{"id":10803,"date":"2020-09-28T13:59:22","date_gmt":"2020-09-28T04:59:22","guid":{"rendered":"https:\/\/ebn2.arkray.co.jp\/english\/?page_id=10803"},"modified":"2020-11-25T17:22:16","modified_gmt":"2020-11-25T08:22:16","slug":"glycation-stress_10","status":"publish","type":"page","link":"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_10\/","title":{"rendered":"\u7cd6\u5316\u5e94\u6fc0\u4e0e\u809d\u75c5"},"content":{"rendered":"\n<h2>\u7cd6\u5316\u5e94\u6fc0\u4e0e\u809d\u75c5<\/h2>\n\n\n<p class=\"author\">A-kit\u682a\u5f0f\u4f1a\u793e\u3000\u751f\u547d\u533b\u79d1\u5b66\u68c0\u67e5\u4e2d\u5fc3&nbsp;\u7cd6\u5316\u5e94\u6fc0\u7814\u7a76\u6240<br>\u516b\u6728\u96c5\u4e4b \u6240\u957f \u4e3b\u7f16<\/p>\n\n\n<h3>\u4f55\u8c13\u809d\u75c5<\/h3>\n\n\n<p>\u809d\u810f\u662f\u8d1f\u8d23\u7ea625\uff05\u57fa\u7840\u4ee3\u8c22\u7684\u5668\u5b98\uff0c\u8d1f\u8d23\u78b3\u6c34\u5316\u5408\u7269\u3001\u8102\u8d28\u3001\u86cb\u767d\u3001\u7ef4\u751f\u7d20\u7684\u4ee3\u8c22\u3001\u6709\u5bb3\u7269\u8d28\u7684\u6392\u6bd2\u548c\u80c6\u6c41\u5206\u6ccc\u7b49\u3002\u5e76\u4e14\uff0c\u809d\u810f\u5177\u6709\u4f18\u5f02\u7684\u518d\u751f\u80fd\u529b\uff0c\u56e0\u6b64\u662f\u4e00\u79cd\u5373\u4f7f\u809d\u7ec6\u80de\u88ab\u7834\u574f\u4e5f\u80fd\u591f\u518d\u751f\u7684\u5668\u5b98\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u809d\u75c5(liver disease)\u5177\u6709\u8868\u73b0\u4e3a\u809d\u708e(hepatitis)\u3001\u809d\u786c\u5316(cirrhosis)\u3001\u8102\u80aa\u809d(fatty liver disease)\u7b49\u75c5\u60c5\u7684\u591a\u79cd\u75be\u75c5\u540d\u79f0\u3002\u809d\u810f\u4e5f\u56e0\u4e0d\u4f1a\u51fa\u73b0\u809d\u75c5\u7684\u4e3b\u89c2\u75c7\u72b6\uff0c\u800c\u88ab\u79f0\u4e3a\u201c\u6c89\u9ed8\u5668\u5b98(silent organ)\u201d\u3002<\/p>\n<p>\u6839\u636e\u75c5\u60c5\uff0c\u809d\u708e\u4e3b\u8981\u5206\u4e3a\u6025\u6027\u809d\u708e\u548c\u6162\u6027\u809d\u708e(\u708e\u75c7\u6301\u7eed6\u4e2a\u6708\u53ca\u4ee5\u4e0a)\u3002\u6b64\u5916\uff0c\u809d\u708e\u6839\u636e\u5176\u75c5\u56e0\u5206\u4e3a\u75c5\u6bd2\u6027(\u7532\u578b\u3001\u4e59\u578b\u3001\u4e19\u578b\u7b49)\u3001\u9152\u7cbe\u6027\u3001\u836f\u7269\u6027\u3001\u81ea\u8eab\u514d\u75ab\u6027\u53ca\u5176\u4ed6<sup>(1)<\/sup>\u3002<\/p>\n<p>\u7532\u578b\u809d\u708e\u662f\u7531\u7532\u578b\u809d\u708e\u75c5\u6bd2(hepatitis A