{"id":10806,"date":"2020-10-05T15:30:51","date_gmt":"2020-10-05T06:30:51","guid":{"rendered":"https:\/\/ebn2.arkray.co.jp\/english\/?page_id=10806"},"modified":"2020-11-24T16:43:34","modified_gmt":"2020-11-24T07:43:34","slug":"glycation-stress_11","status":"publish","type":"page","link":"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_11\/","title":{"rendered":"\u7cd6\u5316\u5e94\u6fc0\u4e0e\u4e0d\u5b55\u75c7"},"content":{"rendered":"\n

\u7cd6\u5316\u5e94\u6fc0\u4e0e\u4e0d\u5b55\u75c7<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/h2>\n\n\n

A-KIT\u682a\u5f0f\u4f1a\u793e  \u751f\u547d\u533b\u79d1\u5b66\u68c0\u67e5\u4e2d\u5fc3  \u7cd6\u5316\u5e94\u6fc0\u7814\u7a76\u6240
\u516b\u6728\u96c5\u4e4b \u6240\u957f \u4e3b\u7f16<\/p>\n\n\n

\u4f55\u4e3a\u4e0d\u5b55\u75c7<\/h3>\n\n\n

\u4e0d\u5b55\u75c7\u662f\u6307\u6ca1\u6709\u660e\u663e\u75be\u75c5\u7684\u7537\u5973\u5e0c\u671b\u598a\u5a20\uff0c\u5e76\u5728\u4e00\u5b9a\u65f6\u95f4\u5185\uff0c\u4e0d\u91c7\u53d6\u907f\u5b55\u63aa\u65bd\u8fdb\u884c\u6027\u751f\u6d3b\u540e\uff0c\u4ecd\u672a\u6210\u529f\u598a\u5a20\u7684\u60c5\u51b5(1)<\/sup>\u3002\u8bca\u65ad\u4e0d\u5b55\u75c7\u7684\u201c\u4e00\u5b9a\u65f6\u95f4\u201d\uff0c\u89c6\u60a3\u8005\u5e74\u9f84\u800c\u5f02\u3002\u4e00\u822c\u60c5\u51b5\u4e0b\uff0c\u5e74\u8f7b\u592b\u5987\u5373\u4fbf\u672a\u80fd\u6210\u529f\u598a\u5a20\u7684\u65f6\u95f4(\u4e0d\u5b55\u65f6\u95f4)\u8f83\u957f\uff0c\u5176\u540e\u53d1\u751f\u81ea\u7136\u598a\u5a20\u7684\u53ef\u80fd\u6027\u4f9d\u7136\u8f83\u9ad8\u3002\u800c\u9ad8\u9f84\u592b\u5987\u5373\u4fbf\u4e0d\u5b55\u65f6\u95f4\u8f83\u77ed\uff0c\u5176\u540e\u53d1\u751f\u81ea\u7136\u598a\u5a20\u7684\u53ef\u80fd\u6027\u4f9d\u7136\u8f83\u4f4e\u3002<\/p>\n

\u65e5\u672c\u5987\u4ea7\u79d1\u5b66\u4f1a\u76842013\u5e74\u7248\u5987\u4ea7\u79d1\u672f\u8bed\u8bcd\u5178\u4e2d\u89c4\u5b9a\uff0c\u4e00\u822c\u5c062\u5e74\u4f5c\u4e3a\u8bca\u65ad\u4e0d\u5b55\u75c7\u7684\u4e00\u5b9a\u65f6\u95f4\u30022009\u5e74\uff0c\u4e16\u754c\u536b\u751f\u7ec4\u7ec7(World Health Organization\uff1aWHO)\u5c06\u4e0d\u5b55\u75c7\u5b9a\u4e49\u4e3a\u201c\u4e0d\u5b55\u65f6\u95f4\u6ee1\u4e00\u5e74\u201d\u3002\u7f8e\u56fd\u751f\u6b96\u533b\u5b66\u4f1a(American Society for Reproductive Medicine\uff1aASRM)\u4e8e2013\u5e74\u8868\u793a\uff1a\u201c\u867d\u7136\u4e0d\u5b55\u65f6\u95f4\u6ee1\u4e00\u5e74\u7684\u80fd\u591f\u5b9a\u4e49\u4e3a\u4e0d\u5b55\u75c7\uff0c\u4f46\u5bf9\u4e8e\u5e74\u6ee135\u5468\u5c81\u53ca\u4ee5\u4e0a\u7684\u5973\u6027\uff0c\u5219\u5728\u4e0d\u5b55\u65f6\u95f4\u8fbe6\u4e2a\u6708\u540e\uff0c\u4fbf\u53ef\u4ee5\u5f00\u59cb\u63a5\u53d7\u76f8\u5173\u68c0\u67e5\u3002\u201d(2)<\/sup><\/p>\n

