{"id":10870,"date":"2020-10-21T09:51:49","date_gmt":"2020-10-21T00:51:49","guid":{"rendered":"https:\/\/ebn2.arkray.co.jp\/english\/?page_id=10870"},"modified":"2020-11-24T16:44:09","modified_gmt":"2020-11-24T07:44:09","slug":"glycation-stress_15","status":"publish","type":"page","link":"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_15\/","title":{"rendered":"\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56\u3000(3) AGEs\u7684\u964d\u89e3\u548c\u6392\u6cc4"},"content":{"rendered":"\n

\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56\u3000(3) AGEs\u7684\u964d\u89e3\u548c\u6392\u6cc4<\/h2>\n\n\n

A-KIT\u682a\u5f0f\u4f1a\u793e\u3000\u751f\u547d\u533b\u79d1\u5b66\u68c0\u67e5\u4e2d\u5fc3\u00a0\u7cd6\u5316\u5e94\u6fc0\u7814\u7a76\u6240
\u516b\u6728\u96c5\u4e4b \u6240\u957f \u4e3b\u7f16<\/p>\n\n\n

\u5728\u80be\u810f\u4e2d\u7684AGEs\u6392\u6cc4<\/h3>\n\n\n

\u901a\u8fc7\u86cb\u767d\u8d28\u4ee3\u8c22\u6e38\u79bb\u5230\u8840\u6db2\u4e2d\u7684AGEs\u548c\u8fdb\u98df\u540e\u88ab\u80a0\u9053\u5438\u6536\u7684AGEs\u4f1a\u88ab\u80be\u810f\u6392\u6cc4\u5230\u5c3f\u4e2d\u3002\u80be\u810f\u7684\u8fd1\u7aef\u5c0f\u7ba1\u4e2d\u5b58\u5728\u4e00\u79cd\u53eb\u4f5c\u5de8\u86cb\u767d(megalin)\u7684\u819c\u53d7\u4f53\uff0c\u53ef\u4ee5\u91cd\u5438\u6536\u4ece\u5c3f\u4e2d\u6ee4\u8fc7\u7684\u4f4e\u5206\u5b50\u91cf\u86cb\u767d\u3002\u8840\u6db2\u4e2d\u7684AGEs\u5728\u80be\u810f\u4e2d\u4e0e\u5de8\u86cb\u767d\u7ed3\u5408\u540e\uff0c\u4f1a\u901a\u8fc7\u7ec6\u80de\u6444\u53d6\u7ec6\u80de\u5916\u7269\u8d28\u7684\u4f5c\u7528\uff0c\u4e5f\u5c31\u662f\u5185\u541e\u4f5c\u7528(endocytosis)\uff0c\u6444\u53d6\u5230\u80be\u5c0f\u7ba1\u7ec6\u80de\u4e2d(\u56fe1)(1)<\/sup>\u3002\u4f46\u662f\uff0c\u5f53\u5927\u91cfAGEs\u88ab\u6444\u53d6\u5230\u5de8\u86cb\u767d\u4e2d\u65f6\uff0c\u5728\u4e00\u79cd\u7ec6\u80de\u5185\u7ec6\u80de\u5668\uff0d\uff0d\u6eb6\u9176\u4f53(lysosome)\u4e2d\u7684AGEs\u964d\u89e3\u5c06\u8fbe\u5230\u9971\u548c\uff0cAGEs\u4f1a\u5728\u80be\u5c0f\u7ba1\u7ec6\u80de\u4e2d\u84c4\u79ef(2-3)<\/sup>\u3002\u4ece\u800c\u5bfc\u81f4\u80be\u529f\u80fd\u4e0b\u964d\uff0cAGEs\u5728\u4f53\u5185\u7684\u84c4\u79ef\u589e\u591a\u3002<\/p>\n