virus\uff1aHAV)\u5f15\u8d77\u7684\u6d88\u5316\u9053\u611f\u67d3\u4e4b\u4e00\u3002\u611f\u67d3\u591a\u7531\u98df\u7528\u53d7\u6c61\u67d3\u7684\u8d1d\u7c7b\u7b49\u98df\u54c1\u5f15\u8d77\uff0c\u6b64\u5916\uff0c\u5728\u536b\u751f\u6761\u4ef6\u5dee\u7684\u5730\u533a\u8f83\u4e3a\u5e38\u89c1\u3002\u5982\u679c\u5e7c\u5e74\u65f6\u611f\u67d3\uff0c\u51e0\u4e4e\u90fd\u4ee5\u9690\u6027\u611f\u67d3\u800c\u544a\u7ec8\uff0c\u4f46\u6210\u5e74\u540e\u611f\u67d3\uff0c\u5219\u591a\u4f1a\u53d1\u75c5\u3002\u4e59\u578b\u809d\u708e\u7531\u4e59\u578b\u809d\u708e\u75c5\u6bd2(HBV)\u5f15\u8d77\uff0c\u6709\u6682\u65f6\u6027\u548c\u6301\u7eed\u6027\u4e24\u79cd\u3002\u6301\u7eed\u6027\u4e59\u578b\u809d\u708e\u5927\u90e8\u5206\u662f\u6bcd\u5a74\u4f20\u64ad\u6240\u81f4\uff0c\u591a\u6570\u60c5\u51b5\u4e0b\u662f\u6025\u6027\u809d\u708e\uff0c\u4e0d\u4f1a\u8f6c\u4e3a\u6162\u6027\u3002\u4e19\u578b\u809d\u708e\u7531\u4e19\u578b\u809d\u708e\u75c5\u6bd2(HCV)\u5f15\u8d77\uff0c\u5176\u53d1\u75c5\u4e0e\u5b63\u8282\u3001\u5e74\u9f84\u3001\u6027\u522b\u65e0\u5173\u3002\u4e19\u578b\u809d\u708e\u5360\u8f93\u8840\u5f15\u8d77\u7684\u809d\u708e\u75c5\u4f8b\u7684\u5927\u591a\u6570\uff0c\u4e14\u8f6c\u4e3a\u6162\u6027\u7684\u6982\u7387\u9ad8\u3002<\/p>\n<p>\u809d\u764c\u662f\u809d\u75c5\u4e4b\u4e00\uff0c\u8fc4\u4eca\u4e3a\u6b62\uff0c\u7edd\u5927\u90e8\u5206\u809d\u764c\u662f\u7531\u4e19\u578b\u809d\u708e\u7b49\u75c5\u6bd2\u6027\u809d\u75c5\u6240\u81f4\u3002\u4f46\u662f\u8fd1\u5e74\u6765\uff0c\u809d\u764c\u7684\u75c5\u56e0\u4e3a\u975e\u75c5\u6bd2\u6027\u7684\u75c5\u4f8b\u6b63\u5728\u589e\u52a0\uff0c\u5176\u5927\u591a\u6570\u88ab\u8ba4\u4e3a\u662f\u7531\u8102\u80aa\u809d(fatty liver)\u5f15\u8d77\u7684\u3002<\/p>\n<p>\u8102\u80aa\u809d\u662f\u7531\u80a5\u80d6\u3001\u9152\u7cbe\u3001\u8fc7\u91cf\u6444\u5165\u7cd6\u5206\u5bfc\u81f4\u80fd\u91cf\u8fc7\u5269\u3001\u7cd6\u5c3f\u75c5\u3001\u8fd0\u52a8\u4e0d\u8db3\u7b49\u539f\u56e0\u5f15\u8d77\u7684\u3002\u5982\u679c\u5c06\u9152\u7cbe\u6444\u5165\u91cf\u6362\u7b97\u6210\u65e5\u672c\u9152\uff0c\u6bcf\u5929\u996e\u75285\u58f6\uff08\u7ea6900ml\uff09\uff0c\u6301\u7eed1\u5468\uff0c\u5373\u4fbf\u662f\u5065\u5eb7\u4eba\uff0c\u4e5f\u4f1a\u60a3\u4e0a\u8102\u80aa\u809d<sup>(2-4)<\/sup>\u3002\u5982\u679c\u9152\u7cbe\u6027\u8102\u80aa\u809d\u60a3\u8005\u4ecd\u7ee7\u7eed\u5927\u91cf\u996e\u9152\uff0c\u90a3\u4e4810\uff5e20\uff05\u7684\u4eba\u4f1a\u5f15\u53d1\u9152\u7cbe\u6027\u809d\u75c5(alcoholic liver disease\uff1aALD)\u3002ALD\u6309\u9152\u7cbe\u6027\u8102\u80aa\u809d\u3001\u9152\u7cbe\u6027\u809d\u708e\u3001\u9152\u7cbe\u6027\u809d\u786c\u5316\u7684\u987a\u5e8f\u8fdb\u5c55\u3002<\/p>\n<p>\u53e6\u4e00\u65b9\u9762\uff0c\u8102\u80aa\u809d\u5305\u62ec\u88ab\u79f0\u4e3a\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u75c5((nonalcoholic