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2015\u5e74\uff0c\u4ee5\u6291\u5236\u7cd6\u5316\u4e3a\u7740\u773c\u70b9\u7684\u918b\u996e\u6599\u201c\u9910\u524d\u918b\u996e\u6599\uff08\u98df\u3079\u308b\u524d\u306e\u3046\u308b\u308b\u9162\uff09\u201d\uff08\u517b\u547d\u9152\u5236\u9020\uff09\u5728\u5168\u56fd\u7684\u8d85\u5e02\u548c\u4fbf\u5229\u5e97\u5f00\u59cb\u9500\u552e\u3002\u800c\u4e14\uff0c\u5728\u5927\u578b\u5206\u9500\u5546\u6c38\u65fa\u96c6\u56e2\u5411\u5ba2\u6237\u63d0\u4f9b\u7684\u4f1a\u5458\u6742\u5fd7\u300amomu\u300b\u4e2d\uff0c\u7279\u522b\u520a\u767b\u4e86\u6297\u7cd6\u5316\u751f\u6d3b\u65b9\u5f0f\u5bf9\u9884\u9632\u8870\u8001\u7684\u610f\u4e49\u3002\u6b64\u5916\uff0cAGEs\u6d4b\u91cf\u4fc3\u8fdb\u59d4\u5458\u4f1a\u8fd8\u53d1\u5e03\u4e86\u300aexAGEs\u624b\u518c\u300b\uff0c\u5176\u4e2d\u89e3\u91ca\u4e86\u81b3\u98df\u6765\u6e90\u7684AGEs\u6444\u5165\u7684\u5f71\u54cd\u4ee5\u53ca\u51cf\u5c11\u6444\u5165\u91cf\u7684\u65b9\u6cd5\u3002\u8be5\u624b\u518c\u8fd8\u63d0\u8bf7\u5927\u5bb6\u6ce8\u610f\u81b3\u98df\u7531\u6765\u7684\u5916\u6e90\u6027AGEs\u7684\u5f71\u54cd\u3002<\/p>\n

\u622a\u6b62\u81f32016\u5e74\uff0c\u8bb8\u591a\u533b\u7597\u4ece\u4e1a\u8005\u548c\u7814\u7a76\u4eba\u5458\u5728\u5b66\u672f\u8bba\u6587\u3001\u4e66\u7c4d\u548c\u5065\u5eb7\u4fe1\u606f\u6742\u5fd7\u4e0a\u53d1\u8868\u4e86\u610f\u89c1\u76f8\u53cd\u7684\u5b66\u8bf4\uff0c\u5373\u9650\u5236\u7cd6\u7c7b\u6444\u5165\u662f\u201c\u5371\u9669\u7684\u201d\u8fd8\u662f\u201c\u6709\u7528\u7684\u201d(10-11)<\/sup>\u3002\u5728\u5411\u666e\u901a\u6d88\u8d39\u8005\u6b63\u786e\u4f20\u8fbe\u7cd6\u5316\u7684\u5f71\u54cd\u548c\u6297\u7cd6\u5316\u7684\u610f\u4e49\u7684\u57fa\u7840\u4e0a\uff0c\u63d0\u4f9b\u6709\u5173\u63a7\u7cd6\uff0c\u7279\u522b\u662f\u6709\u5173\u9910\u540e\u9ad8\u8840\u7cd6\u7684\u6291\u5236\u4f5c\u7528\u7684\u6b63\u786e\u4fe1\u606f\u6210\u4e3a\u4e86\u4e00\u4e2a\u8bfe\u9898\u3002\u540c\u6837\uff0c\u6574\u7406\u6709\u5173\u6291\u5236\u751f\u7269\u4f53\u5185AGEs\u7684\u84c4\u79ef\u3001\u51cf\u5c11\u5916\u6e90\u6027AGE\u7684\u4fe1\u606f\u4e5f\u6210\u4e3a\u4e86\u8bfe\u9898\u3002\u666e\u901a\u6d88\u8d39\u8005\u5bf9\u201c\u7cd6\u5316\u201d\u548c\u201c\u6297\u7cd6\u5316\u201d\u8fd9\u4e9b\u8bcd\u7684\u8ba4\u77e5\u7a0b\u5ea6\u5df2\u8fbe\u5230\u7ea630\uff05(12)<\/sup>\u3002\u672a\u6765\uff0c\u6211\u4eec\u9700\u8981\u901a\u4fd7\u6613\u61c2\u5730\u5411\u666e\u901a\u6d88\u8d39\u8005\u63d0\u4f9b\u7cd6\u5316\u4e0e\u8870\u8001\u3001\u5404\u79cd\u75be\u75c5\u4e4b\u95f4\u7684\u5173\u7cfb\uff0c\u5e76\u63d0\u4f9b\u89e3\u51b3\u7cd6\u5316\uff08\u6297\u7cd6\u5316\uff09\u7684\u4ea7\u54c1\u548c\u670d\u52a1\u3002<\/p>\n\n\n

