{"id":10909,"date":"2020-10-27T11:07:17","date_gmt":"2020-10-27T02:07:17","guid":{"rendered":"https:\/\/ebn2.arkray.co.jp\/english\/?page_id=10909"},"modified":"2020-12-07T15:54:10","modified_gmt":"2020-12-07T06:54:10","slug":"glycation-stress_16","status":"publish","type":"page","link":"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_16\/","title":{"rendered":"\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56(4)\u81b3\u98df\u6765\u6e90\u7684AGEs"},"content":{"rendered":"\n<h2>\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56(4)\u81b3\u98df\u6765\u6e90\u7684AGEs<\/h2>\n\n\n<p class=\"author\">\u540c\u5fd7\u793e\u5927\u5b66\u5927\u5b66\u9662 \u751f\u547d\u533b\u79d1\u5b66\u7814\u7a76\u79d1 \u7cd6\u5316\u5e94\u6fc0\u7814\u7a76\u4e2d\u5fc3<br>\u516b\u6728\u96c5\u4e4b \u6559\u6388 \u4e3b\u7f16<\/p>\n\n\n<h3>\u98df\u54c1\u4e2d\u7684AGEs<\/h3>\n\n\n<p>\u98df\u54c1\u4e2d\u542b\u6709\u5927\u91cf\u7684\u8fd8\u539f\u7cd6\u3001\u7fb0\u57fa\u5316\u5408\u7269\u3001\u6c28\u57fa\u9178\u548c\u86cb\u767d\u8d28\uff0c\u5728\u70f9\u996a\u3001\u52a0\u5de5\u3001\u50a8\u5b58\u8fc7\u7a0b\u4e2d\u4f1a\u53d1\u751f\u7cd6\u5316\u53cd\u5e94\u3002\u8fd9\u4e9b\u53cd\u5e94\u5c31\u662f\u5927\u4f17\u6240\u719f\u77e5\u7684\u98df\u54c1\u7684\u8910\u53d8\u53cd\u5e94\u3002\u5bf9\u4e8e\u98df\u54c1\u7684\u8910\u53d8\u53cd\u5e94\uff0c\u7814\u7a76\u4eba\u5458\u5df2\u7ecf\u4f7f\u7528\u5404\u79cd\u6a21\u578b\u53cd\u5e94\u7cfb\u7edf\u548c\u98df\u54c1\u6765\u9610\u660e\u53cd\u5e94\u673a\u7406\uff0c\u5e76\u5bf9\u8910\u53d8\u7269\u8d28\u8fdb\u884c\u4e86\u5206\u79bb\u548c\u9274\u5b9a<sup>(1)<\/sup>\u3002\u98df\u54c1\u7cd6\u5316\u5f00\u59cb\u4e8e\u4f5c\u4e3a\u539f\u6750\u6599\u548c\u8c03\u5473\u54c1\u4f7f\u7528\u7684\u7cd6\u6240\u542b\u6709\u7684\u679c\u7cd6\u3001\u7cd6\u7c7b\u5206\u89e3\u4ea7\u751f\u7684\u8fd8\u539f\u7cd6\u4e0e\u6c28\u57fa\u9178\u3001\u86cb\u767d\u8d28\u53d1\u751f\u975e\u9176\u4fc3\u53cd\u5e94\uff0c\u5e76\u751f\u6210N-glucoside(\u56fe1)\u3002\u4e4b\u540e\u7ecf\u8fc7Amadori(\u963f\u739b\u5f97\u5229)\u91cd\u6392\uff0c\u751f\u6210N-fructoside\uff0c\u518d\u7ecf\u8fc7\u8131\u6c34\u3001\u8131\u6c28\u53cd\u5e94\uff0c\u751f\u6210\u90bb\u916e\u919b\u7cd6(osone)\u3001\u7ce0\u919b(furfural)\u7b49\u7fb0\u57fa\u5316\u5408\u7269\u3002\u751f\u6210\u7684\u7fb0\u57fa\u5316\u5408\u7269\u6210\u4e3a\u7cd6\u5316\u53cd\u5e94\u7684\u4e2d\u95f4\u4f53\uff