fatty liver disease\uff1aNAFLD)\u4ee5\u53ca\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e(nonalcoholic steatohepatitis\uff1aNASH)\u7684\u75be\u75c5\u3002\u5373\u4fbf\u6ca1\u6709\u996e\u9152\u53f2\uff0cNASH\u4e5f\u4f1a\u53d1\u75c5\u4e8e\u8102\u80aa\u809d\uff0c\u8102\u80aa\u809d\u662f\u7531\u996e\u98df\u8fc7\u91cf\u3001\u8fd0\u52a8\u4e0d\u8db3\u3001\u80a5\u80d6\u3001\u7cd6\u5c3f\u75c5\u3001\u8840\u8102\u5f02\u5e38\u7b49\u5f15\u8d77\u7684\u3002\u5982\u679c\u4e0d\u8fdb\u884c\u6cbb\u7597\u6216\u5e72\u9884\uff0c\u52195\uff5e20\uff05\u7684NFLD\u60a3\u8005\u4f1a\u57285\uff5e10\u5e74\u5185\u53d1\u5c55\u4e3a\u809d\u786c\u5316\u6216\u809d\u764c<sup>(5)<\/sup>\u3002NASH\u548cALD\u5728\u809d\u810f\u7ec4\u7ec7\u5b66\u56fe\u50cf\u4e0a\u6709\u76f8\u4f3c\u4e4b\u5904\uff0c\u4e14\u53d1\u75c5\u673a\u7406\u5747\u5df2\u5f97\u5230\u7814\u7a76\u3002<\/p>\n\n\n<h3>\u809d\u75c5\u4e0eAGEs<\/h3>\n\n\n\n<p>\u62a5\u544a\u663e\u793a\uff0c\u5728\u4f53\u5185\u4ea7\u751f\u7684\u5404\u79cdAGEs\u4e2d\uff0c\u7518\u6cb9\u919b\u884d\u751f\u7684AGEs(Glycer-AGEs)\u548c\u4e59\u919b\u884d\u751f\u7684AGEs(AA-AGEs)\u4e0e\u809d\u75c5\u6709\u5173<sup>(6)<\/sup>\u3002<\/p>\n\n\n\n<p>\u8fc4\u4eca\u4e3a\u6b62\uff0c\u4eba\u4eec\u8ba4\u4e3aAGEs\u5728\u4f53\u5185\u4e3b\u8981\u7531\u8461\u8404\u7cd6\u548c\u86cb\u767d\u4ea7\u751f\u3002\u4f46\u662f\uff0c\u73b0\u5df2\u8bc1\u5b9e\u5176\u4e5f\u53ef\u7531\u8461\u8404\u7cd6\u7684\u4ee3\u8c22\u4e2d\u95f4\u4f53\u548c\u964d\u89e3\u4ea7\u7269\u3001\u7cd6\u5316\u53cd\u5e94\u4e2d\u95f4\u4f53\u3001\u679c\u7cd6\u7b49\u4ea7\u751f(\u56fe1)<sup>(7)<\/sup>\u3002\u6b64\u5916\uff0c\u5176\u4ed6AGEs\u7684\u4ea7\u751f\u65e9\u4e8e\u8461\u8404\u7cd6\u884d\u751f\u7684AGEs(Glc-AGEs)\u548c\u679c\u7cd6\u884d\u751f\u7684AGEs(Fru-AGEs)\u3002\u4f8b\u5982\uff0c\u5f53\u86cb\u767d\u8d28\u662f\u725b\u8840\u6e05\u767d\u86cb\u767d(BSA)\u65f6\uff0c\u5bb9\u6613\u6309\u987a\u5e8f\u751f\u6210Glycer-AGEs\u3001\u4e59\u9187\u919b\u884d\u751f\u7684AGEs(Glycol-AGEs)&gt;\u4e19\u916e\u919b\u884d\u751f\u7684AGEs(MGO-AGEs)\u3001\u4e59\u4e8c\u919b\u884d\u751f\u7684AGEs(GO-AGEs)&gt;&gt;3-\u8131\u6c27\u8461\u8404\u7cd6\u919b\u916e\u884d\u751f\u7684AGEs(3-DG-AGEs)&gt;&gt;&gt;Fru-AGEs\uff1eGlc-AGEs\u3002<\/p>\n\n\n<p><img loading=\"lazy\" class=\"wp-image-12766 aligncenter\" src=\"http:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_10_01_zh.png\" alt=\"\" width=\"700\" height=\"496\" srcset=\"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_10_01_zh.png 801w, https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_10_01_zh-300x212.png 