\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56\u7684\u8bfe\u9898<\/strong><\/h3>\n\n\n
    \n
  1. \u7cd6\u5316\u5e94\u6fc0\u7684\u68c0\u6d4b\u548c\u8bc4\u4ef7<\/strong><\/li>\n

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    \u7cd6\u5316\u53cd\u5e94\u4e2d\u95f4\u4f53\u65e0\u6cd5\u5728\u4f53\u68c0\u4e2d\u6d4b\u91cf\u3002\u8840\u6db2\u4e2d\u76843DG\u53ef\u4ee5\u5728\u67d0\u4e9b\u4e34\u5e8a\u68c0\u67e5\u4e2d\u5fc3\uff08SRL\uff09\u4e2d\u4f5c\u4e3a\u7814\u7a76\u68c0\u67e5\u8fdb\u884c\u6d4b\u91cf\u3002 3DG\u3001\u4e59\u4e8c\u919b\u548c\u7532\u57fa\u4e59\u4e8c\u919b\u53ef\u4ee5\u901a\u8fc7\u9884\u6807\u8bb0HPLC\u6cd5\u8fdb\u884c\u6d4b\u91cf\uff0c\u56e0\u6b64\u5728\u5927\u5b66\u548c\u7814\u7a76\u673a\u6784\u4e2d\u4e5f\u53ef\u4ee5\u8fdb\u884c\u6d4b\u91cf(14)<\/sup>\u3002\u7136\u800c\uff0c\u5b58\u5728\u8bf8\u5982\u6837\u54c1\u9884\u5904\u7406\u6761\u4ef6\u548c\u6807\u8bb0\u540e\u6837\u54c1\u5b58\u50a8\u7a33\u5b9a\u6027\u7b49\u95ee\u9898\u3002\u7532\u57fa\u4e59\u4e8c\u919b\u53ef\u4ee5\u901a\u8fc7\u5e02\u9762\u4e0a\u9500\u552e\u7684\u57fa\u4e8eELISA\u6cd5\u7684\u6d4b\u91cf\u8bd5\u5242\u76d2\uff08Cosmobio\uff09\u8fdb\u884c\u6d4b\u91cf\u3002<\/p>\n

    AGEs\u4e2d\uff0c\u8840\u6db2\u4e2d\u620a\u7cd6\u7d20\u7684\u68c0\u6d4b\u4f5c\u4e3a\u65e9\u671f\u80be\u75c5\u7684\u8bca\u65ad\u6807\u5fd7\u7269\u9002\u7528\u4e8e\u533b\u4fdd\uff0c\u53ef\u4ee5\u5728\u4e34\u5e8a\u68c0\u67e5\u4e2d\u5fc3\uff08LSI Medience\uff09\u8fdb\u884c\u6d4b\u91cf\u3002\u6b64\u5916\uff0c\u620a\u7cd6\u7d20\u3001CML\u548cCEL\u7684ELISA\u6d4b\u91cf\u8bd5\u5242\u76d2\u53ef\u4ece\u591a\u5bb6\u516c\u53f8\uff08\u4f0f\u89c1\u5236\u836f\uff0cCosmobio\uff0cBML\uff0cNikken Seil\u7b49\uff09\u8d2d\u5f97\uff0c\u5e76\u7528\u4e8e\u7814\u7a76\u3002 Toxic AGEs\uff08TAGE\uff1aglyceraldehyde-derived AGEs\uff09\u5df2\u7531\u4e00\u4e9b\u7814\u7a76\u673a\u6784\uff08\u8f6c\u57fa\u56e0\u7b49\uff09\u8fdb\u884c\u4e86\u59d4\u6258\u6d4b\u91cf\u3002AGEs\u5927\u591a\u901a\u8fc7ELISA\u6cd5\u6d4b\u91cf\uff0c\u4f46\u662f\u5373\u4f7fAGEs\u6d4b\u91cf\u503c\u76f8\u540c\uff0c\u56e0\u6240\u7528\u6297\u4f53\u7279\u5f02\u6027\u7684\u5dee\u5f02\u548c\u6837\u54c1\u7684\u9884\u5904\u7406\u6761\u4ef6\u4e0d\u540c\uff0c\u6d4b\u91cf\u503c\u4e5f\u4f1a\u6709\u6240\u4e0d\u540c\u3002\u5c24\u5176\u662f\u5bf9\u4e8e\u8840\u6db2\u4e2d\u620a\u7cd6\u7d20\uff0c\u7531\u4e8eELISA\u6cd5\u548cHPLC\u6cd5\u7684\u9884\u5904\u7406\u65b9\u6cd5\u4e0d\u540c\u800c\u5bfc\u81f4\u6d4b\u91cf\u503c\u5b58\u5728\u5dee\u5f02\uff0c\u8fd9\u5df2\u6210\u4e3a\u4e86\u4e00\u4e2a\u8bfe\u9898(15)<\/sup>\u3002<\/p>\n