0c\u518d\u4e0e\u6c28\u57fa\u5316\u5408\u7269\u53cd\u5e94\uff0c\u901a\u8fc7\u7f29\u5408\u548c\u805a\u5408\u751f\u6210\u9ad8\u5206\u5b50\u8910\u53d8\u7269\u8d28\u7c7b\u9ed1\u7cbe(melanoidin)\u3002\u7c7b\u9ed1\u7cbe\u4e0d\u662f\u5355\u4e00\u5316\u5408\u7269\uff0c\u5176\u7ed3\u6784\u548c\u805a\u5408\u5ea6\u56e0\u6765\u6e90\u7684\u6c28\u57fa\u5316\u5408\u7269\u548c\u53cd\u5e94\u6761\u4ef6\u800c\u5f02\uff0c\u662f\u96be\u4ee5\u6b63\u786e\u5b9a\u91cf\u7684\u7269\u8d28<sup>(2)<\/sup>\u3002<\/p>\n<p><img loading=\"lazy\" class=\"aligncenter size-full wp-image-12840\" src=\"http:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_16_01.jpg\" alt=\"\" width=\"450\" height=\"675\" srcset=\"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_16_01.jpg 450w, https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_16_01-200x300.jpg 200w\" sizes=\"(max-width: 450px) 100vw, 450px\" \/><\/p>\n<h6 style=\"text-align: center;\"><strong>\u56fe<\/strong><strong>1 <\/strong><strong>\u98df\u54c1\u8910\u53d8\u4e2d\u7684\u7cd6\u5316\u53cd\u5e94<br><\/strong>(\u4fee\u6539\u81ea\u672c\u95f4\u6e05\u4e00(2005)<sup>(1)<\/sup>)<\/h6>\n<p>\u98df\u54c1\u4e2d\u542b\u6709\u5927\u91cf\u7684\u7cd6\u5316\u7269\u3001\u7cd6\u5316\u53cd\u5e94\u4e2d\u95f4\u4f53\u3001AGEs(\u88681)<sup>(3)<\/sup>\u3002\u800c\u4e14\uff0c\u98df\u54c1\u4e2d\u7684CML\u662f\u5728\u52a0\u70ed\u70f9\u996a\u7684\u8fc7\u7a0b\u4e2d\u751f\u6210\u7684(\u88682)<sup>(3-4)<\/sup>\u3002\u56e0\u6b64\uff0c\u6211\u4eec\u5728\u65e5\u5e38\u751f\u6d3b\u4e2d\u4f1a\u901a\u8fc7\u98df\u54c1\u6444\u5165AGEs\u3002\u98df\u54c1\u4e2d\u7684AGEs\u9664\u4e86\u542b\u6709\u5bf9\u751f\u7269\u4f53\u65e0\u5bb3\u7684\u6210\u5206\uff0c\u8fd8\u542b\u6709\u53ef\u80fd\u4e0e\u6d3b\u6027\u6c27\u7684\u751f\u6210\u548c\u7cd6\u5c3f\u75c5\u5e76\u53d1\u75c7\u7b49\u6162\u6027\u75be\u75c5\u7684\u8fdb\u5c55\u6709\u5173\u7684\u5316\u5408\u7269\u3002\u4ece\u98df\u54c1\u4e2d\u6444\u5165\u7684AGEs\u4e0e\u5fc3\u810f\u75c5\u3001\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u3001\u7cd6\u5c3f\u75c5\u5e76\u53d1\u75c7\u7b49\u75be\u75c5\u7684\u53d1\u75c5\u6709\u5173\uff0c\u8fd9\u4e9b\u75be\u75c5\u4e0e\u5e74\u9f84\u589e\u957f\u5bc6\u5207\u76f8\u5173\u3002\u53e6\u5916\uff0c\u52a8\u7269\u5b9e\u9a8c\u7ed3\u679c\u8bc1\u5b9e\uff0c\u9650\u5236\u4ece\u81b3\u98df\u6444\u5165AGEs\u4e0e\u5ef6\u957f\u5bff\u547d\u4e4b\u95f4\u5b58\u5728\u5173\u8054<sup>(5)<\/sup>\u3002\u518d\u8005\uff0c\u4f17\u6240\u5468\u77e5\uff0c\u52a0\u70ed\u70f9\u996a\u98df\u54c1\u8fd8\u4f1a\u751f\u6210\u4e0eAGEs\u7c7b\u4f3c\u7684\u6742\u73af\u80fa(heterocyclic