\"\"<\/p>\n

\u56fe1.\u80be\u810f\u7684\u86cb\u767d\u8d28\u4ee3\u8c22\u6392\u6cc4\u4f5c\u7528(\u6539\u7f16\u81eaChristensen et al<\/em>.<\/em>(1)<\/sup>)<\/strong><\/h6>\n\n\n

\u7cd6\u5316\/\u6c27\u5316\u5e94\u6fc0\u5f15\u8d77\u7684\u86cb\u767d\u8d28\u4fee\u9970\u548c\u4ee3\u8c22<\/h3>\n\n\n

\u968f\u7740\u5e74\u9f84\u589e\u957f\uff0c\u795e\u7ecf\u7cfb\u7edf\u3001\u514d\u75ab\u7cfb\u7edf\u3001\u5185\u5206\u6ccc\u7cfb\u7edf\u7684\u529f\u80fd\uff0c\u4ee5\u53ca\u5176\u4ed6\u5404\u79cd\u7ec6\u80de\u3001\u7ec4\u7ec7\u7684\u529f\u80fd\u4f1a\u4e0b\u964d\uff0c\u86cb\u767d\u8d28\u5f02\u5e38\u5728\u5176\u4e2d\u8d77\u7740\u91cd\u8981\u4f5c\u7528\u3002\u5728\u751f\u7269\u4f53\u5185\uff0c\u7cd6\u5316\u5e94\u6fc0\u548c\u6c27\u5316\u5e94\u6fc0\u4f1a\u5bfc\u81f4\u86cb\u767d\u8d28\u53d1\u751f\u5316\u5b66\u4fee\u9970\uff0c\u4ece\u800c\u51fa\u73b0\u5f02\u5e38\u3002\u8fd9\u79cd\u86cb\u767d\u8d28\u53eb\u4f5c\u5f02\u5e38\u86cb\u767d(altered proteins)\uff0c\u5176\u5728\u751f\u7269\u4f53\u5185\u7684\u529f\u80fd\u4f1a\u964d\u4f4e\uff0c\u800c\u4e14\u4f1a\u7834\u574f\u7ec6\u80de\u548c\u7ec4\u7ec7(4)<\/sup>\u3002\u84c4\u79ef\u5728\u963f\u5c14\u8328\u6d77\u9ed8\u75c5(Alzheimer disease)\u60a3\u8005\u5927\u8111\u4e2d\u7684\u03b2-\u6dc0\u7c89\u6837\u86cb\u767d(\u03b2-amyloid)\u662f\u4e00\u79cd\u5f02\u5e38\u86cb\u767d\uff0c\u4f1a\u635f\u4f24\u795e\u7ecf\u7ec6\u80de\uff0c\u4f7f\u8bb0\u5fc6\u548c\u5b66\u4e60\u529f\u80fd\u7b49\u795e\u7ecf\u529f\u80fd\u964d\u4f4e\u3002\u773c\u7403\u6676\u72b6\u4f53\u4e2d\u7684\u6676\u72b6\u4f53\u86cb\u767d(crystalline)\u4e5f\u4f1a\u968f\u7740\u5e74\u9f84\u589e\u957f\u800c\u53d8\u6027\uff0c\u56e0\u51dd\u805a(\u5f02\u5e38\u86cb\u767d\u5316)\u800c\u53d8\u5f97\u6df7\u6d4a\uff0c\u5bfc\u81f4\u767d\u5185\u969c\u3002\u6b64\u5916\uff0c\u5e15\u91d1\u68ee\u75c5(Parkinson\u2019s disease)\u7b49\u8bb8\u591a\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u90fd\u662f\u7531\u4e8e\u7ed3\u6784\u6539\u53d8\u7684\u5f02\u5e38\u86cb\u767d\u7684\u84c4\u79ef\u800c\u5f15\u8d77\u7684(5)<\/sup>\u3002<\/p>\n