\u5728\u65e5\u672c\uff0c\u82e5\u4e00\u5bf9\u60f3\u8981\u5b69\u5b50\u7684\u592b\u5987\u5728\u4e0d\u907f\u5b55\u7684\u60c5\u51b5\u4e0b\u53d1\u751f\u6027\u884c\u4e3a\uff0c\u636e\u8bf46\u4e2a\u6708\u53ca\u4ee5\u5185\u6210\u529f\u598a\u5a20\u7684\u51e0\u7387\u4e3a65%\uff0c1\u5e74\u53ca\u4ee5\u5185\u4e3a80%\uff0c2\u5e74\u53ca\u4ee5\u5185\u4e3a90%\uff0c3\u5e74\u53ca\u4ee5\u5185\u4e3a93%\u3002\u56e0\u6b64\uff0c2\u5e74\u53ca\u4ee5\u5185\u672a\u6210\u529f\u598a\u5a20\u768410%\u7684\u592b\u5987\uff0c\u88ab\u89c6\u4e3a\u4e0d\u5b55\u3002\u6309\u6027\u522b\u5206\u7c7b\u6765\u770b\u4e0d\u5b55\u7684\u53d1\u751f\u6bd4\u4f8b\uff0c\u5219\u7537\u6027\u4e0d\u80b2\u7ea6\u536040%\uff0c\u5973\u6027\u4e0d\u5b55\u7ea6\u536040%\uff0c\u53cc\u65b9\u5747\u4e0d\u5b55\u4e0d\u80b2\u536015%\uff0c\u539f\u56e0\u4e0d\u660e\u53605%(3)<\/sup>\u3002<\/p>\n

\u5173\u4e8e\u4e0d\u5b55\u7684\u539f\u56e0\uff0c\u7537\u6027\u4e0d\u80b2\u7684\u539f\u56e0\u6709\uff0c\u751f\u7cbe\u529f\u80fd\u969c\u788d\u3001\u8f93\u7cbe\u7ba1\u9053\u6897\u963b\u3001\u526f\u6027\u817a\u673a\u80fd\u969c\u788d\u3001\u7537\u6027\u6027\u529f\u80fd\u969c\u788d\u7b49\uff0c\u4f46\u5176\u4e2d\u591a\u4e3a\u7cbe\u5b50\u95ee\u9898\uff0c\u5982\uff1a\u65e0\u7cbe\u5b50\u75c7\u3001\u5c11\u7cbe\u5b50\u75c7\u3001\u7cbe\u5b50\u65e0\u529b\u75c7\u3001\u7578\u5f62\u7cbe\u5b50\u75c7\u7b49\u3002\u5973\u6027\u4e0d\u5b55\u7684\u539f\u56e0\u6709\u8f93\u5375\u7ba1\u5f02\u5e38\u548c\u6392\u5375\u969c\u788d\u8fd9\u4e24\u4e2a\uff0c\u5bfc\u81f4\u8fd9\u4e9b\u539f\u56e0\u7684\u95ee\u9898\u5305\u62ec\u5bab\u9888\u56e0\u7d20\u3001\u5b50\u5bab\u5185\u819c\u5f02\u4f4d\u75c7\u3001\u5b50\u5bab\u808c\u7624\u3001\u5b50\u5bab\u7578\u5f62\u7b49\u3002\u5e76\u4e14\uff0c\u82e5\u4e0a\u8ff0\u539f\u56e0\u4e2d\u6709\u591a\u9879\u5e76\u53d1\u4e8e\u5973\u6027\uff0c\u5219\u4f1a\u5bfc\u81f4\u66f4\u52a0\u590d\u6742\u7684\u4e0d\u5b55\u75c7\u72b6\u3002<\/p>\n

\u7ea6\u670910%\u7684\u592b\u5987\u51fa\u4e8e\u4e0a\u8ff0\u539f\u56e0\u65e0\u6cd5\u6210\u529f\u598a\u5a20\uff0c\u5176\u4e2d\u591a\u4e3a\u592b\u5987\u53cc\u65b9\u5747\u5b58\u5728\u95ee\u9898\u7684\u60c5\u51b5\u3002\u53e6\u5916\uff0c\u4e0d\u5b55\u7684\u539f\u56e0\u662f\u7cbe\u5b50\u548c\u5375\u5b50\u5b58\u5728\u5f02\u5e38\uff0c\u56e0\u6b64\u4e00\u822c\u8ba4\u4e3a\u4e0d\u5b55\u7684\u6cbb\u7597\u4e5f\u9700\u8981\u5206\u9636\u6bb5\u5730\u957f\u671f\u6027\u5730\u8fdb\u884c(3)<\/sup>\u3002<\/p>\n

