{"id":174,"date":"2010-03-16T10:11:53","date_gmt":"2010-03-16T01:11:53","guid":{"rendered":"http:\/\/ebn.jpn.org\/?page_id=174"},"modified":"2025-11-07T12:42:23","modified_gmt":"2025-11-07T03:42:23","slug":"biletin","status":"publish","type":"page","link":"https:\/\/ebn2.arkray.co.jp\/english\/biletin\/","title":{"rendered":"Biletin"},"content":{"rendered":"\n<h2>Biletin<\/h2>\n\n\n<div class=\"sentence\">\n<p>Biletin is a powdered material that was extracted from the pulp of juiced (squeezed) Shiikuwasha and is standardized to contain at least 10% PMF.<br>PMF (polymethoxy flavonoid) is a generic term for flavonoid compounds whose hydroxyl groups are replaced with methoxy groups.<br>Two common PMFs are nobiletin and tangeretin, the former having 6 methoxy groups and the latter having 5.<\/p>\n<h5><img loading=\"lazy\" class=\"wp-image-10526\" src=\"http:\/\/ebn2.arkray.co.jp\/english\/wp-content\/uploads\/sites\/3\/2020\/09\/\u56f31-300x86.png\" alt=\"\" width=\"500\" height=\"143\" srcset=\"https:\/\/ebn2.arkray.co.jp\/english\/wp-content\/uploads\/sites\/3\/2020\/09\/\u56f31-300x86.png 300w, https:\/\/ebn2.arkray.co.jp\/english\/wp-content\/uploads\/sites\/3\/2020\/09\/\u56f31-1024x293.png 1024w, https:\/\/ebn2.arkray.co.jp\/english\/wp-content\/uploads\/sites\/3\/2020\/09\/\u56f31-768x219.png 768w, https:\/\/ebn2.arkray.co.jp\/english\/wp-content\/uploads\/sites\/3\/2020\/09\/\u56f31.png 1393w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><br>Nobiletin and Tangeretin<\/h5>\n<p><!-- \/sentence --><\/p>\n<p>Nobiletin and tangeretin are expected to improve memory impairment (dementia etc.), allergic reactions, sugar metabolism, lipid metabolism and liver function, and inhibit melanin synthesis (lighten the skin), all of which contribute to maintaining good health.<\/p>\n<p>All of the shiikuwasha used for Biletin are produced in Okinawa.<\/p>\n<\/div>\n\n\n<h3>Applicability as an ingredient to drinks<\/h3>\n\n\n<p>PMFs are lipid-soluble and not water-soluble on their own.<\/p>\n<p>As Biletin is encapsulated in cyclic oligosaccharides when made into powder, its recommended daily amount (10 &#8211; 45 mg\/day) can be easily dissolved in water, and is suitable as an ingredient for drinks.&nbsp;<\/p>\n\n\n<h3>Effects on energy metabolism<\/h3>\n\n\n<p>Participants with deteriorating liver functions took 20 or 100 mg\/day of Biletin for 12 consecutive weeks. Their total cholesterol levels, non HDL-C, arteriosclerosis index and triglyceride decreased significantly.<\/p>\n\n\t\t<style type=\"text\/css\">\n\t\t\t#gallery-1 {\n\t\t\t\tmargin: auto;\n\t\t\t}\n\t\t\t#gallery-1 .gallery-item {\n\t\t\t\tfloat: left;\n\t\t\t\tmargin-top: 10px;\n\t\t\t\ttext-align: center;\n\t\t\t\twidth: 33%;\n\t\t\t}\n\t\t\t#gallery-1 img {\n\t\t\t\tborder: 2px solid #cfcfcf;\n\t\t\t}\n\t\t\t#gallery-1 .gallery-caption {\n\t\t\t\tmargin-left: 0;\n\t\t\t}\n\t\t\t\/* see gallery_shortcode() in wp-includes\/media.php *\/\n\t\t<\/style>\n\t\t<div id='gallery-1' class='gallery galleryid-174 gallery-columns-3 gallery-size-medium'><dl class='gallery-item'>\n\t\t\t<dt class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/ebn2.arkray.co.jp\/english\/biletin\/attachment\/nonhdl_en\/'><img width=\"300\" height=\"287\" src=\"https:\/\/ebn2.arkray.co.jp\/english\/wp-content\/uploads\/sites\/3\/2020\/09\/nonHDL_en-300x287.png\" class=\"attachment-medium size-medium\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/ebn2.arkray.co.jp\/english\/wp-content\/uploads\/sites\/3\/2020\/09\/nonHDL_en-300x287.png 300w, https:\/\/ebn2.arkray.co.jp\/english\/wp-content\/uploads\/sites\/3\/2020\/09\/nonHDL_en.png 663w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a>\n\t\t\t<\/dt><\/dl><dl class='gallery-item'>\n\t\t\t<dt