\u901a\u5e38\uff0c\u5f02\u5e38\u86cb\u767d\u4f1a\u88ab\u79f0\u4e3a\u86cb\u767d\u9176\u4f53(proteasome)\u7684\u86cb\u767d\u6c34\u89e3\u9176\u964d\u89e3\u3002\u86cb\u767d\u9176\u4f53\u67092\u79cd\uff0c\u5206\u522b\u662f26S(\u5206\u5b50\u91cf250\u4e07)\u548c20S(\u5206\u5b50\u91cf70\u4e07)\u3002\u591a\u6570\u5f02\u5e38\u86cb\u767d\u5728\u7ecf\u8fc7\u6cdb\u7d20\u5316\u4e4b\u540e\uff0c\u4f1a\u88ab26S\u86cb\u767d\u9176\u4f53\u964d\u89e3\u3002\u800c\u6c27\u5316\u86cb\u767d\u4e5f\u4f1a\u88ab20S\u86cb\u767d\u9176\u4f53\u964d\u89e3(\u56fe2)(5)<\/sup>\u3002\u4f46\u662f\uff0cAGEs\u5316\u7684\u86cb\u767d\u8d28\u5219\u7531\u4e8e\u86cb\u767d\u4ea4\u8054\u7684\u5f62\u6210\u6240\u5f15\u53d1\u7684\u786c\u5316\u53d8\u6027\u7b49\uff0c\u5f88\u96be\u88ab\u86cb\u767d\u9176\u964d\u89e3(6)<\/sup>\u3002<\/p>\n

\"\"<\/p>\n

\u56fe<\/strong>2.<\/strong>\u86cb\u767d\u9176\u4f53\u7684\u6cdb\u7d20\u5316\u86cb\u767d\u964d\u89e3\u4f5c\u7528<\/strong>(Goto S, et al<\/em><\/strong>.<\/em><\/strong>(2001)(4)<\/sup>)<\/strong><\/h6>\n

\u751f\u7269\u4f53\u4f1a\u901a\u8fc7\u91cd\u590d\u8fdb\u884c\u86cb\u767d\u8d28\u7684\u5408\u6210\u548c\u964d\u89e3\uff0c\u4e0d\u65ad\u6e05\u9664\u7ec6\u80de\u4e2d\u4ea7\u751f\u7684\u5f02\u5e38\u86cb\u767d\uff0c\u5e76\u91cd\u65b0\u5229\u7528\u964d\u89e3\u4ea7\u751f\u7684\u6c28\u57fa\u9178\uff0c\u7531\u6b64\u6765\u7ef4\u6301\u529f\u80fd\u3002\u4f46\u5bf9\u4e8e\u8001\u9f84\u52a8\u7269\u800c\u8a00\uff0c\u7ec6\u80de\u7684\u86cb\u767d\u8d28\u5408\u6210\u80fd\u529b\u4f1a\u968f\u5e74\u9f84\u589e\u957f\u800c\u964d\u4f4e\uff0c\u5bfc\u81f4\u4ee3\u8c22\u5468\u8f6c\u53d8\u6162\u3002\u800c\u4e14\uff0c\u7ec6\u80de\u86cb\u767d\u4f1a\u56e0\u5e74\u9f84\u589e\u957f\u5e26\u6765\u7684AGEs\u5316\u800c\u53d8\u5f97\u96be\u4ee5\u964d\u89e3\uff0c\u4f53\u5185\u7684\u5f02\u5e38\u86cb\u767d\u91cf\u589e\u52a0\u3002<\/p>\n\n\n

\u5bf9AGEs\u4ea4\u8054\u6709\u964d\u89e3\u4f5c\u7528\u7684\u7269\u8d28<\/h3>\n\n\n

