{"id":249,"date":"2010-05-10T19:00:32","date_gmt":"2010-05-10T10:00:32","guid":{"rendered":"http:\/\/ebn.jpn.org\/?page_id=249"},"modified":"2020-11-24T12:17:07","modified_gmt":"2020-11-24T03:17:07","slug":"glycation-stress_01","status":"publish","type":"page","link":"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_01\/","title":{"rendered":"\u4ec0\u4e48\u662f\u7cd6\u5316\u5e94\u6fc0\uff1f"},"content":{"rendered":"\n<h2>\u4ec0\u4e48\u662f\u7cd6\u5316\u5e94\u6fc0\uff1f<\/h2>\n\n\n<p class=\"author\">\u540c\u5fd7\u793e\u5927\u5b66\u5927\u5b66\u9662 \u751f\u547d\u533b\u79d1\u5b66\u7814\u7a76\u79d1 \u7cd6\u5316\u5e94\u6fc0\u7814\u7a76\u4e2d\u5fc3<br>\u516b\u6728\u96c5\u4e4b \u6559\u6388 \u4e3b\u7f16<\/p>\n\n\n<h3><strong>\u7cd6\u5316\u548c AGEs<\/strong><\/h3>\n\n\n<p>\u7cd6\u5316\uff08glycation\uff09\u662f\u6cd5\u56fd\u79d1\u5b66\u5bb6 Maillard \u4e8e 1912 \u5e74\u53d1\u73b0\u7684\u4e00\u79cd\u6c28\u57fa\u9178\u3001\u86cb\u767d\u8d28\u548c\u8fd8\u539f\u7cd6\u7684\u975e\u9176\u4fc3\u5316\u5b66\u53cd\u5e94\uff0c\u53c8\u79f0\u4e3a\u7f8e\u62c9\u5fb7\uff08Maillard\uff09\u53cd\u5e94 <sup>(1<\/sup><sup>\uff09<\/sup>\u3002<\/p>\n<p>\u7cd6\u5316\u662f\u4e0e\u98df\u7269\u52a0\u70ed\u8fc7\u7a0b\u4e2d\u53d1\u751f\u7684\u989c\u8272\u3001\u6c14\u5473\u548c\u5473\u9053\u7684\u53d8\u5316\uff0c\u4ee5\u53ca\u50a8\u5b58\u8fc7\u7a0b\u4e2d\u8425\u517b\u4ef7\u503c\u964d\u4f4e\u7684\u76f8\u5173\u53cd\u5e94\uff0c\u56e0\u6b64\u5728\u98df\u54c1\u5316\u5b66\u9886\u57df\u4e00\u76f4\u5907\u53d7\u5173\u6ce8 <sup>(<\/sup><sup>2<\/sup><sup>\uff09<\/sup>\u3002\u6b64\u5916\uff0c\u4eba\u8840\u4e2d\u7684\u7cd6\u5316\u53cd\u5e94\u4ea7\u7269\u8840\u7ea2\u86cb\u767d A1c\uff08HbA1c\uff09\u7684\u68c0\u6d4b\u4f5c\u4e3a\u8840\u7cd6\u63a7\u5236\u6307\u6807\uff0c\u88ab\u4e34\u5e8a\u5e94\u7528\u4e8e\u7cd6\u5c3f\u75c5\u6cbb\u7597\u9886\u57df\u3002<\/p>\n<p>\u4f17\u6240\u5468\u77e5\uff0c\u5728\u4f53\u5185\uff0c\u7cd6\u5316\u4e0d\u4ec5\u53d1\u751f\u5728\u8840\u7ea2\u86cb\u767d\u4e2d\uff0c\u8fd8\u53d1\u751f\u5728\u767d\u86cb\u767d\u3001\u89d2\u86cb\u767d\u3001\u7403\u86cb\u767d\u548c\u80f6\u539f\u86cb\u767d\u7b49\u5404\u79cd\u86cb\u767d\u4e2d\uff0c\u7ecf\u8fc7\u4ee5 3-\u8131\u6c27\u8461\u7cd6\u919b\u916e\uff083-deoxyglucosone : 3Dg\uff09\u3001\u4e59\u4e8c\u919b\uff08glyoxsal : Go\uff09\u3001\u7532\u57fa\u4e59\u4e8c\u919b\uff08methylglyoxsal : MGO\uff09\u3001\u7518\u6cb9\u919b\uff08glyceraldehyde\uff09\u3001\u4e59\u9187\u919b\uff08glycolaldehyde\uff09\u7b49\u7fb0\u57fa\u5316\u5408\u7269\u4e3a\u4e3b\u7684\u4e2d\u95f4\u4ea7\u7269\uff0c\u6700\u7ec8\u751f\u6210\u7cd6\u57fa\u5316\u7ec8\u672b\u4ea7\u7269\uff08advanced