amine)\u3001\u4e19\u70ef\u9170\u80fa(acrylamide)\u7b49\u5177\u6709\u81f4\u7a81\u53d8\u6027\u548c\u81f4\u764c\u6027\u7684\u5316\u5408\u7269\u3002<\/p>\n<h6 style=\"text-align: center;\"><img loading=\"lazy\" class=\"aligncenter size-full wp-image-12843\" src=\"http:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_16_c01_zh.png\" alt=\"\" width=\"645\" height=\"322\" srcset=\"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_16_c01_zh.png 645w, https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_16_c01_zh-300x150.png 300w\" sizes=\"(max-width: 645px) 100vw, 645px\" \/><\/h6>\n<h6 style=\"text-align: center;\"><strong>\u8868<\/strong><strong>1<\/strong><strong>\u3000\u98df\u54c1\u4e2d\u7684\u7cd6\u5316\u53cd\u5e94\u4ea7\u7269\u542b\u91cf<br><\/strong>(\u4fee\u6539\u81ea\u6728\u82d7\u76f4\u79c0(2013)<sup>(3)<\/sup>)<\/h6>\n<p><img loading=\"lazy\" class=\"aligncenter size-full wp-image-12844\" src=\"http:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_16_c02_zh.png\" alt=\"\" width=\"460\" height=\"424\" srcset=\"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_16_c02_zh.png 460w, https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_16_c02_zh-300x277.png 300w\" sizes=\"(max-width: 460px) 100vw, 460px\" \/><\/p>\n<h6 style=\"text-align: center;\"><strong>\u88682\u3000\u98df\u54c1\u4e2d\u7684CML\u542b\u91cf<br><\/strong>(\u4fee\u6539\u81ea\u6728\u82d7\u76f4\u79c0(2013)<sup>(3)<\/sup>)<\/h6>\n<p style=\"text-align: center;\">\u56e0\u6b64\uff0c\u98df\u54c1\u4e2d\u7684\u7fb0\u57fa\u5316\u5408\u7269\u548cAGEs\u53ef\u80fd\u4e0e\u5404\u79cd\u75be\u75c5\u5b58\u5728\u76f8\u5173\u6027\uff0c\u6545\u800c\u88ab\u79f0\u4e3a\u7cd6\u6bd2(glycotoxin)\u3002<\/p>\n\n\n<h3>\u81b3\u98df\u6765\u6e90AGEs\u7684\u5438\u6536\u548c\u6392\u6cc4<\/h3>\n\n\n<p>\u5173\u4e8e\u98df\u54c1\u4e2d\u7684AGEs\u6444\u5165\u4e0e\u6392\u6cc4\u7684\u5173\u7cfb\uff0c\u6709\u591a\u9879\u7814\u7a76\u62a5\u544a\u3002\u57283\u65e5\u5185\uff0c\u9650\u52367\u540d\u5065\u5eb7\u7537\u5973\u6444\u5165\u7119\u70e4\u98df\u54c1\u3001\u9762\u5305\u7c7b\u3001\u5564\u9152\u3001\u5496\u5561\u7b49\u5bcc\u542bAGEs\u7684\u98df\u54c1\uff0c\u53d1\u73b0\u4e0e\u