N<\/em>-phenacylthiazolium bromide(PTB)\u5bf9\u86cb\u767d\u8d28\u7684AGEs\u5316\u6240\u4ea7\u751f\u7684\u4ea4\u8054(AGEs-derived crosslink)\u6709\u5206\u89e3\u4f5c\u7528\uff0c\u5e76\u4f5c\u4e3a\u5177\u6709\u8be5\u4f5c\u7528\u7684\u7269\u8d28\u800c\u5e7f\u4e3a\u4eba\u77e5(7)<\/sup>\u3002PTB\u53ef\u4ee5\u8bc6\u522b\u51fa\u7cd6\u5316\u5e94\u6fc0\u6240\u4ea7\u751f\u7684\u6765\u6e90\u4e8eAmadori\u86cb\u767d\u7684\u86cb\u767d\u8d28\u4ea4\u8054\u7269\u8d28(amadori-protein-ene-dion-derived)\u7684\u03b1-\u4e8c\u916e\u7ed3\u6784\u5e76\u7834\u574fC\u2212C\u952e\uff0c\u964d\u89e3\u86cb\u767d\u8d28-\u86cb\u767d\u8d28\u4ea4\u8054(protein-protein crosslink)(\u56fe3)(7)<\/sup>\u3002\u8fd9\u8868\u660e\uff0c\u8be5\u4f5c\u7528\u53ef\u80fd\u6709\u52a9\u4e8e\u6291\u5236AGEs\u5728\u8840\u7ba1\u4e2d\u7684\u84c4\u79ef\u3001\u6cbb\u7597\u7cd6\u5c3f\u75c5\u8840\u7ba1\u5e76\u53d1\u75c7\u7b49\u3002\u8fde\u7eed4\u5468\u4ee510 mg\/kg\u7684\u5242\u91cf\u5bf9\u7cd6\u5c3f\u75c5\u5927\u9f20\u7ecf\u53e3\u7ed9\u4e88PTB\u7684\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\uff0cPTB\u5bf9\u6291\u5236\u80f6\u539f\u86cb\u767d\u7684AGEs\u4ea4\u8054\u5f62\u6210(7)<\/sup>\u548c\u964d\u89e3\u8840\u7ba1\u4e2d\u7684AGEs\u8d77\u5230\u4e86\u4f5c\u7528(8)<\/sup>\u3002\u5bf9\u7cd6\u5c3f\u75c5\u5927\u9f20\u7ed9\u4e88\u63d0\u9ad8\u4e86PTB\u6c34\u6eb6\u6027\u76843-phenacyl-4,5-dimethylthiazorium chloride(ALT-711)\u7684\u8bd5\u9a8c\u4e5f\u663e\u793a\uff0cPTB\u5bf9\u6291\u5236\u8840\u7ba1\u7684\u786c\u5316\u548cAGEs\u84c4\u79ef\u8d77\u5230\u4e86\u4f5c\u7528(9)<\/sup>\u3002\u5728\u4e00\u9879\u4eba\u4f53\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u4ee5210 mg\/day\u6216420 mg\/day\u7684\u5242\u91cf\u53e3\u670d\u6444\u51658\u5468ALT-711\uff0cALT-711\u5bf9\u8840\u7ba1\u50f5\u786c(vascular stiffening)\u548c\u6536\u7f29\u538b\u63a7\u5236\u4e0d\u826f(uncontrolled systolic blood pressure)\u5177\u6709\u6539\u5584\u6548\u679c(10-11)<\/sup>\u3002\u56e0\u4e3a\u8fd9\u4e9b\u7ed3\u679c\uff0cPTB\u88ab\u51a0\u4ee5\u4e86\u201cAGEs\u964d\u89e3\u5242(AGE breaker)\u201d\u4e4b\u79f0\u3002<\/p>\n

\"\"<\/p>\n

\u56fe<\/strong>3. N<\/em>-phenacylthiazolium bromide (PTB)<\/strong>\u7684<\/strong>AGEs<\/strong>\u4ea4\u8054\u964d\u89e3\u4f5c\u7528<\/strong>(Vasan S, et al<\/em><\/strong>.<\/em><\/strong>(1996)(7)<\/sup><\/strong><\/h6>\n