glycation endproducts : AGEs\uff09\u3002<\/p>\n<p>AGEs\u5728\u5176\u751f\u6210\u8fc7\u7a0b\u4e2d\u7684\u7279\u5f81\u662f\u68d5\u8910\u8272\u3001\u53d1\u8367\u5149\uff08\u4e3b\u8981\u4e3a\u6fc0\u53d1\u6ce2\u957f 370 nm\u3001\u53d1\u5c04\u6ce2\u957f 440 nm\uff09\uff08\u56fe1\uff09\u3001\u86cb\u767d\u4ea4\u8054\u7279\u6027\uff0c\u4f46\u8fd9\u4e9b\u7279\u5f81\u7684\u6709\u65e0\u56e0\u6bcf\u79cd\u7269\u8d28\u4e0d\u540c\u800c\u5f02\u3002<\/p>\n<p><img loading=\"lazy\" class=\"size-full wp-image-12657 aligncenter\" src=\"http:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/stress-figure01_zh.jpg\" alt=\"\" width=\"373\" height=\"227\" srcset=\"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/stress-figure01_zh.jpg 373w, https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/stress-figure01_zh-300x183.jpg 300w\" sizes=\"(max-width: 373px) 100vw, 373px\" \/><\/p>\n<h6 style=\"text-align: center;\"><strong>\u56fe\uff11\u3000\u4eba\u8840\u6e05\u767d\u86cb\u767d<\/strong><strong>&#8211;<\/strong><strong>\u8461\u8404\u7cd6\u53cd\u5e94\u4e2d<\/strong><strong> AGEs <\/strong><strong>\u7684\u8367\u5149\u5149\u8c31<br><\/strong>\u4eba\u8840\u6e05\u767d\u86cb\u767d\uff088 mg\/mL\uff09+ 0.05 mol\/L\u78f7\u9178\u76d0\u7f13\u51b2\u6db2\uff08pH 7.4\uff09+ \u8461\u8404\u7cd6\uff080.2 mol\/L\uff09\uff08\u5b9e\u7ebf\uff09<br>\u6216\u4e0d\u542b\u8461\u8404\u7cd6\uff08\u865a\u7ebf\uff09\u7684\u6eb6\u6db2\u5728 60 \u2103\u4e0b\u57f9\u517b 40 \u5c0f\u65f6\uff0c \u5e76\u5728\u6fc0\u53d1\u6ce2\u957f 370 nm \u4e0b\u6d4b\u5b9a\u8367\u5149\u5149\u8c31<\/h6>\n<p>\u8367\u5149\u6027 AGEs \u4e2d\u542b\u6709\u620a\u7cd6\u7d20\uff08pentosidine : \u6fc0\u53d1\u6ce2\u957f\uff08ex\uff09335 nm \/ \u53d1\u5c04\u6ce2\u957f\uff08em\uff09385 nm\uff09<sup>(3\uff09<\/sup>\u3001\u4ea4\u8054\u7d20\uff08crossline : ex 379 nm \/ em 463 nm\uff09<sup>(4\uff09<\/sup>\u548c\u5421\u54af\u5421\u5576\uff08pyrropyridine : ex 370 nm \/ em 455 nm\uff09<sup>(5\uff09<\/sup>\u7b49\u3002\u975e\u8367\u5149\u6027 AGEs \u4e2d\u542b\u6709 N\u03b5-(carboxymethyl)lysine\uff08CML\uff09<sup>(6\uff09<\/sup>\u3001 N\u03c9-(carboxymethyl) arginine\uff08CMA\uff09<sup>(7\uff09<\/sup>\u7b49\u3002\u620a\u7cd6\u7d20\u3001\u4ea4\u8054\u7d20\u4e3a\u4ea4\u8054\u6027 AGEs \u3002<\/p>\n\n\n<h3>\u7cd6\u5316\u5e94\u6fc0<\/h3>\n\n\n<p>\u7cd6\u5316\u5e94\u6fc0\u662f\u4e00\u4e2a\u7efc\u5408\u5730\u56ca\u62ec\u4e86\u7531\u8fd8\u539f\u7cd6\u3001\u919b\u8d1f\u8377\u5bf9\u751f\u7269\u4f53\u4ea7\u751f\u7684\u5e94\u6fc0\u53ca\u5176\u540e\u7eed\u53cd\u5e94\u7684\u6982\u5ff5\uff08\u56fe2\uff09\u3002<\/p>\n<p><img loading=\"lazy\" class=\"aligncenter