. 2002 ; 277 : 3397-3403.<\/li>\n<li>\u65b0\u4e95\u8aa0\u3089\uff1a\u7cbe\u795e\u7d4c\u8a8c. 2012 ; 114 : 199-208.<\/li>\n<li>\u7cf8\u5ddd\u660c\u6210\u3089\uff1a\u65e5\u672c\u6297\u52a0\u9f62\u533b\u5b66\u4f1a\u8a8c. 2012 ; 8 : 49-54.<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/div>\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<h5><strong>\u7cd6\u5316\u5e94\u6fc0\u548c\u6297\u8870\u8001<\/strong><\/h5>\n\n\n\n<ul><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_01\/\">\u4ec0\u4e48\u662f\u7cd6\u5316\u5e94\u6fc0\uff1f<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_02\">\u7cd6\u5316\u5e94\u6fc0\u6807\u5fd7\u7269\u7684\u68c0\u6d4b\u65b9\u6cd5(1)\u3000\u8840\u7cd6\u3001\u7cd6\u5316\u86cb\u767d\u3001\u7cd6\u5316\u53cd\u5e94\u4e2d\u95f4\u4f53\u7684\u68c0\u6d4b<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_03\">\u7cd6\u5316\u5e94\u6fc0\u6807\u5fd7\u7269\u7684\u68c0\u6d4b\u65b9\u6cd5(2)\u3000AGEs\u7684\u68c0\u6d4b<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_04\">\u7cd6\u5316\u5e94\u6fc0\u6807\u5fd7\u7269\u7684\u68c0\u6d4b\u65b9\u6cd5(3)\u3000\u6297\u7cd6\u5316\u4f5c\u7528\u8bc4\u4ef7<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_05\">\u7cd6\u5316\u5e94\u6fc0\u548cAGEs\u53d7\u4f53<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_06\">\u7cd6\u5316\u5e94\u6fc0\u4e0e\u80be\u75be\u75c5<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_07\/\">\u7cd6\u5316\u5e94\u6fc0\u548c\u76ae\u80a4\u8001\u5316<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_08\">\u7cd6\u5316\u5e94\u6fc0\u4e0e\u52a8\u8109\u786c\u5316<\/a><\/li><li>\u7cd6\u5316\u5e94\u6fc0\u548c\u7cbe\u795e\u5206\u88c2\u75c7<\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_10\">\u7cd6\u5316\u5e94\u6fc0\u4e0e\u809d\u75c5<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_11\">\u7cd6\u5316\u5e94\u6fc0\u4e0e\u4e0d\u5b55\u75c7<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_12\">\u7cd6\u5316\u5e94\u6fc0\u4e0e\u963f\u5c14\u5179\u6d77\u9ed8\u75c7<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_13\/\">\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56(1)\u3000\u8840\u7cd6\u63a7\u5236<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_14\/\">\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56(2)\u3000\u7cd6\u5316\u53cd\u5e94\u7684\u6291\u5236<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_15\/\">\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56(3)\u3000AGEs\u7684\u964d\u89e3\u548c\u6392\u6cc4<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_16\/\">\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56(4)\u3000\u81b3\u98df\u6765\u6e90\u7684AGEs<\/a><\/li>\n<li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_17\/\">\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56\u7684\u8bfe\u9898\u548c\u5c55\u671b<\/a><\/li><\/ul>\n\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<p><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/\">\u5b66\u672f\u4fe1\u606f top<\/a><br><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/\">-Top<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"\u7cd6\u5316\u5e94\u6fc0\u548c\u7cbe\u795e\u5206\u88c2\u75c7 \u540c\u5fd7\u793e\u5927\u5b66\u5927\u5b66\u9662 \u751f\u547d\u533b\u79d1\u5b66\u7814\u7a76\u79d1 \u7cd6\u5316\u5e94\u6fc0\u7814\u7a76\u4e2d\u5fc3\u516b\u6728\u96c5\u4e4b \u6559\u6388 \u4e3b\u7f16 \u4ec0\u4e48\u662f\u7cbe\u795e\u5206\u88c2\u75c7 \u7cbe\u795e\u5206\u88c2\u75c7(schizophreni&#8230;","protected":false},"author":3,"featured_media":0,"parent":9191,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-json\/wp\/v2\/pages\/10795"}],"collection":[{"href":"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-json\/wp\/v2\/comments?post=10795"}],"version-history":[{"count":8,"href":"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-json\/wp\/v2\/pages\/10795\/revisions"}],"predecessor-version":[{"id":12955,"href":"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-json\/wp\/v2\/pages\/10795\/revisions\/12955"}],"up":[{"embeddable":true,"href":"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-json\/wp\/v2\/pages\/9191"}],"wp:attachment":[{"href":"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-json\/wp\/v2\/media?parent=10795"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}