    \u53ef\u4ee5\u4f7f\u7528AGE Reader\uff08DiagnOptics\uff09\u6d4b\u91cf\u76ae\u80a4\u4e2dAGEs\u7684\u84c4\u79ef\u91cf\u3002 AGE Reader\u662f\u4e00\u79cd\u975e\u5e38\u7b80\u4fbf\u7684\u8bbe\u5907\uff0c\u5b83\u53ef\u4ee5\u5149\u5b66\u5730\u975e\u4fb5\u5165\u5f0f\u5730\u6d4b\u91cf\u5177\u6709\u8367\u5149\u6027\u7684AGEs\u3002\u7136\u800c\uff0c\u8be5\u6d4b\u91cf\u8bbe\u5907\u7f3a\u4e4f\u5bf9\u6d4b\u91cf\u503c\u7684\u6821\u51c6\u529f\u80fd\uff0c\u5e76\u4e14\u8bbe\u5907\u95f4\u5dee\u5f02\u7684\u6821\u6b63\u4e5f\u662f\u4e00\u4e2a\u8bfe\u9898\u3002\u76ee\u524d\uff0c\u65e5\u672c\u6709\u591a\u5bb6\u5bb6\u7528\u7535\u5668\u5236\u9020\u5546\u6b63\u5728\u5f00\u53d1\u8bbe\u5907\uff0c\u590f\u666e\u8ba1\u5212\u57282016\u5e74\u79cb\u5b63\u53d1\u5e03\u7b2c\u4e00\u6b3e\u56fd\u4ea7\u4ea7\u54c1(16)<\/sup>\u3002<\/p>\n

    \u8981\u4f7f\u7528AGEs\u8bc4\u4ef7\u7cd6\u5316\u5e94\u6fc0\uff0c\u5c31\u6709\u5fc5\u8981\u5f04\u6e05\u695a\u54ea\u4e9bAGEs\u4e0e\u8870\u8001\u7684\u5404\u79cd\u73b0\u8c61\u548c\u5404\u79cd\u75be\u75c5\u6709\u5173\u3002\u5f53\u524d\uff0c\u8bba\u6587\u7b49\u4e2d\u5f88\u591a\u90fd\u6d4b\u91cf\u5e76\u62a5\u544a\u4e86AGEs\u662f\u620a\u7cd6\u7d20\u548cCML\u3002\u4f46\u662f\uff0c\u8fd9\u4e24\u79cdAGEs\u5bb9\u6613\u6d4b\u91cf\uff0c\u6240\u4ee5\u88ab\u6311\u9009\u4e86\u51fa\u6765\uff0c\u56e0\u6b64\u5c1a\u4e0d\u6e05\u695a\u5b83\u4eec\u4e0e\u5176\u4ed6AGEs\u76f8\u6bd4\u5728\u751f\u7269\u4f53\u5185\u662f\u5426\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002\u5c06\u6765\u7684\u8bfe\u9898\u662f\uff0c\u5728\u8bc4\u4ef7\u7cd6\u5316\u5e94\u6fc0\u5bf9\u751f\u7269\u4f53\u7684\u5f71\u54cd\u65f6\uff0c\u7814\u53d1\u9488\u5bf9\u5404\u79cdAGE\u7684\u51c6\u786e\u800c\u7b80\u5355\u7684\u6d4b\u91cf\u65b9\u6cd5\uff0c\u4ee5\u53ca\u5728\u516c\u5f00\u8fd9\u4e9b\u6d4b\u91cf\u65b9\u6cd5\u7684\u540c\u65f6\uff0c\u666e\u53ca\u5ec9\u4ef7\u4e14\u5feb\u901f\u7684\u6d4b\u91cf\u670d\u52a1\u3002<\/p>\n

