{"id":10820,"date":"2020-10-08T13:22:35","date_gmt":"2020-10-08T04:22:35","guid":{"rendered":"https:\/\/ebn2.arkray.co.jp\/english\/?page_id=10820"},"modified":"2020-11-19T10:51:48","modified_gmt":"2020-11-19T01:51:48","slug":"glycation-stress_13","status":"publish","type":"page","link":"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_13\/","title":{"rendered":"\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56\u3000(1)\u8840\u7cd6\u63a7\u5236"},"content":{"rendered":"\n<h2>\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56\u3000(1)\u8840\u7cd6\u63a7\u5236<\/h2>\n\n\n<p class=\"author\">A-kit\u682a\u5f0f\u4f1a\u793e \u751f\u547d\u533b\u79d1\u5b66\u68c0\u67e5\u4e2d\u5fc3\u7cd6\u5316\u5e94\u6fc0\u7814\u7a76\u6240<br>\u516b\u6728\u96c5\u4e4b \u6240\u957f \u4e3b\u7f16<\/p>\n\n\n<h3>\u8840\u7cd6\u4e0e\u7cd6\u4ee3\u8c22\u7684\u6fc0\u7d20\u8c03\u8282\u529f\u80fd<\/h3>\n\n\n<p>\u5728\u751f\u7269\u4f53\u5185\uff0c\u7ec6\u80de\u4f1a\u4ece\u8840\u6db2\u4e2d\u5438\u6536\u8461\u8404\u7cd6\uff0c\u7528\u4e8e\u5408\u6210\u4f5c\u4e3a\u80fd\u91cf\u6765\u6e90\u7684ATP(adenosine triphosphate)\u3002\u5728\u8111\u5185\uff0cATP\u5408\u6210\u4f9d\u8d56\u8461\u8404\u7cd6\u7684\u6bd4\u91cd\u8f83\u5927\uff0c\u56e0\u6b64\uff0c\u5f53\u8840\u7cd6\u503c\u964d\u4f4e\u65f6\uff0cATP\u5408\u6210\u4f1a\u53d7\u5230\u4e25\u91cd\u5f71\u54cd\u3002\u56e0\u6b64\uff0c\u4e3a\u4e86\u5347\u9ad8\u8840\u7cd6\u503c\uff0c\u9632\u6b62\u5176\u964d\u4f4e\uff0c\u4eba\u4f53\u5185\u5b58\u5728\u7740\u80f0\u9ad8\u8840\u7cd6\u7d20(glucagon)\u3001\u751f\u957f\u6fc0\u7d20(growth hormone)\u3001\u80be\u4e0a\u817a\u7d20(epinephrine\u6216adrenaline)\u3001\u76ae\u8d28\u7c7b\u56fa\u9187(corticosteroid)\u7b49\u591a\u79cd\u6fc0\u7d20\u3002\u8fd9\u4e9b\u6fc0\u7d20\u4f1a\u901a\u8fc7\u8461\u8404\u7cd6\u8f6c\u8fd0\u86cb\u767d\uff0c\u5c06\u8461\u8404\u7cd6\u6444\u53d6\u5230\u9aa8\u9abc\u808c\u548c\u8102\u80aa\u7ec6\u80de\u4e2d\uff0c\u63a7\u5236\u7ec6\u80de\u5185\u7684\u7cd6\u4ee3\u8c22\uff0c\u8d77\u5230\u8c03\u8282\u8840\u7cd6\u503c\u7684\u4f5c\u7528\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u53ef\u4ee5\u964d\u4f4e\u8840\u7cd6\u503c\u7684\u6fc0\u7d20\u53ea\u6709\u80f0\u5c9b\u7d20(insulin)\u3002\u4e00\u822c\u8ba4\u4e3a\uff0c\u8fd9\u79cd\u4e0d\u5e73\u8861\u7684\u673a\u5236\u662f\u4e3a\u4e86\u8ba9\u4eba\u7c7b\u5bf9\u6297\u9965\u997f\u751f\u5b58\u4e0b\u53bb\u6240\u505a\u7684\u51c6\u5907(\u56fe1)<sup>(1)<\/sup>\u3002<\/p>\n<p><img loading=\"lazy\" class=\"aligncenter wp-image-12805 size-full\" src=\"http:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_13_01_zh.png\" alt=\"\" width=\"630\" height=\"377\" srcset=\"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_13_01_zh.png 630w, https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_13_01_zh-300x180.png 300w\" sizes=\"(max-width: 630px) 100vw, 630px\" \/><\/p>\n<h6 style=\"text-align: center;\"><strong>\u56fe<\/strong><strong>1. <\/strong><strong>\u7cd6\u4ee3\u8c22\u548c\u8840\u7cd6\u8c03\u8282\u673a\u5236<br><\/strong>\u6c38\u4e95\u9f99\u513f\u7b49\u4eba(2013\u5e74)<sup>(1)<\/sup><\/h6>\n<p style=\"text-align: left;\">\u5065\u5eb7\u4eba\u7684\u8840\u7cd6\u503c\u5728\u7a7a\u8179\u65f6\u4e3a70\uff5e90 mg\/dL\u3002\u4f46\u662f\uff0c\u9910\u540e\u8840\u7cd6\u503c\u56e0\u81b3\u98df\u91cf\u800c\u5f02\uff0c\u4f1a\u5347\u9ad8\u5230140 mg\/dL\u5de6\u53f3\u3002\u8840\u7cd6\u503c\u7684\u5347\u9ad8\u88ab\u5927\u8111\u7684\u4e0b\u4e18\u8111\u611f\u77e5\uff0c\u7531\u526f\u4ea4\u611f\u795e\u7ecf\u4f20\u9012\u5230\u80f0\u817a\u7684\u03b2\u7ec6\u80de(beta cells)\uff0c\u4fc3\u4f7f\u80f0\u5c9b\u7d20\u5206\u6ccc\u3002\u03b2\u7ec6\u80de\u4e2d\u5b58\u5728\u7740\u8461\u8404\u7cd6\u8f6c\u8fd0\u86cb\u767dGLUT2(glucose transporter 2)\uff0c\u4f1a\u6839\u636e\u8840\u7cd6\u503c(\u8840\u6db2\u4e2d\u7684\u8461\u8404\u7cd6\u6d53\u5ea6)\u5c06\u8461\u8404\u7cd6\u6444\u53d6\u5230\u7ec6\u80de\u4e2d\u3002\u968f\u4e4b\u800c\u6765\u7684\u662f\u03b2\u7ec6\u80de \u4f1a\u611f\u77e5\u5230\u8840\u7cd6\u503c\u7684\u5347\u9ad8\u5e76\u5206\u6ccc\u80f0\u5c9b\u7d20\u3002\u53e6\u5916\uff0c\u80f0\u5c9b\u7d20\u5728\u9aa8\u9abc\u808c\u548c\u8102\u80aa\u7ec6\u80de\u4e2d\u53ef\u4fc3\u8fdbGLUT4(glucose transporter 4)\u4ecb\u5bfc\u7684\u8461\u8404\u7cd6\u6444\u53d6\uff0c\u540c\u65f6\u4f5c\u7528\u4e8e\u7cd6\u9175\u89e3\u7cfb\u7edf\uff0c\u4fc3\u8fdb\u7cd6\u4ee3\u8c22\u3002\u8fd9\u53ef\u4ee5\u4f7f\u56e0\u8fdb\u9910\u800c\u5347\u9ad8\u7684\u8840\u7cd6\u503c\u964d\u4f4e\u5230100 mg\/dL\u5de6\u53f3\u3002<\/p>\n<p style=\"text-align: left;\">\u53e6\u4e00\u65b9\u9762\uff0c\u5f53\u4e0b\u4e18\u8111\u611f\u77e5\u5230\u8840\u7cd6\u503c\u964d\u4f4e\u65f6\uff0c\u80f0\u817a\u7684\u03b1\u7ec6\u80de(alpha cells)\u4f1a\u901a\u8fc7\u4ea4\u611f\u795e\u7ecf\u53d7\u5230\u523a\u6fc0\uff0c\u5206\u6ccc\u80f0\u9ad8\u8840\u7cd6\u7d20\u3002\u5728\u809d\u810f\u4e2d\uff0c\u80f0\u9ad8\u8840\u7cd6\u7d20\u901a\u8fc7\u78f7\u9178\u5316\u7cd6\u539f\u78f7\u9178\u5316\u9176(glycogen phosphorylase)\u88ab\u6fc0\u6d3b\uff0c\u50a8\u5b58\u7684\u7cd6\u539f\u88ab\u5206\u89e3\u4e3a\u8461\u8404\u7cd6\u5e76\u5206\u6ccc\u5230\u8840\u6db2\u4e2d\uff0c\u8840\u7cd6\u503c\u5347\u9ad8\u3002<\/p>\n<p style=\"text-align: left;\">\u4f34\u968f\u81b3\u98df\u6240\u4ea7\u751f\u7684\u8840\u7cd6\u503c\u6ce2\u52a8\uff0c\u4e3b\u8981\u662f\u4f9d\u9760\u8fd9\u4e00\u6fc0\u7d20\u4f5c\u7528\u673a\u5236\uff0c\u5728\u4e24\u9910\u4e4b\u95f4\u88ab\u63a7\u5236\u5728100 mg\/dL\u5de6\u53f3\u3002<\/p>\n\n\n<h3>\u7cd6\u7c7b\u7684\u6d88\u5316\u5438\u6536\u4e0e\u80a0\u4fc3\u80f0\u5c9b\u7d20<\/h3>\n\n\n<p>\u81b3\u98df\u4e2d\u542b\u6709\u7684\u591a\u7cd6\u7c7b(\u7cd6\u7c7b)\uff0c\u4f1a\u88ab\u553e\u6db2\u548c\u80f0\u6db2\u4e2d\u7684\u03b1-\u6dc0\u7c89\u9176\u5206\u89e3\u4e3a\u4e8c\u7cd6\u3002\u4e4b\u540e\uff0c\u5230\u8fbe\u5c0f\u80a0\u7684\u4e8c\u7cd6\u53c8\u88ab\u5177\u6709\u5fae\u7ed2\u6bdb(microvillus)\u7684\u9ecf\u819c\u4e0a\u76ae\u7ec6\u80de\u5237\u72b6\u7f18(brush border)\u4e2d\u7684\u03b1-\u8461\u8404\u7cd6\u82f7\u9176(\u03b1-glucosidase)\u5206\u89e3\u4e3a\u5355\u7cd6\uff0c\u8fdb\u800c\u88ab\u5438\u6536\u3002\u03b1-\u8461\u8404\u7cd6\u82f7\u9176\u5305\u62ec\u5206\u89e3\u9ea6\u82bd\u7cd6(maltose)\u5e76\u5c06\u5176\u8f6c\u5316\u4e3a2\u5206\u5b50\u8461\u8404\u7cd6\u7684\u9ea6\u82bd\u7cd6\u9176(maltase)\u3001\u5c06\u8517\u7cd6(sucrose)\u5206\u89e3\u6210\u679c\u7cd6(fructose)\u548c\u8461\u8404\u7cd6\u7684\u8517\u7cd6\u9176(sucrase)\u3001\u5206\u89e3\u5f02\u9ea6\u82bd\u7cd6(isomaltose)\u5e76\u5c06\u5176\u8f6c\u5316\u4e3a2\u5206\u5b50\u8461\u8404\u7cd6\u7684\u5f02\u9ea6\u82bd\u7cd6\u9176(isomaltase)\u7b49<sup>(1)<\/sup>\u3002<\/p>\n<p>\u5728\u751f\u7269\u4f53\u5185\uff0c\u53d7\u5230\u8fdb\u9910\u7684\u523a\u6fc0\u540e\uff0c\u5c0f\u80a0\u4f1a\u5206\u6ccc\u8461\u8404\u7cd6\u4f9d\u8d56\u6027\u4fc3\u80f0\u5c9b\u7d20\u591a\u80bd(gastric inhibitory polypeptide\uff1aGIP)\u548c\u80f0\u9ad8\u8840\u7cd6\u7d20\u6837\u80bd-1(glucagon-like peptide-1\uff1aGLP-1)\u8fd9\u4e24\u79cd\u6fc0\u7d20\u3002\u8fd9\u4e9b\u80c3\u80a0\u6fc0\u7d20\u53eb\u4f5c\u80a0\u4fc3\u80f0\u5c9b\u7d20(incretin)\u3002\u6b64\u5916\uff0c\u5728\u8fde\u7eed\u8fdb\u9910\u65f6\uff0c\u589e\u591a\u7684\u80a0\u4fc3\u80f0\u5c9b\u7d20\u4f1a\u6fc0\u6d3b\u80f0\u817a\u03b2\u7ec6\u80de\uff0c\u80f0\u5c9b\u7d20\u7684\u5206\u6ccc\u589e\u52a0\uff0c\u4f7f\u9910\u540e\u7684\u8840\u7cd6\u5347\u9ad8\u53d7\u5230\u6291\u5236\u3002\u80a0\u4fc3\u80f0\u5c9b\u7d20\u662f\u4fc3\u8fdb\u80f0\u5c9b\u7d20\u5206\u6ccc\u589e\u591a\u7684\u80c3\u80a0\u9053\u56e0\u5b50\uff0c\u5176\u5bf9\u4e8e\u80f0\u5c9b\u7d20\u5206\u6ccc\u6240\u8d77\u5230\u7684\u4fc3\u8fdb\u4f5c\u7528\u6709\u52a9\u4e8e\u4fdd\u6301\u9910\u540e\u8840\u7cd6\u503c\u7684\u7a33\u5b9a\u3002<\/p>\n<p>\u5206\u6cccGIP\u7684K\u7ec6\u80de(K