300w, https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_10_01_zh-768x544.png 768w\" sizes=\"(max-width: 700px) 100vw, 700px\" \/><\/p>\n\n\n<h6 class=\"has-text-align-center\"><strong>\u56fe1\u3000\u4f53\u5185AGEs\u7684\u4ea7\u751f\u9014\u5f84<\/strong><br>Glc-AGEs\uff1a\u8461\u8404\u7cd6\u884d\u751f\u7684AGEs\uff0cFru-AGEs\uff1a\u679c\u7cd6\u884d\u751f\u7684AGEs\uff0cGlycer-AGEs\uff1a\u7518\u6cb9\u919b\u884d\u751f\u7684AGEs\uff0c<br>Glycol-AGEs:\u4e59\u9187\u919b\u884d\u751f\u7684AGEs\uff0cMGO-AGEs\uff1a\u4e19\u916e\u919b\u884d\u751f\u7684AGEs\uff0c<br>GO-AGEs\uff1a\u4e59\u4e8c\u919b\u884d\u751f\u7684AGEs\uff0c3-DG-AGEs\uff1a3-\u8131\u6c27\u8461\u8404\u7cd6\u919b\u916e\u884d\u751f\u7684AGEs\uff0cCML\uff1aN-\u7fa7\u7532\u57fa\u8d56\u6c28\u9178\uff0c<br>AR\uff1a\u919b\u7cd6\u8fd8\u539f\u9176\uff0cSDH\uff1a\u5c71\u68a8\u9187\u8131\u6c22\u9176\uff0cFK\uff1a\u679c\u7cd6\u6fc0\u9176\uff0cH2N-P\uff1a\u86cb\u767d\u8d28\u4e2d\u7684\u6e38\u79bb\u6c28\u57fa<br>\u7af9\u5185\u6b63\u7fa9(2012)<sup>(3)<\/sup><\/h6>\n\n\n<p>\u5c24\u5176\u662fGlycer-AGEs\u901a\u8fc7AGEs\u53d7\u4f53(receptor for AGEs\uff1aRAGE)\uff0c\u5bc6\u5207\u53c2\u4e0e\u7cd6\u5c3f\u75c5\u8840\u7ba1\u5e76\u53d1\u75c7\u7684\u53d1\u75c5\u548c\u8fdb\u5c55<sup>(8-9)<\/sup>\u3002\u5c06Glycer-AGEs\u6dfb\u52a0\u5230\u809d\u7ec6\u80de(hepatocyte)\u57f9\u517b\u7cfb\u7edf\u4e2d\u65f6\uff0c\u4f1a\u4f7f\u708e\u75c7\u6807\u5fd7\u7269\u4e4b\u4e00\u7684C\u53cd\u5e94\u86cb\u767d(C reactive protein\uff1aCRP)\u5347\u9ad8\uff0c\u7c7b\u4f3c\u5730\uff0c\u5c06\u5176\u6dfb\u52a0\u5230\u4e0e\u809d\u7ec6\u80de\u7ea4\u7ef4\u5316\u6709\u5173\u7684\u661f\u72b6\u7ec6\u80de(hepatic stellate cell)\u57f9\u517b\u7cfb\u7edf\u4e2d\u65f6\uff0c\u4f1a\u901a\u8fc7RAGE\u8bf1\u5bfc\u6c27\u5316\u5e94\u6fc0\u5e76\u5f15\u8d77\u708e\u75c7<sup>(10)<\/sup>\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u8fd8\u8bc1\u5b9e\u4e86Glycer-AGEs\u4f1a\u5728\u7cd6\u8010\u91cf\u65e0\u5f02\u5e38\u7684NASH\u60a3\u8005\u7684\u809d\u810f\u5185\u84c4\u79ef<sup>(11)<\/sup>\uff0c\u5c06\u7518\u6cb9\u919b\u6dfb\u52a0\u5230\u4eba\u809d\u764c\u7ec6\u80de\u7684Hep3B\u7ec6\u80de\u57f9\u517b\u7cfb\u7edf\u4e2d\u65f6\uff0c\u4f1a\u968f\u7740\u809d\u7ec6\u80de\u4e2dGlycer-AGEs\u91cf\u7684\u589e\u52a0\u800c\u5f15\u8d77\u7ec6\u80de\u6b7b\u4ea1\uff0c\u5e76\u4e14\u5f53\u5206\u5b50\u4f34\u4fa3\u4e4b\u4e00\u7684heat shock cognate 70(Hsc70)\u8f6c\u5316\u4e3aGlycer-AGEs\u65f6\uff0c\u4f34\u4fa3\u6d3b\u6027\u964d\u4f4e\uff0c\u7ecf\u8fc7\u86cb\u767d\u8d28\u529f\u80fd\u969c\u788d\uff0c\u8fdb\u5c55\u4e3a\u809d\u7ec6\u80de\u635f\u4f24(\u56fe2)(7,12)\u3002<img