  2. \u6297\u7cd6\u5316\u539f\u6599<\/strong><\/li>\n

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    \u5f00\u53d1\u51fa\u4e86\u8bb8\u591a\u98df\u54c1\u548c\u5316\u5986\u54c1\u539f\u6599\u4f5c\u4e3a\u6291\u5236\u7cd6\u5316\u53cd\u5e94\u4e2d\u95f4\u4f53\u548cAGEs\u751f\u6210\u7684\u539f\u6599\u3002\u98df\u54c1\u539f\u6599\u6709\u201c\u590d\u65b9\u8349\u836f\u63d0\u53d6\u7269(\u4ea7\u54c1\u540d\u79f0\uff1aAG Herb MIX)\u201d(\u7231\u79d1\u6765)\u3001\u201c\u7d2b\u83ca\u82b1\u201d (Unial)\u3001\u201c\u6a31\u82b1\u63d0\u53d6\u7269\u201d(Oryza\u6cb9\u5316)\u3001\u201c\u5c71\u7af9\u63d0\u53d6\u7269\u201d(\u65e5\u672c\u65b0\u836f)\u3001\u201c\u4e18\u89d2\u83f1\u679c\u76ae\u63d0\u53d6\u7269\u201d(\u6797\u517c\u4ea7\u4e1a)\u3001\u201c\u590d\u65b9\u8349\u836f\u8336\u63d0\u53d6\u7269\u201d\uff08AntiAging Communication)\u7b49\uff0c\u5177\u6709\u5728\u5404\u4e2a\u90e8\u4f4d\u6291\u5236\u590d\u6742\u591a\u8def\u5f84\u7684\u7cd6\u5316\u53cd\u5e94\u7684\u4f5c\u7528(18)<\/sup>\u3002\u5df2\u7ecf\u8bc1\u5b9e\uff0c\u8fd9\u4e9b\u539f\u6599\u53ef\u4ee5\u901a\u8fc7\u53e3\u670d\u6765\u6291\u5236\u8840\u6db2\u548c\u76ae\u80a4\u4e2dAGEs\u7684\u751f\u6210\u548c\u84c4\u79ef\u3002\u5316\u5986\u54c1\u539f\u6599\u6709\u201c\u6b27\u6d32\u4e03\u53f6\u6811\u63d0\u53d6\u7269\u201d\u201c \u5927\u8f66\u524d\u63d0\u53d6\u7269\u201d(\u4e00\u4e38\u81ea\u7136\u7f8e\u5065)\u3001\u201c\u73ab\u7470\u63d0\u53d6\u7269\u201d(\u65e5\u51b7)\u3001\u201c \u79ef\u96ea\u8349\u63d0\u53d6\u7269\u201d\u201cPterocarpus marsupium\u6811\u76ae\u63d0\u53d6\u7269\u201d(\u677e\u672c\u4ea4\u5546)\u7b49\uff0c\u5bf9\u76ae\u80a4\u86cb\u767d\u8d28\u7684\u7cd6\u5316\u5177\u6709\u6291\u5236\u4f5c\u7528\u3002\u53e6\u5916\uff0c\u5316\u5986\u54c1\u4e2d\u6240\u542b\u7684\u7cd6\u5316\u53cd\u5e94\u6291\u5236\u539f\u6599\uff0c\u901a\u5e38\u662f\u7531\u5404\u4e2a\u5236\u9020\u5546\u72ec\u7acb\u7814\u7a76\u5f00\u53d1\u7684\u539f\u59cb\u539f\u6599\u3002\u5176\u4e2d\u5305\u62ec\u201c\u73ab\u7470\u63d0\u53d6\u7269\u201d(\u4e09\u7701\u5236\u836f)\u3001\u201cAlsage\u201d(\u4e50\u6566\u5236\u836f)\u3001\u201c\u7d2b\u82cf\u63d0\u53d6\u7269\u201d(\u8d44\u751f\u5802)\u7b49\u3002\u7cd6\u5316\u53cd\u5e94\u6291\u5236\u539f\u6599\u88ab\u8ba4\u4e3a\u662f\u9632\u6b62AGEs\u751f\u6210\u548c\u9884\u9632\u7cd6\u5316\u5e94\u6fc0\u7684\u63aa\u65bd\u3002<\/p>\n