cell)\u4e3b\u8981\u5b58\u5728\u4e8e\u4ee5\u5341\u4e8c\u6307\u80a0\u3001\u7a7a\u80a0\u4e3a\u4e3b\u7684\u5c0f\u80a0\u4e0a\u90e8\u3002\u800c\u4e00\u822c\u8ba4\u4e3a\uff0c\u5206\u6cccGLP-1\u7684L\u7ec6\u80de(L cell)\u5b58\u5728\u4e8e\u5c0f\u80a0\u4e0b\u90e8(\u56fe2)<sup>(3)<\/sup>\u3002K\u7ec6\u80de\u548cL\u7ec6\u80de\u611f\u77e5\u5230\u5230\u8fbe\u80a0\u9053\u5185\u7684\u8425\u517b\u7269\u8d28\u540e\uff0c\u4fbf\u4f1a\u5404\u81ea\u5728\u7ec6\u80de\u57fa\u5e95\u819c\u4fa7\u5206\u6cccGIP\u548cGLP-1\u3002\u8fdb\u9910\u540e\u53ef\u7acb\u523b\u89c2\u5bdf\u5230GLP-1\u7684\u8840\u4e2d\u6d53\u5ea6\u5347\u9ad8\uff0c\u5e76\u4f1a\u7ef4\u63011\uff5e2\u5c0f\u65f6\u3002GIP\u540c\u6837\u4f1a\u5728\u8fdb\u9910\u540e\u7acb\u523b\u5347\u9ad8\uff0c\u4e14\u8840\u6db2\u4e2d\u6d53\u5ea6\u7684\u5347\u9ad8\u4f1a\u7ef4\u6301\u6570\u5c0f\u65f6\u4ee5\u4e0a\u3002\u7cd6\u7c7b\u662f\u4fc3\u8fdb\u80a0\u4fc3\u80f0\u5c9b\u7d20\u5206\u6ccc\u7684\u8425\u517b\u7269\u8d28\u3002\u4e00\u822c\u8ba4\u4e3a\uff0c\u7cd6\u7c7b\u5bf9\u80a0\u4fc3\u80f0\u5c9b\u7d20\u5206\u6ccc\u7684\u4fc3\u8fdb\u673a\u5236\u662f\u88ab\u94a0\u4f9d\u8d56\u6027\u8461\u8404\u7cd6\u8f6c\u8fd0\u86cb\u767d1(sodium-glucose cotransporter 1\uff1aSGLT1)\u5438\u6536\u7684\u7cd6\u7c7b\uff0c\u901a\u8fc7\u5f15\u8d77\u7ec6\u80de\u819c\u7684\u53bb\u6781\u5316\uff0c\u4fc3\u8fdbGLP-1\u548cGIP\u7684\u5206\u6ccc\u3002\u4e00\u822c\u8ba4\u4e3a\uff0c\u9664\u7cd6\u7c7b\u5916\uff0c\u86cb\u767d\u8d28\u548c\u8102\u8d28\u4e5f\u53ef\u4ee5\u4fc3\u8fdb\u80a0\u4fc3\u80f0\u5c9b\u7d20\u7684\u5206\u6ccc\u3002<\/p>\n<p><img loading=\"lazy\" class=\"size-full wp-image-12806 aligncenter\" src=\"http:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_13_02_zh.png\" alt=\"\" width=\"685\" height=\"409\" srcset=\"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_13_02_zh.png 685w, https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_13_02_zh-300x179.png 300w\" sizes=\"(max-width: 685px) 100vw, 685px\" \/><\/p>\n<h6 style=\"text-align: center;\"><strong>\u56fe<\/strong><strong>2. <\/strong><strong>\u80a0\u4fc3\u80f0\u5c9b\u7d20\u7684\u5408\u6210\u5206\u6ccc<br><\/strong>\u5927\u6749 \u6e80(2010\u5e74)<sup>(3)<\/sup><\/h6>\n\n\n<h3>\u8fd0\u52a8\u4e0e\u7cd6\u4ee3\u8c22<\/h3>\n\n\n<p>\u8840\u6db2\u4e2d\u7684\u8461\u8404\u7cd6(\u8840\u7cd6)\u901a\u8fc7GLUT4\u88ab\u6444\u53d6\u5230\u7ec6\u80de\u5185\u3002\u5065\u5eb7\u4eba\u7684\u8840\u7cd6\u503c\u56e0\u8fdb\u9910\u800c\u5347\u9ad8\u65f6\uff0c\u80f0\u817a\u4f1a\u5206\u6ccc\u76f8\u5e94\u91cf\u7684\u80f0\u5c9b\u7d20\u3002\u4e4b\u540e\uff0c\u80f0\u5c9b\u7d20\u4e0e\u4f4d\u4e8e\u7ec6\u80de\u8868\u9762\u7684\u80f0\u5c9b\u7d20\u53d7\u4f53(insulin receptor)\u7ed3\u5408\uff0c\u53d7\u4f53\u7ee7\u800c\u91ca\u653e\u51fa\u5c06\u8461\u8404\u7cd6\u6444\u53d6\u5230\u7ec6\u80de\u5185\u7684\u4fe1\u53f7\u3002\u901a\u8fc7\u4f20\u9012\u8fd9\u4e00\u4fe1\u53f7\uff0c\u7ec6\u80de\u5185\u90e8\u7684GLUT4\u4f1a\u51fa\u73b0\u5728\u7ec6\u80de\u8868\u9762\uff0c\u5c06\u8840\u6db2\u4e2d\u7684\u8461\u8404\u7cd6\u6444\u53d6\u5230\u7ec6\u80de\u5185\u3002\u4f46\u662f\uff0c\u82e5\u80f0\u5c9b\u7d20\u7684\u529f\u80fd\u56e0\u5e74\u9f84\u589e\u957f\u6216\u7cd6\u5c3f\u75c5\u800c\u51cf\u5f31\uff0c\u90a3\u4e48\u80f0\u5c9b\u7d20\u53d7\u4f53\u4ecb\u5bfc\u7684\u4fe1\u53f7\u5c31\u4e0d\u80fd\u987a\u5229\u4f20\u9012\uff0cGLUT4\u65e0\u6cd5\u51fa\u73b0\u5728\u7ec6\u80de\u8868\u9762\uff0c\u5c06\u8840\u6db2\u4e2d\u7684\u8461\u8404\u7cd6\u6444\u53d6\u5230\u7ec6\u80de\u5185\u7684\u4f5c\u7528\u4fbf\u4f1a\u968f\u4e4b\u964d\u4f4e(\u80f0\u5c9b\u7d20\u62b5\u6297\uff1ainsulin