loading=\"lazy\" class=\"aligncenter wp-image-12970\" src=\"http:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_10_02_zh.png\" alt=\"\" width=\"700\" height=\"480\" srcset=\"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_10_02_zh.png 882w, https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_10_02_zh-300x206.png 300w, https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_10_02_zh-768x527.png 768w\" sizes=\"(max-width: 700px) 100vw, 700px\" \/><\/p>\n<h6 style=\"text-align: center;\"><strong>\u56fe2\u3000Glycer-AGEs\u5728NASH\u7684\u53d1\u75c5\u548c\u8fdb\u5c55\u4e2d\u5bf9\u809d\u7ec6\u80de\u7684\u5f71\u54cd<br \/><\/strong>HSC-70\uff1a\u70ed\u4f11\u514b\u86cb\u767d-70\uff0cGlycer-AGEs\uff1a\u7518\u6cb9\u919b\u884d\u751f\u7684AGEs\uff0c<br \/>RAGE\uff1aAGEs\u53d7\u4f53\uff0cROS\uff1a\u6d3b\u6027\u6c27\uff0cVEGF\uff1a\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\uff0c<br \/>\u7af9\u5185\u6b63\u7fa9(2012)<sup>(3)<\/sup><\/h6>\n<p>\u53e6\u4e00\u65b9\u9762\uff0c\u4e59\u919b\u662f\u9152\u7cbe\u7684\u4ee3\u8c22\u4ea7\u7269\uff0c\u5b83\u7684\u4e00\u90e8\u5206\u4e0e\u86cb\u767d\u7ed3\u5408\uff0c\u751f\u6210AA-AGEs(\u56fe3)\u3002AA-AGEs\u5177\u6709\u5f88\u5f3a\u7684\u809d\u7ec6\u80de\u635f\u4f24\u4f5c\u7528\uff0c\u4e14\u4e3b\u8981\u5728\u4e2d\u592e\u9759\u8109\u5468\u56f4\u7684\u809d\u7ec6\u80de\u4e2d\u4ea7\u751f\uff0c\u56e0\u6b64\u4e0eALD\u7684\u53d1\u75c5\u548c\u8fdb\u5c55\u5bc6\u5207\u76f8\u5173<sup>(13)<\/sup>\u3002\u8fd8\u6709\u62a5\u544a\u663e\u793a\uff0cAA-AGEs\u5b58\u5728\u4e8e\u9152\u7cbe\u6210\u763e\u8005\u7684\u8840\u6db2\u548c\u5927\u8111\u4e2d<sup>(14)<\/sup>\uff0c\u4ee5\u53ca\u5728\u6162\u6027\u9152\u7cbe\u6444\u5165\u7684\u5927\u9f20\u6a21\u578b\u4e2d\uff0cAA-AGEs\u84c4\u79ef\u5728\u4e2d\u592e\u9759\u8109\u533a\u7684\u809d\u7ec6\u80de\u4e2d\u3002\u7efc\u4e0a\u53ef\u77e5\uff0c\u5373\u4f7f\u4e59\u919b\u901a\u8fc7\u9152\u7cbe\u4ee3\u8c22\u4ece\u8840\u6db2\u4e2d\u6d88\u9664\uff0cAA-AGEs\u4ecd\u53ef\u80fd\u5bf9\u795e\u7ecf\u7ec6\u80de\u548c\u809d\u7ec6\u80de\u4ea7\u751f\u6bd2\u6027\uff0c\u5e76\u53c2\u4e0e\u9152\u7cbe\u6027\u809d\u635f\u4f24\u7684\u53d1\u75c5\u8fdb\u5c55\u3002<\/p>\n<p><img loading=\"lazy\" class=\"size-full wp-image-12761 aligncenter\" src=\"http:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_10_03.jpg\" alt=\"\" width=\"550\" height=\"269\" srcset=\"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_10_03.jpg 