wp-image-12658 size-full\" src=\"http:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/stress-figure02_zh.png\" alt=\"\" width=\"592\" height=\"408\" srcset=\"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/stress-figure02_zh.png 592w, https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/stress-figure02_zh-300x207.png 300w\" sizes=\"(max-width: 592px) 100vw, 592px\" \/><\/p>\n<h6 style=\"text-align: center;\"><strong>\u56fe\uff12\u3000\u7cd6\u5316\u5e94\u6fc0\u6982\u5ff5\u56fe<br><\/strong>3DG : 3-\u8131\u6c27\u8461\u7cd6\u919b\u3001 GO : \u4e59\u4e8c\u919b\u3001 MG : \u7532\u57fa\u4e59\u4e8c\u919b\u3001 GA : \u7518\u6cb9\u919b\u3001<br>CML : \u7fa7\u7532\u57fa\u8d56\u6c28\u9178\u3001 CMA : \u7fa7\u7532\u57fa\u7cbe\u6c28\u9178<\/h6>\n<p>\u72ed\u4e49\u7684\u7cd6\u5316\u662f\u6307\u901a\u8fc7\u8fd8\u539f\u7cd6\u548c\u86cb\u767d\u7684\u975e\u9176\u4fc3\u53cd\u5e94\uff0c\u7ecf\u8fc7\u5e2d\u592b\uff08Schiff\uff09\u78b1\u7684\u5f62\u6210\u3001\u7cd6\u5316\u86cb\u767d\u3001\u5404\u79cd\u4e2d\u95f4\u4f53\u7684\u5f62\u6210\uff0c\u6700\u7ec8\u751f\u6210 AGEs \u7684\u53cd\u5e94\u7cfb\u7edf\u3002\u8be5\u53cd\u5e94\u4f1a\u5f15\u8d77\u7ec4\u7ec7\u86cb\u767d\u53d8\u6027\uff0c\u5e76\u5bfc\u81f4\u529f\u80fd\u964d\u4f4e\u3002<\/p>\n<p>\u53e6\u4e00\u65b9\u9762\uff0c\u4f53\u5185\u8102\u8d28\u7684\u03b2\u6c27\u5316\u548c\u8fc7\u6c27\u5316\u8fd8\u4f1a\u4ea7\u751f\u919b\u57fa\u548c\u916e\u57fa\u3002\u5f53\u7535\u5b50\u88ab\u5438\u5f15\u5230\u5177\u6709\u7535\u8d1f\u6027\u8f83\u9ad8\u7684\u6c27\u539f\u5b50\u4e0a\u65f6\uff0c\u5b58\u5728\u4e8e\u919b\u6216\u916e\u5206\u5b50\u4e2d\u7684\u7fb0\u57fa\u88ab\u6781\u5316\uff0c\u78b3\u539f\u5b50\u66f4\u6613\u53d7\u5230\u4eb2\u6838\u653b\u51fb\u3002\u6b64\u5916\uff0c\u5f53\u8fd9\u4e9b\u5b98\u80fd\u56e2\u4e0e\u6784\u6210\u8d56\u6c28\u9178\u548c\u7cbe\u6c28\u9178\u7b49\u7684\u86cb\u767d\u8d28\u4e0d\u53ef\u63a7\u5236\u5730\u53cd\u5e94\u65f6\uff0c\u86cb\u767d\u8d28\u7684\u529f\u80fd\u53d7\u635f\u3002<\/p>\n<p>\u5e76\u4e14\uff0c\u5982\u679c\u7ec6\u80de\u5185\u5b58\u5728\u8fc7\u91cf\u7684\u8461\u8404\u7cd6\uff0c\u5219 TCA \u5faa\u73af\u53cd\u5e94\u53d8\u5dee\uff0c\u5bfc\u81f4\u5bcc\u9a6c\u9178\u589e\u591a<sup>(8<\/sup><sup>\uff09<\/sup><sup>(9<\/sup><sup>\uff09<\/sup>\u3002\u5bcc\u9a6c\u9178\u4e0e\u6784\u6210\u86cb\u767d\u8d28\u7684\u6c28\u57fa\u9178\uff08\u534a\u80f1\u6c28\u9178\uff09\u8fdb\u884c\u53cd\u5e94\uff0c\u5f62\u6210 