\u636e\u8bf4\u5728\u4e3b\u8981\u7684\u53d1\u8fbe\u56fd\u5bb6\u4e2d\uff0c\u7ea6\u670910%\u7684\u592b\u5987\u4e3a\u4e0d\u5b55\u75c7\u6240\u82e6\u3002\u5176\u4e2d\uff0c\u4e00\u822c\u8ba4\u4e3a\u89e3\u5256\u5b66\u3001\u514d\u75ab\u5b66\u3001\u9057\u4f20\u3001\u5185\u5206\u6ccc\u65b9\u9762\u7684\u539f\u56e0\u5360\u52305%\uff0c\u4e3b\u8981\u56e0\u7d20\u5219\u5305\u62ec\u611f\u67d3\u3001\u73af\u5883\u56e0\u7d20\u3001\u793e\u4f1a\u56e0\u7d20\u7b49(4)<\/sup>\u3002<\/p>\n

\u4e0d\u5b55\u75c7\u7684\u6cbb\u7597\u65b9\u6cd5\u5305\u62ec\uff1a\u9884\u6d4b\u6392\u5375\u671f\u540e\u8fdb\u884c\u6027\u884c\u4e3a\u7684\u65f6\u673a\u6cbb\u7597\u6cd5\u3001\u53e3\u670d\u548c\u6ce8\u5c04\u6fc0\u7d20\u836f\u7269\u7b49\u7684\u836f\u7269\u7597\u6cd5\u7b49\u3002\u82e5\u5728\u63a5\u53d7\u4e0a\u8ff0\u6cbb\u7597\u534a\u5e74\u81f3\u4e00\u5e74\u540e\u4ecd\u672a\u598a\u5a20\uff0c\u5219\u53ef\u8003\u8651\u9009\u62e9\u4e0b\u8ff0\u7684\u8f85\u52a9\u751f\u6b96\u6280\u672f(assisted reproductive technology\uff1aART)\u3002 ART\u6307\u7684\u662f\u5bf9\u5375\u5b50\u548c\u7cbe\u5b50\u8fdb\u884c\u64cd\u4f5c\u5904\u7406\u7684\u4e0d\u5b55\u4e0d\u80b2\u6cbb\u7597\uff0c\u5305\u62ec\u4f53\u5916\u53d7\u7cbe(in vitro fertilization\uff1aIVF)\u3001IVF\uff0b\u663e\u5fae\u6388\u7cbe(intracytoplasmic sperm injection\uff1aICSI)\u3001\u914d\u5b50\u8f93\u5375\u7ba1\u5185\u79fb\u690d(gamete intrafallopian transfer\uff1aGIFT)\u3001\u5408\u5b50\u8f93\u5375\u7ba1\u5185\u79fb\u690d(zygote intrafallopian transfer\uff1aZIFT)\u7b49\u3002\u5728\u5168\u7403\u8303\u56f4\u5185\uff0c\u4ee5IVF\u548cIVF\uff0bICSI\u7684\u4f7f\u7528\u6700\u4e3a\u5e7f\u6cdb(4)<\/sup>\u3002\u5728\u65e5\u672c\u56fd\u5185\uff0c\u4e0d\u5b55\u6cbb\u7597\u7684\u75c5\u4f8b\u6570\u9010\u5e74\u9012\u589e\uff0c\u5e76\u57282010\u5e74\u8fbe\u523024\u4e07\u4f8b(\u56fe1)(5)<\/sup>\u3002
\"\"<\/p>\n

\u56fe<\/strong>1. <\/strong>\u4e0d\u5b55\u6cbb\u7597\u7684\u5b9e\u65bd\u75c5\u4f8b\u6570
<\/strong>\u539a\u751f\u52b3\u52a8\u7701(2013\u5e74)(5)<\/sup><\/h6>\n\n\n