550w, https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_10_03-300x147.jpg 300w\" sizes=\"(max-width: 550px) 100vw, 550px\" \/><\/p>\n<h6 style=\"text-align: center;\"><strong>\u56fe<\/strong><strong>3<\/strong><strong>\u3000\u9152\u7cbe\u6444\u5165\u5bfc\u81f4\u4e59\u919b\u884d\u751f<\/strong><strong>AGEs<\/strong><strong>\u7684\u751f\u6210\u53ca\u5176\u5f71\u54cd<br \/><\/strong>Hayashi N,<em> et al.<\/em> (2013)<sup>(14)<\/sup><\/h6>\n<h3>\u996e\u98df\u6027AGEs\u5bf9\u809d\u810f\u7684\u5f71\u54cd<\/h3>\n<p>\u5728\u5404\u79cd\u98df\u54c1\u7684\u52a0\u70ed\u548c\u52a0\u5de5\u5904\u7406\u8fc7\u7a0b\u4e2d\uff0c\u98df\u54c1\u4e2d\u4f1a\u751f\u6210\u5404\u79cdAGEs\u3002\u5927\u591a\u5e02\u552e\u98df\u54c1\u4e2d\u4e3b\u8981\u542b\u6709Glc-AGEs\u548cFru-AGEs\u3002\u5411\u6b63\u5e38\u5927\u9f20\u7ecf\u53e3\u7ed9\u4e88Glc-AGEs\u542b\u91cf\u9ad8\u7684\u996e\u6599\uff0c\u7814\u7a76Glycer-AGEs\u7684RAGE\u8868\u8fbe\u7cfb\u7edf\u7684\u7ed3\u679c\u663e\u793a\uff0c\u809d\u810f\u4e2d\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50(vascular endothelial growth factor\uff1aVEGF)\u57fa\u56e0\u7684\u8868\u8fbe\u589e\u52a0\uff0c\u809d\u810f\u4e2d\u7684Glc-AGEs\u548cGlycer-AGEs\u84c4\u79ef<sup>(15)<\/sup>\u3002<\/p>\n<p>\u53e6\u5916\uff0c\u57282\u578b\u7cd6\u5c3f\u75c5\u6a21\u578b\u5927\u9f20\u7684\u9650\u5236\u6027\u9972\u5582\u5b9e\u9a8c\u7cfb\u7edf\u4e2d\uff0c\u8bc1\u5b9e\u4e86Glycer-AGE\u968f\u9910\u540e\u8840\u7cd6\u6ce2\u52a8\u4ea7\u751f<sup>(16)<\/sup>\u3002\u53e6\u6709\u62a5\u544a\u663e\u793a\uff0c\u5bf92\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u8fdb\u884c\u03b1\u8461\u8404\u7cd6\u82f7\u9176\u6291\u5236\u5242\u7ed9\u836f\u65f6\uff0c\u8840\u6db2Glycer-AGE\u6c34\u5e73\u4e0e\u7ed9\u836f\u524d\u76f8\u6bd4\u663e\u8457\u6027\u964d\u4f4e<sup>(17)<\/sup>\u3002\u6b64\u5916\uff0c\u6709\u62a5\u544a\u79f0\uff0cNAFLD\u60a3\u8005\u4ece\u6e05\u51c9\u996e\u6599\u4e2d\u6444\u5165\u7684\u7cd6\u91cf\u662f\u5065\u5eb7\u4eba\u76845\u500d\uff0c\u5e76\u6307\u51fa\u7802\u7cd6\u548c\u679c\u7cd6\u8461\u8404\u7cd6\u6db2\u7cd6\u7b49\u4f5c\u4e3a\u751c\u5473\u5242\u88ab\u6dfb\u52a0\u5230\u996e\u6599\u4e2d\uff0c\u8fd9\u4e9b\u6210\u5206\u7684\u8fc7\u91cf\u6444\u5165\u4e0eNAFLD\u7684\u53d1\u75c5\u8fdb\u5c55\u6709\u5173\u3002\u4ee5\u4e0a\u7ed3\u679c\u8868\u660e\uff0c\u6765\u81ea\u996e\u98df\u7684AGEs\u548c\u9910\u540e\u9ad8\u8840\u7cd6\u53ef\u80fd\u4f1a\u4f7f\u8840\u6db2\u4e2dGlycer-AGEs\u7684\u6c34\u5e73\u5347\u9ad8\uff0c\u589e\u5f3a\u4e0eRAGE\u8868\u8fbe\u7cfb\u7edf\uff08\u7ecf\u7531Glycer-AGEs\uff09\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u5f15\u8d77\u809d\u75c5<sup>(18)<\/sup>\u3002<\/p>\n<div class=\"ref_css\">\n<h5><span lang=\"en\">References<\/span><\/h5>\n<ol class=\"ref_css\">\n<li style=\"list-style-type: none;\">\n<ol>\n<li>\u539f\u7530 \u5c1a : \u65e5\u5185\u4f1a\u8a8c. 1991 ; 80 : 1563-1567.