S-\uff082-succinyl\uff09cysteine\uff082SC\uff09\u7b49\u3002\u8be5\u53cd\u5e94\u88ab\u79f0\u4e3a\u7425\u73c0\u9170\u5316\uff0c\u7531\u4e8e\u86cb\u767d\u7684\u7425\u73c0\u9170\u5316\u5bfc\u81f4\u529f\u80fd\u964d\u4f4e\u6216\u4e27\u5931\uff0c\u4ece\u800c\u5f15\u8d77\u673a\u4f53\u5931\u8c03\u3002\u8fdb\u884c\u7425\u73c0\u9170\u5316\u7684\u751f\u7269\u4f53\u5185\u7684\u86cb\u767d\u4e2d\uff0c\u5305\u62ec\u7ec6\u80de\u9aa8\u67b6\u86cb\u767d\u3001\u70ed\u4f11\u514b\u86cb\u767d<sup>(8<\/sup><sup>\uff09<\/sup>\u548c\u8102\u8054\u7d20<sup>(9<\/sup><sup>\uff09<\/sup>\u7b49\u3002<\/p>\n<p>\u53e6\u5916\uff0c\u84c4\u79ef\u5728\u7ec4\u7ec7\u5185\u7684 AGEs \u4e0e AGEs \u53d7\u4f53\u7684RAGE\uff08Receptor for AGEs\uff09\u7ed3\u5408\uff0c\u6fc0\u6d3b\u7ec6\u80de\u4fe1\u53f7\uff0c\u5e76\u8bf1\u5bfc\u4ea7\u751f\u708e\u6027\u7ec6\u80de\u56e0\u5b50<sup>(10<\/sup><sup>\uff09<\/sup>\u3002 RAGE \u901a\u8fc7\u7ec6\u80de\u5185\u4fe1\u53f7\u8f6c\u5bfc\u4ea7\u751f\u7ec6\u80de\u5e94\u7b54\uff0c\u5e76\u5728\u53d1\u75c5\u8fc7\u7a0b\u4e2d\u4f5c\u4e3a AGE \u53d7\u4f53\u53d1\u6325\u4f5c\u7528<sup>(11<\/sup><sup>\uff09<\/sup>\u3002<\/p>\n<p>\u9664AGEs \u5916\uff0c\u4e0e RAGE \u7ed3\u5408\u7684\u914d\u4f53\u5305\u62ec\uff1a\u6c27\u5316\u635f\u4f24\u4ea7\u7269\u4e14\u662f\u6c27\u5316\u5e94\u6fc0\u4ecb\u8d28\u4e4b\u4e00\u7684 advanced oxidation protein products\uff08AOPP\uff09\u3001\u56e0\u963f\u5c14\u5179\u6d77\u9ed8\u75c7\u800c\u5728\u8111\u5185\u84c4\u79ef\u7684\u03b2-\u6dc0\u7c89\u6837\u86cb\u767d\u3001\u56e0\u5bb6\u65cf\u6027\u6dc0\u7c89\u6837\u591a\u53d1\u6027\u795e\u7ecf\u75c5\u800c\u84c4\u79ef\u7684 transthyretin\u3001\u8ba4\u4e3a\u4e0e\u764c\u75c7\u8f6c\u79fb\u548c\u708e\u75c7\u6709\u5173\u7684 High mobility group B-1 \uff08HMGB-1\uff09\/amphoterin\u3001\u708e\u75c7\u4ecb\u8d28S100\u86cb\u767d\u4ee5\u53ca\u767d\u7ec6\u80de\u8868\u9762\u7684 Mac13\u3002\u6b64\u5916\uff0c\u5728 AGEs \u4e2d\uff0c\u8ba4\u4e3a CML\u3001\u7518\u6cb9\u919b\uff08glyceraldehyde\uff09\u548c\u4e59\u9187\u919b\uff08glycolaldehyde\uff09\u6539\u6027\u5242\u7684 RAGE \u7ed3\u5408\u6027\u8f83\u9ad8<sup>(12\uff09<\/sup>\u3002<\/p>\n<p style=\"text-align: left;\">\u7cd6\u5316\u5e94\u6fc0\u662f\u4fc3\u8fdb\u86cb\u767d\u529f\u80fd\u969c\u788d\u3001\u86cb\u767d\u53d8\u6027\uff08\u7ffb\u8bd1\u540e\u4fee\u9970\uff09\u3001\u5e9f\u7269\u5806\u79ef\u3001 TCA \u5faa\u73af\u969c\u788d\u3001\u7ec6\u80de\u5185\u4fe1\u53f7\u6fc0\u6d3b\u548c\u7ec4\u7ec7\u635f\u4f24\u8bf1\u5bfc\u53ca\u5e74\u9f84\u76f8\u5173\u6027\u9000\u884c\u6027\u6539\u53d8\u7b49\u7684\u56e0\u7d20\u3002\u800c\u4e14\uff0c\u7d2b\u5916\u7ebf\u548c\u6c27\u5316\u5e94\u6fc0\u88ab\u5b9a\u4f4d\u4e3a\u52a0\u901f\u7cd6\u5316\u5e94\u6fc0\u7684\u56e0\u7d20\u3002<\/p>\n\n\n<h3>\u6297\u8870\u8001\u533b\u5b66\u4e2d\u7684\u7cd6\u5316\u5e94\u6fc0<\/h3>\n\n\n<p>\u4eba\u4f53\u7684\u4e3b\u8981\u80fd\u91cf\u6e90\u662f\u98df\u7269\u4e2d\u7684\u78b3\u6c34\u5316\u5408\u7269\uff0c\u56e0\u6b64\u4e00\u751f\u4e2d\u65e0\u6cd5\u907f\u514d\u8840\u7cd6\uff08\u8461\u8404\u7cd6\uff09\u548c\u86cb\u767d\u95f4\u53d1\u751f\u7684\u7cd6\u5316<sup>(13<\/sup><sup>\uff09<\/sup>\u3002\u8fd9\u4e00\u4e8b\u5b9e\u56e0\u6b63\u5e38\u4eba\u76ae\u80a4\u7684\u80f6\u539f\u4e2d