    \u4f46\u662f\uff0c\u4e5f\u6709\u9884\u8ba1\u53ef\u5bf9\u5df2\u84c4\u79ef\u7684AGEs\u8fdb\u884c\u5206\u89e3\u4f5c\u7528\u7684\u6297\u7cd6\u5316\u539f\u6599\u3002 2009\u5e74POLA\u7814\u53d1\u7684B.A. The Cream\u4e2d\u542b\u6709\u8be5\u516c\u53f8\u7684\u539f\u59cb\u539f\u6599\u201c\u4e94\u6708\u827e\u63d0\u53d6\u7269”\uff0c\u5df2\u8868\u660e\u5b83\u53ef\u4ee5\u5206\u89e3\u548c\u4fee\u590d\u7531\u4e8e\u86cb\u767d\u8d28\u4e2dAGEs\u7684\u4ea7\u751f\u800c\u5f62\u6210\u7684\u4ea4\u8054\u7ed3\u6784\u3002\u540c\u6837\uff0c\u8fd8\u786e\u8ba4\u4e86\u201c\u7ebf\u72b6\u963f\u53f8\u5df4\u62c9\u59a5\u63d0\u53d6\u7269\u201d\u548c\u201c\u7d2b\u4e91\u82f1\u63d0\u53d6\u7269\u201d(Pola)\u5177\u6709\u7c7b\u4f3c\u7684\u6548\u679c\u3002\u62a5\u544a\u663e\u793a\uff0c\u8fd9\u4e9b\u5316\u5986\u54c1\u539f\u6599\u5728\u5206\u89e3\u80f6\u539f\u86cb\u767d\u51dd\u80f6\u4e0a\u751f\u6210\u7684AGEs\u7684\u540c\u65f6\uff0c\u8fde\u7eed\u4f7f\u7528\u542b\u6709\u8fd9\u4e9b\u6210\u5206\u7684\u5316\u5986\u54c1\u8fd8\u80fd\u51cf\u5c11\u89d2\u8d28\u5c42\u4e2d\u7684AGEs(19)<\/sup>\u3002\u6b64\u5916\uff0c\u8fd8\u786e\u8ba4\u4e86\u5316\u5986\u54c1\u539f\u6599\u201c\u828d\u836f\u63d0\u53d6\u7269\u201d(\u4e00\u4e38\u81ea\u7136\u7f8e\u5065)\u4e5f\u6709\u7c7b\u4f3c\u7684\u6548\u679c\u3002 \u8fd8\u6709\u62a5\u544a\u663e\u793a\u4e86\u5728\u8336\u3001\u8349\u836f\u548c\u852c\u83dc\u7b49\u98df\u54c1\u539f\u6599\u4e2d\u4e5f\u6709AGEs\u7684\u4ea4\u8054\u5206\u89e3\u4f5c\u7528\u3002\u5df2\u7ecf\u8bc1\u5b9e\u77f3\u69b4\u679c\u5b9e\u4e2d\u5177\u6709AGEs\u7684\u4ea4\u8054\u5206\u89e3\u4f5c\u7528\uff0c\u62a5\u544a\u663e\u793a\u8fd9\u4e0e\u97a3\u82b1\u5355\u5b81\u7684\u4e09\u7f9f\u57fa\u82ef\u7ed3\u6784\u6709\u5173(\u56fe2)(20)<\/sup>\u3002\u4f46\u662f\uff0c\u5c1a\u4e0d\u6e05\u695a\u5728\u7ecf\u53e3\u6444\u53d6\u65f6\u7684\u6548\u679c\u3002 \u4eba\u4eec\u671f\u5f85AGEs\u7684\u4ea4\u8054\u5206\u89e3\u4f5c\u7528\u5bf9\u5df2\u7ecf\u84c4\u79ef\u7684AGEs\u6709\u5206\u89e3\/\u6392\u6cc4\u4f5c\u7528\uff0c\u56e0\u6b64\u671f\u671b\u5176\u5c06\u6765\u53ef\u4ee5\u4f5c\u4e3a\u5bf9\u6297\u7cd6\u5316\u5e94\u6fc0\u7684\u63aa\u65bd\u3002<\/p>\n