\u4f46\u662f\uff0c\u6709\u62a5\u544a\u79f0\uff0cPTB\u5bf9\u4e8e\u7cd6\u5c3f\u75c5\u5927\u9f20\u7684\u76ae\u80a4\u548c\u5c3e\u90e8\u80f6\u539f\u86cb\u767d\u7684AGEs\u4ea4\u8054\u964d\u89e3\u65e0\u6548(12)<\/sup>\uff0c\u4e5f\u6709\u5bf9PTB\u7684\u4f5c\u7528\u8868\u793a\u6000\u7591\u7684\u89c1\u89e3\u3002<\/p>\n

\u5df2\u77e5\u4e0ePTB\u5177\u6709\u76f8\u540c\u4f5c\u7528\u7684\u690d\u7269\u6210\u5206\u6709\u4e94\u6708\u827e(Artemisia indica<\/em>)\u3001\u7ebf\u72b6\u963f\u53f8\u5df4\u62c9\u59a5(Aspalathus linearis<\/em>)\u3001\u7d2b\u4e91\u82f1(Astragalus sinicus<\/em>)(13)<\/sup>\u3001\u9999\u6a59(Citrus junos<\/em>)(14)<\/sup>\u3001\u77f3\u69b4(Punica granatum<\/em>)(15)<\/sup>\u63d0\u53d6\u7269\u3002<\/p>\n

YAC\u63d0\u53d6\u7269\u4f5c\u4e3a\u4e94\u6708\u827e\u7684\u4e59\u9187\u63d0\u53d6\u7269\uff0c\u53ef\u4ee5\u964d\u89e3\u80f6\u539f\u86cb\u767d\u51dd\u80f6-\u8461\u8404\u7cd6\u53cd\u5e94\u7cfb\u7edf\u6a21\u578b\u4e2d\u751f\u6210\u7684AGEs\u4ea4\u8054(AGE-crosslink)\u3002\u6b64\u5916\uff0c\u8fde\u7eed6\u4e2a\u6708\u4f7f\u7528\u542b\u6709YAC\u63d0\u53d6\u7269\u7684\u5316\u5986\u6c34\u3001\u4e73\u6db2\u3001\u4e73\u971c\u7684\u8bd5\u9a8c\u7ed3\u679c\u8868\u660e\uff0c\u8be5\u7269\u8d28\u5bf9\u76ae\u80a4\u5f39\u6027\u548c\u808c\u80a4\u6cdb\u9ec4(b*)\u8d77\u5230\u4e86\u6539\u5584\u4f5c\u7528(13)<\/sup>\u3002<\/p>\n

\u6709\u7814\u7a76\u8868\u660e\uff0cterpinen-4-ol\u4f5c\u4e3a\u9999\u6a59(Citrus junos<\/em>)\u4e2d\u542b\u6709\u7684\u4e00\u79cd\u5355\u841c\u9187(monoterpene alcohols)\uff0c\u5728\u4e0e\u6c22\u8fc7\u6c27\u5316\u7269(hydroperoxide)\u8fdb\u884c\u4eb2\u6838\u53d6\u4ee3\u53cd\u5e94(nucleophilic substitution)\u540e\uff0c\u7ecf\u62dc\u8033-\u7ef4\u7acb\u683c\u6c27\u5316(Baeyer-Villiger oxidation)\u91cd\u6392\u53cd\u5e94\u751f\u6210\u7fa7\u9178\u916f(carboxylate ester)\uff0c\u4f7f\u9178\u9150(acid anhydride)\u6c34\u89e3\uff0c\u5bf9AGEs\u4ea4\u8054\u7684\u964d\u89e3\u8d77\u5230\u4e86\u4f5c\u7528(14)<\/sup>\u3002<\/p>\n