975e\u9650\u5236\u671f\u76f8\u6bd4\uff0c\u53d7\u8bd5\u8005\u5c3f\u6db2\u4e2d\u7684\u5421\u54af\u7d20\u542b\u91cf\u5728\u9650\u5236\u671f\u5185\u4e0b\u964d\u3002\u7531\u6b64\u8868\u660e\uff0c\u6392\u6cc4\u5230\u5c3f\u6db2\u4e2d\u7684AGEs\u91cf\u53ef\u53cd\u6620\u81b3\u98df\u5185\u5bb9\uff0c\u81b3\u98df\u6765\u6e90AGEs\u4e0e\u5c3f\u6bd2\u75c7\u5b58\u5728\u76f8\u5173\u6027<sup>(6)<\/sup>\u3002<\/p>\n<p>\u53e6\u5916\uff0c\u7ec8\u672b\u671f\u80be\u8870\u7aed\u60a3\u8005(end-stage renal disease\uff1aESRD)\u4ece\u81b3\u98df\u4e2d\u6444\u5165\u7684AGEs\u91cf\u4e0e\u8840\u6e05CML\u91cf\u5b58\u5728\u76f8\u5173\u6027\uff0c\u4ee5\u53ca\u8840\u6e05\u4e2d\u7684CML\u6216\u7532\u57fa\u4e59\u4e8c\u919b\u91cf\u4e0eBUN(blood urea nitrogen\uff1a\u8840\u5c3f\u7d20\u6c2e)\u4e5f\u5b58\u5728\u76f8\u5173\u6027\uff0c\u7531\u6b64\u53ef\u89c1\uff0c\u63a7\u5236\u81b3\u98df\u4e2d\u7684AGEs\u5bf9\u7ba1\u7406\u75c5\u60c5\u5c24\u4e3a\u91cd\u8981<sup>(7)<\/sup>\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u86cb\u6e05(\u86cb\u767d\u8d28\u91cf55.5g)\u4e2d\u6dfb\u52a0\u679c\u7cd6(100g)\u540e\u52a0\u70ed\u70f9\u996a(90\u2103\uff0c1\uff5e3\u5c0f\u65f6)\u800c\u6210\u7684\u9ad8AGEs\u98df\u7269(1617 units AGE\/mg)\u6216\u53ea\u542b\u86cb\u6e05\u7684\u4f4eAGEs\u98df\u7269(7.0 units AGE\/mg)\uff0c38\u540d\u7cd6\u5c3f\u75c5\u60a3\u8005\u548c5\u540d\u5065\u5eb7\u4eba\u6444\u5165\u8fd9\u4e9b\u98df\u7269\u540e\uff0c\u9910\u540e48\u5c0f\u65f6\u8840\u6db2\u53ca\u5c3f\u6db2\u4e2d\u7684AGEs\u91cf\u7684\u6d4b\u91cf\u7ed3\u679c\u663e\u793a\uff0c\u4ece\u81b3\u98df\u8f6c\u79fb\u5230\u8840\u6db2\u4e2d\u7684AGEs\uff0c\u60a3\u6709\u80be\u75c5\u7684\u7cd6\u5c3f\u75c5\u60a3\u8005\u4e3a30\uff05\uff0c\u5065\u5eb7\u4eba\u4e2d\u4e3a10\uff05<sup>(8)<\/sup>\u3002\u6b64\u5916\uff0c\u5728\u5065\u5eb7\u4eba\u4e2d\uff0c1\/3(3\uff05)\u8f6c\u79fb\u5230\u8840\u6db2\u4e2d\u7684AGEs\u4f1a\u572848\u5c0f\u65f6\u5185\u6392\u6cc4\u5230\u5c3f\u6db2\u4e2d\uff0c2\/3(7\uff05)\u6b8b\u7559\u5728\u4f53\u5185(\u56fe2)\u3002<\/p>\n<p><img loading=\"lazy\" class=\"aligncenter size-full wp-image-12841\" src=\"http:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_16_02_zh.png\" alt=\"\" width=\"650\" height=\"482\" srcset=\"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_16_02_zh.png 650w, https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_16_02_zh-300x222.png 300w\" sizes=\"(max-width: 