resistance)\u3002GLUT4\u51fa\u73b0\u5728\u7ec6\u80de\u8868\u9762\u7684\u6570\u91cf\u4e5f\u53ef\u4ee5\u901a\u8fc7\u8fd0\u52a8\u4ea7\u751f\u7684\u808c\u8089\u6536\u7f29\u523a\u6fc0\u800c\u589e\u52a0\u3002\u6b64\u5916\uff0c\u7531\u4e8eGLUT4\u51fa\u73b0\u5728\u7ec6\u80de\u8868\u9762\u7684\u6570\u91cf\u4e5f\u53ef\u4ee5\u901a\u8fc7\u6301\u7eed\u8fd0\u52a8\u800c\u589e\u52a0\uff0c\u6444\u53d6\u5230\u7ec6\u80de\u5185\u7684\u8461\u8404\u7cd6\u4e5f\u4f1a\u56e0\u6b64\u589e\u591a\u3002\u7531\u6b64\uff0c\u53ef\u4fdd\u6301\u8840\u7cd6\u503c\u7a33\u5b9a\u6027<sup>(4)<\/sup>\u3002<\/p>\n<p>\u8fd0\u52a8\u7684\u6548\u679c\u5206\u4e3a\u6025\u6027\u6548\u679c\u548c\u6162\u6027\u6548\u679c\u3002\u6025\u6027\u6548\u679c\u5c31\u662f\u80fd\u91cf\u7684\u6d88\u8017\uff0c\u6709\u5047\u8bf4\u8ba4\u4e3aAMP\u6fc0\u9176\u611f\u77e5\u5230\u9aa8\u9abc\u808c\u7684\u6536\u7f29\u6240\u5f15\u53d1\u7684AMP\/ATP\u5347\u9ad8\uff0c\u901a\u8fc7\u52a0\u5927\u7cd6\u7684\u6444\u5165\u6765\u964d\u4f4e\u8840\u7cd6\u503c<sup>(5)<\/sup>\u3002\u8fd0\u52a8\u5bf9\u7cd6\u8f6c\u8fd0\u7684\u4fc3\u8fdb\u4f5c\u7528\u4e0e\u80f0\u5c9b\u7d20\u5e94\u7b54\u53cd\u5e94\u662f\u4e0d\u540c\u7684\u673a\u5236\uff0c\u56e0\u6b64\uff0c\u5373\u4fbf\u662f\u5177\u6709\u80f0\u5c9b\u7d20\u62b5\u6297\u7684\u60a3\u8005\uff0c\u4e5f\u53ef\u4ee5\u901a\u8fc7\u8fd0\u52a8\u964d\u4f4e\u8840\u7cd6\u503c\u3002\u9274\u4e8e\u8840\u7cd6\u503c\u4f1a\u5728\u9910\u540e30\u5206\u949f\uff5e1\u5c0f\u65f6\u8fbe\u5230\u6700\u9ad8\u503c\uff0c\u5728\u8fd9\u6bb5\u671f\u95f4\u8fdb\u884c\u6709\u6c27\u8fd0\u52a8\uff0c\u53ef\u4ee5\u6291\u5236\u9910\u540e\u8840\u7cd6\u503c\u7684\u5feb\u901f\u5347\u9ad8<sup>(6)<\/sup>\u3002<\/p>\n<p>\u6162\u6027\u6548\u679c\u5219\u5305\u62ec\u80f0\u5c9b\u7d20\u654f\u611f\u6027\u589e\u5f3a\u3002\u8fd9\u4e00\u673a\u5236\u8868\u660e\uff0cGLUT4\u86cb\u767d\u91cf\u7684\u5347\u9ad8\u3001\u8fd0\u52a8\u808c\u8089\u7684\u8840\u6d41\u7684\u589e\u52a0\u3001\u4f53\u8102\u80aa\u7684\u51cf\u5c11\u3001\u80f0\u5c9b\u7d20\u4fe1\u53f7\u86cb\u767d\u7684\u589e\u591a\u7b49<sup>(7)<\/sup>\u3002\u56e0\u6b64\uff0c\u8fd0\u52a8\u53ef\u4ee5\u6291\u5236\u8840\u7cd6\u503c\u5347\u9ad8\uff0c\u662f\u6539\u5584\u80f0\u5c9b\u7d20\u62b5\u6297\u7684\u4e3b\u8981\u56e0\u7d20\u3002<\/p>\n<p>\u8fd0\u52a8\u79cd\u7c7b\u65b9\u9762\uff0c\u4e00\u822c\u8ba4\u4e3a\u6b65\u884c\u3001\u6162\u8dd1\u3001\u6e38\u6cf3\u7b49\u6709\u6c27\u8fd0\u52a8\u4ee5\u53ca\u808c\u8089\u8bad\u7ec3\u3001\u62c9\u4f38\u7b49\u662f\u6709\u6548\u7684\u3002<\/p>\n\n\n<h3>\u81b3\u98df\u4e0e\u9176\u6291\u5236\u5242<\/h3>\n\n\n<p>\u03b1-\u8461\u8404\u7cd6\u82f7\u9176\u6291\u5236\u5242(alpha glucosidase inhibitor\uff1aGI)\u662f\u4e00\u79cd\u836f\u7269\uff0c\u5176\u901a\u8fc7\u6291\u5236\u5c06\u7531\u81b3\u98df\u800c\u6444\u5165\u7684\u78b3\u6c34\u5316\u5408\u7269\u5206\u89e3\u4e3a\u5355\u7cd6\u7684\u5206\u89e3\u9176\u4f5c\u7528\uff0c\u6291\u5236\u4e0a\u90e8\u5c0f\u80a0\u5bf9\u7cd6\u7684\u5438\u6536\uff0c\u4ece\u800c\u6291\u5236\u9910\u540e\u8840\u7cd6\u503c\u5347\u9ad8\u3002\u5728\u65e5\u672c\uff0c\u4e34\u5e8a\u4e2d\u4f7f\u7528\u7684\u6709\u963f\u5361\u6ce2\u7cd6(acarbose\uff0c\u836f\u54c1\u540d\u79f0\uff1a\u62dc\u5510\u82f9)\u3001\u4f0f\u683c\u5217\u6ce2\u7cd6(voglibose\uff0c\u836f\u54c1\u540d\u79f0\uff1a\u500d\u6b23)\u3001\u7c73\u683c\u5217\u9187(miglitol\uff0c\u836f\u54c1\u540d\u79f0\uff1aSeibule(\u53e3\u5d29\u7247))\u8fd9\u4e09\u79cd\u3002\u963f\u5361\u6ce2\u7cd6\u548c\u4f0f\u683c\u5217\u6ce2\u7cd6\u57fa\u672c\u4e0d\u4f1a\u88ab\u80a0\u9053\u5438\u6536\u3002\u4f46\u662f\u7c73\u683c\u5217\u9187\u4f1a\u90e8\u5206\u88ab\u5c0f\u80a0\u5438\u6536\uff0c\u5e76\u7ecf\u80be\u810f\u4e0d\u53d8\u6027\u5730\u6392\u6cc4\u5230\u5c3f\u6db2\u4e2d\u3002\u963f\u5361\u6ce2\u7cd6\u4e0d\u4ec5\u53ef\u6291\u5236\u03b1-\u8461\u8404\u7cd6\u82f7\u9176\uff0c\u8fd8\u6709\u6291\u5236\u03b1-\u6dc0\u7c89\u9176\u7684\u4f5c\u7528(\u56fe3)<sup>(2)<\/sup>\u3002<\/p>\n<p>\u98df\u7269\u4e2d\u4e5f\u5b58\u5728\u5bf9\u03b1-\u8461\u8404\u7cd6\u82f7\u9176\u7684\u6291\u5236\u4f5c\u7528\u3002\u756a\u77f3\u69b4\u53f6\u591a\u915a(\u5bf9\u9ea6\u82bd\u7cd6\u9176\u3001\u8517\u7cd6\u9176\u3001\u6dc0\u7c89\u9176\u6709\u6291\u5236\u4f5c\u7528)\u3001\u5c0f\u9ea6\u767d\u86cb\u767d(\u5bf9\u6dc0\u7c89\u9176\u6709\u6291\u5236\u4f5c\u7528