{"id":10863,"date":"2020-10-19T17:33:10","date_gmt":"2020-10-19T08:33:10","guid":{"rendered":"https:\/\/ebn2.arkray.co.jp\/english\/?page_id=10863"},"modified":"2020-11-19T10:53:21","modified_gmt":"2020-11-19T01:53:21","slug":"glycation-stress_14","status":"publish","type":"page","link":"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_14\/","title":{"rendered":"\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56\u3000(2)\u7cd6\u5316\u53cd\u5e94\u7684\u6291\u5236"},"content":{"rendered":"\n<h2>\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56\u3000(2)\u7cd6\u5316\u53cd\u5e94\u7684\u6291\u5236<\/h2>\n\n\n<p class=\"author\">A-KIT\u682a\u5f0f\u4f1a\u793e&nbsp; \u751f\u547d\u533b\u79d1\u5b66\u68c0\u67e5\u4e2d\u5fc3&nbsp; \u7cd6\u5316\u5e94\u6fc0\u7814\u7a76\u6240<br>\u516b\u6728\u96c5\u4e4b \u6240\u957f \u4e3b\u7f16<\/p>\n\n\n<h3>\u751f\u7269\u4f53\u5185\u7cd6\u5316\u53cd\u5e94<\/h3>\n\n\n<p>\u751f\u7269\u4f53\u5185\u7684\u6c28\u57fa\u9178\u548c\u86cb\u767d\u4e0e\u4e3b\u8981\u4e3a\u8461\u8404\u7cd6\u7b49\u7684\u8fd8\u539f\u7cd6\u53d1\u751f\u975e\u9176\u53cd\u5e94\uff0c\u5f62\u6210\u5e2d\u592b\u78b1(schiff base)\u540e\uff0c\u901a\u8fc7Amadori \u91cd\u6392(amadori rearrangement)\uff0c\u751f\u6210\u7cd6\u5316\u86cb\u767d(glycated protein)\u7684Amadori \u5316\u5408\u7269(amadori product)\uff0c\u8fd9\u4e00\u4e0d\u53ef\u9006\u7684\u7269\u8d28\u3002<\/p>\n<p>Amadori \u5316\u5408\u7269\u901a\u8fc7\u751f\u62103-\u8131\u6c27\u8461\u7cd6\u919b(3-deoxyglucosone\uff1a3DG)\u3001\u4e59\u4e8c\u919b(glyoxal)\u3001\u7532\u57fa\u4e59\u4e8c\u919b(methylglyoxal)\u3001\u7518\u6cb9\u919b(glyceraldehyde)\u3001\u620a\u4e8c\u919b(glutaraldehyde)\u7b49\u7684\u7fb0\u57fa\u5316\u5408\u7269(carbonyl product)\u4e3a\u4e3b\u7684\u4e2d\u95f4\u4f53\uff0c\u6700\u7ec8\u751f\u6210\u7cd6\u57fa\u5316\u7ec8\u672b\u4ea7\u7269(advanced glycation endproducts\uff1aAGEs)\u3002\u72ed\u4e49\u7684\u7cd6\u5316\u53cd\u5e94\u6307\u7684\u662f\u8fd9\u4e00\u8fde\u4e32\u7684\u53cd\u5e94\u8fc7\u7a0b\u3002<\/p>\n<p>AGEs\u4e0d\u4ec5\u6765\u81ea\u4e8e\u8840\u6db2\u4e2d\u7684\u8461\u8404\u7cd6\uff0c\u8fd8\u4f1a\u751f\u6210\u4e8e\u7fb0\u57fa\u5316\u53cd\u5e94(carbonylation)\uff0c\u8be5\u53cd\u5e94\u662f\u5728\u7531\u9152\u7cbe\u4ee3\u8c22\u548c\u8102\u8d28\u9178\u5316\u800c\u751f\u6210\u7684\u919b\u6216\u916e\u4e0e\u86cb\u767d\u8d28\u4e4b\u95f4\u53d1\u751f\u7684\u3002\u56e0\u6b64\uff0c\u5728AGEs\u4e2d\u5b58\u5728\u4e0d\u540c\u751f\u6210\u8def\u5f84\u7684\u591a\u79cd\u7269\u8d28(\u56fe1)<sup>(1)<\/sup>\u3002<img loading=\"lazy\" class=\"size-full wp-image-12817 aligncenter\" style=\"font-size: inherit;\" src=\"http:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_14_01_zh.png\" alt=\"\" width=\"600\" height=\"346\" srcset=\"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_14_01_zh.png 600w, https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_14_01_zh-300x173.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<h6 style=\"text-align: center;\"><strong>\u56fe<\/strong><strong>1.<\/strong><strong>\u3000\u751f\u7269\u4f53\u4e2d<\/strong><strong>AGEs<\/strong><strong>\u7684\u751f\u6210\u9014\u5f84<\/strong><strong><sup>(1)<br><\/sup><\/strong><\/h6>\n<p>AGEs\u4e2d\u6709\u8367\u5149\u6027\u548c\u975e\u8367\u5149\u6027\u7269\u8d28\u3002\u8367\u5149\u6027AGEs\u4e2d\u6709\u620a\u7cd6\u7d20\uff08pentosidine\uff09\u3001\u4ea4\u8054\u7d20\uff08crossline\uff09\u548c\u5421\u54af\u5421\u5576\uff08pyrropyridine\uff09\u7b49\u3002\u975e\u8367\u5149\u6027 AGEs \u4e2d\u6709 N\u03b5-(carboxymethyl)lysine(CML)\u3001 N\u03c9-(carboxymethyl) arginine(CMA)\u7b49\u3002\u6b64\u5916\uff0c\u620a\u7cd6\u7d20\u3001\u4ea4\u8054\u7d20\u7b49\u5177\u6709\u86cb\u767d\u4ea4\u8054\u6027\uff0c\u56e0\u6b64\u86cb\u767d\u7684AGEs\u5316\u4f1a\u5e26\u6765\u7ec4\u7ec7\u7684\u7269\u7406\u6027\u53d8\u5316\u3002AGEs\u4e0e\u53d7\u4f53RAGE(Receptor