650px) 100vw, 650px\" \/><\/p>\n<h6 style=\"text-align: center;\"><strong>\u56fe<\/strong><strong>2<\/strong><strong>\u3000\u81b3\u98df\u6765\u6e90<\/strong><strong>AGEs<\/strong><strong>\u7684\u5438\u6536\u548c\u6392\u6cc4<br><\/strong>(\u4fee\u6539\u81eaKoschinsky T, et al. (1997)<sup>(8)<\/sup>)(Adapted from Koschinsky T, et al. (1997)<sup>8)<\/sup>)<\/h6>\n\n\n<h3>\u81b3\u98df\u6765\u6e90AGEs\u7684\u6291\u5236<\/h3>\n\n\n<p>\u4e00\u822c\u8ba4\u4e3a\uff0c\u9009\u62e9AGEs\u751f\u6210\u8f83\u5c11\u7684\u70f9\u996a\u65b9\u6cd5\uff0c\u5e76\u6291\u5236\u81b3\u98df\u6765\u6e90AGEs\u5728\u4f53\u5185\u7684\u5438\u6536\uff0c\u53ef\u4ee5\u6291\u5236\u81b3\u98df\u6765\u6e90AGEs\u5bf9\u8eab\u4f53\u7684\u5f71\u54cd\u3002<\/p>\n<p>\u5bf9\u5404\u79cd\u98df\u54c1\u4e2d\u7684CML\u91cf\u8fdb\u884c\u6d4b\u91cf\u7684\u8c03\u67e5\u7ed3\u679c\u663e\u793a\uff0c\u8102\u80aa\u548c\u8089\u4e2d\u7684CML\u751a\u81f3\u9ad8\u4e8e\u78b3\u6c34\u5316\u5408\u7269<sup>(9)<\/sup>\u3002\u800c\u5728\u70f9\u996a\u65b9\u6cd5\u4e0a\uff0c\u5bf9\u4e8e\u76f8\u540c\u7684\u98df\u6750\uff0c\u76f8\u6bd4\u6cb9\u70b8\u548c\u70e4\u5236\uff0c\u6c34\u716e\u66f4\u4e0d\u6613\u751f\u6210AGEs\u3002\u6b64\u5916\uff0c\u70e4\u8089\u65f6\uff0c\u901a\u8fc7\u9884\u5148\u7528\u67e0\u6aac\u6c41\u548c\u918b\u814c\u52361\u5c0f\u65f6\uff0c\u751f\u6210\u7684AGEs\u53ef\u4ee5\u51cf\u5c11\u52301\/2(\u56fe3)<sup>(10)<\/sup>\u3002\u53e6\u6709\u7814\u7a76\u8868\u660e\uff0c\u5c06\u9e21\u8089\u4e38\u653e\u5165\u7528\u9ca3\u9c7c\u5e72\u3001\u6d77\u5e26\u3001\u5c0f\u719f\u9c7c\u5e72\u7b49\u71ac\u5236\u7684\u9ad8\u6c64\u4e2d\u52a0\u70ed\u70f9\u996a\u65f6\uff0c\u76f8\u6bd4\u4f7f\u7528\u70ed\u6c34\u70f9\u996a\uff0c\u53ef\u4f9d\u8352\u8282\u9ca3\u9c7c\u5e72\u9ad8\u6c64\uff1e\u67af\u8282\u9ca3\u9c7c\u5e72\u9ad8\u6c64\uff1e\u5c0f\u719f\u9c7c\u5e72\u9ad8\u6c64\uff1e\u6d77\u5e26\u9ad8\u6c64\uff1e\u9999\u83c7\u9ad8\u6c64\u7684\u987a\u5e8f\u4e25\u683c\u6291\u5236\u9e21\u8089\u4e2dCML\u7684\u751f\u6210<sup>(11)<\/sup>\u3002<\/p>\n<p><img loading=\"lazy\" class=\"aligncenter size-full wp-image-12842\" src=\"http:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_16_03.jpg\" alt=\"\" width=\"600\" height=\"316\" srcset=\"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_16_03.jpg 600w, https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/glycation-stress_16_03-300x158.