\u6839\u636e\u63a8\u6d4b\uff0c\u77f3\u69b4\u6c41\u63d0\u53d6\u7269\u53ca\u77f3\u69b4\u6765\u6e90\u6210\u5206\u7684AGEs\u4ea4\u8054\u964d\u89e3\u4f5c\u7528\uff0c\u53ef\u80fd\u4e0e\u97a3\u82b1\u5355\u5b81\u7684\u4e09\u7f9f\u57fa\u82ef(trihydroxybenzene)\u7ed3\u6784\u6709\u5173(15)<\/sup>\u3002<\/p>\n

\u8fd9\u4e9b\u5929\u7136\u4ea7\u7269\u7684AGEs\u4ea4\u8054\u964d\u89e3\u4f5c\u7528\uff0c\u53ef\u80fd\u6709\u52a9\u4e8e\u5bf9\u5df2\u7ecf\u84c4\u79ef\u5728\u4f53\u5185\u7684AGEs\u8fdb\u884c\u964d\u89e3\u6392\u6cc4\u3002<\/p>\n\n\n

\u6c27\u5316\u86cb\u767d\u6c34\u89e3\u9176\u7684AGE\u964d\u89e3\u4f5c\u7528(13)<\/sup><\/h3>\n\n\n

\u6c27\u5316\u86cb\u767d\u6c34\u89e3\u9176(oxidized protein hydrolase\uff1aOPH)\u662f\u4e00\u79cd\u4e1d\u6c28\u9178\u86cb\u767d\u9176(serine protease)\uff0c\u5e7f\u6cdb\u5b58\u5728\u4e8e\u732a\u809d\u3001\u4eba\u8840\u3001\u5927\u9f20\u5927\u8111\u7b49\u751f\u7269\u4f53\u7ec4\u7ec7\u4e2d(\u56fe4)(16-17)<\/sup>\u3002\u6709\u62a5\u544a\u663e\u793a\uff0c\u5728\u4eba\u7684\u76ae\u80a4\u4e2d\uff0cOPH\u5b58\u5728\u4e8e\u89d2\u8d28\u5c42(18-19)<\/sup>\u3002 OPH\u662f\u91ca\u653e\u86cb\u767d\u8d28N\u672b\u7aef\u9170\u5316\u6c28\u57fa\u9178\u7684\u9176\uff0c\u56e0\u6b64\u4e5f\u4f5c\u4e3a\u9170\u57fa\u6c28\u57fa\u9178\u91ca\u653e\u9176(acylamino-acid releasing enzyme\uff1aAARE)\u800c\u88ab\u719f\u77e5\u3002 OPH\u9664\u4e86\u4f5c\u7528\u4e8eacyl\u5316\uff0c\u8fd8\u5bf9formyl\u5316\u3001acetyl\u5316\u3001butyl\u5316\u3001propyl\u5316\u7684\u86cb\u767d\u8d28\u7684N\u672b\u7aef\u6c28\u57fa\u9178(20)<\/sup>\uff0c\u4ee5\u53ca\u53d7\u5230\u4e86\u6c27\u5316\u548c\u7cd6\u5316\u4fee\u9970\u7684\u8001\u5316\u86cb\u767d\u6709\u964d\u89e3\u4f5c\u7528(21)<\/sup>\u3002\u800c\u4e14\uff0cOPH\u548c\u86cb\u767d\u9176\u4f53\u534f\u540c\u4f5c\u7528\u4e8e\u8001\u5316\u86cb\u767d\u7684\u964d\u89e3(22)<\/sup>\u3002\u5728\u7cd6\u5c3f\u75c5\u5927\u9f20\u4f53\u5185\uff0c\u8840\u6e05OPH\u6d3b\u6027\u663e\u8457\u5347\u9ad8\uff0c\u8840\u4e2d\u7fb0\u57fa\u4fee\u9970\u86cb\u767d\u91cf\u964d\u4f4e(23)<\/sup>\u3002<\/p>\n