<\/li>\n<li>Bellentani S,\u00a0<i>et al.<\/i>\u00a0: Gut. 1997 ; 41: 845\u2013850.<\/li>\n<li>Becker U,\u00a0<i>et al.<\/i>\u00a0: HEPATOLOGY. 1996 ; 23 : 1025-1029.<\/li>\n<li>\u77f3\u4e95\u88d5\u6b63\uff1a\u65e5\u672c\u5185\u79d1\u5b66\u4f1a\u96d1\u8a8c. 2003 ; 92 : 45-49.<\/li>\n<li>\u65e5\u672c\u809d\u81d3\u5b66\u4f1a\uff1aNASH\u30fbNAFLD\u306e\u8a3a\u7642\u30ac\u30a4\u30c92010<\/li>\n<li>\u7af9\u5185\u6b63\u7fa9\uff1a\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u533b\u5b66. 2013 ; 8\uff1a55-61.<\/li>\n<li>\u7af9\u5185\u6b63\u7fa9\uff1a\u91d1\u533b\u5927\u8a8c. 2012 ; 37\uff1a141-161.<\/li>\n<li>\u7af9\u5185\u6b63\u7fa9\u3089\uff1a\u751f\u4f53\u306e\u79d1\u5b66. 2007 ; 58\uff1a502\uff0d511.<\/li>\n<li>Takeuchi M,\u00a0<i>et al.<\/i>\u00a0: Curr Drug Targets. 2010 ; 11 : 468-1482.<\/li>\n<li>Iwamoto K,\u00a0<i>et al.<\/i>\u00a0: J Gastroenterol. 2008 ; 43 : 298-304.<\/li>\n<li>Hyogo H,\u00a0<i>et al.<\/i>\u00a0: J Gastroenterol Hepatol. 2007 ; 22 : 1112-1119.<\/li>\n<li>Takino J,\u00a0<i>et al.<\/i>\u00a0: J Gastroenterol Hepatol. 2010 ; 45 : 646-655.<\/li>\n<li>Takeuchi M,\u00a0<i>et al.<\/i>\u00a0: J Neuropathol Exp Neuro. 2003 ; 62 : 486-496.<\/li>\n<li>Hayashi N,\u00a0<i>et al.<\/i>\u00a0: PLoS ONE 8(7) : e70034.<\/li>\n<li>Patel R,\u00a0<i>et al.<\/i>\u00a0: PLoS ONE 7(4): e35143.<\/li>\n<li>Kitahara Y.\u00a0<i>et al.<\/i>\u00a0: Clin Exp Med. 2008 ; 8 : 175-177.<\/li>\n<li>Tsunosue M,\u00a0<i>et al.<\/i>\u00a0: Clin Exp Med. 2010; 10 : 139-141.<\/li>\n<li>Sato T,\u00a0<i>et al.<\/i>\u00a0: Eur J Nutr. 2009 ; 48 : 6-11.<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/div>\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<h5><strong>\u7cd6\u5316\u5e94\u6fc0\u548c\u6297\u8870\u8001<\/strong><\/h5>\n\n\n\n<ul><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_01\/\">\u4ec0\u4e48\u662f\u7cd6\u5316\u5e94\u6fc0\uff1f<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_02\">\u7cd6\u5316\u5e94\u6fc0\u6807\u5fd7\u7269\u7684\u68c0\u6d4b\u65b9\u6cd5(1)\u3000\u8840\u7cd6\u3001\u7cd6\u5316\u86cb\u767d\u3001\u7cd6\u5316\u53cd\u5e94\u4e2d\u95f4\u4f53\u7684\u68c0\u6d4b<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_03\">\u7cd6\u5316\u5e94\u6fc0\u6807\u