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<h6 style=\"text-align: center;\"><strong>\u56fe3.\u4f7f\u7528\u4e0d\u540c\u70f9\u996a\u65b9\u6cd5\u65f6\u725b\u8089\u4e2d\u7684AGEs\u751f\u6210\u91cf(Uribarri J,&nbsp;<em>et al.<\/em>&nbsp;(2010)<sup>(10)<\/sup>)<br><\/strong>\u4f7f\u7528\u918b(A)\u6216\u67e0\u6aac\u6c41(B)\uff0c\u5c06\u725b\u808925g\u5728150\u2103\u4e0b\u70e4\u523615\u5206\u949f<br>1.\u725b\u8089(\u751f)<br>2.\u4e0d\u4f7f\u7528\u918b\u6216\u67e0\u6aac\u6c41\u70e4\u5236\u725b\u8089<br>3.\u4f7f\u7528\u918b\u6216\u67e0\u6aac\u6c4110mL\u814c\u52361\u5c0f\u65f6\u540e\u70e4\u5236<\/h6>\n<p>\u6b64\u5916\uff0c\u4f17\u6240\u5468\u77e5\uff0c\u514b\u91cc\u7f8e\u51c0(Kremezine)\u662f\u6291\u5236\u81b3\u98df\u6765\u6e90AGEs\u5728\u4f53\u5185\u5438\u6536\u7684\u836f\u54c1\u3002\u514b\u91cc\u7f8e\u51c0\u662f\u53e3\u670d\u836f\u7269\uff0c\u5b83\u662f\u5c06\u6765\u81ea\u77f3\u6cb9\u70c3\u7684\u7403\u5f62\u5fae\u7c92\u591a\u5b54\u78b3\u5728\u9ad8\u6e29\u4e0b\u8fdb\u884c\u6c27\u5316\u53ca\u8fd8\u539f\u5904\u7406\u5236\u5f97\u7684\u7403\u5f62\u5438\u9644\u78b3\uff0c\u5176\u4f7f\u7528\u76ee\u7684\u662f\u901a\u8fc7\u5728\u6d88\u5316\u9053\u5185\u5438\u9644\u6162\u6027\u80be\u8870\u7aed\u60a3\u8005\u7684\u5c3f\u6bd2\u75c7\u6bd2\u7d20\uff0c\u4f7f\u5176\u968f\u7caa\u4fbf\u4e00\u540c\u6392\u51fa\u4f53\u5916\uff0c\u4ee5\u4fbf\u6539\u5584\u75c7\u72b6\u548c\u5ef6\u7f13\u5bfc\u5165\u900f\u6790\u3002\u7cd6\u5c3f\u75c5\u80be\u75c5\u60a3\u8005\u4ee56g\/\u5929\u5242\u91cf\u8fde\u7eed\u670d\u75283\u4e2a\u6708\u514b\u91cc\u7f8e\u51c0\u7684\u8bd5\u9a8c\u7ed3\u679c\u8bc1\u5b9e\uff0c\u8840\u6db2\u4e2d\u7684CML\u91cf\u6709\u6240\u4e0b\u964d<sup>(12)<\/sup>\u3002\u8fd8\u8868\u660e\u4e86\uff0c\u4f5c\u4e3a\u94c1\u7ed3\u5408\u86cb\u767d\u7684\u4e73\u94c1\u86cb\u767d\u5177\u6709AGEs\u7ed3\u5408\u6027\uff0c\u56e0\u6b64\u82e5\u5c06\u5176\u968f\u540c\u81b3\u98df\u6444\u5165\uff0c\u6216\u8bb8\u53ef\u4ee5\u6355\u6349\u6d88\u5316\u9053\u5185\u7684AGEs\uff0c\u5e76\u5c06\u5176\u6392\u51fa\u4f53\u5916<sup>(13)<\/sup>\u3002<\/p>\n<p>\u5982\u4e0a\u6240\u8ff0\uff0c\u98df\u54c1\u4e2d\u7684AGEs\u53ef\u80fd\u7ea6\u67097\uff05\u4f1a\u6b8b\u7559\u5728\u5065\u5eb7\u4eba\u4f53\u5185\u3002\u800c\u80be\u529f\u80fd\u4e0b\u964d\u7684\u7cd6\u5c3f\u75c5\u60a3\u8005\u5411\u5c3f\u6db2\u6392\u6cc4AGEs\u7684\u529f\u80fd\u4e0b\u964d\uff0c\u56e0\u6b64\u9700\u8981\u6ce8\u610f\u907f\u514d\