\"\"<\/p>\n

\u56fe4.\u6c27\u5316\u86cb\u767d\u6c34\u89e3\u9176(OPH)\u7684\u6c27\u5316\/\u7cd6\u5316\u86cb\u767d\u964d\u89e3\u4f5c\u7528(Fujino T, et al<\/em><\/strong>.<\/em><\/strong>(21)<\/sup><\/strong>)
<\/strong>A\uff1a\u6c27\u5316\u725b\u8840\u6e05\u767d\u86cb\u767d(BSA), B\uff1a\u6c27\u5316\u514d\u75ab\u7403\u86cb\u767dG(IgG), C\uff1a\u7cd6\u5316BSA
\u25cf\uff1a\u672a\u5904\u7406(\u5bf9\u7167), \u25cb\uff1a\u6c27\u5316\u6216\u7cd6\u5316\u86cb\u767d<\/h6>\n

\u5df2\u77e5\u5f71\u54cdOPH\u6d3b\u6027\u7684\u5929\u7136\u4ea7\u7269\u6709\u8336\u53f6\u3001\u836f\u8349\u3001\u852c\u83dc\u7b49\u690d\u7269\u7684\u63d0\u53d6\u7269\u3002\u6709\u7684\u836f\u8349\u7c7b\u548c\u5065\u5eb7\u8336\u4f1a\u4fc3\u8fdbOPH\u6d3b\u6027\u3002\u800c\u6765\u6e90\u4e8e\u8336\u6811\u7684\u8336\u53f6\u548c\u513f\u8336\u7d20\u7c7b\u5219\u4f1a\u6291\u5236OPH\u6d3b\u6027(24-26)<\/sup>\u3002 OPH\u5177\u6709\u964d\u89e3\u5e7f\u6cdb\u5b58\u5728\u4e8e\u751f\u7269\u4f53\u7ec4\u7ec7\u4e2d\u7684\u7cd6\u5316\u86cb\u767d\u548cAGEs\u7684\u4f5c\u7528\u3002\u56e0\u6b64\uff0c\u5929\u7136\u4ea7\u7269\u7684OPH\u6fc0\u6d3b\u4f5c\u7528\u53ef\u80fd\u6709\u52a9\u4e8e\u4fc3\u8fdb\u4f53\u5185AGEs\u7684\u964d\u89e3\u6392\u6cc4\u3002<\/p>\n

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References<\/h5>\n
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    23. Shimizu K, et al.<\/i>\uff1aBiol Pharm Bull. 2009; 32: 1632-1635.<\/li>\n
    24. \u516b\u6728\u96c5\u4e4b\u3089\uff1a\u7b2c13\u56de\u65e5\u672c\u6297\u52a0\u9f62\u533b\u5b66\u4f1a\u7dcf\u4f1a\u30d7\u30ed\u30b0\u30e9\u30e0\u6284\u9332\u96c6. 2013: 253.<\/li>\n
    25. \u4e09\u6a4b\u7483\u5b50\u3089\uff1a\u7b2c13\u56de\u65e5\u672c\u6297\u52a0\u9f62\u533b\u5b66\u4f1a\u7dcf\u4f1a\u30d7\u30ed\u30b0\u30e9\u30e0\u6284\u9332\u96c6. 2013: 254.<\/li>\n
    26. \u4e09\u6a4b\u7483\u5b50\u3089\uff1a\u7b2c14\u56de\u65e5\u672c\u6297\u52a0\u9f62\u533b\u5b66\u4f1a\u7dcf\u4f1a\u30d7\u30ed\u30b0\u30e9\u30e0\u6284\u9332\u96c6. 2014: 362.<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/div>\n\n\n
      \n\n\n\n
      \u7cd6\u5316\u5e94\u6fc0\u548c\u6297\u8870\u8001<\/strong><\/h5>\n\n\n\n