\u4e0d\u5b55\u75c7\u4e0e\u7cd6\u5316\u5e94\u6fc0<\/h3>\n\n\n\n

\u5375\u5de2\u529f\u80fd\u5f02\u5e38\u3001\u7537\u6027\u4e0d\u80b2\u3001\u5375\u5b50\u5f02\u5e38\u662f\u4e0d\u5b55\u75c7\u7684\u4e09\u5927\u539f\u56e0\u3002\u5375\u5de2\u529f\u80fd\u5f02\u5e38\u6700\u4e3a\u5e38\u89c1\u7684\u539f\u56e0\u662f\u591a\u56ca\u5375\u5de2\u7efc\u5408\u5f81(polycytic ovary syndrome\uff1aPCOS)\u3002\u4e00\u822c\u8ba4\u4e3aPCOS\u7684\u4e3b\u8981\u75c5\u56e0\u662f\u80f0\u5c9b\u7d20\u62b5\u6297(insulin resistance)(6)<\/sup>\uff0c\u901a\u8fc7\u4f7f\u7528\u53cc\u80cd\u7c7b\u7cd6\u5c3f\u75c5\u6cbb\u7597\u836f\u7269\u4e8c\u7532\u53cc\u80cd\uff0c\u6539\u5584\u6392\u5375\u548c\u598a\u5a20\u7387(7)<\/sup>\u3002\u6b64\u5916\uff0c\u7531\u4e8e\u7126\u8651\u3001\u538b\u529b\u3001\u8870\u8001\u3001\u80a5\u80d6\u3001\u7626\u5f31\u3001\u8fd0\u52a8\u4e0d\u8db3\u3001\u7761\u7720\u4e0d\u8db3\u3001\u996e\u9152\u3001\u5438\u70df\u3001\u996e\u98df\u4e0d\u89c4\u5f8b\u5747\u4f1a\u5bfc\u81f4\u80f0\u5c9b\u7d20\u62b5\u6297\uff0c\u5bf9\u4e8ePCOS\u4ee5\u5916\u7684\u5375\u5de2\u529f\u80fd\u5f02\u5e38\uff0c\u4f7f\u7528\u4e8c\u7532\u53cc\u80cd\u4e5f\u53ef\u6539\u5584\u80da\u80ce\u53d1\u80b2\u548c\u598a\u5a20\u7387(8)<\/sup>\u3002\u90e8\u5206\u8f93\u5375\u7ba1\u5f02\u5e38\u548c\u7740\u5e8a\u5f02\u5e38\u4e5f\u4e0e\u5b50\u5bab\u5185\u819c\u7684\u80f0\u5c9b\u7d20\u62b5\u6297\u6709\u5173\u3002<\/p>\n\n\n\n

\u5173\u4e8e\u4e0d\u5b55\u75c7\u548cAGEs\u7684\u7814\u7a76\u8fd8\u4e3a\u6570\u4e0d\u591a\u3002\u4e0e\u5065\u5eb7\u5973\u6027\u76f8\u6bd4\uff0c\u5728PCOS\u7684\u5973\u6027\u5375\u5de2\u4e2d\uff0c\u5375\u5de2\u7ec6\u80de\u6216\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u4e2d\u7684AGEs\u548cRAGE\u8868\u8fbe\u66f4\u9ad8(9)<\/sup>\u3002\u800c\u5728\u7a7a\u8179\u8840\u7cd6\u6b63\u5e38\u4f46\u9910\u540e\u8840\u7cd6\u503c\u7565\u9ad8\u7684PCOS\u5973\u6027\u4e2d\uff0c\u8840\u6e05AGEs\u503c\u3001\u5355\u6838\u7ec6\u80de\u4e2dRAGE\u7684\u8868\u8fbe\u4e5f\u9ad8\u4e8e\u5065\u5eb7\u5973\u6027(\u88681)(10)<\/sup>\u3002\u6b64\u5916\uff0c\u5df2\u8bc1\u5b9e\u5728\u539f\u59cb\u5375\u6bcd\u7ec6\u80de\u3001\u521d\u7ea7\u5375\u6ce1\u548c\u95ed\u9501\u5375\u6ce1\u4e2d\u5b58\u5728\u620a\u7cd6\u7d20\uff0c\u4e14\u8868\u660e\u5176\u968f\u7740\u5e74\u9f84\u589e\u957f\u800c\u589e\u52a0(11)<\/sup>\u3002\u5411\u4eba\u7ed2\u6bdb\u819c\u7ec6\u80de\u57f9\u517b\u7cfb\u7edf\u6dfb\u52a0AGEs\u540e\u4f1a\u8bf1\u53d1\u7ec6\u80de\u51cb\u4ea1\uff0c\u8fd9\u8868\u660eAGEs\u53ef\u80fd\u4f1a\u635f\u4f24\u7740\u5e8a\u548c\u80ce\u76d8\u529f\u80fd(12)<\/sup>\u3002<\/p>\n\n\n