u6444\u5165\u9ad8AGEs\u98df\u7269\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u98df\u54c1\u7684\u52a0\u70ed\u70f9\u996a\u6216\u52a0\u5de5\u4f1a\u901a\u8fc7\u8d4b\u4e88\u98df\u7269\u98ce\u5473\u548c\u8272\u6cfd\u6765\u6539\u5584\u5473\u9053\uff0c\u8fdb\u800c\u63d0\u9ad8\u50a8\u5b58\u7a33\u5b9a\u6027\u3002\u98df\u54c1\u4e2d\u751f\u6210\u7684AGEs\u91cf\u6216\u8bb8\u53ef\u4ee5\u901a\u8fc7\u9009\u62e9\u539f\u6599\u548c\u70f9\u996a\u65b9\u6cd5\u6765\u51cf\u5c11\uff0c\u6240\u9009\u539f\u6599\u53ef\u80fd\u662fAGEs\u5438\u9644\u6392\u6cc4\u539f\u6599\u3002\u56e0\u6b64\uff0c\u5728\u5e94\u5bf9\u98df\u54c1\u4e2dAGEs\u7684\u5f71\u54cd\u65f6\uff0c\u9700\u8981\u4ece\u996e\u98df\u751f\u6d3b\u6574\u4f53\u8003\u8651\u3002<\/p>\n<div class=\"ref_css\">\n<h5>References<\/h5>\n<ol class=\"ref_css\">\n<li style=\"list-style-type: none;\">\n<ol>\n<li>\u672c\u9593\u6e05\u4e00\uff1a\u65e5\u672c\u6804\u990a\u30fb\u98df\u7ce7\u5b66\u4f1a\u8a8c. 2005; 2: 85-98.<\/li>\n<li>\u672c\u9593\u6e05\u4e00\uff1a\u6fb1\u7c89\u79d1\u5b66, 1991 ; 1 : 73-79.<\/li>\n<li>\u6728\u82d7\u76f4\u79c0\uff1aAGEs\u3068\u8001\u5316, \u30e1\u30c7\u30a3\u30ab\u30eb\u30ec\u30d3\u30e5\u30fc\u793e, 2013 ; 39 : 37-46.<\/li>\n<li>Assar S.H.&nbsp;<i>et al.<\/i>&nbsp;: Amino Acids, 2009; 36: 317-326.<\/li>\n<li>Luevano-Contreras C et al\uff1aNutrients, 2010; 2: 1247-1265.<\/li>\n<li>Foerster A,&nbsp;<i>et al.<\/i>\uff1aBiochem Soc Trans, 2003; 31: 1383-1385.<\/li>\n<li>Uribarri J,&nbsp;<i>et al.<\/i>\uff1aAm J Kidney Dis, 2003; 42: 532-538.<\/li>\n<li>Koschinsky T,&nbsp;<i>et al.<\/i>\uff1aProc Natl Acad Sci USA, 1997; 94: 6474-6479.<\/li>\n<li>Uribarri J,&nbsp;<i>et al.<\/i>\uff1aAnn. N.Y. Acad. Sci, 2005; 1043: 461\u2013466.<\/li>\n<li>Uribarri J,&nbsp;<i>et al.<\/i>\uff1aAm Diet Assoc. 2010; 110(6): 911\u2013916.<\/li>\n<li>\u5c71\u7530\u3000\u6f64\u3089\uff1a2014\u5e74\u5ea6\u65e5\u672c\u8abf\u7406\u5b66\u4f1a\u8b1b\u6f14\u8981\u65e8<\/li>\n<li>Ueda S,&nbsp;<i>et al.<\/i>\uff1aMol Med, 2008; 2(7-8): 180-184.<\/li>\n<li>\u4e95\u4e0a\u6d69\u7fa9, \u98df\u54c1\u5de5\u696d, 2008; 6: 26-31.