)\u3001L-\u963f\u62c9\u4f2f\u7cd6(\u5bf9\u8517\u7cd6\u9176\u6709\u6291\u5236\u4f5c\u7528)\u3001\u8c46\u8c49\u63d0\u53d6\u7269(\u5bf9\u03b1-\u8461\u8404\u7cd6\u82f7\u9176\u6709\u6291\u5236\u4f5c\u7528)\u7b49\u90fd\u662f\u6709\u671b\u5bf9\u9910\u540e\u8840\u7cd6\u503c\u5347\u9ad8\u4ea7\u751f\u6291\u5236\u6548\u679c\u7684\u98df\u54c1\u539f\u6599\uff0c\u5df2\u7ecf\u88ab\u5e94\u7528\u5230\u4e86\u7279\u5b9a\u4fdd\u5065\u7528\u98df\u54c1\u4e2d\u3002<\/p>\n<p>\u80a0\u4fc3\u80f0\u5c9b\u7d20\u662f\u4e00\u79cd\u5728\u8fdb\u9910\u540e\u7531\u80c3\u80a0\u9053\u5206\u6ccc\u7ec6\u80de\u5206\u6ccc\u7684\uff0c\u589e\u5f3a\u80f0\u5c9b\u7d20\u5206\u6ccc\u7684\u6fc0\u7d20\u3002\u4f46\u662f\uff0c\u5728\u80a0\u4fc3\u80f0\u5c9b\u7d20\u4e2d\uff0cGLP-1\u4f1a\u88ab\u5b58\u5728\u4e8e\u4eba\u4f53\u5168\u8eab\u7684dipeptidyl Peptidase-4(DPP-4)\u8fc5\u901f\u964d\u89e3\u5e76\u706d\u6d3b\uff0c\u8840\u6d46\u534a\u8870\u671f\u4ec5\u4e3a1\uff5e2\u5206\u949f\u3002\u56e0\u6b64\uff0c\u8fd1\u5e74\u6765\uff0c\u80a0\u4fc3\u80f0\u5c9b\u7d20\u76f8\u5173\u836f\u7269\u4f5c\u4e3a\u65b0\u578b\u7684\u7cd6\u5c3f\u75c5\u6cbb\u7597\u7528\u836f\u800c\u5907\u53d7\u5173\u6ce8\u3002\u5728\u65e5\u672c\uff0c\u88ab\u6279\u51c6\u7684\u836f\u54c1\u6709\uff1a\u5229\u62c9\u9c81\u80bd(liraglutide\uff0c\u836f\u54c1\u540d\u79f0\uff1a\u8bfa\u548c\u529b)\u548c\u827e\u585e\u90a3\u80bd(exenatide\uff0c\u836f\u54c1\u540d\u79f0\uff1a\u767e\u6ccc\u8fbe\u3001\u767e\u8fbe\u626c)\u8fd9\u4e24\u4e2aDPP-4\u8010\u836f\u7684GLP-1\u53d7\u4f53\u836f\u7269\uff0c\u4ee5\u53ca\u897f\u683c\u5217\u6c40(sitagliptin\uff0c\u836f\u54c1\u540d\u79f0\uff1a\u6377\u8bfa\u7ef4\u3001\u78f7\u9178\u897f\u4ed6\u5217\u6c40\u7247)\u3001\u7ef4\u8fbe\u5217\u6c40(vildagliptin\uff0c\u836f\u54c1\u540d\u79f0\uff1a\u5929\u51ac\u9170\u82ef\u4e19\u6c28\u9178\u7532\u916f)\u548c\u963f\u683c\u5217\u6c40(alogliptin\uff0c\u836f\u54c1\u540d\u79f0\uff1a\u5c3c\u6b23\u90a3)DPP-4\u6291\u5236\u5242\u7b49<sup>(3)<\/sup>\u3002<\/p>\n<p><img loading=\"lazy\" class=\"size-full wp-image-12807 aligncenter\" src=\"http:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_13_03_zh.png\" alt=\"\" width=\"647\" height=\"430\" srcset=\"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_13_03_zh.png 647w, https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_13_03_zh-300x199.png 300w\" sizes=\"(max-width: 647px) 100vw, 647px\" \/><\/p>\n<h6 style=\"text-align: center;\"><strong>\u56fe<\/strong><strong>3. <\/strong><strong>\u03b1<\/strong><strong>&#8211;<\/strong><strong>\u8461\u8404\u7cd6\u82f7\u9176\u6291\u5236\u5242\u7684\u4f5c\u7528\u70b9<br><\/strong>\u85e4\u539f\u548c\u54c9\u7b49\u4eba(2010\u5e74)<sup>(2)<\/sup><\/h6>\n\n\n<h3>\u4e0d\u6613\u5bfc\u81f4\u9910\u540e\u8840\u7cd6\u503c\u5347\u9ad8\u7684\u81b3\u98df<\/h3>\n\n\n<p>Jenkins\u7b49\u4eba\u57281981\u5e74\u89c2\u5bdf\u5230\uff0c\u5373\u4f7f\u81b3\u98df\u7684\u7cd6\u7c7b\u542b\u91cf\u76f8\u540c\uff0c\u5404\u7c7b\u4ee5\u7cd6\u7c7b\u4e3a\u4e3b\u7684\u98df\u7269\u4e2d\uff0c\u5bfc\u81f4\u8840\u7cd6\u503c\u5347\u9ad8\u7684\u901f\u5ea6\u548c\u7a0b\u5ea6\u4e0a\u4e5f\u5b58\u5728\u5dee\u5f02(\u56fe4)<sup>(8)<\/sup>\u3002\u4e4b\u540e\uff0c\u4ed6\u4eec\u5bf9\u6bd4\u4e86\u6ca1\u6709\u7cd6\u5c3f\u75c5\u7684\u5065\u5eb7\u5fd7\u613f\u8005\u5206\u522b\u8fdb\u98df50g\u768462\u79cd\u98df\u7269\u540e\u548c\u8fdb\u98df\u7b49\u91cf\u8461\u8404\u7cd6\u540e\u7684\u8840\u7cd6\u66f2\u7ebf\u4e0b\u9762\u79ef(area under the glucose response curve\uff1aAUC)\uff0c\u8ba1\u7b97\u5e76\u53d1\u8868\u4e86\u98df\u7269\u7684\u5347\u7cd6\u6307\u6570(glycemic