AGEs \u84c4\u79ef\u91cf\u968f\u5e74\u9f84\u7684\u589e\u52a0\u800c\u589e\u52a0\uff0c\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u84c4\u79ef\u91cf\u9ad8\u4e8e\u540c\u9f84\u6b63\u5e38\u4eba<sup>(14<\/sup><sup>\uff09<\/sup>\uff0c\u4ee5\u53ca\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u76ae\u80a4\u5f39\u6027\u4f4e\u4e8e\u975e\u7cd6\u5c3f\u75c5\u60a3\u8005<sup>(15<\/sup><sup>\uff09<\/sup>\u7b49\u800c\u53d8\u5f97\u66f4\u52a0\u6e05\u6670\u660e\u4e86\u3002<\/p>\n<p>\u7cd6\u5316\u5f15\u8d77\u7684 AGEs \u7684\u751f\u6210\u548c\u84c4\u79ef\uff0c\u4e0d\u4ec5\u4e0e\u7cd6\u5c3f\u75c5\u5e76\u53d1\u75c7\u6709\u5173\uff0c\u800c\u4e14\u4e0e\u76ae\u80a4\u8870\u8001<sup>(16<\/sup><sup>\uff09<\/sup>\u3001\u963f\u5c14\u5179\u6d77\u9ed8\u75c7<sup>(17<\/sup><sup>\uff09<\/sup>\u3001\u9ad8\u8840\u538b<sup>(18<\/sup><sup>\uff09<\/sup>\u3001\u52a8\u8109\u786c\u5316<sup>(19<\/sup><sup>\uff09<\/sup>\u548c\u9aa8\u8d28\u758f\u677e<sup>(20<\/sup><sup>\uff09<\/sup>\u7b49\u7684\u8fdb\u5c55\u6709\u5173\u3002\u7279\u522b\u662f\u76ae\u80a4\u3001\u9aa8\u9abc\u3001\u8f6f\u9aa8\u7b49\u80f6\u539f\u7ec4\u7ec7\u7684 AGEs \u5316\u4f34\u6709\u7ec4\u7ec7\u68d5\u8272\u5316\u548c\u5f39\u6027\u964d\u4f4e\uff0c\u56e0\u6b64\u5728\u7f8e\u5bb9\u548c\u5065\u5eb7\u9886\u57df\u5907\u53d7\u5173\u6ce8\u3002<\/p>\n<p>\u6297\u8870\u8001\u533b\u5b66\u662f\u4e00\u79cd\u9884\u9632\u533b\u5b66\uff0c\u662f\u65e8\u5728\u6539\u5584\u751f\u6d3b\u8d28\u91cf\uff08quality of life : QOL\uff09\u548c\u5065\u5eb7\u957f\u5bff\u7684\u7814\u7a76<sup>(21<\/sup><sup>\uff09<\/sup>\u3002\u4eba\u4f53\u7684\u8870\u8001\u8868\u73b0\u5305\u62ec\uff1a\u8840\u7ba1\u7684\u8001\u5316\uff08\u52a8\u8109\u786c\u5316\uff09\u3001\u795e\u7ecf\u7684\u8001\u5316\uff08\u75f4\u5446\u3001\u963f\u5c14\u5179\u6d77\u9ed8\u75c7\uff09\u548c\u9aa8\u9abc\u7684\u8001\u5316\uff08\u9aa8\u8d28\u758f\u677e\uff09\u7b49\u3002\u4f46\u5b58\u5728\u4e2a\u4f53\u5dee\u5f02\uff0c\u5e76\u4e14\u6bcf\u4e2a\u4e2a\u4f53\u5177\u6709\u7684\u8870\u8001\u98ce\u9669\u56e0\u7d20\u4e5f\u5404\u4e0d\u76f8\u540c\u3002<\/p>\n<p>\u56e0\u6b64\uff0c\u5728\u6297\u8870\u8001\u4f53\u68c0\u4e2d\uff0c\u5c06\u8870\u8001\u7a0b\u5ea6\uff08\u673a\u80fd\u5e74\u9f84\uff09\u5206\u4e3a\u808c\u8089\u5e74\u9f84\u3001\u8840\u7ba