5fd7\u7269\u7684\u68c0\u6d4b\u65b9\u6cd5(2)\u3000AGEs\u7684\u68c0\u6d4b<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_04\">\u7cd6\u5316\u5e94\u6fc0\u6807\u5fd7\u7269\u7684\u68c0\u6d4b\u65b9\u6cd5(3)\u3000\u6297\u7cd6\u5316\u4f5c\u7528\u8bc4\u4ef7<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_05\">\u7cd6\u5316\u5e94\u6fc0\u548cAGEs\u53d7\u4f53<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_06\">\u7cd6\u5316\u5e94\u6fc0\u4e0e\u80be\u75be\u75c5<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_07\/\">\u7cd6\u5316\u5e94\u6fc0\u548c\u76ae\u80a4\u8001\u5316<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_08\">\u7cd6\u5316\u5e94\u6fc0\u4e0e\u52a8\u8109\u786c\u5316<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_09\">\u7cd6\u5316\u5e94\u6fc0\u548c\u7cbe\u795e\u5206\u88c2\u75c7<\/a><\/li><li>\u7cd6\u5316\u5e94\u6fc0\u4e0e\u809d\u75c5<\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_11\">\u7cd6\u5316\u5e94\u6fc0\u4e0e\u4e0d\u5b55\u75c7<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_12\">\u7cd6\u5316\u5e94\u6fc0\u4e0e\u963f\u5c14\u5179\u6d77\u9ed8\u75c7<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_13\/\">\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56(1)\u3000\u8840\u7cd6\u63a7\u5236<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_14\/\">\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56(2)\u3000\u7cd6\u5316\u53cd\u5e94\u7684\u6291\u5236<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_15\/\">\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56(3)\u3000AGEs\u7684\u964d\u89e3\u548c\u6392\u6cc4<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_16\/\">\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56(4)\u3000\u81b3\u98df\u6765\u6e90\u7684AGEs<\/a><\/li>\n<li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_17\/\">\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56\u7684\u8bfe\u9898\u548c\u5c55\u671b<\/a><\/li><\/ul>\n\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<p><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/\">\u5b66\u672f\u4fe1\u606f top<\/a><br><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/\">-Top<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"\u7cd6\u5316\u5e94\u6fc0\u4e0e\u809d\u75c5 A-kit\u682a\u5f0f\u4f1a\u793e\u3000\u751f\u547d\u533b\u79d1\u5b66\u68c0\u67e5\u4e2d\u5fc3&nbsp;\u7cd6\u5316\u5e94\u6fc0\u7814\u7a76\u6240\u516b\u6728\u96c5\u4e4b \u6240\u957f \u4e3b\u7f16 \u4f55\u8c13\u809d\u75c5 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