for AGEs)\u7ed3\u5408\uff0c\u6fc0\u6d3b\u7ec6\u80de\u4fe1\u53f7\uff0c\u5e76\u8bf1\u5bfc\u4ea7\u751f\u708e\u6027\u7ec6\u80de\u56e0\u5b50\u3002\u56e0\u6b64\uff0c\u751f\u7269\u4f53\u5185\u7684AGEs\u751f\u6210\u548c\u84c4\u79ef\u4f1a\u7ed9\u5404\u79cd\u7ec6\u80de\u548c\u7ec4\u7ec7\u5e26\u6765\u635f\u4f24\u3002<\/p>\n<p>\u7531\u8fd8\u539f\u7cd6\u548c\u919b\u8d1f\u8377\u800c\u4ea7\u751f\u7684\u751f\u7269\u4f53\u5e94\u6fc0\u53ca\u5176\u540e\u7eed\u53cd\u5e94\uff0c\u8fd9\u4e9b\u7edf\u5408\u8d77\u6765\u7684\u6982\u5ff5\u88ab\u79f0\u4e3a\u7cd6\u5316\u5e94\u6fc0(glycation stress)\u3002\u7cd6\u5316\u5e94\u6fc0\u7684\u5bf9\u7b56\u4e4b\u4e00\uff0c\u5c31\u662f\u6291\u5236\u8fd9\u4e9b\u751f\u7269\u4f53\u5185\u7684\u7cd6\u5316\u53cd\u5e94\u3002<\/p>\n\n\n<h3>\u5929\u7136\u4ea7\u7269\u7684<em>in vitro<\/em>\u7cd6\u5316\u53cd\u5e94\u6291\u5236\u4f5c\u7528<\/h3>\n\n\n<p>\u7cd6\u5316\u53cd\u5e94\u6291\u5236\u4f5c\u7528\uff0c\u662f\u6307\u5728\u4eba\u8840\u6e05\u767d\u86cb\u767d(HSA)\u548c\u80f6\u539f\u86cb\u767d\u7b49\u5404\u79cd\u86cb\u767d\u548c\u8461\u8404\u7cd6\u53cd\u5e94\u7cfb\u7edf\u4e2d\u6dfb\u52a0\u591a\u79cd\u591a\u6837\u7684\u53d7\u8bd5\u7269\uff0c\u7528\u53cd\u5e94\u6db2\u4e2d\u7684\u7cd6\u5316\u53cd\u5e94\u4e2d\u95f4\u4f53\u548c\u5404\u79cdAGEs\u7684\u751f\u6210\u91cf\u503c\u7b97\u51fa\u7684\u53d7\u8bd5\u7269\u7684IC<sub>50<\/sub>(50%\u751f\u6210\u6291\u5236\u6d53\u5ea6\uff1a50% inhibitory concentration)\u8fdb\u884c\u8bc4\u4f30<sup>(2)<\/sup>\u3002<\/p>\n<p>\u901a\u5e38\u4f7f\u7528\u7cd6\u5316\u53cd\u5e94\u6291\u5236\u5242\u7684\u6c28\u57fa\u80cd(aminoguanidine)\u4f5c\u4e3a\u7cd6\u5316\u53cd\u5e94\u6291\u5236\u4f5c\u7528\u7684\u9633\u6027\u5bf9\u7167\u3002\u901a\u8fc7\u8fd9\u4e00\u8bc4\u4ef7\u4f53\u7cfb\uff0c\u786e\u8ba4\u4e86\u590d\u65b9\u8349\u836f<sup>(3)<\/sup>\u3001\u7d2b\u83ca\u82b1<sup>(4)<\/sup>\u3001\u65e5\u672c\u77ee\u7af9<sup>(5)<\/sup>\u3001\u8349\u672c\u8336<sup>(6)<\/sup>\u3001\u6c34\u679c<sup>(7)<\/sup>\u3001\u852c\u83dc<sup>(8)<\/sup>\u7b49\u4f17\u591a\u539f\u6599\u4e2d\u7684\u7cd6\u5316\u53cd\u5e94\u6291\u5236\u4f5c\u7528\u3002<\/p>\n<p>\u63a8\u6d4b\u690d\u7269\u4e2d\u7684\u7cd6\u5316\u53cd\u5e94\u6291\u5236\u4f5c\u7528\u4e3b\u8981\u6e90\u81ea\u591a\u915a\u7c7b\u6210\u5206\u3002\u6709\u62a5\u544a\u6307\u51fa\uff0c\u7cd6\u5316\u53cd\u5e94\u6291\u5236\u4f5c\u7528\u7269\u8d28\u6709\u8089\u6842\u9178(cinnamic acid)\u3001\u82ef\u7532\u9178(benzoic acid)\u7c7b\u4f3c\u7269\u7b49\u7684\u915a\u9178(phenolic acids)(\u56fe2)\uff0c\u7c7b\u9ec4\u916e(flavonoids )(\u56fe3)\uff0c\u5f02\u9ec4\u916e(isoflavones)\u548c\u539f\u82b1\u9752\u7d20(procyanidins)(\u56fe4)\u7b49<sup>(9)<\/sup>\u3002\u53e6\u5916\uff0c\u5176\u4ed6\u915a\u7c7b\u5316\u5408\u7269\uff0c\u841c\u70ef(terpenes)\u3001\u7c7b\u80e1\u841d\u535c\u7d20(carotenoids)\u3001\u4e0d\u9971\u548c\u8102\u80aa\u9178\u3001\u591a\u7cd6\u7c7b\uff0c\u7c7b\u9ed1\u7cbe(melanoidine)\u548c\u7ef4\u751f\u7d20\u7c7b\uff0c\u4e5f\u5177\u6709\u7cd6\u5316\u53cd\u5e94\u6291\u5236\u4f5c\u7528\u3002<\/p>\n<p><img loading=\"lazy\" class=\"size-full wp-image-12818 aligncenter\" src=\"http:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_14_02.jpg\" alt=\"\" width=\"600\" height=\"311\" srcset=\"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_14_02.jpg 600w, https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_14_02-300x156.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<h6 style=\"text-align: center;\"><strong>\u56fe<\/strong><strong>2.