    \"\"<\/p>\n

    \u56fe<\/strong>2.<\/strong>\u77f3\u69b4\u4e2d\u7684<\/strong>AGEs<\/strong>\u4ea4\u8054\u5206\u89e3\u6210\u5206
    <\/strong>\uff08\u6539\u7f16\u81eaYagi M et al.<\/em>(2015)(20)<\/sup>)<\/h6>\n

    \u8fd1\u6765\uff0c\u4eba\u4eec\u6b63\u5728\u8003\u8651\u5e94\u7528\u6c27\u5316\u86cb\u767d\u6c34\u89e3\u9176(oxidized protein hydrolase\uff1aOPH)\uff0c\u5b83\u662f\u4e00\u79cd\u53ef\u80fd\u53c2\u4e0e\u751f\u7269\u4f53\u5185\u7cd6\u5316\u86cb\u767d\u548cAGEs\u5206\u89e3\u7684\u9176\u3002 OPH\u53ef\u4ee5\u8bc6\u522b\u5728\u86cb\u767d\u8d28\u548c\u80bd\u7684N\u672b\u7aef\u7684\u4fee\u9970\u57fa\u56e2\uff08\u9170\u57fa\u3001\u4e59\u9170\u57fa\u7b49\uff09\uff0c\u7136\u540e\u91ca\u653e\u5e76\u5206\u89e3\u4fee\u9970\u57fa\u56e2(21)<\/sup>\u3002\u5b83\u8fd8\u4f5c\u7528\u4e8eCML\u5316\u7684\u86cb\u767d\u8d28\u5206\u89e3(22)<\/sup>\u3002 OPH\u8fd8\u5b58\u5728\u4e8e\u89d2\u8d28\u5c42\u4e2d\uff0c\u5176\u6d3b\u6027\u968f\u5e74\u9f84\u800c\u964d\u4f4e(23)<\/sup>\u3002\u4f46\u662f\uff0c\u89d2\u8d28\u5c42CML\u968f\u5e74\u9f84\u589e\u52a0\u3002 \u5404\u79cd\u8336\u3001\u836f\u8349\u7b49\u5df2\u88ab\u8bc1\u660e\u662f\u589e\u5f3aOPH\u6d3b\u6027\u7684\u6709\u6548\u6210\u5206\u3002\u5e0c\u671b\u5c06\u6765\u53ef\u4ee5\u9610\u8ff0OPH\u7684\u4f5c\u7528\u673a\u7406\uff0c\u540c\u65f6\u901a\u8fc7\u589e\u5f3aOPH\u6d3b\u6027\u6765\u4fc3\u8fdbAGEs\u7684\u5206\u89e3\u4f5c\u7528\u3002<\/p>\n

    \u4eba\u4eec\u8ba4\u4e3a\u6297\u7cd6\u5316\u539f\u6599\u7684\u5173\u952e\u5728\u4e8e\u5b83\u4eec\u7684\u4f5c\u7528\u548c\u539f\u6599\u7684\u7ec4\u5408\u3002\u5173\u4e8e\u4f5c\u7528\u65b9\u9762\uff0c\u5fc5\u987b\u91c7\u53d6\u63aa\u65bd\uff0c\u901a\u8fc7\u7ec4\u5408\u8840\u7cd6\u5bf9\u7b56\u3001\u6291\u5236AGEs\u751f\u6210\u3001AGEs\u5206\u89e3\u7b49\uff0c\u6765\u5bf9\u6574\u4e2a\u7cd6\u5316\u5e94\u6fc0\u53d1\u751f\u4f5c\u7528\u3002\u8fd8\u9700\u8981\u91c7\u53d6\u63aa\u65bd\u89e3\u51b3\u52a0\u901f\u7cd6\u5316\u5e94\u6fc0\u7684\u56e0\u7d20\uff0c\u4f8b\u5982\u6c27\u5316\u3001\u7d2b\u5916\u7ebf\u3001\u8102\u8d28\u8fc7\u5269\u3001\u5438\u70df\u3001\u9152\u7cbe\uff08\u559d\u9152\uff09\u3001\u538b\u529b\u7b49\u3002\u53e6\u5916\uff0c\u4ece\u751f\u7269\u4f53\u7684\u5185\u90e8\u548c\u5916\u90e8\u91c7\u53d6\u63aa\u65bd\u4e5f\u5f88\u91cd\u8981\uff0c\u9700\u8981\u5c06\u5316\u5986\u54c1\u548c\u98df\u7269\u7ed3\u5408\u8d77\u6765\uff08\u56fe3\uff09\u3002<\/p>\n