\"\"<\/p>\n

\u88681. \u5065\u5eb7\u5973\u6027\u4e0ePCOS\u5973\u6027\u7684\u8840\u6e05AGEs\u548cRAGE\u8868\u8fbe<\/strong><\/strong><\/strong><\/h6>\n

\u4e0d\u5b55\u75c7\u7684\u75c5\u56e0\u4e0e2\u578b\u7cd6\u5c3f\u75c5\u6709\u76f8\u540c\u70b9\u3002\u80f0\u5c9b\u7d20\u62b5\u6297\u5f15\u8d77\u7684\u5375\u6ce1\u4e2d\u80f0\u5c9b\u7d20\u7684\u76f8\u5bf9\u7f3a\u4e4f\uff0c\u4f1a\u589e\u52a0\u5375\u5b50\u548c\u5375\u6ce1\u4e2d\u7684\u6c27\u5316\u5e94\u6fc0\uff0c\u6216\u56e0\u80f0\u5c9b\u7d20\u5206\u6ccc\u80fd\u529b\u4e0b\u964d\u5f15\u53d1\u9910\u540e\u9ad8\u8840\u7cd6\uff0c\u968f\u7740\u7ec4\u7ec7\u4e2d\u5f62\u6210\u7684AGEs\u8d8a\u6765\u8d8a\u591a\u800c\u51fa\u73b0RAGE\u9ad8\u8868\u8fbe\u3002\u5176\u7ed3\u679c\u662f\uff0c\u5728\u5375\u6ce1\u53ca\u5176\u5fae\u8109\u7ba1\u7cfb\u7edf\u7684\u7ec6\u80de\u7ec4\u7ec7\u4e2d\uff0c\u52a0\u901f\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u635f\u4f24\u3001\u8840\u6813\u5f62\u6210\u503e\u5411\u3001\u8bf1\u53d1\u708e\u75c7\uff0c\u4e00\u822c\u8ba4\u4e3a\u8fd9\u5c06\u5bfc\u81f4\u5375\u5b50\u548c\u5375\u6ce1\u53d1\u80b2\u4e0d\u826f\uff0c\u5e76\u4fc3\u4f7f\u5375\u6ce1\u95ed\u9501\u3002\u4f46\u662f\uff0c\u4e0d\u5b55\u4e5f\u53ef\u80fd\u4ec5\u5728\u5375\u6ce1\u548c\u5b50\u5bab\u5185\u819c\u5185\u5b58\u5728\u80f0\u5c9b\u7d20\u529f\u80fd\u969c\u788d\u65f6\u53d1\u751f\uff0c\u56e0\u6b64\u4e0d\u4e00\u5b9a\u4f34\u6709\u9ad8\u8840\u7cd6\u3001\u7cd6\u5c3f\u75c5\u68c0\u67e5\u503c\u5f02\u5e38\u7b49\u5168\u8eab\u75c7\u72b6(13)<\/sup>\u3002<\/p>\n\n\n

AGEs\u7684\u84c4\u79ef\u4e0e\u8f85\u52a9\u751f\u6b96\u6280\u672f\u7684\u7ed3\u679c<\/strong><\/h3>\n\n\n

\u6709157\u4f8b\u8f85\u52a9\u751f\u6b96\u6280\u672f(ART)\u75c5\u4f8b\u62a5\u544a\u4e86AGEs\u7684\u84c4\u79ef\u4e0eART\u7ed3\u679c\u7684\u76f8\u5173\u6027(14)<\/sup>\u3002\u8fd9\u4e00\u7ed3\u679c\u8868\u660e\uff0c\u8840\u6e05\u3001\u5375\u6ce1\u6db2\u4e2d\u7684toxic AGE(TAGE)\u3001\u5375\u6ce1\u4e2d\u7684\u620a\u7cd6\u7d20\u548c\u5375\u6ce1\u4e2d\u7684\u7fa7\u7532\u57fa\u8d56\u6c28\u9178(CML)\uff0c\u4e0e\u53d1\u80b2\u5375\u6ce1\u6570\u3001\u8840\u6e05\u96cc\u4e8c\u9187(estradiol\uff1a E2)\u6c34\u5e73\u3001\u91c7\u5375\u6570\u3001\u53d7\u7cbe\u5375\u6570\u3001\u80da\u80ce\u6570\u548c\u4f18\u826f\u80da\u80ce\u6570\u5448\u663e\u8457\u6027\u8d1f\u76f8\u5173\u3002\u4f46\u662f\uff0c\u4e0e\u8840\u6d46\u620a\u7cd6\u7d20\u3001\u8840\u6d46CML\u3001\u76ae\u80a4\u4e2dAGEs\u84c4\u79ef\u91cf\u65e0\u5173\u3002\u6b64\u5916\uff0c\u672a\u598a\u5a20\u75c5\u4f8b\u548c\u6d41\u4ea7\u75c5\u4f8b\u4e2d\u7684\u5375\u6ce1\u6db2\u620a\u7cd6\u7d20\u663e\u8457\u6027\u9ad8\u4e8e\u6301\u7eed\u598a\u5a20\u75c5\u4f8b(\u56fe2)\u3002<\/p>\n