<\/strong><strong>\u690d\u7269\u4e2d\u542b\u6709\u7684\u915a\u9178<\/strong><strong><sup>(9)<\/sup><\/strong><\/h6>\n<p><img loading=\"lazy\" class=\"size-full wp-image-12819 aligncenter\" src=\"http:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_14_03.jpg\" alt=\"\" width=\"550\" height=\"491\" srcset=\"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_14_03.jpg 550w, https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_14_03-300x268.jpg 300w\" sizes=\"(max-width: 550px) 100vw, 550px\" \/><\/p>\n<h6 style=\"text-align: center;\"><strong>\u56fe3. \u690d\u7269\u4e2d\u542b\u6709\u7684\u7c7b\u9ec4\u916e<sup>(9)<\/sup><\/strong><\/h6>\n<p><img loading=\"lazy\" class=\"size-full wp-image-12820 aligncenter\" src=\"http:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_14_04.jpg\" alt=\"\" width=\"600\" height=\"378\" srcset=\"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_14_04.jpg 600w, https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_14_04-300x189.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<h6 style=\"text-align: center;\"><strong>\u56fe<\/strong><strong>4. <\/strong><strong>\u690d\u7269\u4e2d\u542b\u6709\u7684\u539f\u82b1\u9752\u7d20<\/strong><strong><sup>(9)<\/sup><\/strong><\/h6>\n<p><em>in vitro<\/em>\u548c\u52a8\u7269\u5b9e\u9a8c\u4e2d\u591a\u6b21\u62a5\u544a\u4e86\u690d\u7269\u539f\u6599\u4e2d\u5b58\u5728\u6297\u7cd6\u5316\u4f5c\u7528\u3002\u8fd9\u4e9b\u4f5c\u7528\u4e3b\u8981\u4e0e\u591a\u915a\u7c7b\u76f8\u5173\u3002\u690d\u7269\u4e2d\u542b\u6709\u7684\u591a\u915a\u5206\u5e03\u4e0e\u690d\u7269\u7684\u8fdb\u5316\u548c\u5206\u7c7b\u5bc6\u5207\u76f8\u5173\uff0c\u662f\u5316\u5b66\u6027\u7684\u690d\u7269\u5206\u7c7b\u5b66\uff08chemotaxonomy\uff09\u7684\u6307\u6807\u4e4b\u4e00\u3002\u53ef\u4ee5\u63a8\u6d4b\u5728\u5206\u7c7b\u5b66\u4e2d\u5c5e\u4e8e\u540c\u79d1\uff08family\uff09\u6216\u65cf\uff08tribe\uff09\u7684\u690d\u7269\u4e2d\uff0c\u542b\u6709\u76f8\u4f3c\u7ed3\u6784\u7684\u591a\u915a<sup>(10)<\/sup>\u3002\u4f46\u662f\uff0c\u751f\u7269\u4f53\u4e2dAGEs\u7684\u751f\u6210\u8def\u5f84\u4e0d\u4ec5\u4f34\u968f\u7740\u591a\u8def\u5f84\u4e2d\u7684\u65c1\u8def\u6216\u5206\u652f\uff0c\u800c\u4e14\u7cd6\u5316\u548c\u6c27\u5316\u53cd\u5e94\u4e5f\u590d\u6742\u5730\u4ea4\u7ec7\u5728\u4e00\u8d77(\u56fe1)\u3002\u56e0\u6b64\uff0c\u4e3a\u4e86\u5728\u751f\u7269\u4f53\u5185\u83b7\u5f97\u6709\u6548\u7684\u7cd6\u5316\u53cd\u5e94\u6291\u5236\u4f5c\u7528\uff0c\u9700\u8981\u591a\u79cd\u6210\u5206\u540c\u65f6\u6291\u5236\u591a\u8def\u5f84\u3002\u57fa\u4e8e\u8fd9\u4e9b\u539f\u56e0\uff0c\u4e3a\u4e86\u6709\u6548\u83b7\u5f97\u7cd6\u5316\u53cd\u5e94\u6291\u5236\u4f5c\u7528\uff0c\u5728\u9009\u62e9\u548c\u7ec4\u5408\u690d\u7269\u539f\u6599\u65f6\uff0c\u9700\u8981\u8003\u8651\u690d\u7269\u5206\u7c7b\u5b66\u7684\u77e5\u8bc6\u3002<\/p>\n\n\n<h3><strong><strong>\u590d\u65b9\u8349\u836f\u63d0\u53d6\u7269\u7684<em>in vitro<\/em>\u7cd6\u5316\u53cd\u5e94\u6291\u5236\u4f5c\u7528<\/strong><\/strong><\/h3>\n\n\n<p>\u590d\u65b9\u8349\u836f\u63d0\u53d6\u7269\u662f\u9c7c\u8165\u8349\uff08<em>Houttuynia cordata<\/em>\uff09\u7684\u5730\u4e0a\u90e8\u5206\u3001\u897f\u6d0b\u5c71\u6942\uff08<em>Crataegus oxyacantha<\/em>\uff09\u7684\u679c\u5b9e\u3001\u7f57\u9a6c\u6d0b\u7518\u83ca\uff08<em>Chamaemelum nobile<\/em>\uff09\u7684\u82b1\u3001\u8461\u8404\uff08<em>Vitis vinifera<\/em>\uff09\u7684\u53f6\u5b50\u7684\u70ed\u6c34\u63d0\u53d6\u7269\uff0c\u8fd9\u4e9b\u690d\u7269\u4e3a\u65e5\u672c\u4eba\u6240\u719f\u77e5\uff0c\u88ab\u5e7f\u6cdb\u98df\u7528\uff0c\u4e14\u5728\u690d\u7269\u5206\u7c7b\u5b66\u4e2d\u5c5e\u4e8e\u4e0d\u540c\u690d\u7269\u79cd\u7c7b\u3002\u4e0a\u8ff0\u539f\u6599\u5bf9\u8367\u5149\u6027AGEs\u30013DG\u3001\u620a\u7cd6\u7d20\u548cCML\u751f\u6210\u6291\u5236\u4f5c\u7528\u6709\u4e0d\u540c\u7684\u6548\u679c\uff0c\u56e0\u6b64\uff0c\u5c06\u8fd9\u4e9b\u539f\u6599\u6df7\u5408\u800c\u6210\u7684\u590d\u65b9\u8349\u836f\u63d0\u53d6\u7269\u662f\u6291\u5236\u7cd6\u5316\u53cd\u5e94\u7684\u539f\u6599\u4e4b\u4e00\u3002\u8be5\u590d\u65b9\u8349\u836f\u63d0\u53d6\u7269\u4f5c\u4e3a\u529f\u80fd\u6027\u98df\u54c1\u539f\u6599\uff0c2006\u5e74\u88ab\u7231\u79d1\u6765\u682a\u5f0f\u4f1a\u793e\u4ea7\u54c1\u5316\u4e3a\u201cAG