class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/ebn2.arkray.co.jp\/english\/biletin\/attachment\/tc_en\/'><img width=\"300\" height=\"298\" src=\"https:\/\/ebn2.arkray.co.jp\/english\/wp-content\/uploads\/sites\/3\/2020\/09\/TC_en-300x298.png\" class=\"attachment-medium size-medium\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/ebn2.arkray.co.jp\/english\/wp-content\/uploads\/sites\/3\/2020\/09\/TC_en-300x298.png 300w, https:\/\/ebn2.arkray.co.jp\/english\/wp-content\/uploads\/sites\/3\/2020\/09\/TC_en-150x150.png 150w, https:\/\/ebn2.arkray.co.jp\/english\/wp-content\/uploads\/sites\/3\/2020\/09\/TC_en-120x120.png 120w, https:\/\/ebn2.arkray.co.jp\/english\/wp-content\/uploads\/sites\/3\/2020\/09\/TC_en.png 698w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a>\n\t\t\t<\/dt><\/dl><dl class='gallery-item'>\n\t\t\t<dt class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/ebn2.arkray.co.jp\/english\/biletin\/attachment\/triglyceride_en\/'><img width=\"300\" height=\"287\" src=\"https:\/\/ebn2.arkray.co.jp\/english\/wp-content\/uploads\/sites\/3\/2020\/09\/Triglyceride_en-300x287.png\" class=\"attachment-medium size-medium\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/ebn2.arkray.co.jp\/english\/wp-content\/uploads\/sites\/3\/2020\/09\/Triglyceride_en-300x287.png 300w, https:\/\/ebn2.arkray.co.jp\/english\/wp-content\/uploads\/sites\/3\/2020\/09\/Triglyceride_en.png 663w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a>\n\t\t\t<\/dt><\/dl><br style=\"clear: both\" \/><dl class='gallery-item'>\n\t\t\t<dt class='gallery-icon portrait'>\n\t\t\t\t<a href='https:\/\/ebn2.arkray.co.jp\/english\/biletin\/attachment\/arteriosclerosis-index_en\/'><img width=\"297\" height=\"300\" src=\"https:\/\/ebn2.arkray.co.jp\/english\/wp-content\/uploads\/sites\/3\/2020\/09\/Arteriosclerosis-index_en-297x300.png\" class=\"attachment-medium size-medium\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/ebn2.arkray.co.jp\/english\/wp-content\/uploads\/sites\/3\/2020\/09\/Arteriosclerosis-index_en-297x300.png 297w, https:\/\/ebn2.arkray.co.jp\/english\/wp-content\/uploads\/sites\/3\/2020\/09\/Arteriosclerosis-index_en-120x120.png 120w, https:\/\/ebn2.arkray.co.jp\/english\/wp-content\/uploads\/sites\/3\/2020\/09\/Arteriosclerosis-index_en.png 663w\" sizes=\"(max-width: 297px) 100vw, 297px\" \/><\/a>\n\t\t\t<\/dt><\/dl>\n\t\t\t<br style='clear: both' \/>\n\t\t<\/div>\n\n<p>Based on the above, we can expect Biletin to have beneficial properties that can lower cholesterol and triglyceride, and help prevent arteriosclerosis.<\/p>\n<p><!-- \/wp:paragraph --><\/p>\n<p><!-- wp:heading {\"level\":3} --><\/p>\n<h3>Effects on the liver function<\/h3>\n<p><!-- \/wp:heading --><\/p>\n<p>Participants with deteriorating liver functions took 20 or 100 mg\/day of Biletin for 12 consecutive weeks. Their yGTP levels decreased significantly.<br \/><img loading=\"lazy\" class=\"alignnone wp-image-10592\" src=\"http:\/\/ebn2.arkray.co.jp\/english\/wp-content\/uploads\/sites\/3\/2020\/09\/\u03b3GTP_en-300x289.png\" alt=\"\" width=\"350\" height=\"337\" srcset=\"https:\/\/ebn2.arkray.co.jp\/english\/wp-content\/uploads\/sites\/3\/2020\/09\/\u03b3GTP_en-300x289.png 300w, https:\/\/ebn2.arkray.co.jp\/english\/wp-content\/uploads\/sites\/3\/2020\/09\/\u03b3GTP_en.png 663w\" sizes=\"(max-width: 350px) 100vw, 350px\" \/><br \/>Based on the above, we can expect Biletin to have beneficial properties that can improve the liver function.<\/p>\n<p><!-- wp:heading {\"level\":3} --><\/p>\n<h3>Product Specifications<\/h3>\n<p><!