\"\"<\/p>\n

\u56fe2. 157\u4f8bART(IVF\/ICSI)\u6cbb\u7597\u75c5\u4f8b\u7684
<\/strong>AGEs<\/strong>\u84c4\u79ef\u91cf\u4e0eART\u7ed3\u679c<\/strong><\/h6>\n

\u5bf9\u75c5\u4f8b\u7684\u5e74\u9f84\u3001BMI\u3001day-3-FSH(day 3 levels of follicle stimulating hormone)\u3001\u65e2\u5f80ART\u4e0d\u6210\u529f\u6b21\u6570\u3001\u6709\u65e0\u8f93\u5375\u7ba1\u56e0\u7d20\u3001\u6709\u65e0\u5375\u5de2\u75be\u75c5\u3001\u8840\u6db2\u548c\u5375\u6ce1\u6db2\u4e2dTAGE\u3001\u620a\u7cd6\u7d20\u3001CML\u8fd9\u5341\u4e8c\u9879\u56e0\u7d20\u8fdb\u884c\u76f8\u5173\u6027\u5206\u6790\u7684\u7ed3\u679c\u663e\u793a\uff0c\u5e74\u9f84\u3001\u8840\u6e05TAGE\u3001\u5375\u6ce1\u6db2\u4e2d\u7684\u620a\u7cd6\u7d20\u8fd9\u4e09\u9879\u56e0\u7d20\u662f\u663e\u8457\u6027\u6301\u7eed\u598a\u5a20\u7684\u9884\u6d4b\u56e0\u7d20\u3002<\/p>\n

\u53e6\u5916\uff0c\u4e0e\u8840\u6e05TAGE\u4f4e\u4e8e7.24 U\/mL\u7684\u5973\u6027\u76f8\u6bd4\uff0c\u5728\u8840\u6e05TAGE\u4e3a7.24 U\/mL\u53ca\u4ee5\u4e0a\u7684\u5973\u6027\u8eab\u4e0a\u89c2\u5bdf\u5230\uff0c\u91c7\u5375\u6570\u3001\u6301\u7eed\u598a\u5a20\u7387\u5747\u4f1a\u53d1\u751f\u6bd4\u968f\u5e74\u9f84\u589e\u957f\u7684\u4e0b\u964d\u800c\u66f4\u52a0\u6025\u5267\u7684\u4e0b\u964d\u3002\u5e76\u4e14\uff0c\u82e5\u8840\u6e05TAGE\u4e3a7.24 U\/mL\u53ca\u4ee5\u4e0a\uff0c\u5373\u4f7fday-3-FSH\u6b63\u5e38\uff0c\u91c7\u5375\u6570\u548c\u6301\u7eed\u598a\u5a20\u7387\u4f9d\u7136\u4e0d\u4f73\u3002<\/p>\n

\u6839\u636e\u4ee5\u4e0a\u7ed3\u679c\uff0c\u63a8\u6d4bTAGE\u5347\u9ad8\u4e0e\u5375\u6ce1\u6570\u7684\u51cf\u5c11\u6709\u5173\uff0c\u5e76\u8ba4\u4e3a\u5982\u679c\u5728TAGE\u5f00\u59cb\u5347\u9ad8\u524d\u91c7\u53d6\u63aa\u65bd\uff0c\u4fbf\u6709\u53ef\u80fd\u9632\u6b62\u5375\u6ce1\u88ab\u7834\u574f\u800c\u51cf\u5c11\u3002<\/p>\n

\u901a\u8fc7\u6291\u5236\u7cd6\u5316\u5e94\u6fc0\u6765\u6cbb\u7597\u5375\u5de2\u529f\u80fd\u5f02\u5e38\u7684\u53ef\u80fd\u6027<\/h3>\n