Herb MIX<sup>TM<\/sup>\u201d<sup>(11)<\/sup>\u3002\u5df2\u8bc1\u5b9e\uff0c\u7cd6\u5316\u53cd\u5e94\u6291\u5236\u4f5c\u7528\u6210\u5206\u4e4b\u4e00\u4e3a\u7f57\u9a6c\u6d0b\u7518\u83ca\u4e2d\u7684\u5927\u6ce2\u65af\u83ca\u82f7\uff08chamaemeloside\uff1a apigenin 7-O-\u03b2-D-glucopyranoside-6\u2019\u2019-(3\u2019\u2019\u2019-hydroxy-3\u2019\u2019\u2019-methylglutarate)\uff09<sup>(12)<\/sup>\u3002<\/p>\n<p>\u5728<em>in vitro<\/em>\u7cd6\u5316\u53cd\u5e94\u8bc4\u4ef7\u5b9e\u9a8c\u4f53\u7cfb\u4e2d\uff0c\u590d\u65b9\u8349\u836f\u63d0\u53d6\u7269\u6d53\u5ea6\u4f9d\u8d56\u5730\u6291\u5236\u8367\u5149\u6027AGEs\u30013DG\u3001CML\u7684\u751f\u6210\u3002\u4e0e\u6c28\u57fa\u80cd\u76f8\u6bd4\uff0c\u8be5\u590d\u65b9\u8349\u836f\u63d0\u53d6\u7269\u5bf9CML\u548c\u620a\u7cd6\u7d20\u7684\u5f62\u6210\u5177\u6709\u5f88\u5f3a\u7684\u6291\u5236\u4f5c\u7528\u3002\u6b64\u5916\uff0c\u590d\u65b9\u8349\u836f\u63d0\u53d6\u7269\u4e0eHSA\u76f8\u540c\uff0c\u4e5f\u5bf9\u80f6\u539f\u86cb\u767d\u6709\u6291\u5236\u8367\u5149\u6027AGEs\u751f\u6210\u7684\u4f5c\u7528\uff0c\u6b64\u5916\uff0c\u8fd8\u80fd\u6291\u5236\u80f6\u539f\u86cb\u767d\u4e2d\u7279\u5f02\u6027\u751f\u6210\u7684CMA\u7684\u5f62\u6210\u3002\u5728in vitro\u7cd6\u5316\u53cd\u5e94\u7cfb\u7edf\u4e2d\uff0c\u590d\u65b9\u8349\u836f\u63d0\u53d6\u7269\u663e\u793a\u51fa\u4e86\u7b49\u540c\u6216\u9ad8\u4e8e\u6c28\u57fa\u80cd\u7684\u7cd6\u5316\u53cd\u5e94\u6291\u5236\u6548\u679c\uff0c\u540c\u65f6\u8fd8\u80fd\u963b\u788d\u591a\u8def\u5f84\u7684\u7cd6\u5316\u53cd\u5e94\uff0c\u5e76\u5177\u5907\u6709\u6548\u6291\u5236\u590d\u6742\u7684\u751f\u7269\u4f53\u5185\u7cd6\u5316\u53cd\u5e94\u7684\u53ef\u80fd\u6027\u3002<\/p>\n\n\n<h3>\u590d\u65b9\u8349\u836f\u63d0\u53d6\u7269\u5bf9\u94fe\u8132\u4f50\u83cc\u7d20\u8bf1\u5bfc\u7684\u7cd6\u5c3f\u75c5\u5927\u9f20\u7684\u4f5c\u7528<sup>(13)<\/sup><\/h3>\n\n\n<p>\u5728\u8fd9\u9879\u52a8\u7269\u5b9e\u9a8c\u4e2d\uff0c\u4ee5\u5b8c\u5168\u968f\u673a\u5206\u914d\u7684\u5f62\u5f0f\uff0c\u5c066\u5468\u5927\u7684\u96c4\u6027Sprague-Dawley\u5927\u9f20\u5206\u4e3a4\u7ec4\uff0c\u6bcf\u7ec4\u54047\u53ea\uff1a\u5bf9\u7167\u7ec4(G1)\uff0c\u94fe\u8132\u4f50\u83cc\u7d20(STZ)\u7ed9\u836f\u7ec4(G2)\uff0c\u590d\u65b9\u8349\u836f\u63d0\u53d6\u7269\u7ed9\u836f\u7ec4(G3)\uff0c\u6c28\u57fa\u80cd\u7ed9\u836f\u7ec4(G4)\u3002\u5728G2\u81f3G4\u7ec4\u4e2d\uff0c\u6839\u636e\u6bcf\u53ea\u5927\u9f20\u7684\u4f53\u91cd\u5728\u5c3e\u9759\u8109\u4e2d\u5355\u6b21\u7ed9\u836f55 mg \/ kg\u7684STZ\uff0c\u4ee5\u4f7f\u5b83\u4eec\u8bf1\u53d1\u7cd6\u5c3f\u75c5\uff0c\u5e76\u9972\u517b12\u5468\u3002\u5173\u4e8e\u9972\u6599\uff0c\u7ed9\u4e88G1\u3001G2\u7ec4\u9972\u517b\u5c0f\u9f20\/\u5927\u9f20\u7684MF\u7c89\u672b\u9972\u6599(MF)\uff0c\u7ed9\u4e88G3\u3001G4\u7ec4\u6df7\u5408\u4e86\u590d\u65b9\u8349\u836f\u63d0\u53d6\u7269\u6216\u6c28\u57fa\u80cd\u7684MF\u9972\u6599\u3002<\/p>\n<p>\u7ed3\u679c\u53d1\u73b0\uff0c\u4e0eSTZ\u7ed9\u836f\u7ec4(G2)\u76f8\u6bd4\uff0c\u590d\u65b9\u8349\u836f\u6df7\u5408\u7269\u7ec4(G3)\u548c\u6c28\u57fa\u80cd\u7ec4(G4)\u5747\u663e\u793a\u51fa\u6291\u5236\u8840\u6e05\u620a\u7cd6\u7d20\u548cCML\u589e\u52a0\u7684\u8d8b\u52bf\u3002\u6b64\u5916\u8fd8\u663e\u793a\u51fa\u4e86\u63a7\u5236\u80be\u6e7f\u91cd\u91cf\u589e\u52a0\u7684\u8d8b\u52bf\u3002\u590d\u65b9\u8349\u836f\u63d0\u53d6\u7269\u5bf9\u4e8eSTZ\u8bf1\u5bfc\u7684\u7cd6\u5c3f\u75c5\u5927\u9f20\uff0c\u5177\u6709\u4e0e\u6c28\u57fa\u80cd\u540c\u7b49\u6216\u4ee5\u4e0a\u7684\u7cd6\u5316\u53cd\u5e94\u6291\u5236\u4f5c\u7528\uff0c\u5e76\u6709\u671b\u51cf\u7f13\u7cd6\u5c3f\u75c5\u5e76\u53d1\u75c7\u7684\u8fdb\u5c55\u98ce\u9669\u4ee5\u53ca\u9884\u9632\u8870\u8001\u53d1\u5c55\u3002<\/p>\n\n\n<h3><strong><strong>\u4ee5\u7cd6\u5c3f\u75c5\u9ad8\u5371\u4eba\u7fa4\u4e3a\u5bf9\u8c61\uff0c\u8fdb\u884c\u7684\u590d\u65b9\u8349\u836f\u63d0\u53d6\u7269\u7684\u6444\u5165\u5b9e\u9a8c<sup>(14)<\/sup><\/strong><\/strong><\/h3>\n\n\n<p>\u5728\u8fd9\u9879\u4eba\u4f53\u4e34\u5e8a\u5b9e\u9a8c\u4e2d\uff0c\u5c0626\u4f4d\u7cd6\u5c3f\u75c5\u9ad8\u5371\u4eba\u7fa4(\u968f\u673a\u8840\u7cd6\u503c\u4e3a 