index\uff1aGI)\u3002\u4e4b\u540e\uff0c\u98df\u7269\u7684GI\u503c\u4fbf\u6210\u4e3a\u4e86\u4e34\u5e8a\u5b9e\u8df5\u4e2d\u7528\u4e8e\u6307\u5bfc\u7cd6\u5c3f\u75c5\u548c\u4ee3\u8c22\u7efc\u5408\u5f81\u60a3\u8005\u81b3\u98df\u7684\u6709\u6548\u4fe1\u606f\u4e4b\u4e00\u3002\u4f46\u662f\uff0cGI\u4f53\u73b0\u7684\u662f\u6444\u5165\u4e00\u5b9a\u7cd6\u7c7b\u65f6\uff0c\u7cd6\u7c7b\u7684\u201c\u8d28\u201d\u5bf9\u8840\u7cd6\u503c\u7684\u5f71\u54cd\uff0c\u4f46\u8840\u7cd6\u503c\u8fd8\u4f1a\u53d7\u5230\u6444\u5165\u7cd6\u7c7b\u7684\u201c\u91cf\u201d\u7684\u5f71\u54cd\u3002\u56e0\u6b64\uff0cSalmeron\u7b49\u4eba\u8003\u8651\u5c06\u5728\u5355\u6b21\u81b3\u98df\u4e2d\u6444\u5165\u7684\u7cd6\u7c7b\u7684\u201c\u8d28\u201d\u548c\u201c\u91cf\u201d\u4f5c\u4e3a\u6307\u6807\uff0c\u63d0\u51fa\u4e86\u5347\u7cd6\u8d1f\u8377(glycemic load\uff1a GL)<sup>(9)<\/sup>\u3002GL\u7684\u8ba1\u7b97\u65b9\u6cd5\u662f\uff0c\u7528\u767e\u5206\u6bd4(%)\u6765\u8868\u793a\u98df\u7269\u4e2d\u7cd6\u7c7b\u542b\u91cf\u7684\u6bd4\u4f8b\uff0c\u5c06\u8fd9\u4e00\u6bd4\u4f8b\u4e58\u4ee5\u98df\u7269\u7684GI\uff0c\u5f97\u51fa\u8be5\u503c\u3002<\/p>\n<h6><img loading=\"lazy\" class=\"size-full wp-image-12808 aligncenter\" src=\"http:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_13_04_en.jpg\" alt=\"\" width=\"500\" height=\"426\" srcset=\"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_13_04_en.jpg 500w, https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_13_04_en-300x256.jpg 300w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><\/h6>\n<h6 style=\"text-align: center;\"><strong>\u56fe4. \u5065\u5eb7\u4eba\u6444\u5165\u8461\u8404\u7cd6\u3001\u5168\u9ea6\u9762\u5305\u3001\u6241\u8c46<\/strong><br><strong>\u540e\u7684\u8840\u7cd6\u503c\u53d8\u5316<\/strong><\/h6>\n<p>\u4e00\u822c\u800c\u8a00\uff0cGI\u503c\u572870\u53ca\u4ee5\u4e0a\u7684\u98df\u54c1\u5c5e\u4e8e\u9ad8GI\u98df\u54c1\uff0c56\u201369\u7684\u5c5e\u4e8e\u4e2dGI\u98df\u54c1\uff0c55\u53ca\u4ee5\u4e0b\u7684\u5c5e\u4e8e\u4f4eGI\u98df\u54c1\u3002\u4e0e\u6444\u5165\u9ad8GI\u98df\u54c1\u76f8\u6bd4\uff0c\u6444\u5165\u4f4eGI\u98df\u54c1\u540e\u7684AUC\u8f83\u5c0f\uff0c\u56e0\u6b64\u9910\u540e\u8840\u7cd6\u503c\u7684\u5347\u9ad8\u6709\u671b\u8d8b\u4e8e\u5e73\u7f13\u3002GI\u503c\u56e0\u98df\u7269\u7684\u78b3\u6c34\u5316\u5408\u7269\u542b\u91cf\u3001\u7cbe\u5236\u7a0b\u5ea6\u3001\u81b3\u98df\u7ea4\u7ef4\u542b\u91cf\u3001\u8102\u8d28\u542b\u91cf\u3001\u86cb\u767d\u8d28\u542b\u91cf\u3001\u52a0\u5de5\u7a0b\u5ea6\u7b49\u56e0\u7d20\u800c\u5f02\u3002\u53e6\u5916\uff0cGI\u539f\u672c\u662f\u4e00\u9879\u5c06\u6444\u516550g\u78b3\u6c34\u5316\u5408\u7269\u540e\u8840\u7cd6\u503c\u5347\u9ad8\u7a0b\u5ea6\uff0c\u4e0e\u7b49\u91cf\u8461\u8404\u7cd6\u4f5c\u4e3a\u6807\u51c6\u98df\u54c1\u5e76\u8bbe\u4e3a100\u65f6\u7684\u76f8\u5bf9\u503c\u6765\u8868\u793a\u7684\u6307\u6807\u3002\u4f46\u662f\uff0c\u4ee5GI\u503c\u7684\u5f62\u5f0f\u8868\u793a\u7684\u4fe1\u606f\u4e2d\u9700\u8981\u6ce8\u610f\u7684\u662f\uff0c\u53c2\u8003\u996e\u98df\u7684\u98df\u54c1\u79cd\u7c7b(\u7c73\u996d\u3001\u9762\u5305\u7b49)\u6216\u7cd6\u7c7b\u542b\u91cf\u53ef\u80fd\u4e0d\u540c\u3002\u5728\u65e5\u672c\uff0c\u65e5\u672cGlycemic Index\u7814\u7a76\u4f1a(\u65e5\u672cGI\u7814\u7a76\u4f1a)\u63a8\u8350\u6267\u884c\u4ee5147g\u888b\u88c5\u5927\u7c73(\u76f8\u5f53\u4e8e50g\u7cd6\u7c7b)\u4e3a\u53c2\u8003\u996e\u98df\u7684\u89c4\u5b9a\uff08\u7edf\u4e00\u65b9\u6cd5\uff09<sup>(10)<\/sup>\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u8fd8\u53ef\u901a\u8fc7\u5728\u98df\u54c1\u4e2d\u6dfb\u52a0\u81b3\u98df\u7ea4\u7ef4\u6765\u4f7f\u9910\u540e\u8840\u7cd6\u503c\u7684\u4e0a\u5347\u8d8b\u4e8e\u5e73\u7f13\u3002\u6c34\u6eb6\u6027\u81b3\u98df\u7ea4\u7ef4\u96be\u6d88\u5316\u7cca\u7cbe\uff0c\u5728\u4e0e\u78b3\u6c34\u5316\u5408\u7269\u6216\u5355\u7cd6\u7c7b\u4e00\u540c\u6444\u5165\u65f6\uff0c\u4f1a\u53d1\u751f\u6c34\u6eb6\u80c0\uff0c\u51cf\u6162\u4ece\u80c3\u6392\u5165\u80a0\u7684\u901f\u5ea6\uff0c\u5e76\u5728\u5c0f\u80a0\u4e2d\u8f6c\u53d8\u4e3a\u6709\u7c98\u6027\u7684\u51dd\u80f6\u72b6\uff0c\u963b\u788d\u98df\u7269\u6269\u6563\uff0c\u4ee4\u5206\u89e3\u9176\u96be\u4ee5\u63a5\u89e6\u5230\u98df\u7269\uff0c\u5ef6\u7f13\u7cd6\u7c7b\u7684\u6d88\u5316\u5438