1\u5e74\u9f84\u3001\u795e\u7ecf\u5e74\u9f84\u3001\u6fc0\u7d20\u5e74\u9f84\u548c\u9aa8\u9f84\u8fdb\u884c\u8bc4\u4f30<sup>(22\uff09<\/sup>\u3002\u6b64\u5916\uff0c\u5c06\u4e0e\u673a\u80fd\u964d\u4f4e\u76f8\u5173\u7684\u56e0\u7d20\u5b9a\u4f4d\u4e3a\u8870\u8001\u98ce\u9669\u56e0\u7d20\uff0c\u5e76\u5206\u4e3a\u514d\u75ab\u5e94\u6fc0\u3001\u6c27\u5316\u5e94\u6fc0\u3001\u8eab\u5fc3\u5e94\u6fc0\u3001\u7cd6\u5316\u5e94\u6fc0\u548c\u751f\u6d3b\u4e60\u60ef\u8fdb\u884c\u8bc4\u4f30\uff08\u56fe3\uff09<\/p>\n<p><img loading=\"lazy\" class=\"aligncenter wp-image-12941 size-full\" src=\"http:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/stress-figure03_zh.png\" alt=\"\" width=\"686\" height=\"359\" srcset=\"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/stress-figure03_zh.png 686w, https:\/\/ebn2.arkray.co.jp\/chinese\/wp-content\/uploads\/sites\/2\/2020\/11\/stress-figure03_zh-300x157.png 300w\" sizes=\"(max-width: 686px) 100vw, 686px\" \/><\/p>\n<h6 style=\"text-align: center;\"><strong>\u56fe\uff13\u3000\u6297\u8870\u8001\u4f53\u68c0\u4e2d\u7684\u8870\u8001\u8bc4\u4f30<\/strong><\/h6>\n<p>\u6297\u8870\u8001\u4f53\u68c0\u7684\u8bc4\u4f30\u7ed3\u679c\uff0c\u96c6\u4e2d\u5728\u8870\u8001\u7a0b\u5ea6\u6700\u9ad8\u7684\u9879\u76ee\u548c\u8870\u8001\u98ce\u9669\u56e0\u7d20\u6700\u5927\u7684\u9879\u76ee\uff0c\u65e8\u5728\u7ea0\u6b63\u4e25\u91cd\u8870\u8001\u7684\u9879\u76ee\uff0c\u4f7f\u8870\u8001\u7a0b\u5ea6\u6574\u4f53\u5e73\u8861\u3002<\/p>\n<p>\u6297\u8870\u8001\u533b\u5b66\u4e2d\u7684\u7cd6\u5316\u5e94\u6fc0\uff0c\u4f5c\u4e3a\u5168\u9762\u638c\u63e1\u8fd8\u539f\u7cd6\u548c\u919b\u8d1f\u8377\u5bf9\u751f\u7269\u4f53\u4ea7\u751f\u7684\u5e94\u6fc0\u53ca\u5176\u540e\u7eed\u53cd\u5e94\u7684\u5f71\u54cd\uff0c\u88ab\u8ba4\u4e3a\u662f\u8870\u8001\u7684\u98ce\u9669\u56e0\u7d20\u4e4b\u4e00\u3002<\/p>\n<div class=\"ref_css\">\n<h5>References<\/h5>\n<ol class=\"ref_css\">\n<li style=\"list-style-type: none;\">\n<ol>\n<li>Maillard LC. Compt Rend Acad Sci (Paris). 1912; 154: 66-68.<\/li>\n<li>Friedman M. J Agric Food Chem. 1996; 44: 631-653.<\/li>\n<li>Sell DR, <i>et al.<\/i> : J Biol Chem. 1989; 264: 21597-21602.<\/li>\n<li>Obayashi H, <i>et al.<\/i> : Biochem Biophys Res Commun. 1996; 226: 37-41.<\/li>\n<li>Hayase F. Food Science and Technology Research. 2000; 6: 79-86.<\/li>\n<li>Ahmed MU, <i>et al.<\/i> : J Biol Chem. 1986; 261: 4889-4894.<\/li>\n<li>Iijima K, <i>et al.<\/i> : Biochem J. 2000; 347: 23-27.<\/li>\n<li>Nagai R, <i>et al.<\/i> : J Biol Chem. 2007; 282: 34219-34228.<\/li>\n<li>Frizzell N, <i>et al.<\/i> : J Biol Chem. 2009; 284: 25772-25781.<\/li>\n<li>Yamagishi S, <i>et al.