110\uff5e199 mg\/dL\uff0cHbA1c\u4e3a5.5\uff5e6.5\uff05(JDS\u503c))\u7684\u6210\u5e74\u7537\u6027\u548c\u5973\u6027\uff0c\u5206\u4e3a\u53d7\u8bd5\u98df\u54c1\u6444\u5165\u7ec4\u548c\u5b89\u6170\u5242\u6444\u5165\u7ec4\uff0c\u6bcf\u7ec4\u540413\u4eba\uff0c\u8fde\u7eed8\u5468\u670d\u7528\u590d\u65b9\u8349\u836f\u63d0\u53d6\u72693,000 mg \/\u5929(\u5efa\u8bae\u6444\u5165\u91cf\u76845\u500d)\uff0c\u6216\u540c\u7b49\u5242\u91cf\u7684\u5b89\u6170\u5242\u98df\u54c1\u3002\u5728\u670d\u7528\u53d7\u8bd5\u98df\u54c1\u524d\u548c8\u5468\u540e\uff0c\u5bf9\u5404\u53d7\u8bd5\u8005\u8fdb\u884c\u91c7\u8840\uff0c\u68c0\u6d4b\u8840\u4e2d\u7684\u7cd6\u5316\u53cd\u5e94\u751f\u6210\u72693DG\u3001CML\u3002\u8be5\u4e34\u5e8a\u5b9e\u9a8c\u5df2\u83b7\u5f97\u4f26\u7406\u59d4\u5458\u4f1a\u7684\u6279\u51c6\uff0c\u5e76\u6839\u636e\u8d6b\u5c14\u8f9b\u57fa\u5ba3\u8a00\u7684\u7cbe\u795e\u8fdb\u884c\u3002\u53d7\u8bd5\u8005\u5145\u5206\u7406\u89e3\u5b9e\u9a8c\u5185\u5bb9\uff0c\u63d0\u4ea4\u540c\u610f\u4e66\uff0c\u5e76\u81ea\u613f\u53c2\u52a0\u3002<\/p>\n<p>\u5728\u6444\u5165\u671f\u95f4\uff0c\u5bf9\u809d\u529f\u80fd\u3001\u80be\u529f\u80fd\u3001\u7cd6\/\u8102\u8d28\u4ee3\u8c22\u529f\u80fd\u7b49\u68c0\u67e5\u4e2d\uff0c\u6ca1\u6709\u53d1\u73b0\u7591\u4f3c\u56e0\u6444\u5165\u590d\u65b9\u8349\u836f\u63d0\u53d6\u7269\u800c\u5f15\u53d1\u7684\u4e0d\u826f\u53cd\u5e94(\u5065\u5eb7\u72b6\u6001\u7684\u53d8\u5316)\uff0c\u786e\u8ba4\u4e86\u5176\u4f5c\u4e3a\u98df\u54c1\u7684\u6444\u5165\u5b89\u5168\u6027\u3002\u53e6\u5916\uff0c\u68c0\u6d4b\u5e76\u6bd4\u8f83\u6444\u5165\u524d\u548c8\u5468\u540e\u7684\u8840\u6db2\u4e2dAGEs\u503c\uff0c\u7ed3\u679c\u663e\u793a\uff0c\u53d7\u8bd5\u98df\u54c1\u6444\u5165\u7ec4\u4e0e\u5b89\u6170\u5242\u98df\u54c1\u6444\u5165\u7ec4\u76f8\u6bd4\uff0c\u5728\u8840\u7cd6\u503c\u4e3a110mg\/dL\u53ca\u4ee5\u4e0a\u7684\u4e9a\u7ec4\u5206\u6790\u4e2d\uff0c\u663e\u793a\u51fa\u5bf9\u8840\u6db2\u4e2d3DG\u5347\u9ad8\u7684\u6291\u5236\u4f5c\u7528(p = 0.094)\uff0c\u5728HbA1c\uff08JDS\u503c\uff09\u4e3a5.9\uff05\u53ca\u4ee5\u4e0a\u7684\u4e9a\u7ec4\u5206\u6790\u4e2d\uff0c\u53d1\u73b0CML\u663e\u8457\u6027\u964d\u4f4e(p = 0.048)\u3002\u8be5\u7ed3\u679c\u8868\u660e\uff0c\u590d\u65b9\u8349\u836f\u63d0\u53d6\u7269\u5728\u4eba\u4f53\u4e2d\uff0c\u6291\u5236\u4e86\u4f34\u968f\u7cd6\u4ee3\u8c22\u5f02\u5e38\u800c\u751f\u6210\u7684\u7cd6\u5316\u53cd\u5e94\u4e2d\u95f4\u4f53\u548cAGEs\u7684\u5f62\u6210\u3002<\/p>\n<h3>\u5bf9\u7cd6\u5c3f\u75c5\u60a3\u8005\u8fdb\u884c\u7684\u590d\u65b9\u8349\u836f\u63d0\u53d6\u7269\u7684\u6444\u5165\u5b9e\u9a8c<sup>(15)<\/sup><\/h3>\n<p>\u5728\u8fd9\u9879\u4eba\u4f53\u4e34\u5e8a\u5b9e\u9a8c\u4e2d\uff0c7\u4f4d\u60a3\u67092\u578b\u7cd6\u5c3f\u75c5\u7684\u6210\u5e74\u7537\u5973(HbA1c(JDS\u503c)\uff1a 5.7\uff5e9.2\uff05)\uff0c\u8fde\u7eed12\u5468\u6444\u5165\u4f5c\u4e3a\u53d7\u8bd5\u98df\u54c1\u7684\u590d\u65b9\u8349\u836f\u63d0\u53d6\u7269600 mg\/\u65e5\u3002\u5404\u53d7\u8bd5\u8005\u5728\u670d\u7528\u53d7\u8bd5\u98df\u54c1\u524d\u3001\u7b2c8\u5468\u3001\u7b2c12\u5468\u8fdb\u884c\u91c7\u8840\uff0c\u68c0\u6d4b\u8840\u4e2d\u7684\u7cd6\u5316\u53cd\u5e94\u751f\u6210\u72693DG\u3001CML\u3002\u5728\u6444\u5165\u524d\u53ca\u6444\u5165\u7b2c2\u5468\u3001\u7b2c4\u5468\u3001\u7b2c8\u5468\u3001\u7b2c12\u5468\uff0c\u4f7f\u7528\u7cbe\u5bc6\u4eea\u5668\u6d4b\u91cf\u4e86\u76ae\u80a4\u5f39\u6027\u3002\u8be5\u4e34\u5e8a\u5b9e\u9a8c\u5df2\u83b7\u5f97\u4f26\u7406\u59d4\u5458\u4f1a\u7684\u6279\u51c6\uff0c\u5e76\u6839\u636e\u8d6b\u5c14\u8f9b\u57fa\u5ba3\u8a00\u7684\u7cbe\u795e\u8fdb\u884c\u3002\u53d7\u8bd5\u8005\u5145\u5206\u7406\u89e3\u5b9e\u9a8c\u5185\u5bb9\uff0