    \"\"<\/p>\n

    \u56fe<\/strong> 3<\/strong>\uff0e\u7cd6\u5316\u5e94\u6fc0\u6291\u5236\u539f\u6599\u7684\u4f5c\u7528\u8bc4\u4ef7\u8981\u70b9
    <\/strong>\u7ea2\u7ebf\u548c\u84dd\u7ebf\u663e\u793a\u4e86\u6bcf\u4e2a\u9879\u76ee\u7684\u8bc4\u4f30\u503c\u793a\u4f8b\u3002
    \u9910\u540e\u9ad8\u8840\u7cd6\u6291\u5236\uff1a\u6dc0\u7c89\u9176\u6291\u5236\u4f5c\u7528\u3001\u03b1\u8461\u8404\u7cd6\u82f7\u9176\u6291\u5236\u4f5c\u7528
    \u6297\u7cd6\u5316\u6d3b\u6027\uff1a \u8367\u5149\u6027AGEs\u751f\u6210\u6291\u5236\u4f5c\u7528
    \u5404\u79cdAGEs\u751f\u6210\u6291\u5236\uff1a 3DG\u751f\u6210\u6291\u5236\u4f5c\u7528\u3001 CML\u751f\u6210\u6291\u5236\u4f5c\u7528\u3001 \u620a\u7cd6\u7d20\u751f\u6210\u6291\u5236\u4f5c\u7528
    AGEs\u5206\u89e3\u6027\uff1a AGEs\u4ea4\u8054\u5207\u65ad\u4f5c\u7528
    OPH\u6d3b\u6027\u5316\uff1a OPH\u6d3b\u6027\u589e\u5f3a\u4f5c\u7528
    \u4e34\u5e8a\u6027\u8bc4\u4ef7(\u4eba\u4f53\u4e34\u5e8a\u5b9e\u9a8c) \u3000\u3000\u9910\u540e\u9ad8\u8840\u7cd6\u503c\uff1a \u9910\u540e\u8840\u7cd6\u503c\u68c0\u6d4b
    \u7cd6\u5316\u53cd\u5e94\u4e2d\u95f4\u4f53\uff1a \u8840\u6db2\u4e2d3DG\u68c0\u6d4b
    AGEs: \u8840\u6db2\u4e2dCML\u68c0\u6d4b,\u3001\u8840\u6db2\u4e2d\u620a\u7cd6\u7d20\u68c0\u6d4b
    \u89d2\u8d28\u5c42AGEs\uff1a \u89d2\u8d28\u5c42CML\u68c0\u6d4b
    \u76ae\u80a4AGEs\u84c4\u79ef\uff1a \u76ae\u80a4AGEs\u6765\u6e90\u8367\u5149\u68c0\u6d4b<\/h6>\n

    \u5728\u7ec4\u5408\u539f\u6599\u65f6\uff0c\u7ec4\u5408\u5404\u79cd\u7269\u8d28\u6765\u6291\u5236\u7cd6\u5316\u53cd\u5e94\u7cfb\u7edf\uff0c\u9632\u6b62AGEs\u7684\u751f\u6210\u548c\u84c4\u79ef\uff0c\u5e76\u901a\u8fc7\u63a5\u89e6\u5404\u79cd\u86cb\u767d\u8d28\u6765\u51cf\u5c11\u5168\u8eab\u7684AGEs\uff0c\u901a\u8fc7\u8fd9\u4e9b\u65b9\u6cd5\u5e94\u8be5\u53ef\u4ee5\u51cf\u5c11\u7cd6\u5316\u5e94\u6fc0\u3002<\/p>\n<\/ol>\n