\u6536\uff0c\u4ece\u800c\u6291\u5236\u9910\u540e\u8840\u7cd6\u503c\u7684\u5347\u9ad8\u3002\u6df7\u5408\u4e86\u96be\u6d88\u5316\u7cca\u7cbe\u7684\u98df\u54c1\u6709\u671b\u5177\u6709\u63a7\u5236\u9910\u540e\u8840\u7cd6\u503c\u5347\u9ad8\u7684\u6548\u679c\uff0c\u5e76\u4f5c\u4e3a\u5177\u6709\u8be5\u6548\u679c\u7684\u98df\u54c1\u539f\u6599\uff0c\u5e94\u7528\u4e8e\u7279\u5b9a\u4fdd\u5065\u98df\u54c1\u7b49\u4e2d<sup>(11)<\/sup>\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u9910\u540e\u8840\u7cd6\u503c\u7684\u5347\u9ad8\u6c34\u5e73\u4e5f\u4f1a\u56e0\u8fdb\u98df\u65f6\u98df\u7269\u7684\u6444\u5165\u987a\u5e8f\u800c\u53d8\u5316\u3002\u62a5\u544a\u663e\u793a\uff0c\u5728\u540c\u65f6\u98df\u7528200g\u7c73\u996d\u548c60g\u852c\u83dc(\u6c99\u62c9)\u65f6\uff0c\u5148\u98df\u7528\u852c\u83dc\u540e\u98df\u7528\u7c73\u996d\u65f6\uff0c\u8840\u7cd6\u503c\u5347\u9ad8\u548c\u80f0\u5c9b\u7d20\u5206\u6ccc\u66f4\u4e3a\u5e73\u7f13<sup>(12)<\/sup>\u3002\u5728\u8fd9\u9879\u7ed3\u679c\u53d1\u8868\u4e4b\u540e\uff0c\u57fa\u4e8e\u8fdb\u98df\u987a\u5e8f\u7684\u5065\u5eb7\u7ba1\u7406\u65b9\u6cd5\u53d7\u5230\u5173\u6ce8<sup>(13)<\/sup>\u3002\u53e6\u6709\u62a5\u544a\u663e\u793a\uff0c\u65e0\u8bba\u91c7\u7528\u4f55\u79cd\u8fdb\u98df\u987a\u5e8f\uff0c\u5982\u679c\u5728\u4e4c\u51ac\u9762\u6216\u7c73\u996d\u4e0a\u6dfb\u52a0\u852c\u83dc\u3001\u6e29\u6cc9\u86cb\u7b49\u914d\u83dc\u540c\u65f6\u98df\u7528\uff0c\u4e5f\u53ef\u6291\u5236\u9910\u540e\u8840\u7cd6\u503c\u7684\u5347\u9ad8(\u56fe5)<sup>(14)<\/sup>\u3002<\/p>\n<p><strong style=\"color: inherit; font-size: 0.8em; text-align: center;\"><img loading=\"lazy\" class=\"size-full wp-image-12809 aligncenter\" src=\"http:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_13_05_en.jpg\" alt=\"\" width=\"600\" height=\"543\" srcset=\"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_13_05_en.jpg 600w, https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_13_05_en-300x272.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/strong><\/p>\n<h6 style=\"text-align: center;\"><strong>\u56fe<\/strong><strong>5. <\/strong><strong>\u5728\u4e4c\u51ac\u9762\u4e2d\u6dfb\u52a0\u6c99\u62c9\u6216\u6e29\u6cc9\u86cb\u98df\u7528\u65f6\u7684\u9910\u540e\u8840\u7cd6\u503c\u53d8\u5316<\/strong><\/h6>\n<p>\u78b3\u6c34\u5316\u5408\u7269\u4e0e\u8840\u7cd6\u503c\u5347\u9ad8\u6709\u5173\uff0c\u56e0\u6b64\uff0c\u8fd1\u5e74\u6765\uff0c\u51cf\u5c11\u5176\u6444\u5165\u91cf\u7684\u51cf\u7cd6\u996e\u98df\u6210\u4e3a\u4e86\u70ed\u95e8\u8bdd\u9898\u3002\u4f46\u8981\u6ce8\u610f\u7684\u662f\uff0c\u78b3\u6c34\u5316\u5408\u7269\u4e5f\u662f\u4e00\u79cd\u91cd\u8981\u7684\u8425\u517b\u7269\u8d28\uff0c\u5df2\u6709\u7814\u7a76\u7ed3\u679c\u6307\u51fa\uff0c\u6781\u5ea6\u63a7\u5236\u7cd6\u7c7b\u6444\u5165\u4f1a\u589e\u52a0\u6b7b\u4ea1\u98ce\u9669<sup>(15)<\/sup>\u3002<\/p>\n<p><span style=\"color: inherit; font-size: 1em; font-weight: 600;\">References<\/span><\/p>\n<div class=\"ref_css\">\n<ol class=\"ref_css\">\n<li style=\"list-style-type: none;\">\n<ol>\n<li>\u6c38\u4e95\u7adc\u5150\u3089\uff1a\u57fa\u790e\u751f\u5316\u5b66\u3000\u5065\u5eb7\u30fb\u75be\u75c5\u3068\u306e\u3064\u306a\u304c\u308a. 2013, \u30a2\u30a4\u30b1\u30a4\u30b3\u30fc\u30dd\u30ec\u30fc\u30b7\u30e7\u30f3 (\u6771\u4eac).<\/li>\n<li>\u85e4\u539f\u548c\u54c9\u3089\uff1a\u7cd6\u5c3f\u75c5\u306e\u6700\u65b0\u6cbb\u7642. 2010\uff1b2\uff1a6-15.<\/li>\n<li>\u5927\u6749\u3000\u6e80\uff1a\u7cd6\u5c3f\u75c5\u306e\u6700\u65b0\u6cbb\u7642. 2010\uff1b2\uff1a21-26.<\/li>\n<li>\u6625\u65e5\u96c5\u4eba\uff1a\u7b2c116\u56de\u533b\u5b66\u4f1a\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0\u8a18\u9332\u96c6\u3000\u751f\u6d3b\u7fd2\u6163\u3068\u7cd6\u5c3f\u75c5\u306e\u767a\u75c7. 2000\uff1b13-18.<\/li>\n<li>Winder WW,&nbsp;<i>et al.<\/i>\uff1aAm J. Physiol. 1999\uff1b277\uff1aE1-E10.<\/li>\n<li>Derave W,&nbsp;<i>et al.<\/i>\uff1aObesity. 