c\u63d0\u4ea4\u540c\u610f\u4e66\uff0c\u5e76\u81ea\u613f\u53c2\u52a0\u3002<\/p>\n<p>\u5728\u6444\u5165\u671f\u95f4\u7684\u809d\u529f\u80fd\u3001\u80be\u529f\u80fd\u3001\u7cd6\/\u8102\u8d28\u4ee3\u8c22\u529f\u80fd\u7b49\u68c0\u67e5\u4e2d\uff0c\u6ca1\u6709\u53d1\u73b0\u7591\u4f3c\u56e0\u6444\u5165\u590d\u65b9\u8349\u836f\u63d0\u53d6\u7269\u800c\u5f15\u53d1\u7684\u4e0d\u826f\u53cd\u5e94(\u5065\u5eb7\u72b6\u6001\u7684\u53d8\u5316)\uff0c\u786e\u8ba4\u4e86\u5176\u4f5c\u4e3a\u98df\u54c1\u7684\u6444\u5165\u5b89\u5168\u6027\u3002\u6b64\u5916\uff0c\u4e0e\u6444\u5165\u524d\u76f8\u6bd4\u7b2c8\u5468\u3001\u7b2c12\u5468\uff0c3DG\u663e\u8457\u6027\u964d\u4f4e(p &lt; 0.001)\uff0c\u7b2c12\u5468CML\u663e\u8457\u6027\u51cf\u5c11(p &lt; 0.001)\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0c\u5df2\u5728<em>in vitro<\/em>\u548c\u52a8\u7269\u5b9e\u9a8c\u4e2d\u786e\u8ba4\u7684\u590d\u65b9\u8349\u836f\u63d0\u53d6\u7269\u7684\u7cd6\u5316\u53cd\u5e94\u6291\u5236\u4f5c\u7528\uff0c\u5bf9\u4eba\u4f53\u4e5f\u6709\u6548\u3002\u6b64\u5916\uff0c\u76ae\u80a4\u5f39\u6027\u4e0e\u6444\u5165\u524d\u76f8\u6bd4\uff0c\u7b2c8\u5468(p = 0.001)\u3001\u7b2c12\u5468(p &lt; 0.001)\u7684\u76ae\u80a4\u5f39\u6027\u6307\u6570(R2\uff1a Ua\/Uf)\u663e\u8457\u6027\u6539\u5584\u3002\u4e00\u822c\u8ba4\u4e3a\uff0c\u76ae\u80a4\u5f39\u6027\u7684\u6539\u5584\u662f\u7531\u4e8e\u6444\u5165\u590d\u65b9\u8349\u836f\u63d0\u53d6\u7269\u6291\u5236\u4e86\u4ea4\u8054\u6027AGEs\u7684\u751f\u6210\uff0c\u4ece\u800c\u6291\u5236\u4e86\u86cb\u767d\u8d28\u7684\u786c\u5316\uff0c\u5e76\u901a\u8fc7\u76ae\u80a4\u4ee3\u8c22\u63d0\u9ad8\u4e86\u5f39\u6027\u3002<\/p>\n<h3>\u590d\u65b9\u8349\u836f\u63d0\u53d6\u7269\u7684\u76ae\u80a4\u4e2dAGEs\u84c4\u79ef\u6291\u5236\u6548\u679c<sup>(16)<\/sup><\/h3>\n<p>\u5728\u8fd9\u9879\u4e34\u5e8a\u5b9e\u9a8c\u4e2d\uff0c\u6210\u5e74\u7537\u5973\u5065\u5eb7\u7ec48\u4eba\u3001\u7cd6\u5c3f\u75c5\/\u9ad8\u8840\u7cd6\u7ec44\u4eba\uff0c\u8fde\u7eed12\u5468\u670d\u7528\u590d\u65b9\u8349\u836f\u63d0\u53d6\u7269600 mg \/\u5929\u4ee5\u53ca\u542b\u6709\u751f\u59dc\u548c\u82b1\u6912\u7684\u8bd5\u9a8c\u996e\u98df\u3002 \u6444\u5165\u524d\u3001\u7b2c8\u5468\u548c\u7b2c12\u5468\uff0c\u4f7f\u7528AGE Reader\u6d4b\u91cfAGEs\u84c4\u79ef\u6c34\u5e73\u3002\u8be5\u4e34\u5e8a\u5b9e\u9a8c\u5df2\u83b7\u5f97\u4f26\u7406\u59d4\u5458\u4f1a\u7684\u6279\u51c6\uff0c\u5e76\u6839\u636e\u8d6b\u5c14\u8f9b\u57fa\u5ba3\u8a00\u7684\u7cbe\u795e\u8fdb\u884c\u3002\u53d7\u8bd5\u8005\u5145\u5206\u7406\u89e3\u5b9e\u9a8c\u5185\u5bb9\uff0c\u63d0\u4ea4\u540c\u610f\u4e66\uff0c\u5e76\u81ea\u613f\u53c2\u52a0\u3002<\/p>\n<p>\u5728\u6444\u5165\u671f\u95f4\u7684\u809d\u529f\u80fd\u3001\u80be\u529f\u80fd\u3001\u7cd6\/\u8102\u8d28\u4ee3\u8c22\u529f\u80fd\u7b49\u68c0\u67e5\u4e2d\uff0c\u6ca1\u6709\u53d1\u73b0\u7591\u4f3c\u56e0\u6444\u5165\u590d\u65b9\u8349\u836f\u63d0\u53d6\u7269\u800c\u5f15\u53d1\u7684\u4e0d\u826f\u53cd\u5e94(\u5065\u5eb7\u72b6\u6001\u7684\u53d8\u5316)\uff0c\u786e\u8ba4\u4e86\u5176\u4f5c\u4e3a\u98df\u54c1\u7684\u6444\u5165\u5b89\u5168\u6027\u3002\u6b64\u5916\uff0c\u4e0e\u6444\u5165\u524d\u76f8\u6bd4\uff0c\u5065\u5eb7\u7ec4\u57288\u5468\u540e\u4e3a\uff08p = 0.035\uff09\uff0c12\u5468\u540e\u4e3a\uff08p = 0.020\uff09\uff0c\u76ae\u80a4\u4e2dAGEs\u84c4\u79ef\u91cf\u663e\u8457\u6027\u964d\u4f4e\u3002\u6b64\u5916\uff0c\u7cd6\u5c3f\u75c5\/\u9ad8\u8840\u7cd6\u7ec4\u76844\u4eba\u4e2d\u67093\u4eba\u88ab\u53d1\u73b0\u964d\u4f4e\u3002\u5e26\u8367\u5149\u7684AGEs\u4e2d\u5305\u62ec\u4e0e\u86cb\u767d\u7684\u4ea4\u8054\u5f62\u6210\u76f8\u5173\u7684\u4ea4\u8054\u7d20\u548c\u620a\u7cd6\u7d20\u7b49\uff0c\u8fd9\u8868\u660e\uff0c\u590d\u65b9\u8349\u836f\u63d0\u53d6\u7269\u7684\u6444\u5165\u53ef\u80fd\u4f1a\u6291\u5236\u8001\u5316\uff0c\u5982\u56e0\u76ae\u80a4\u86cb\u767d\u8d28\u7684AGEs\u5316\u800c\u53d1\u751f\u786c\u5316\u7b49\u3002<\/p>\n<h3>\u690d\u7269\u539f\u6599\u7684<em>in