<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/div>\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<h5><strong>\u7cd6\u5316\u5e94\u6fc0\u548c\u6297\u8870\u8001<\/strong><\/h5>\n\n\n\n<ul><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_01\/\">\u4ec0\u4e48\u662f\u7cd6\u5316\u5e94\u6fc0\uff1f<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_02\">\u7cd6\u5316\u5e94\u6fc0\u6807\u5fd7\u7269\u7684\u68c0\u6d4b\u65b9\u6cd5(1)\u3000\u8840\u7cd6\u3001\u7cd6\u5316\u86cb\u767d\u3001\u7cd6\u5316\u53cd\u5e94\u4e2d\u95f4\u4f53\u7684\u68c0\u6d4b<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_03\">\u7cd6\u5316\u5e94\u6fc0\u6807\u5fd7\u7269\u7684\u68c0\u6d4b\u65b9\u6cd5(2)\u3000AGEs\u7684\u68c0\u6d4b<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_04\">\u7cd6\u5316\u5e94\u6fc0\u6807\u5fd7\u7269\u7684\u68c0\u6d4b\u65b9\u6cd5(3)\u3000\u6297\u7cd6\u5316\u4f5c\u7528\u8bc4\u4ef7<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_05\">\u7cd6\u5316\u5e94\u6fc0\u548cAGEs\u53d7\u4f53<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_06\">\u7cd6\u5316\u5e94\u6fc0\u4e0e\u80be\u75be\u75c5<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_07\/\">\u7cd6\u5316\u5e94\u6fc0\u548c\u76ae\u80a4\u8001\u5316<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_08\">\u7cd6\u5316\u5e94\u6fc0\u4e0e\u52a8\u8109\u786c\u5316<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_09\">\u7cd6\u5316\u5e94\u6fc0\u548c\u7cbe\u795e\u5206\u88c2\u75c7<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_10\">\u7cd6\u5316\u5e94\u6fc0\u4e0e\u809d\u75c5<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_11\">\u7cd6\u5316\u5e94\u6fc0\u4e0e\u4e0d\u5b55\u75c7<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_12\">\u7cd6\u5316\u5e94\u6fc0\u4e0e\u963f\u5c14\u5179\u6d77\u9ed8\u75c7<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_13\/\">\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56(1)\u3000\u8840\u7cd6\u63a7\u5236<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_14\/\">\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56(2)\u3000\u7cd6\u5316\u53cd\u5e94\u7684\u6291\u5236<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_15\/\">\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56(3)\u3000AGEs\u7684\u964d\u89e3\u548c\u6392\u6cc4<\/a><\/li><li>\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56(4)\u3000\u81b3\u98df\u6765\u6e90\u7684AGEs<\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_17\/\">\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56\u7684\u8bfe\u9898\u548c\u5c55\u671b<\/a><\/li><\/ul>\n\n\n\n<hr 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