2007\uff1b15\uff1a704-711.<\/li>\n<li>Chibalin AV,&nbsp;<i>et al.<\/i>\uff1aPro Natl Acad Sci. 2000\uff1b97\uff1a38-43.<\/li>\n<li>Jenkins DJA,&nbsp;<i>et al.<\/i>\uff1aAm J Clin Nutr. 1981\uff1a362-366.<\/li>\n<li>Salmeron J,&nbsp;<i>et al.<\/i>\uff1aJAMA. 1997 ; 277\uff1a472-477.<\/li>\n<li>\u65e5\u672cGlycemic Index \u7814\u7a76\u4f1a\uff1ahttp:\/\/www.gikenkyukai.com\/protocol.html.<\/li>\n<li>\u6cb3\u5408\u535a\u6210\u3089\uff1a\u5065\u5eb7\u30fb\u6804\u990a\u98df\u54c1\u7814\u7a76. 2002\uff1b5\uff1a33-45.<\/li>\n<li>\u91d1\u672c\u90c1\u7537\u3089\uff1a\u7cd6\u5c3f\u75c5. 2010\uff1b53\uff1a96-101.<\/li>\n<li>\u68b6\u5c71\u9759\u592b\u3089\uff1a\u306a\u305c\u3001\u300c\u98df\u3079\u308b\u9806\u756a\u300d\u304c\u4eba\u3092\u3053\u3053\u307e\u3067\u5065\u5eb7\u306b\u3059\u308b\u306e\u304b\uff1a\u3053\u306e\u98df\u3079\u65b9\u3067\u9ad8\u8840\u5727\u3001\u7cd6\u5c3f\u75c5\u3001\u9ad8\u8102\u8840\u75c7\u306b\u306a\u3089\u306a\u3044! 2012, \u4e09\u7b20\u66f8\u623f(\u6771\u4eac).<\/li>\n<li>Matsushima M,&nbsp;<i>et al.<\/i>\uff1aGlycative Stress Research. 2014\uff1b1\uff1a53-59.<\/li>\n<li>Noto H,&nbsp;<i>et al.<\/i>\uff1aPLoS ONE 8(1)\uff1ae55030. doi:10.1371 \/ journal.pone.0055030<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/div>\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n<h5>\u7cd6\u5316\u5e94\u6fc0\u548c\u6297\u8870\u8001<\/h5>\n\n\n<ul><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_01\/\">\u4ec0\u4e48\u662f\u7cd6\u5316\u5e94\u6fc0\uff1f<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_02\">\u7cd6\u5316\u5e94\u6fc0\u6807\u5fd7\u7269\u7684\u68c0\u6d4b\u65b9\u6cd5(1)\u3000\u8840\u7cd6\u3001\u7cd6\u5316\u86cb\u767d\u3001\u7cd6\u5316\u53cd\u5e94\u4e2d\u95f4\u4f53\u7684\u68c0\u6d4b<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_03\">\u7cd6\u5316\u5e94\u6fc0\u6807\u5fd7\u7269\u7684\u68c0\u6d4b\u65b9\u6cd5(2)\u3000AGEs\u7684\u68c0\u6d4b<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_04\">\u7cd6\u5316\u5e94\u6fc0\u6807\u5fd7\u7269\u7684\u68c0\u6d4b\u65b9\u6cd5(3)\u3000\u6297\u7cd6\u5316\u4f5c\u7528\u8bc4\u4ef7<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_05\">\u7cd6\u5316\u5e94\u6fc0\u548cAGEs\u53d7\u4f53<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_06\">\u7cd6\u5316\u5e94\u6fc0\u4e0e\u80be\u75be\u75c5<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_07\/\">\u7cd6\u5316\u5e94\u6fc0\u548c\u76ae\u80a4\u8001\u5316<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_08\">\u7cd6\u5316\u5e94\u6fc0\u4e0e\u52a8\u8109\u786c\u5316<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_09\">\u7cd6\u5316\u5e94\u6fc0\u548c\u7cbe\u795e\u5206\u88c2\u75c7<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_10\">\u7cd6\u5316\u5e94\u6fc0\u4e0e\u809d\u75c5<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_11\">\u7cd6\u5316\u5e94\u6fc0\u4e0e\u4e0d\u5b55\u75c7<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_12\">\u7cd6\u5316\u5e94\u6fc0\u4e0e\u963f\u5c14\u5179\u6d77\u9ed8\u75c7<\/a><\/li><li>\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56(1)\u3000\u8840\u7cd6\u63a7\u5236<\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_14\/\">\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56(2)\u3000\u7cd6\u5316\u53cd\u5e94\u7684\u6291\u5236<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_15\/\">\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56(3)\u3000AGEs\u7684\u964d\u89e3\u548c\u6392\u6cc4<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_16\/\">\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56(4)\u3000\u81b3\u98df\u6765\u6e90\u7684AGEs<\/a><\/li>\n<li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_17\/\">\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56\u7684\u8bfe\u9898\u548c\u5c55\u671b<\/a><\/li><\/ul>\n\n\n\n<hr 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