vitro<\/em>\u7cd6\u5316\u53cd\u5e94\u6291\u5236\u4f5c\u7528\u548c\u5bf9\u4eba\u4f53\u7684\u7cd6\u5316\u5e94\u6fc0\u6291\u5236\u4f5c\u7528<\/h3>\n<p>\u5728\u590d\u65b9\u8349\u836f\u63d0\u53d6\u7269\u4e2d\uff0c\u53d1\u73b0\u4e86\u5728<em>in vitro<\/em>\u7684\u7cd6\u5316\u53cd\u5e94\u6291\u5236\u4f5c\u7528\uff0c\u4e14\u4eba\u5728\u6444\u5165\u6b64\u63d0\u53d6\u7269\u65f6\uff0c\u4e5f\u88ab\u53d1\u73b0\u4e86\u540c\u6837\u7684\u7cd6\u5316\u5e94\u6fc0\u6291\u5236\u4f5c\u7528\u3002\u4e0a\u8ff0\u8868\u660e\uff0c\u590d\u65b9\u8349\u836f\u63d0\u53d6\u7269\u5728<em>in vitro<\/em>\u7cd6\u5316\u53cd\u5e94\u7cfb\u7edf\u4e2d\uff0c\u53ef\u80fd\u963b\u788d\u4e86\u591a\u8def\u5f84\u7684\u7cd6\u5316\u53cd\u5e94\uff0c\u6709\u6548\u6291\u5236\u4e86\u590d\u6742\u751f\u7269\u4f53\u5185\u7684\u7cd6\u5316\u53cd\u5e94\u3002<\/p>\n<p>\u5728\u83bd\u5409\u67ff\uff08<em>Garcinia mangostana<\/em>\uff09<sup>(<\/sup><sup>17)<\/sup>\u3001\u77f3\u69b4 \uff08<em>Punica granatum<\/em>\uff09<sup>(18)<\/sup>\u7684\u679c\u5b9e\u7b49\u5355\u4e00\u539f\u6599\u7684\u63d0\u53d6\u7269\u4e2d\uff0c\u4e5f\u83b7\u53d6\u4e86\u4e0e\u590d\u65b9\u8349\u836f\u63d0\u53d6\u7269\u76f8\u540c\u7684\u7ed3\u679c\u3002\u83bd\u5409\u67ff\u4e2d\u5305\u542b\u591a\u79cd\u7c7b\u7684\u5355\u5b81\uff08tannin\uff09<sup>(19)<\/sup>\u3001\u915a\u9178\uff08phenolic acid\uff09<sup>(20)<\/sup>\u3001 \u6c27\u6742\u84bd\u916e \uff08xanthones\uff09\u7c7b<sup>(21)<\/sup>\u3001\u97a3\u82b1\u5355\u5b81\uff08ellagitannin\uff09\u7c7b<sup>(22)<\/sup>\u3002\u5355\u4e00\u539f\u6599\u4f5c\u7528\u7684\u7cd6\u5316\u53cd\u5e94\u6291\u5236\u4f5c\u7528\uff0c\u53ef\u80fd\u4f1a\u8ba9\u8fd9\u4e9b\u7269\u8d28\u901a\u8fc7\u80a0\u9053\u83cc\u7fa4\u88ab\u5206\u89e3\u6210\u5bb9\u6613\u88ab\u751f\u7269\u4f53\u5185\u5438\u6536\u7684\u591a\u79cd\u7c7b\u7684\u4f4e\u5206\u5b50\u7269\u8d28\uff0c\u4f5c\u7528\u4e8e\u591a\u8def\u5f84\u7684\u7cd6\u5316\u53cd\u5e94\u7cfb\u7edf\u3002<\/p>\n<p>\u60f3\u8981\u6709\u6548\u5229\u7528\u7cd6\u5316\u53cd\u5e94\u6291\u5236\u4f5c\u7528\u4f5c\u4e3a\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56\uff0c\u539f\u6599\u7684\u9009\u62e9\u548c\u7ec4\u5408\u662f\u5173\u952e\u3002<\/p>\n<div class=\"ref_css\">\n<h5>References<\/h5>\n<ol class=\"ref_css\">\n<li style=\"list-style-type: none;\">\n<ol>\n<li>\u4e09\u6d66\u96c5\u4e00\u3089\uff1a\u751f\u4f53\u5185AGEs\u306e\u6e2c\u5b9a, AGEs\u7814\u7a76\u306e\u6700\u524d\u7dda. 2004, 37-50, \u30e1\u30c7\u30a3\u30ab\u30eb\u30ec\u30d3\u30e5\u30fc.<\/li>\n<li>Hori M,\u00a0<i>et al.<\/i>\uff1aAnti-Aging Medicine. 2012 ; 9 : 125-134.<\/li>\n<li>Yonei Y,\u00a0<i>et al.<\/i>\uff1aAnti-Aging Medicine. 2008 ; 5 : 93-98.<\/li>\n<li>Yagi M,\u00a0<i>et al.<\/i>\uff1aAnti-Aging Medicine. 2012 ; 9 : 61-74.<\/li>\n<li>\u5800\u672a\u592e\u3089\uff1a\u540c\u5fd7\u793e\u5927\u5b66\u7406\u5de5\u5b66\u7814\u7a76. 2011 ; 52 : 61-67.<\/li>\n<li>Hori M,\u00a0<i>et al.<\/i>\uff1aAnti-Aging Medicine. 2012 ; 9 : 135-148.<\/li>\n<li>Lanny P,\u00a0<i>et al.<\/i>\uff1aAnti-Aging Medicine. 2013 ; 10 : 70-76.<\/li>\n<li>Ishioka Y,\u00a0<i>et al.<\/i>\uff1aGlycative Stress Research. 2015 ; 2 : 22-34.<\/li>\n<li>Odjakova M,\u00a0<i>et al.<\/i>\uff1aGlycosylation. 2012 : 223-256, InTech<\/li>\n<li>Robards K,\u00a0<i>et al.<\/i>\uff1aAnalyst. 1997 ; 122 : 11R-34R.<\/li>\n<li>\u516b\u6728\u96c5\u4e4b\u3089\uff1aCOSMETIC STAGE. 2011 ; 15 : 23-32.<\/li>\n<li>\u516b\u6728\u96c5\u4e4b\u3089\uff1aaromatopia. 2007 ; l16 : 26-29.<\/li>\n<li>Yonei Y,\u00a0<i>et al.<\/i>\uff1aAnti-Aging Medicine. 2008 ; 5 : 93-98.<\/li>\n<li>Yonei Y,\u00a0<i>et al.<\/i>\uff1aAnti-Aging Medicine. 2010 ; 7 : 26-35.<\/li>\n<li>Kubo M,\u00a0<i>et al.<\/i>\uff1aJ Clin Biochem Nutr. 2008 ; 43(Suppl 1) : 66-69.<\/li>\n<li>\u7530\u6751\u9686\u6717\u3089\uff1a\u540c\u5fd7\u793e\u5927\u5b66\u7406\u5de5\u5b66\u7814\u7a76\u5831\u544a. 2012 ; 52 : 244-252.