<\/i> : J Biol Chem. 1997; 272: 8723-8730.<\/li>\n<li>Nagai R, <i>et al.<\/i> : Anti-Aging Medicine. 2010; 7: 112-119.<\/li>\n<li>Yamamoto Y, <i>et al.<\/i> : Diabetes Res Clin Pract. 2007; 77: S30-40.<\/li>\n<li>Cerami A, <i>et al.<\/i> : Sci Am. 1987; 256: 90-96.<\/li>\n<li>Dyer DG, <i>et al.<\/i> : J Clin Invest. 1993; 91: 2463-2469.<\/li>\n<li>Kubo M, <i>et al.<\/i> : Journal of Clinical Biochemistry and Nutrition. 2008; 43(Suppl 1): 66-69.<\/li>\n<li>Reiser KM, <i>et al.<\/i> : Pros Soc Exp Biol Med. 1998; 8: 23-37.<\/li>\n<li>Reddy VP, <i>et al.<\/i> : Neurotox Res. 2002; 4: 191-209.<\/li>\n<li>Miranda TS, <i>et al.<\/i> : Hypertension. 2005; 46: 232-237.<\/li>\n<li>Brownlee M, <i>et al.<\/i> : Science. 1986; 232: 1629-1632.<\/li>\n<li>Saito M, <i>et al.<\/i> : Osteoporos Int. 2006; 17: 986-995.<\/li>\n<li>\u7c73\u4e95\u5609\u4e00. \u6297\u52a0\u9f62\u533b\u5b66\u5165\u9580 \u6539\u5b9a\u7b2c2\u7248. \u6176\u61c9\u7fa9\u587e\u5927\u5b66\u51fa\u7248\u4f1a(\u6771\u4eac) 2011.<\/li>\n<li>\u5409\u5ddd\u654f\u4e00(\u76e3\u4fee). \u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u30c9\u30c3\u30af. \u8a3a\u65ad\u3068\u6cbb\u7642\u793e(\u6771\u4eac) 2007.<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/div>\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<h5>\u7cd6\u5316\u5e94\u6fc0\u548c\u6297\u8870\u8001<\/h5>\n\n\n\n<ul><li>\u4ec0\u4e48\u662f\u7cd6\u5316\u5e94\u6fc0\uff1f<\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_02\">\u7cd6\u5316\u5e94\u6fc0\u6807\u5fd7\u7269\u7684\u68c0\u6d4b\u65b9\u6cd5(1)\u3000\u8840\u7cd6\u3001\u7cd6\u5316\u86cb\u767d\u3001\u7cd6\u5316\u53cd\u5e94\u4e2d\u95f4\u4f53\u7684\u68c0\u6d4b<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_03\">\u7cd6\u5316\u5e94\u6fc0\u6807\u5fd7\u7269\u7684\u68c0\u6d4b\u65b9\u6cd5(2)\u3000AGEs\u7684\u68c0\u6d4b<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_04\">\u7cd6\u5316\u5e94\u6fc0\u6807\u5fd7\u7269\u7684\u68c0\u6d4b\u65b9\u6cd5(3)\u3000\u6297\u7cd6\u5316\u4f5c\u7528\u8bc4\u4ef7<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_05\">\u7cd6\u5316\u5e94\u6fc0\u548cAGEs\u53d7\u4f53<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_06\">\u7cd6\u5316\u5e94\u6fc0\u4e0e\u80be\u75be\u75c5<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_07\/\">\u7cd6\u5316\u5e94\u6fc0\u548c\u76ae\u80a4\u8001\u5316<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_08\">\u7cd6\u5316\u5e94\u6fc0\u4e0e\u52a8\u8109\u786c\u5316<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_09\">\u7cd6\u5316\u5e94\u6fc0\u548c\u7cbe\u795e\u5206\u88c2\u75c7<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_10\">\u7cd6\u5316\u5e94\u6fc0\u4e0e\u809d\u75c5<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_11\">\u7cd6\u5316\u5e94\u6fc0\u4e0e\u4e0d\u5b55\u75c7<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_12\">\u7cd6\u5316\u5e94\u6fc0\u4e0e\u963f\u5c14\u5179\u6d77\u9ed8\u75c7<\/a><\/li><li><a