\u76ee\u524d\u6b63\u5728\u63a2\u8ba8\u4f7f\u7528\u5177\u6709\u6291\u5236AGEs\u5f62\u6210\u529f\u80fd\u7684\u7ef4\u751f\u7d20B1\u884d\u751f\u7269\u82ef\u78f7\u786b\u80fa\uff0c\u80f0\u5c9b\u7d20\u62b5\u6297\u6539\u5584\u836f\u7269\u4e8c\u7532\u53cc\u80cd\u548c\u80a0\u4fc3\u80f0\u5c9b\u7d20\u5206\u89e3\u9176DPP-4\u6291\u5236\u5242\u897f\u683c\u5217\u6c40\uff0c\u5bf9\u8f85\u52a9\u751f\u6b96\u6280\u672f(ART)\u7ed3\u679c\u7684\u6539\u5584\u6548\u679c\u3002<\/p>\n

\u5bf9\u63a5\u53d7\u4e86\u81f3\u5c113\u6b21ART\u6cbb\u7597\u540e\u4ecd\u672a\u6301\u7eed\u598a\u5a20\u76847\u4f8b\u75c5\u4f8b\uff0c\u630975 mg\/\u65e5\u7684\u5242\u91cf\u8fdb\u884c\u82ef\u78f7\u786b\u80fa\u7ed9\u836f2\u4e2a\u6708\uff0c\u4e4b\u540e\u518d\u6b21\u8fdb\u884cART\uff0c\u7ed3\u679c\u663e\u793a\u5375\u6ce1\u6db2CML\u548cTAGE\u5747\u663e\u8457\u6027\u964d\u4f4e\uff0c\u5355\u53ea\u5375\u5b50\u7684\u4f18\u826f\u80da\u80ce\u7387\u5347\u9ad8(13)<\/sup>\u3002<\/p>\n

\u5bf933\u4f8b\u63a8\u65ad\u4e8c\u7532\u53cc\u80cd\u6709\u6548\u7684\u975ePCOS\u7684ART\u53cd\u590d\u4e0d\u6210\u529f\u75c5\u4f8b(37.5\u00b10.8\u5c81)\uff0c\u4ece\u7ecf\u671f\u7b2c3\u5929\u8d77\u6309125 mg\/\u65e5\u7684\u5242\u91cf\u8fdb\u884c\u4e8c\u7532\u53cc\u80cd\u7ed9\u836f\uff0c\u5176\u540e\u7ed9\u836f\u5242\u91cf\u6bcf5\u5929\u9012\u589e125 mg\/\u65e5\uff0c\u6700\u7ec8\u7ef4\u6301\u5728500\uff5e750 mg\/\u65e5\uff0c\u518d\u4e8e8\uff5e12\u5468\u540e\u8fdb\u884cART\u3002\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u4e8c\u7532\u53cc\u80cd\u672a\u7ed9\u836f\u7ec4\u76f8\u6bd4\uff0c\u5375\u6ce1\u76f4\u5f84\u3001\u8840\u6e05E2\u503c\u3001\u5355\u53ea\u5375\u6ce1\u7684E2\u503c\u3001\u4f18\u826f\u80da\u80ce\u6570\u3001\u6301\u7eed\u598a\u5a20\u7387\u5747\u663e\u8457\u6027\u5347\u9ad8(\u56fe3)(7)<\/sup>\u3002<\/p>\n

\"\"<\/p>\n

\u56fe<\/strong>3. <\/strong>\u5bf9<\/strong>ART<\/strong>\u53cd\u590d\u4e0d\u6210\u529f\u75c5\u4f8b<\/strong>(<\/strong>\u975e<\/strong>PCOS)
<\/strong>\u8fdb\u884c\u4e8c\u7532\u53cc\u80cd<\/strong>ART<\/strong>\u6cbb\u7597\u7684\u4e34\u5e8a\u7ed3\u679c
<\/strong>\u795e\u91ce\u6b63\u96c4(2008\u5e74)(7)<\/sup><\/h6>\n