    \n
    References<\/h5>\n
      \n
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      1. \u4e26\u6728\u6e80\u592b\u3089\uff1a\u5316\u5b66\u3068\u751f\u7269\uff0e1983\uff1b21\uff1a368-380.<\/li>\n
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      3. Rabbani N, et al.<\/i>\uff1aAmino Acids. 2012\uff1b42\uff1a1087\u20131096.<\/li>\n
      4. Rahbar S\uff1aClin Chim Acta. 1968\uff1b22\uff1a296\u2013298.<\/li>\n
      5. Tahara Y, et al.<\/i>\uff1aDiabetes Care\uff0e1995\uff1b18\uff1a441-447.<\/li>\n
      6. Bolton WK, et al.<\/i>\uff1aAm J Nephrol, 2004\uff1b24\uff1a32-40.<\/li>\n
      7. Nakamura S, et al.<\/i>\uff1aDiabetes\uff0e1997\uff1b46\uff1a895\u2013899.<\/li>\n
      8. \u91d1\u672c\u90c1\u592b\u3089\uff1a\u7cd6\u5c3f\u75c5\uff0e2010\uff1b53\uff1a96-101.<\/li>\n
      9. \u4eca\u4e95\u4f50\u6075\u5b50\u3089\uff1a\u7cd6\u5c3f\u75c5\uff0e2010\uff1b53\uff1a112-115.<\/li>\n
      10. Noto H, et al.<\/i>\uff1aPLoS ONE 8(1)\uff1ae55030. doi:10.1371\/journal.pone.0055030.<\/li>\n
      11. Shai I, et al.<\/i>\uff1aN Engl J Med. 2008\uff1b359\uff1a229-341.<\/li>\n
      12. AGE\u6e2c\u5b9a\u63a8\u9032\u5354\u8b70\u4f1a\uff1a\u30cb\u30e5\u30fc\u30b9\u30ea\u30ea\u30fc\u30b9\uff0e2014\u5e7411\u670827\u65e5
        http:\/\/www.age-sokutei.jp\/news\/parts\/pdf\/20141127.pdf<\/a><\/li>\n
      13. Benjamin EM\uff1aClinical Diabetes. 2002\uff1b20\uff1a45-47.<\/li>\n
      14. Kusunoki H, et al.<\/i>\uff1aDiabetes Care. 2003\uff1b26\uff1a1889-1894.<\/li>\n
      15. Nakano M, et al.<\/i>\uff1aAnti-Aging Medicine. 2010\uff1b7\uff1a92-93.<\/li>\n
      16. \u5c71\u4e2d\u5e79\u5b8f\uff1a\u7b2c10\u56de\u7cd6\u5316\u30b9\u30c8\u30ec\u30b9\u7814\u7a76\u4f1a\u8b1b\u6f14\u8981\u65e8\uff0e2016\uff1b6.<\/li>\n
      17. \u85e4\u539f\u548c\u54c9\u3089\uff1a\u7cd6\u5c3f\u75c5\u306e\u6700\u65b0\u6cbb\u7642. 2010\uff1b2\uff1a6-15.<\/li>\n
      18. \u516b\u6728\u96c5\u4e4b\u3089\uff1a\u98df\u54c1\u3068\u958b\u767a. 2013\uff1b48\uff1a4-7.<\/li>\n
      19. \u591a\u7530\u660e\u5f18\uff1aCOSMETIC STAGE. 2011\uff1b5\uff1a33-38.<\/li>\n
      20. Yagi M, et al.<\/i>\uff1aGlycative Stress Research. 2015\uff1b2\uff1a58-66.<\/li>\n
      21. Krishna RG, et al.<\/i>\uff1aProtein Science. 1992\uff1bI\uff1a582-589.<\/li>\n
      22. \u516b\u6728\u96c5\u4e4b\u3089\uff1a\u7b2c13\u56de\u65e5\u672c\u6297\u52a0\u9f62\u533b\u5b66\u4f1a\u7dcf\u4f1a\u30d7\u30ed\u30b0\u30e9\u30e0\u6284\u9332\u96c6\uff0e2013\uff1a253.<\/li>\n
      23. \u77f3\u795e\u653f\u9053\u3089\uff1a\u7b2c16\u56de\u65e5\u672c\u6297\u52a0\u9f62\u533b\u5b66\u4f1a\u7dcf\u4f1a\u30d7\u30ed\u30b0\u30e9\u30e0\u6284\u9332\u96c6\uff0e2016\uff1a219.<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/div>\n\n\n
        \n\n\n\n
        \u7cd6\u5316\u5e94\u6fc0\u548c\u6297\u8870\u8001<\/strong><\/h5>\n\n\n\n