-- \/wp:heading --><\/p>\n<table class=\"table_border_horizontal\" border=\"0\" cellspacing=\"0\" cellpadding=\"0\">\n<tbody>\n<tr>\n<td width=\"325\">Properties<\/td>\n<td width=\"485\">Powder, pale-brown to brown in color, <br \/>with a characteristic extract smell<\/td>\n<\/tr>\n<tr>\n<td width=\"325\">Loss on drying<\/td>\n<td width=\"485\">8% or less<\/td>\n<\/tr>\n<tr>\n<td width=\"325\">Arcenic<\/td>\n<td width=\"485\">2 ppm or less<\/td>\n<\/tr>\n<tr>\n<td width=\"325\">Heavy metals<\/td>\n<td width=\"485\">20 ppm or less<\/td>\n<\/tr>\n<tr>\n<td width=\"325\">Total viable count<\/td>\n<td width=\"485\">1,000\/g or less<\/td>\n<\/tr>\n<tr>\n<td width=\"325\">Fungi count<\/td>\n<td width=\"485\">300\/g or less<\/td>\n<\/tr>\n<tr>\n<td width=\"325\">Coliform bacteria<\/td>\n<td width=\"485\">Negative<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><!-- wp:heading {\"level\":3} --><\/p>\n<h3>Recommended daily intake<\/h3>\n<p><!-- \/wp:heading --><\/p>\n<p>10 &#8211; 45 mg\/day<\/p>\n<p><!-- wp:heading {\"level\":3} --><\/p>\n<h3>Use for<\/h3>\n<p><!-- \/wp:heading --><\/p>\n<p>Anti-metabolic syndrome, Improving lipid metabolism, Anti-inflammation<\/p>\n<p><!-- wp:heading {\"level\":3} --><\/p>\n<h3>Examples of application<\/h3>\n<p><!-- \/wp:heading --><\/p>\n<p>Supplements, beverages, etc.<\/p>\n<p><!-- wp:separator --><\/p>\n<p><!-- \/wp:paragraph --><\/p>\n<p><!-- wp:heading {\"level\":3} --><\/p>\n<h3>Download<\/h3>\n<p><!-- \/wp:heading --><\/p>\n<p><!-- wp:image {\"id\":11133,\"sizeSlug\":\"medium\",\"linkDestination\":\"none\"} --><\/p>\n<figure class=\"wp-block-image size-medium\"><a href=\"http:\/\/ebn2.arkray.co.jp\/english\/wp-content\/uploads\/sites\/3\/2020\/09\/Biletin_En.pdf\" target=\"_blank\" rel=\"nofollow noopener\"><img loading=\"lazy\" width=\"212\" height=\"300\" class=\"wp-image-11133\" src=\"https:\/\/ebn2.arkray.co.jp\/english\/wp-content\/uploads\/sites\/3\/2023\/11\/Biletin_En-212x300.png\" alt=\"\" srcset=\"https:\/\/ebn2.arkray.co.jp\/english\/wp-content\/uploads\/sites\/3\/2023\/11\/Biletin_En-212x300.png 212w, https:\/\/ebn2.arkray.co.jp\/english\/wp-content\/uploads\/sites\/3\/2023\/11\/Biletin_En-724x1024.png 724w, https:\/\/ebn2.arkray.co.jp\/english\/wp-content\/uploads\/sites\/3\/2023\/11\/Biletin_En-768x1086.png 768w, https:\/\/ebn2.arkray.co.jp\/english\/wp-content\/uploads\/sites\/3\/2023\/11\/Biletin_En-1086x1536.png 1086w, https:\/\/ebn2.arkray.co.jp\/english\/wp-content\/uploads\/sites\/3\/2023\/11\/Biletin_En-1448x2048.png 1448w, https:\/\/ebn2.arkray.co.jp\/english\/wp-content\/uploads\/sites\/3\/2023\/11\/Biletin_En.png 1654w\" sizes=\"(max-width: 212px) 100vw, 212px\" \/><\/a><\/figure>\n<p><!-- \/wp:image --><\/p>\n<p><!-- wp:separator --><\/p>\n<hr class=\"wp-block-separator\" \/><!-- \/wp:separator -->\n<p>\u00a0<\/p>\n<p><!-- wp:paragraph --><\/p>\n<p><a href=\"https:\/\/ebn2.arkray.co.jp\/english\/products\/\">-Product Information<\/a><br \/><a href=\"https:\/\/ebn2.arkray.co.jp\/english\/\">-Top<\/a><\/p>\n<p><!-- \/wp:paragraph --><\/p>","protected":false},"excerpt":{"rendered":"Biletin Biletin is a powdered material that was extracted from the pulp of &#8230;","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/ebn2.arkray.co.jp\/english\/wp-json\/wp\/v2\/pages\/174"}],"collection":[{"href":"https:\/\/ebn2.arkray.co.jp\/english\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ebn2.arkray.co.jp\/english\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ebn2.arkray.co.jp\/english\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ebn2.arkray.co.jp\/english\/wp-json\/wp\/v2\/comments?post=174"}],"version-history":[{"count":23,"href":"https:\/\/ebn2.arkray.co.jp\/english\/wp-json\/wp\/v2\/pages\/174\/revisions"}],"predecessor-version":[{"id":11177,"href":"https:\/\/ebn2.arkray.co.jp\/english\/wp-json\/wp\/v2\/pages\/174\/revisions\/11177"}],"wp:attachment":[{"href":"https:\/\/ebn2.arkray.co.jp\/english\/wp-json\/wp\/v2\/media?parent=174"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}