<\/li>\n<li>Ohno R,\u00a0<i>et al.<\/i>\uff1aJ Clin Biochem Nutr. 2015 ; 57 : 27-32.<\/li>\n<li>Yagi M,\u00a0<i>et al.<\/i>\uff1aGlycative Stress Research. 2014; 1 : 60-67.<\/li>\n<li>Moosophin K,\u00a0<i>et al.<\/i>\uff1aKKU Res J. 2010 ; 15 : 377-384.<\/li>\n<li>Zadernowski R,\u00a0<i>et al.<\/i>\uff1aFood Chemistry. 2009 ; 112 : 685\u2013689.<\/li>\n<li>Shan T,\u00a0<i>et al.<\/i>\uff1aCurr Mol Med. 2011 ; 11 : 666\u2013677.<\/li>\n<li>Ito H,\u00a0<i>et al.<\/i>\uff1aFood Chem. 2014 ; 152 : 323-330.<\/li>\n<li>Verzelloni E,\u00a0<i>et al.<\/i>\uff1aMol Nutr Food Res. 2011 ; 55 : S35-S43.<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/div>\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<h5><strong>\u7cd6\u5316\u5e94\u6fc0\u548c\u6297\u8870\u8001<\/strong><\/h5>\n\n\n\n<ul><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_01\/\">\u4ec0\u4e48\u662f\u7cd6\u5316\u5e94\u6fc0\uff1f<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_02\">\u7cd6\u5316\u5e94\u6fc0\u6807\u5fd7\u7269\u7684\u68c0\u6d4b\u65b9\u6cd5(1)\u3000\u8840\u7cd6\u3001\u7cd6\u5316\u86cb\u767d\u3001\u7cd6\u5316\u53cd\u5e94\u4e2d\u95f4\u4f53\u7684\u68c0\u6d4b<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_03\">\u7cd6\u5316\u5e94\u6fc0\u6807\u5fd7\u7269\u7684\u68c0\u6d4b\u65b9\u6cd5(2)\u3000AGEs\u7684\u68c0\u6d4b<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_04\">\u7cd6\u5316\u5e94\u6fc0\u6807\u5fd7\u7269\u7684\u68c0\u6d4b\u65b9\u6cd5(3)\u3000\u6297\u7cd6\u5316\u4f5c\u7528\u8bc4\u4ef7<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_05\">\u7cd6\u5316\u5e94\u6fc0\u548cAGEs\u53d7\u4f53<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_06\">\u7cd6\u5316\u5e94\u6fc0\u4e0e\u80be\u75be\u75c5<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_07\/\">\u7cd6\u5316\u5e94\u6fc0\u548c\u76ae\u80a4\u8001\u5316<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_08\">\u7cd6\u5316\u5e94\u6fc0\u4e0e\u52a8\u8109\u786c\u5316<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_09\">\u7cd6\u5316\u5e94\u6fc0\u548c\u7cbe\u795e\u5206\u88c2\u75c7<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_10\">\u7cd6\u5316\u5e94\u6fc0\u4e0e\u809d\u75c5<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_11\">\u7cd6\u5316\u5e94\u6fc0\u4e0e\u4e0d\u5b55\u75c7<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_12\">\u7cd6\u5316\u5e94\u6fc0\u4e0e\u963f\u5c14\u5179\u6d77\u9ed8\u75c7<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_13\/\">\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56(1)\u3000\u8840\u7cd6\u63a7\u5236<\/a><\/li><li>\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56(2)\u3000\u7cd6\u5316\u53cd\u5e94\u7684\u6291\u5236<\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_15\/\">\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56(3)\u3000AGEs\u7684\u964d\u89e3\u548c\u6392\u6cc4<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_16\/\">\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56(4)\u3000\u81b3\u98df\u6765\u6e90\u7684AGEs<\/a><\/li>\n<li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_17\/\">\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56\u7684\u8bfe\u9898\u548c\u5c55\u671b<\/a><\/li><\/ul>\n\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<p><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/\">-\u5b66\u672f\u4fe1\u606f top<\/a><br><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/\">-Top<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56\u3000(2)\u7cd6\u5316\u53cd\u5e94\u7684\u6291\u5236 A-KIT\u682a\u5f0f\u4f1a\u793e&nbsp; \u751f\u547d\u533b\u79d1\u5b66\u68c0\u67e5\u4e2d\u5fc3&nbsp; \u7cd6\u5316\u5e94\u6fc0\u7814\u7a76\u6240\u516b\u6728\u96c5\u4e4b \u6240\u957f \u4e3b\u7f16 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