href=\"\/chinese\/academicinfo\/glycation-stress_13\/\">\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56(1)\u3000\u8840\u7cd6\u63a7\u5236<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_14\/\">\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56(2)\u3000\u7cd6\u5316\u53cd\u5e94\u7684\u6291\u5236<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_15\/\">\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56(3)\u3000AGEs\u7684\u964d\u89e3\u548c\u6392\u6cc4<\/a><\/li><li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_16\/\">\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56(4)\u3000\u81b3\u98df\u6765\u6e90\u7684AGEs<\/a><\/li>\n<li><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/glycation-stress_17\/\">\u7cd6\u5316\u5e94\u6fc0\u5bf9\u7b56\u7684\u8bfe\u9898\u548c\u5c55\u671b<\/a><\/li><\/ul>\n\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<p><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/academicinfo\/\">-\u5b66\u672f\u4fe1\u606f top<\/a><br><a href=\"https:\/\/ebn2.arkray.co.jp\/chinese\/\">-Top<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"\u4ec0\u4e48\u662f\u7cd6\u5316\u5e94\u6fc0\uff1f \u540c\u5fd7\u793e\u5927\u5b66\u5927\u5b66\u9662 \u751f\u547d\u533b\u79d1\u5b66\u7814\u7a76\u79d1 \u7cd6\u5316\u5e94\u6fc0\u7814\u7a76\u4e2d\u5fc3\u516b\u6728\u96c5\u4e4b \u6559\u6388 \u4e3b\u7f16 \u7cd6\u5316\u548c AGEs \u7cd6\u5316\uff08glycation\uff09\u662f\u6cd5\u56fd\u79d1\u5b66\u5bb6 &#8230;","protected":false},"author":3,"featured_media":0,"parent":9191,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-json\/wp\/v2\/pages\/249"}],"collection":[{"href":"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-json\/wp\/v2\/comments?post=249"}],"version-history":[{"count":29,"href":"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-json\/wp\/v2\/pages\/249\/revisions"}],"predecessor-version":[{"id":12943,"href":"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-json\/wp\/v2\/pages\/249\/revisions\/12943"}],"up":[{"embeddable":true,"href":"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-json\/wp\/v2\/pages\/9191"}],"wp:attachment":[{"href":"https:\/\/ebn2.arkray.co.jp\/chinese\/wp-json\/wp\/v2\/media?parent=249"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}