\u4ee544\u4f8b\u63a5\u53d7\u5404\u79cd\u5375\u5de2\u523a\u6fc0\u65b9\u6cd5\u4f46ART\u53cd\u590d\u4e0d\u6210\u529f\u7684\u9ad8\u9f84\u5973\u6027(41.0\u00b10.5\u5c81)\u75c5\u4f8b\u4e3a\u5bf9\u8c61\uff0c\u630950 mg\/\u65e5\u7684\u5242\u91cf\u8fdb\u884c\u897f\u683c\u5217\u6c40\u7ed9\u836f1\u4e2a\u6708\uff0c\u5176\u540e\u8fdb\u884cART\uff0c\u7ed3\u679c\u76f8\u6bd4\u672a\u4f7f\u7528\u897f\u683c\u5217\u6c40\u7684ART\u75c5\u4f8b\uff0c\u5176\u53d1\u80b2\u5375\u6ce1\u6570\u3001\u91c7\u5375\u6570\u3001\u80da\u80ce\u6570\u3001\u4f18\u826f\u80da\u80ce\u6570\u548c\u6301\u7eed\u598a\u5a20\u7387\u5747\u6709\u589e\u52a0(13)<\/sup>\u3002<\/p>\n

\u7efc\u4e0a\uff0c\u6291\u5236\u7cd6\u5316\u5e94\u6fc0\u53ef\u80fd\u80fd\u5bf9\u751f\u6b96\u533b\u7597\u4e2d\u7684\u5375\u6ce1\u53d1\u80b2\u3001\u80da\u80ce\u53d1\u80b2\u548c\u6301\u7eed\u598a\u5a20\u6709\u6548(15)<\/sup>\u3002\u6b64\u5916\uff0c\u6539\u5584AGEs\u7684\u84c4\u79ef\u53ef\u80fd\u4f1a\u662f\u4e00\u79cd\u6cbb\u7597\u4e0d\u5b55\u75c7\u7684\u65b0\u65b9\u6cd5\u3002<\/p>\n

\n
References<\/span><\/h5>\n
    \n
  1. \n
      \n
    1. \u65e5\u672c\u751f\u6b96\u533b\u5b66\u4f1a\uff1a\u4e0d\u598a\u75c7Q&A. 2012.<\/li>\n
    2. Basco D, et al.<\/i> : J Law Med Ethics. 2010 ; 38 : 832\u2013839.<\/li>\n
    3. \u6797\u8c37\u5553\u7f8e\u3089 : \u5ddd\u5d0e\u533b\u7642\u798f\u7949\u5b66\u4f1a\u8a8c. 2009 ; 19 : 13-23.<\/li>\n
    4. Journal of International Health. 2009 ; 24 : 23-29.<\/li>\n
    5. \u539a\u751f\u52b4\u50cd\u7701 : \u4e0d\u598a\u306b\u60a9\u3080\u65b9\u3078\u306e\u7279\u5b9a\u6cbb\u7642\u652f\u63f4\u4e8b\u696d\u7b49\u306e\u3042\u308a\u65b9\u306b\u95a2\u3059\u308b\u691c\u8a0e\u4f1a\u30fb\u5831\u544a\u66f8\uff08\u95a2\u4fc2\u8cc7\u65993\uff09. 2013\/08\/23.<\/li>\n
    6. Dunaif A. : Endocrine Reviews. 1997 ; 18 : 774\u2013800.<\/li>\n
    7. \u795e\u91ce\u6b63\u96c4 : \u65e5\u7523\u5a66\u8a8c. 2008 ; 60 : 239-244.<\/li>\n
    8. Jinno M, et al.<\/i> : Hormones. 2010 ; 9 : 161-170.<\/li>\n
    9. Diamanti-Kandarakis E, et al.<\/i> : Histochem Cell Biol. 2007 ; 127 : 581\u2013589.<\/li>\n
    10. Diamanti-Kandarakis E, et al.<\/i> : Clinical Endocrinology. 2005 ; 62 : 37\u201343.<\/li>\n
    11. Matsumine M, et al.<\/i> : Acta Histchem Cytochem. 2008 ; 41 : 97-104.<\/li>\n
    12. Konishi H, et al.<\/i> : Human Reproduction. 2004 ; 19 : 2156-2162.<\/li>\n
    13. \u795e\u91ce\u6b63\u96c4 : AGEs\u3068\u751f\u6b96\u533b\u7642, AGEs\u3068\u8001\u5316 \u592a\u7530\u535a\u660e(\u76e3). 2013 ; 251-259, \u30e1\u30c7\u30a3\u30ab\u30eb\u30ec\u30d3\u30e5\u30fc\u793e.<\/li>\n
    14. Jinno M, et al.<\/i> : Human Reproduction. 2011 ; 26 : 604-610.<\/li>\n
    15. Jinno M, et al.<\/i> : Anti-Aging Medicine. 2012 ; 9 : 6-13.<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/div>\n\n\n
      \n\n\n\n
      \u7cd6\u5316\u5e94\u6fc0\u548c\u6297\u8870\u8001<\/strong><\/h5>\n\n\n\n